PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33430871-9 2021 Western-blot, immunohistochemical analysis and qPCR suggested that gastroprotective properties of lactate were mediated by its modulatory effects on the expression of the apoptosis regulator gene Bax, the apoptotic executive protein gene Casp3, and genes critical for gastric mucosal integrity, including those encoding tight junction proteins Occludin, Claudin-1, Claudin-5, and that for lactate receptor GPR81. Lactic Acid 98-105 hydrocarboxylic acid receptor 1 Mus musculus 406-411 33430871-10 2021 CONCLUSION: Lactate mitigates ethanol-induced GMI by curtailing local gastric inflammatory response, down-regulating the expression of the apoptosis regulator and executor genes Bax and Casp3, and up-regulating the expression of genes encoding tight junction proteins Occludin, Claudin-1, and Claudin-5 and the lactate receptor GPR81. Lactic Acid 12-19 hydrocarboxylic acid receptor 1 Mus musculus 328-333 32848615-10 2020 This raises the possibility that some effects of lactate on group III muscle afferents may be mediated by HCAR1. Lactic Acid 49-56 hydrocarboxylic acid receptor 1 Mus musculus 106-111 32899645-8 2020 Our data suggest that the HCA1-containing fibroblasts and ependymal cells have the ability to respond to alterations in CSF lactate in body-brain signaling, but also as a sign of neuropathology (e.g., stroke and Alzheimer"s disease biomarker). Lactic Acid 124-131 hydrocarboxylic acid receptor 1 Mus musculus 26-30 33284607-3 2020 Here we hypothesized that dietary lactate supplementation might activate GPR81 to promote adipose browning. Lactic Acid 34-41 hydrocarboxylic acid receptor 1 Mus musculus 73-78 33284607-8 2020 Collectively, our findings revealed a critical role of GPR81 in adipose browning and provided a new insight into obesity management by modulating lactate-GPR81 signaling axis. Lactic Acid 146-153 hydrocarboxylic acid receptor 1 Mus musculus 55-60 33284607-8 2020 Collectively, our findings revealed a critical role of GPR81 in adipose browning and provided a new insight into obesity management by modulating lactate-GPR81 signaling axis. Lactic Acid 146-153 hydrocarboxylic acid receptor 1 Mus musculus 154-159 31220454-4 2019 Lactate exerts its biological effects via G-protein-coupled receptor 81 (GPR81) in several tissues; however, its physiological functions and mechanisms of action in the retina remain poorly understood. Lactic Acid 0-7 hydrocarboxylic acid receptor 1 Mus musculus 73-78 32200679-1 2020 GPR81 (G-protein-coupled receptor 81) is highly expressed in adipocytes, and activation by the endogenous ligand lactate inhibits lipolysis. Lactic Acid 113-120 hydrocarboxylic acid receptor 1 Mus musculus 0-5 32200679-1 2020 GPR81 (G-protein-coupled receptor 81) is highly expressed in adipocytes, and activation by the endogenous ligand lactate inhibits lipolysis. Lactic Acid 113-120 hydrocarboxylic acid receptor 1 Mus musculus 7-36 32071396-0 2020 The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment. Lactic Acid 4-11 hydrocarboxylic acid receptor 1 Mus musculus 21-26 32071396-1 2020 GPR81 is a G-protein-coupled receptor for lactate, which is upregulated in breast cancer and plays an autocrine role to promote tumor growth by tumor cell-derived lactate. Lactic Acid 42-49 hydrocarboxylic acid receptor 1 Mus musculus 0-5 32071396-1 2020 GPR81 is a G-protein-coupled receptor for lactate, which is upregulated in breast cancer and plays an autocrine role to promote tumor growth by tumor cell-derived lactate. Lactic Acid 163-170 hydrocarboxylic acid receptor 1 Mus musculus 0-5 32071396-2 2020 Here we asked whether lactate has any paracrine role via activation of GPR81 in cells present in tumor microenvironment to help tumor growth. Lactic Acid 22-29 hydrocarboxylic acid receptor 1 Mus musculus 71-76 32071396-8 2020 Antigen-presenting dendritic cells expressed Gpr81 and activation of this receptor by lactate suppressed cell-surface presentation of MHCII. Lactic Acid 86-93 hydrocarboxylic acid receptor 1 Mus musculus 45-50 32071396-10 2020 These findings suggest that tumor cell-derived lactate activates GPR81 in dendritic cells and prevents presentation of tumor-specific antigens to other immune cells. Lactic Acid 47-54 hydrocarboxylic acid receptor 1 Mus musculus 65-70 32071396-11 2020 This paracrine mechanism is complementary to the recently discovered autocrine mechanism in which lactate induces PD-L1 in tumor cells via activation of GPR81 in tumor cells, thus providing an effective means for tumor cells to evade immune system. Lactic Acid 98-105 hydrocarboxylic acid receptor 1 Mus musculus 153-158 31999787-6 2020 Importantly, high-fat feeding upregulates expression of the lactate receptor hydroxycarboxylic acid receptor 1 (HCAR1) in female C57BL/6J mice, whereas male C57BL/6J mice show reduced HCAR1 expression in BAT. Lactic Acid 60-67 hydrocarboxylic acid receptor 1 Mus musculus 77-110 31999787-6 2020 Importantly, high-fat feeding upregulates expression of the lactate receptor hydroxycarboxylic acid receptor 1 (HCAR1) in female C57BL/6J mice, whereas male C57BL/6J mice show reduced HCAR1 expression in BAT. Lactic Acid 60-67 hydrocarboxylic acid receptor 1 Mus musculus 112-117 31999787-6 2020 Importantly, high-fat feeding upregulates expression of the lactate receptor hydroxycarboxylic acid receptor 1 (HCAR1) in female C57BL/6J mice, whereas male C57BL/6J mice show reduced HCAR1 expression in BAT. Lactic Acid 60-67 hydrocarboxylic acid receptor 1 Mus musculus 184-189 31220454-4 2019 Lactate exerts its biological effects via G-protein-coupled receptor 81 (GPR81) in several tissues; however, its physiological functions and mechanisms of action in the retina remain poorly understood. Lactic Acid 0-7 hydrocarboxylic acid receptor 1 Mus musculus 42-71 32669546-0 2020 Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling. Lactic Acid 0-7 hydrocarboxylic acid receptor 1 Mus musculus 100-105 32669546-4 2020 Increased release of BM lactate preferentially promotes neutrophil mobilization by reducing endothelial VE-Cadherin expression, increasing BM vascular permeability via endothelial lactate-receptor GPR81 signaling. Lactic Acid 24-31 hydrocarboxylic acid receptor 1 Mus musculus 197-202 31220454-6 2019 Lactate-stimulated GPR81 Muller cells produce numerous angiogenic factors, including Wnt ligands and particularly Norrin, which contributes significantly in triggering inner retinal blood vessel formation. Lactic Acid 0-7 hydrocarboxylic acid receptor 1 Mus musculus 19-24 31220454-8 2019 Lactate accumulation during ischemic retinopathy selectively activates GPR81-extracellular signal-regulated kinase 1/2-Norrin signaling to accelerate inner retinal vascularization in wild-type animals, but not in the retina of GPR81-null mice. Lactic Acid 0-7 hydrocarboxylic acid receptor 1 Mus musculus 71-76 31220454-9 2019 Altogether, we reveal that lactate via GPR81-Norrin participates in inner vascular network development and in restoration of the vasculature in response to injury. Lactic Acid 27-34 hydrocarboxylic acid receptor 1 Mus musculus 39-44 30424795-14 2018 HCAR1 stimulation by lactate or ketones from the ketogenic diet reduced inflammasome formation, as shown by reduced mRNA and protein expression of NLRP3 and IL-1beta. Lactic Acid 21-28 hydrocarboxylic acid receptor 1 Mus musculus 0-5 30926749-1 2019 The discovery of a G-protein-coupled receptor for lactate named hydroxycarboxylic acid receptor 1 (HCAR1) in neurons has pointed to additional nonmetabolic effects of lactate for regulating neuronal network activity. Lactic Acid 50-57 hydrocarboxylic acid receptor 1 Mus musculus 64-97 30926749-1 2019 The discovery of a G-protein-coupled receptor for lactate named hydroxycarboxylic acid receptor 1 (HCAR1) in neurons has pointed to additional nonmetabolic effects of lactate for regulating neuronal network activity. Lactic Acid 50-57 hydrocarboxylic acid receptor 1 Mus musculus 99-104 30926749-1 2019 The discovery of a G-protein-coupled receptor for lactate named hydroxycarboxylic acid receptor 1 (HCAR1) in neurons has pointed to additional nonmetabolic effects of lactate for regulating neuronal network activity. Lactic Acid 167-174 hydrocarboxylic acid receptor 1 Mus musculus 64-97 30926749-1 2019 The discovery of a G-protein-coupled receptor for lactate named hydroxycarboxylic acid receptor 1 (HCAR1) in neurons has pointed to additional nonmetabolic effects of lactate for regulating neuronal network activity. Lactic Acid 167-174 hydrocarboxylic acid receptor 1 Mus musculus 99-104 30926749-4 2019 Using fast calcium imaging, we show that HCAR1 agonists 3,5-dihydroxybenzoic acid, 3Cl-HBA, and lactate decreased by 40% spontaneous calcium spiking activity of primary cortical neurons from WT but not from HCAR1 KO mice. Lactic Acid 96-103 hydrocarboxylic acid receptor 1 Mus musculus 41-46 30926749-4 2019 Using fast calcium imaging, we show that HCAR1 agonists 3,5-dihydroxybenzoic acid, 3Cl-HBA, and lactate decreased by 40% spontaneous calcium spiking activity of primary cortical neurons from WT but not from HCAR1 KO mice. Lactic Acid 96-103 hydrocarboxylic acid receptor 1 Mus musculus 207-212 30884529-1 2019 Purpose: Besides being actively metabolized, lactate may also function as a signaling molecule by activation of the G-protein-coupled receptor 81 (GPR81). Lactic Acid 45-52 hydrocarboxylic acid receptor 1 Mus musculus 116-145 30884529-1 2019 Purpose: Besides being actively metabolized, lactate may also function as a signaling molecule by activation of the G-protein-coupled receptor 81 (GPR81). Lactic Acid 45-52 hydrocarboxylic acid receptor 1 Mus musculus 147-152 30884529-12 2019 However, GPR81 activation diminished lactate release allowing lactate to be metabolized intracellularly. Lactic Acid 37-44 hydrocarboxylic acid receptor 1 Mus musculus 9-14 30884529-12 2019 However, GPR81 activation diminished lactate release allowing lactate to be metabolized intracellularly. Lactic Acid 62-69 hydrocarboxylic acid receptor 1 Mus musculus 9-14 30884529-15 2019 Conclusions: The present study revealed dual properties of lactate via functioning as an active metabolic energy substrate and a regulatory molecule by activation of the GPR81 receptor in primary Muller cells. Lactic Acid 59-66 hydrocarboxylic acid receptor 1 Mus musculus 170-175 30543778-8 2018 Our results demonstrate that LAB-type symbiont-derived lactate plays a pivotal role in promoting ISC-mediated epithelial development in a Gpr81-dependent manner. Lactic Acid 55-62 hydrocarboxylic acid receptor 1 Mus musculus 138-143 29386257-0 2018 GPR81, a Cell-Surface Receptor for Lactate, Regulates Intestinal Homeostasis and Protects Mice from Experimental Colitis. Lactic Acid 35-42 hydrocarboxylic acid receptor 1 Mus musculus 0-5 29386257-3 2018 In this study, we report that signaling by GPR81, a receptor for lactate, in colonic dendritic cells and macrophages plays an important role in suppressing colonic inflammation and restoring colonic homeostasis. Lactic Acid 65-72 hydrocarboxylic acid receptor 1 Mus musculus 43-48 27615440-0 2017 Lactate produced during labor modulates uterine inflammation via GPR81 (HCA1). Lactic Acid 0-7 hydrocarboxylic acid receptor 1 Mus musculus 65-70 28978803-1 2017 GPR81 is a receptor for the metabolic intermediate lactate with an established role in regulating adipocyte lipolysis. Lactic Acid 51-58 hydrocarboxylic acid receptor 1 Mus musculus 0-5 28534495-4 2017 High-intensity interval exercise (5 days weekly for 7 weeks), as well as L-lactate subcutaneous injection that leads to an increase in blood lactate levels similar to exercise, increases brain VEGFA protein and capillary density in wild-type mice, but not in knockout mice lacking HCAR1. Lactic Acid 75-82 hydrocarboxylic acid receptor 1 Mus musculus 281-286 27615440-7 2017 STUDY DESIGN: We investigated the expression of GPR81 in the uterus and the pharmacological role of lactate acting via GPR81 during labor, using shRNA-GPR81 and GPR81-/- mice. Lactic Acid 100-107 hydrocarboxylic acid receptor 1 Mus musculus 119-124 27615440-4 2017 Aside from its metabolic function, lactate has been shown to activate a G protein-coupled receptor, GPR81, reported to regulate inflammation. Lactic Acid 35-42 hydrocarboxylic acid receptor 1 Mus musculus 100-105 27615440-7 2017 STUDY DESIGN: We investigated the expression of GPR81 in the uterus and the pharmacological role of lactate acting via GPR81 during labor, using shRNA-GPR81 and GPR81-/- mice. Lactic Acid 100-107 hydrocarboxylic acid receptor 1 Mus musculus 119-124 27615440-7 2017 STUDY DESIGN: We investigated the expression of GPR81 in the uterus and the pharmacological role of lactate acting via GPR81 during labor, using shRNA-GPR81 and GPR81-/- mice. Lactic Acid 100-107 hydrocarboxylic acid receptor 1 Mus musculus 119-124 27615440-5 2017 We therefore hypothesize that lactate produced during labor may act via GPR81 in the uterus to exert in a feedback manner antiinflammatory effects, to resolve or mitigate inflammation. Lactic Acid 30-37 hydrocarboxylic acid receptor 1 Mus musculus 72-77 27615440-11 2017 (4) In primary myometrial smooth muscle cell and ex vivo uteri from wild-type mice, lactate decreased interleukin-1beta-induced transcription of key proinflammatory Il1b, Il6, Ccl2, and Pghs2; suppressive effects of lactate were not observed in cells and tissues from GPR81-/- mice. Lactic Acid 84-91 hydrocarboxylic acid receptor 1 Mus musculus 268-273 27615440-6 2017 OBJECTIVE: We sought to investigate the role of lactate produced during labor and its receptor, GPR81, in regulating inflammation in the uterus. Lactic Acid 48-55 hydrocarboxylic acid receptor 1 Mus musculus 96-101 27846210-4 2016 While lipopolysaccharide (LPS) triggered expression of IL-6 and IL-12 p40, and CD40 in bone marrow-derived macrophages, lactate was able to abrogate these responses in a dose dependent manner in Gpr81-/- cells as well as in wild type cells. Lactic Acid 120-127 hydrocarboxylic acid receptor 1 Mus musculus 195-200 27615440-14 2017 CONCLUSION: Collectively, our data uncover a novel link between the anaerobic glycolysis and the control of uterine inflammation wherein the high levels of lactate produced during labor act on uterine GPR81 to down-regulate key proinflammatory genes. Lactic Acid 156-163 hydrocarboxylic acid receptor 1 Mus musculus 201-206 27846210-0 2016 Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner. Lactic Acid 0-7 hydrocarboxylic acid receptor 1 Mus musculus 102-107 27846210-6 2016 Remarkably, lactate was found to inhibit LPS-induced glycolysis in wild type as well as in Gpr81-/- cells. Lactic Acid 12-19 hydrocarboxylic acid receptor 1 Mus musculus 91-96 27846210-2 2016 Recently, lactate was shown to signal through the G protein coupled receptor 81 (GPR81) and to thus modulate inflammatory processes. Lactic Acid 10-17 hydrocarboxylic acid receptor 1 Mus musculus 50-79 27846210-2 2016 Recently, lactate was shown to signal through the G protein coupled receptor 81 (GPR81) and to thus modulate inflammatory processes. Lactic Acid 10-17 hydrocarboxylic acid receptor 1 Mus musculus 81-86 27846210-3 2016 This study demonstrates that lactate inhibits pro-inflammatory signaling in a GPR81-independent fashion. Lactic Acid 29-36 hydrocarboxylic acid receptor 1 Mus musculus 78-83 27846210-7 2016 In conclusion, our study suggests that lactate can induce GPR81-independent metabolic changes that modulate macrophage pro-inflammatory activation. Lactic Acid 39-46 hydrocarboxylic acid receptor 1 Mus musculus 58-63 25495836-2 2015 G protein-coupled receptor 81 (GPR81) is an endogenous receptor for lactate. Lactic Acid 68-75 hydrocarboxylic acid receptor 1 Mus musculus 0-29 25495836-2 2015 G protein-coupled receptor 81 (GPR81) is an endogenous receptor for lactate. Lactic Acid 68-75 hydrocarboxylic acid receptor 1 Mus musculus 31-36 25495836-10 2015 Lactate may aggravate ischemic brain injury by activating GPR81. Lactic Acid 0-7 hydrocarboxylic acid receptor 1 Mus musculus 58-63 25495836-3 2015 We aimed to explore whether lactate is involved in ischemic injury via activating GPR81. Lactic Acid 28-35 hydrocarboxylic acid receptor 1 Mus musculus 82-87 24486398-2 2014 Similar to GPR109a, the activation of GPR81 by lactate suppresses lipolysis, suggesting that GPR81 may be a potential drug target for treating dyslipidemia. Lactic Acid 47-54 hydrocarboxylic acid receptor 1 Mus musculus 38-43 24657625-0 2014 Lactate reduces liver and pancreatic injury in Toll-like receptor- and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity. Lactic Acid 0-7 hydrocarboxylic acid receptor 1 Mus musculus 110-115 24657625-13 2014 The administration of lactate reduced inflammation and organ injury in mice with immune hepatitis; this reduction required Gpr81 dependence in vivo. Lactic Acid 22-29 hydrocarboxylic acid receptor 1 Mus musculus 123-128 24657625-15 2014 CONCLUSIONS: Lactate negatively regulates TLR induction of the NLRP3 inflammasome and production of IL1beta, via ARRB2 and GPR81. Lactic Acid 13-20 hydrocarboxylic acid receptor 1 Mus musculus 123-128 24486398-2 2014 Similar to GPR109a, the activation of GPR81 by lactate suppresses lipolysis, suggesting that GPR81 may be a potential drug target for treating dyslipidemia. Lactic Acid 47-54 hydrocarboxylic acid receptor 1 Mus musculus 93-98 24486398-5 2014 In the present study, we showed that lactate-induced suppression of lipolysis in explants of white adipose tissue (WAT) depends on the presence of GPR81. Lactic Acid 37-44 hydrocarboxylic acid receptor 1 Mus musculus 147-152 22842580-3 2012 The endogenous ligands for GPR109A and GPR81 are beta-hydroxybutyrate and lactate, respectively, both of which are hydroxycarboxylic acids and intermediates of energy metabolism. Lactic Acid 74-81 hydrocarboxylic acid receptor 1 Mus musculus 39-44 19047060-0 2009 Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81. Lactic Acid 0-7 hydrocarboxylic acid receptor 1 Mus musculus 100-105 20374963-0 2010 An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81. Lactic Acid 13-20 hydrocarboxylic acid receptor 1 Mus musculus 85-90 20374963-2 2010 Here we show that lactate activates the G protein-coupled receptor GPR81, which is expressed in adipocytes and mediates antilipolytic effects through G(i)-dependent inhibition of adenylyl cyclase. Lactic Acid 18-25 hydrocarboxylic acid receptor 1 Mus musculus 67-72 20374963-5 2010 Thus, lactate and its receptor GPR81 unexpectedly function in an autocrine and paracrine loop to mediate insulin-induced antilipolytic effects. Lactic Acid 6-13 hydrocarboxylic acid receptor 1 Mus musculus 31-36 22434674-2 2012 HCA1 (aka GPR81), predominantly expressed in adipocytes, was recently identified as a receptor for lactate. Lactic Acid 99-106 hydrocarboxylic acid receptor 1 Mus musculus 10-15 21751047-2 2011 GPR81 is activated by lactate resulting in the inhibition of lipolysis. Lactic Acid 22-29 hydrocarboxylic acid receptor 1 Mus musculus 0-5 19047060-3 2009 Here we show that GPR81, an orphan G-protein-coupled receptor highly expressed in fat, is in fact a sensor for lactate. Lactic Acid 111-118 hydrocarboxylic acid receptor 1 Mus musculus 18-23 19047060-4 2009 Lactate activates GPR81 in its physiological concentration range of 1-20 mM and suppresses lipolysis in mouse, rat, and human adipocytes as well as in differentiated 3T3-L1 cells. Lactic Acid 0-7 hydrocarboxylic acid receptor 1 Mus musculus 18-23 19047060-6 2009 Lactate specifically induces internalization of GPR81 after receptor activation. Lactic Acid 0-7 hydrocarboxylic acid receptor 1 Mus musculus 48-53 19047060-7 2009 Site-directed mutagenesis of GPR81 coupled with homology modeling demonstrates that classically conserved key residues in the transmembrane binding domains are responsible for interacting with lactate. Lactic Acid 193-200 hydrocarboxylic acid receptor 1 Mus musculus 29-34 19047060-8 2009 Our results indicate that lactate suppresses lipolysis in adipose tissue through a direct activation of GPR81. Lactic Acid 26-33 hydrocarboxylic acid receptor 1 Mus musculus 104-109 34588991-1 2021 The glycolytic product of exercise, lactate, has long been recognized to promote lipid accumulation by activation of G-protein-coupled receptor 81 (GPR81) and inhibition of the cyclic adenosine monophosphate-protein kinase A (cAMP -PKA) pathway in adipose tissue. Lactic Acid 36-43 hydrocarboxylic acid receptor 1 Mus musculus 117-146 34588991-1 2021 The glycolytic product of exercise, lactate, has long been recognized to promote lipid accumulation by activation of G-protein-coupled receptor 81 (GPR81) and inhibition of the cyclic adenosine monophosphate-protein kinase A (cAMP -PKA) pathway in adipose tissue. Lactic Acid 36-43 hydrocarboxylic acid receptor 1 Mus musculus 148-153 34588991-6 2021 Corresponding expression level changes of GPR81, P-PKA/PKA, P-CREB/cAMP-response element binding protein (CREB), and proteins related to lipid metabolism suggest that lactate could induce intramuscular triglyceride accumulation partly through the inhibition of the cAMP-PKA pathway. Lactic Acid 167-174 hydrocarboxylic acid receptor 1 Mus musculus 42-47 34093243-4 2021 While there is evidence of a metabolic effect of lactate providing energy to deprived neurons, it can also activate the hydroxycarboxylic acid receptor 1 (HCAR1), a Gi-coupled protein receptor that modulates neuronal firing rates. Lactic Acid 49-56 hydrocarboxylic acid receptor 1 Mus musculus 120-153 34497346-8 2021 These results suggest that microbiota-derived lactate stimulates SCF secretion by LepR+ BM MSCs and subsequently activates hematopoiesis and erythropoiesis in a Gpr81-dependent manner. Lactic Acid 46-53 hydrocarboxylic acid receptor 1 Mus musculus 161-166 34093243-8 2021 Our results suggest that the protective effects of lactate after hypoxia-ischemia come rather from the metabolic effects of lactate than its signaling through HCAR1. Lactic Acid 51-58 hydrocarboxylic acid receptor 1 Mus musculus 159-164 34093243-8 2021 Our results suggest that the protective effects of lactate after hypoxia-ischemia come rather from the metabolic effects of lactate than its signaling through HCAR1. Lactic Acid 124-131 hydrocarboxylic acid receptor 1 Mus musculus 159-164 35107038-4 2022 Herein, we hypothesize that lactate via its G-protein coupled receptor (GPR81) controls postnatal brain angiogenesis and plays a protective role after HI injury. Lactic Acid 28-35 hydrocarboxylic acid receptor 1 Mus musculus 72-77 35107038-8 2022 HI injury in GPR81-null animals curtailed vascular density and consequently increased infarct size compared to changes seen in WT mice; conversely intracerebroventricular lactate injection increased vascular density and diminished infarct size in WT but not in GPR81-null mice. Lactic Acid 171-178 hydrocarboxylic acid receptor 1 Mus musculus 13-18 35107038-8 2022 HI injury in GPR81-null animals curtailed vascular density and consequently increased infarct size compared to changes seen in WT mice; conversely intracerebroventricular lactate injection increased vascular density and diminished infarct size in WT but not in GPR81-null mice. Lactic Acid 171-178 hydrocarboxylic acid receptor 1 Mus musculus 261-266 35107038-9 2022 Collectively, we show that lactate acting via GPR81 participates in developmental brain angiogenesis, and attenuates HI injury by restoring compromised microvasculature. Lactic Acid 27-34 hydrocarboxylic acid receptor 1 Mus musculus 46-51