PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30811636-8	2019	Lactate mediated part of the crosstalk between tumor cells and Mphis, promoting secretion of IL-1beta, IL-10, IL-6, and up-regulation of hypoxia induced factor-1alpha expression, and down-regulation of p65-NFkappaB phosphorylation in Mphis.	Lactic Acid	0-7	interleukin 1 alpha	Homo sapiens	93-101	
23144702-11	2012	It identifies two X-linked genes associated with altered risk of severe malaria in females, identifies mutations in ADCY9, IL1A and CD40L as being associated with altered risk of severe respiratory distress and acidosis, both of which are characterised by high serum lactate levels, and also identifies novel genetic associations with severe malaria (TRIM5) and cerebral malaria(IL-13 and RTN3).	Lactic Acid	267-274	interleukin 1 alpha	Homo sapiens	123-127	
9828188-0	1998	Interleukin 1alpha stimulates lactate dehydrogenase A expression and lactate production in cultured porcine sertoli cells.	Lactic Acid	30-37	interleukin 1 alpha	Homo sapiens	0-18	
9828188-1	1998	By using cultured porcine Sertoli cells as a model, the action of interleukin 1alpha (IL-1alpha) on lactate production and the site of this action were studied.	Lactic Acid	100-107	interleukin 1 alpha	Homo sapiens	66-84	
9828188-1	1998	By using cultured porcine Sertoli cells as a model, the action of interleukin 1alpha (IL-1alpha) on lactate production and the site of this action were studied.	Lactic Acid	100-107	interleukin 1 alpha	Homo sapiens	86-95	
9828188-2	1998	IL-1alpha stimulated Sertoli cell lactate production in a time- and dose-dependent manner (with a half-maximal effect [ED50] of 6 pM).	Lactic Acid	34-41	interleukin 1 alpha	Homo sapiens	0-9	
9828188-6	1998	Second, IL-1alpha increased the activity of the lactate dehydrogenase (LDH) A4 isoform, which is involved in the conversion of pyruvate into lactate.	Lactic Acid	48-55	interleukin 1 alpha	Homo sapiens	8-17	
9828188-9	1998	Assuming that IL-1alpha might be produced in the seminiferous tubules by both Sertoli and germ cells, which utilize lactate for their energy metabolism, we suggest that these results together show 1) that the cytokine may represent a signal in the metabolic cooperation existing between Sertoli cells and germ cells, and 2) that a redistribution of LDH isoforms in favor of LDH A4 under IL-1alpha control is a key mechanism(s) in such cooperation used by germ cells to enhance lactate production in Sertoli cells.	Lactic Acid	116-123	interleukin 1 alpha	Homo sapiens	14-23	
9828188-9	1998	Assuming that IL-1alpha might be produced in the seminiferous tubules by both Sertoli and germ cells, which utilize lactate for their energy metabolism, we suggest that these results together show 1) that the cytokine may represent a signal in the metabolic cooperation existing between Sertoli cells and germ cells, and 2) that a redistribution of LDH isoforms in favor of LDH A4 under IL-1alpha control is a key mechanism(s) in such cooperation used by germ cells to enhance lactate production in Sertoli cells.	Lactic Acid	477-484	interleukin 1 alpha	Homo sapiens	14-23	
9565081-10	1998	Fragments of meniscus, but not meniscal cells in monolayer culture, increased their production of matrix metalloproteinases, lactate, and, especially, prostaglandin E2 in response to interleukin-1.	Lactic Acid	125-132	interleukin 1 alpha	Homo sapiens	183-196	
34691015-12	2021	Lactate significantly reduced the concentrations of TNF and IL-1beta produced by human macrophages in response to Mtb but did not alter IL-10 and IL-6 production.	Lactic Acid	0-7	interleukin 1 alpha	Homo sapiens	60-68	
2380175-1	1990	Exposure of quiescent cultures of human gingival fibroblasts (HuGi) and porcine synovicocytes (PSF) to human recombinant interleukin 1 alpha or -beta (IL1 alpha and -beta) enhanced the rate of glycolysis as judged by increased lactate production.	Lactic Acid	227-234	interleukin 1 alpha	Homo sapiens	121-149	
2380175-1	1990	Exposure of quiescent cultures of human gingival fibroblasts (HuGi) and porcine synovicocytes (PSF) to human recombinant interleukin 1 alpha or -beta (IL1 alpha and -beta) enhanced the rate of glycolysis as judged by increased lactate production.	Lactic Acid	227-234	interleukin 1 alpha	Homo sapiens	151-170	
8154008-3	1994	Admission geometric mean venous blood lactate concentrations were almost twice as high in fatal cases as in survivors (7.1 mmol/L vs. 3.6 mmol/L; P < 0.001) and were correlated with levels of tumour necrosis factor (r = 0.42, n = 79; P < 0.0001) and interleukin 1-alpha (r = 0.6, n = 34; P < 0.0001).	Lactic Acid	38-45	interleukin 1 alpha	Homo sapiens	256-275	
3128273-1	1988	Recombinant-derived human interleukin 1 (IL1) alpha and beta and interferon gamma (IFN-gamma) each produced similar increases in rheumatoid synovial cell (RSC) glycolysis, as judged by increased values for glucose uptake, lactate production and cellular fructose 2,6-bisphosphate [Fru(2,6)P2].	Lactic Acid	222-229	interleukin 1 alpha	Homo sapiens	26-51	
34124933-0	2021	Rewiring of lactate-IL-1beta auto-regulatory loop with Clock-Bmal1: A feed-forward circuit in glioma.	Lactic Acid	12-19	interleukin 1 alpha	Homo sapiens	20-28	
34124933-3	2021	Tumor metabolite lactate- mediated increase in pro-inflammatory cytokine IL-1beta was concomitant with elevated levels of core circadian regulators Clock and Bmal1.	Lactic Acid	17-24	interleukin 1 alpha	Homo sapiens	73-81	
34124933-5	2021	Lactate mediated deacetylation of Bmal1 and its interaction with Clock, regulate IL-1beta levels and vice versa.	Lactic Acid	0-7	interleukin 1 alpha	Homo sapiens	81-89	
34124933-7	2021	ChIP-re-ChIP revealed that lactate-IL-1beta crosstalk positively affects co-recruitment of Clock-Bmal1 to these E-box sites.	Lactic Acid	27-34	interleukin 1 alpha	Homo sapiens	35-43	
34124933-10	2021	TCGA data analysis suggested the presence of lactate- IL-1beta-crosstalk in other cancers.	Lactic Acid	45-52	interleukin 1 alpha	Homo sapiens	54-62	
34124933-13	2021	Our findings provide evidence for a potential cancer-specific axis wiring of IL-1beta and LDHA through Clock -Bmal1, the outcome of which is to fuel an IL-1beta-lactate autocrine loop that drives pro-inflammatory and oncogenic signals.	Lactic Acid	161-168	interleukin 1 alpha	Homo sapiens	77-85	
34124933-13	2021	Our findings provide evidence for a potential cancer-specific axis wiring of IL-1beta and LDHA through Clock -Bmal1, the outcome of which is to fuel an IL-1beta-lactate autocrine loop that drives pro-inflammatory and oncogenic signals.	Lactic Acid	161-168	interleukin 1 alpha	Homo sapiens	152-160	
35532840-11	2022	In turn, gastric cancer cells increase lactate production and promote gastric cell proliferation through Muc-13 and IL-1alpha stimulation.	Lactic Acid	39-46	interleukin 1 alpha	Homo sapiens	116-125	
6611596-6	1984	The structural and secretory (acute-phase reactants) in vitro protein synthesis in livers of normal rats injected intraperitoneally with IL-1 or PIF was significantly greater than that of normal rats or those injected with Ringer"s lactate (p less than 0.01).	Lactic Acid	232-239	interleukin 1 alpha	Homo sapiens	137-141	
32290188-7	2020	In vitro validation experiments revealed that co-incubation with lactate and pyruvate enhances IL-10 production and attenuates the release of pro-inflammatory IL-1beta and IL-6 by LPS-stimulated leukocytes.	Lactic Acid	65-72	interleukin 1 alpha	Homo sapiens	159-167