PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12077722-2 2002 In various skeletal muscles of normal rats, monocarboxylate transporter 1 (MCT1) has been found to be highly correlated to lactate uptake, as well as to oxidative capacity, whereas the distribution and characteristics of MCT4 make it a good candidate for the extrusion of lactic acid from glycolytic muscle cells. Lactic Acid 272-283 solute carrier family 16 member 3 Rattus norvegicus 221-225 12434405-8 2002 The inhibition constant of L-lactic acid for the lovastatin acid uptake was 32 mM, and this value is comparable to the Michaelis constant (>20 mM) of L-lactic acid for MCT4 described elsewhere. Lactic Acid 27-40 solute carrier family 16 member 3 Rattus norvegicus 171-175 12434405-8 2002 The inhibition constant of L-lactic acid for the lovastatin acid uptake was 32 mM, and this value is comparable to the Michaelis constant (>20 mM) of L-lactic acid for MCT4 described elsewhere. Lactic Acid 153-166 solute carrier family 16 member 3 Rattus norvegicus 171-175 11701447-3 2001 Compared with controls, the maximal rate of lactate uptake and affinity were decreased in SV of Zucker rats (approximately 30%) in which MCT4 content was significantly decreased (P < 0.05). Lactic Acid 44-51 solute carrier family 16 member 3 Rattus norvegicus 137-141 9168967-7 1997 In summary, MCT3"s unique expression in RPE cells, multiple potential phosphorylation sites, and basolateral distribution suggest that MCT3 may regulate lactate levels in the interphotoreceptor space. Lactic Acid 153-160 solute carrier family 16 member 3 Rattus norvegicus 12-16 11820324-9 2001 Collectively, these data suggest that MCT1 and MCT4 are primarily responsible for lactate uptake from the circulation and lactate extrusion out of muscle, respectively. Lactic Acid 82-89 solute carrier family 16 member 3 Rattus norvegicus 47-51 11820324-9 2001 Collectively, these data suggest that MCT1 and MCT4 are primarily responsible for lactate uptake from the circulation and lactate extrusion out of muscle, respectively. Lactic Acid 122-129 solute carrier family 16 member 3 Rattus norvegicus 47-51 10926847-0 2000 The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells. Lactic Acid 78-85 solute carrier family 16 member 3 Rattus norvegicus 45-49 10926847-9 2000 First, MCT4 is a low-affinity MCT: for L-lactate K(m) values of 17+/-3 mM (pH-electrode) and 34+/-5 mM (flux measurements with L-[U-(14)C]lactate) were determined. Lactic Acid 41-48 solute carrier family 16 member 3 Rattus norvegicus 7-11 10926847-10 2000 Secondly, lactate is the preferred substrate of MCT4. Lactic Acid 10-17 solute carrier family 16 member 3 Rattus norvegicus 48-52 9632638-0 1998 Lactic acid efflux from white skeletal muscle is catalyzed by the monocarboxylate transporter isoform MCT3. Lactic Acid 0-11 solute carrier family 16 member 3 Rattus norvegicus 102-106 9632638-3 1998 Thus MCT3 appears to be the major MCT isoform responsible for efflux of glycolytically derived lactic acid from white skeletal muscle. Lactic Acid 95-106 solute carrier family 16 member 3 Rattus norvegicus 5-9 9632638-4 1998 MCT3 is also expressed in several other tissues requiring rapid lactic acid efflux. Lactic Acid 64-75 solute carrier family 16 member 3 Rattus norvegicus 0-4 9841555-8 1998 The demonstration of MCT1 on the apical membrane and MCT3 on the basal membrane identifies specific proteins involved in the discriminate and critical regulation of water and lactate transport from the retina to the choroid. Lactic Acid 175-182 solute carrier family 16 member 3 Rattus norvegicus 53-57 9168967-7 1997 In summary, MCT3"s unique expression in RPE cells, multiple potential phosphorylation sites, and basolateral distribution suggest that MCT3 may regulate lactate levels in the interphotoreceptor space. Lactic Acid 153-160 solute carrier family 16 member 3 Rattus norvegicus 135-139 26299481-3 2015 Monocarboxylate transporter (MCT), responsible for the transport of lactate and other monocarboxylates via the cell membrane, is abundant in the testes and sperm (MCT1, MCT2, and MCT4). Lactic Acid 68-75 solute carrier family 16 member 3 Rattus norvegicus 179-183 34052758-6 2021 Inhibition of AMPK promoted the production of pyruvate and lactate via increased expression of the glycolysis-related genes Pgam1 and the lactate production-related proteins GLUT1, LDHA, and MCT4. Lactic Acid 59-66 solute carrier family 16 member 3 Rattus norvegicus 191-195 34052758-7 2021 Activating AMPK inhibited the production of lactate and pyruvate by suppressing the expression of glycolysis-related genes HK1, Pgam1, and Gpi1 and that of lactate production-related proteins LDHA and MCT4. Lactic Acid 44-51 solute carrier family 16 member 3 Rattus norvegicus 201-205 33936203-7 2021 Consistent with its function as lactate and proton exporter, MCT4 expression levels correlated inversely with extracellular pH and proportionally with extracellular lactate concentrations. Lactic Acid 32-39 solute carrier family 16 member 3 Rattus norvegicus 61-65 33936203-7 2021 Consistent with its function as lactate and proton exporter, MCT4 expression levels correlated inversely with extracellular pH and proportionally with extracellular lactate concentrations. Lactic Acid 165-172 solute carrier family 16 member 3 Rattus norvegicus 61-65 26553531-6 2016 The expression of the monocarboxylate transporter 4 responsible for the export of lactate to the extracellular space was also diminished with RGN overexpression. Lactic Acid 82-89 solute carrier family 16 member 3 Rattus norvegicus 22-51 34782470-6 2021 Interestingly, MCT4 down-regulated animals showing no BOLD response were rescued by peripheral lactate infusion, while this treatment had no effect on MCT2 down-regulated rats. Lactic Acid 95-102 solute carrier family 16 member 3 Rattus norvegicus 15-19 25827488-9 2015 However, neuronal cell death in co-cultures was increased by exposure to MCT4- or MCT2-specific siRNA, and this effect was attenuated by the addition of lactate into the extracellular medium of neuronal cultures prior to OGD. Lactic Acid 153-160 solute carrier family 16 member 3 Rattus norvegicus 73-77 26521871-8 2015 AMPK and PKC activation increased MCT4 expression level and lactate efflux by MCT4. Lactic Acid 60-67 solute carrier family 16 member 3 Rattus norvegicus 78-82 24030048-10 2013 CONCLUSION: Increased MCT4 expression facilitates lactate extrusion during the ischemic period, while increased MCT1 may facilitate lactate transport into and out of cells simultaneously during early reperfusion, with increases in AMPK phosphorylation status during the myocardial I/R period. Lactic Acid 50-57 solute carrier family 16 member 3 Rattus norvegicus 22-26 25146899-3 2014 During hypoxia/ischemia (H/I), lactate released from astrocytes is taken up by neurons and is stored for energy, a process mediated by monocarboxylate transporter 4 (MCT4) in astroglia. Lactic Acid 31-38 solute carrier family 16 member 3 Rattus norvegicus 135-164 25146899-3 2014 During hypoxia/ischemia (H/I), lactate released from astrocytes is taken up by neurons and is stored for energy, a process mediated by monocarboxylate transporter 4 (MCT4) in astroglia. Lactic Acid 31-38 solute carrier family 16 member 3 Rattus norvegicus 166-170 23638108-3 2013 Hypothalamic glial cells (tanycytes) release lactate through MCT1 and MCT4; however, similar analyses in neuroendocrine neurons have yet to be undertaken. Lactic Acid 45-52 solute carrier family 16 member 3 Rattus norvegicus 70-74 23201632-6 2013 Astroglial monocarboxylates transporters MCT1 and MCT4 isoforms transfer lactate from blood to astrocytes and release lactate to the extracellular space, whilst the neuronal MCT2 isoform permits neuronal lactate uptake. Lactic Acid 73-80 solute carrier family 16 member 3 Rattus norvegicus 50-54 23201632-6 2013 Astroglial monocarboxylates transporters MCT1 and MCT4 isoforms transfer lactate from blood to astrocytes and release lactate to the extracellular space, whilst the neuronal MCT2 isoform permits neuronal lactate uptake. Lactic Acid 118-125 solute carrier family 16 member 3 Rattus norvegicus 50-54 23201632-6 2013 Astroglial monocarboxylates transporters MCT1 and MCT4 isoforms transfer lactate from blood to astrocytes and release lactate to the extracellular space, whilst the neuronal MCT2 isoform permits neuronal lactate uptake. Lactic Acid 118-125 solute carrier family 16 member 3 Rattus norvegicus 50-54 15682832-3 2004 It is thought that MCT1 transports lactic acid into the skeletal muscle from outside the skeletal muscle cells, while MCT4 is involved in the extrusion of lactic acid out of the muscle cells. Lactic Acid 155-166 solute carrier family 16 member 3 Rattus norvegicus 118-122 21297988-7 2011 Using primary tanycyte cultures, kinetic analyses and sensitivity to inhibitors were undertaken to confirm that MCT1 and MCT4 were functional for lactate influx. Lactic Acid 146-153 solute carrier family 16 member 3 Rattus norvegicus 121-125 21297988-9 2011 Because the expression of both MCT1 and MCT4 has been linked to lactate efflux, we propose that tanycytes participate in glucose sensing based on a metabolic interaction with neurons of the arcuate nucleus, which are stimulated by lactate released from MCT1 and MCT4-expressing tanycytes. Lactic Acid 64-71 solute carrier family 16 member 3 Rattus norvegicus 40-44 21297988-9 2011 Because the expression of both MCT1 and MCT4 has been linked to lactate efflux, we propose that tanycytes participate in glucose sensing based on a metabolic interaction with neurons of the arcuate nucleus, which are stimulated by lactate released from MCT1 and MCT4-expressing tanycytes. Lactic Acid 231-238 solute carrier family 16 member 3 Rattus norvegicus 40-44 21297988-9 2011 Because the expression of both MCT1 and MCT4 has been linked to lactate efflux, we propose that tanycytes participate in glucose sensing based on a metabolic interaction with neurons of the arcuate nucleus, which are stimulated by lactate released from MCT1 and MCT4-expressing tanycytes. Lactic Acid 231-238 solute carrier family 16 member 3 Rattus norvegicus 262-266 19477938-9 2009 Furthermore, exercise-induced lactate accumulation was effectively prevented by stimulation of a lactate shuttle, driven by the increases in monocarboxylate transporters-4 and -1 in white muscle. Lactic Acid 30-37 solute carrier family 16 member 3 Rattus norvegicus 141-178 19477938-9 2009 Furthermore, exercise-induced lactate accumulation was effectively prevented by stimulation of a lactate shuttle, driven by the increases in monocarboxylate transporters-4 and -1 in white muscle. Lactic Acid 97-104 solute carrier family 16 member 3 Rattus norvegicus 141-178