PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35561786-5 2022 We hypothesized that the monocarboxylate transporter, MCT4 which is implicated in lactate efflux from the CAFs, must be overexpressed in the CAFs. Lactic Acid 82-89 solute carrier family 16 member 3 Homo sapiens 54-58 34471053-2 2021 Monocarboxylate transporters (MCTs), especially MCT1 and MCT4, play a critical role in maintaining an appropriate pH environment through lactate transport, and their high expression is associated with poor prognosis in breast cancer. Lactic Acid 137-144 solute carrier family 16 member 3 Homo sapiens 57-61 35509603-2 2022 SLC16A3 is responsible for the extracellular transport of lactate, which is a key component of glycolysis. Lactic Acid 58-65 solute carrier family 16 member 3 Homo sapiens 0-7 35239073-2 2022 Monocarboxylate transporter 1 (MCT1) and 4 (MCT4) are critical symporters mediating lactate efflux and preventing intracellular acidification during tumor growth. Lactic Acid 84-91 solute carrier family 16 member 3 Homo sapiens 44-48 35102189-4 2022 Multiple linear regression revealed that phosphofructokinase, monocarboxylate transporter (MCT)1, MCT4, and citrate synthase equally contribute to the lactate production volume at high-intensity exercise within physiological adaptations, such as EX, not PGC-1alpha OE. Lactic Acid 151-158 solute carrier family 16 member 3 Homo sapiens 98-102 34619707-4 2022 To investigate the metabolic phenotype of malignant lymphoma associated with lactate transport, we analyzed immunohistochemical expressions of MCT1, MCT4, and CD147 in 247 cases of various malignant lymphomas. Lactic Acid 77-84 solute carrier family 16 member 3 Homo sapiens 149-153 35075123-4 2022 MRI-derived tumour (1-13C)lactate labelling correlated with epithelial mRNA expression of the enzyme lactate dehydrogenase (LDHA and LDHB combined), and the ratio of lactate transporter expression between the epithelial and stromal compartments (epithelium-to-stroma MCT4). Lactic Acid 26-33 solute carrier family 16 member 3 Homo sapiens 267-271 35050463-8 2022 Further analysis revealed that HSPA12A interacted with MCT4 and increased its membrane localization, thereby promoting export of lactate generated from glycolysis; this led, ultimately, to HCC cell migration. Lactic Acid 129-136 solute carrier family 16 member 3 Homo sapiens 55-59 35043976-8 2022 CONCLUSIONS: Our results revealed that lactate exportation by MCT4 has a tumor-intrinsic function in generating an immunosuppressive HCC environment and demonstrated the proof of the concept of targeting MCT4 in tailoring HCC immunotherapeutic approaches. Lactic Acid 39-46 solute carrier family 16 member 3 Homo sapiens 62-66 35043976-8 2022 CONCLUSIONS: Our results revealed that lactate exportation by MCT4 has a tumor-intrinsic function in generating an immunosuppressive HCC environment and demonstrated the proof of the concept of targeting MCT4 in tailoring HCC immunotherapeutic approaches. Lactic Acid 39-46 solute carrier family 16 member 3 Homo sapiens 204-208 33968927-1 2021 Purpose: Monocarboxylate transporter 4 (MCT4) can influence the amount of lactate in the tumor microenvironment and further control cancer cell proliferation, migration, and angiogenesis. Lactic Acid 74-81 solute carrier family 16 member 3 Homo sapiens 9-38 33968927-1 2021 Purpose: Monocarboxylate transporter 4 (MCT4) can influence the amount of lactate in the tumor microenvironment and further control cancer cell proliferation, migration, and angiogenesis. Lactic Acid 74-81 solute carrier family 16 member 3 Homo sapiens 40-44 33614502-7 2020 Altogether, our study shows that inhibition of MCT1 or MCT4 impairs leukemic cell proliferation, suggesting that targeting lactate metabolism may be a new therapeutic strategy for AML, and points to MCT4 as a potential therapeutic target in AML patients and to syrosingopine as a new anti-proliferative drug and inducer of autophagy to be used in combination with conventional chemotherapeutic agents in AML treatment. Lactic Acid 123-130 solute carrier family 16 member 3 Homo sapiens 55-59 33596451-7 2021 A monocarboxylate transporter-4 (MCT4) inhibitor, syrosingopine, inhibited lactate release from roxadustat-treated cells and reduced the elution of Ni ions by the cells at 10 microM. Lactic Acid 75-82 solute carrier family 16 member 3 Homo sapiens 2-31 33596451-7 2021 A monocarboxylate transporter-4 (MCT4) inhibitor, syrosingopine, inhibited lactate release from roxadustat-treated cells and reduced the elution of Ni ions by the cells at 10 microM. Lactic Acid 75-82 solute carrier family 16 member 3 Homo sapiens 33-37 33614502-0 2020 Targeting Lactate Metabolism by Inhibiting MCT1 or MCT4 Impairs Leukemic Cell Proliferation, Induces Two Different Related Death-Pathways and Increases Chemotherapeutic Sensitivity of Acute Myeloid Leukemia Cells. Lactic Acid 10-17 solute carrier family 16 member 3 Homo sapiens 51-55 33614502-3 2020 Understanding whether monocarboxylate transporters MCT1 and MCT4, which remove the excess of lactate produced by cancer cells, represent new hematological targets, and whether their respective inhibitors, AR-C155858 and syrosingopine, can be useful in leukemia therapy, may reveal a novel treatment strategy for patients with AML. Lactic Acid 93-100 solute carrier family 16 member 3 Homo sapiens 60-64 32650130-4 2020 To maintain the hyperglycolytic phenotype, cancer cells efficiently export lactate through the monocarboxylate transporters MCT1 and MCT4. Lactic Acid 75-82 solute carrier family 16 member 3 Homo sapiens 133-137 33540599-8 2021 In the presence of glucose and glutamine, oxidative cells can survive when lactate uptake is blocked, and proliferating cells compensate MCT1 inhibition by overexpressing MCT4, a specialized facilitator of lactate export. Lactic Acid 206-213 solute carrier family 16 member 3 Homo sapiens 171-175 32633891-8 2020 These events resulted in high levels of glycolysis products such as lactate, which was secreted by up-regulated monocarboxylate transporter 4 (MCT4) in PSCs. Lactic Acid 68-75 solute carrier family 16 member 3 Homo sapiens 112-141 32782531-2 2020 Monocarboxylate transporter 4 (MCT-4) is a key marker of tumour glycolysis and lactic acid production; however, the role of MCT-4 in breast cancer remains unclear. Lactic Acid 79-90 solute carrier family 16 member 3 Homo sapiens 0-29 32782531-2 2020 Monocarboxylate transporter 4 (MCT-4) is a key marker of tumour glycolysis and lactic acid production; however, the role of MCT-4 in breast cancer remains unclear. Lactic Acid 79-90 solute carrier family 16 member 3 Homo sapiens 31-36 33184582-11 2020 MCT4 inhibition significantly boosted lactate M2 polarization, while blocking of MCT1/2 failed to reverse the immunosuppressive effect of lactate, correlating with the result of gene expression that lactate increased MCT4 expression, but downregulated the expression of MCT1/2. Lactic Acid 38-45 solute carrier family 16 member 3 Homo sapiens 0-4 32633891-8 2020 These events resulted in high levels of glycolysis products such as lactate, which was secreted by up-regulated monocarboxylate transporter 4 (MCT4) in PSCs. Lactic Acid 68-75 solute carrier family 16 member 3 Homo sapiens 143-147 32468005-1 2020 Monocarboxylate transporter 4 (MCT4) is a high-capacity lactate transporter in cells and the alteration in MCT4 expression harms cellular survival. Lactic Acid 56-63 solute carrier family 16 member 3 Homo sapiens 0-29 32468005-1 2020 Monocarboxylate transporter 4 (MCT4) is a high-capacity lactate transporter in cells and the alteration in MCT4 expression harms cellular survival. Lactic Acid 56-63 solute carrier family 16 member 3 Homo sapiens 31-35 32468005-1 2020 Monocarboxylate transporter 4 (MCT4) is a high-capacity lactate transporter in cells and the alteration in MCT4 expression harms cellular survival. Lactic Acid 56-63 solute carrier family 16 member 3 Homo sapiens 107-111 31711985-1 2020 Endothelial cells (ECs) primarily rely on glycolysis for their energy metabolism, and the final product of glycolysis-lactate-is transferred out of cells via monocarboxylate transporter 4 (MCT4). Lactic Acid 118-125 solute carrier family 16 member 3 Homo sapiens 158-187 31964840-4 2020 Expression of lactate dehydrogenase A (LDHA), which catalyzes 13C label exchange between pyruvate and lactate, hypoxia-inducible factor-1 (HIF1alpha), and the monocarboxylate transporters MCT1 and MCT4 were quantified using immunohistochemistry and RNA sequencing. Lactic Acid 14-21 solute carrier family 16 member 3 Homo sapiens 197-201 31963392-4 2020 SLMP53-1 also downregulated the monocarboxylate transporter 4 (MCT4), causing the subsequent reduction of lactate export by cancer cells. Lactic Acid 106-113 solute carrier family 16 member 3 Homo sapiens 32-61 31963392-4 2020 SLMP53-1 also downregulated the monocarboxylate transporter 4 (MCT4), causing the subsequent reduction of lactate export by cancer cells. Lactic Acid 106-113 solute carrier family 16 member 3 Homo sapiens 63-67 31711985-5 2020 MCT4 was shown to be a direct target gene of miR-425-5p, and miR-425-5p expression led to MCT4 downregulation, lactate accumulation and increased apoptosis in HUVECs. Lactic Acid 111-118 solute carrier family 16 member 3 Homo sapiens 0-4 32695876-6 2020 Next, we showed that knockdown of MCT4 increased intracellular lactate concentration and induced a reactive oxygen species (ROS)-dependent cellular apoptosis in the aerobic glycolysis-preference NSCLC cell subtype. Lactic Acid 63-70 solute carrier family 16 member 3 Homo sapiens 34-38 31395464-10 2020 MAJOR CONCLUSIONS: Lactate and MCTs, especially MCT1 and MCT4, are important contributors to tumor aggressiveness. Lactic Acid 19-26 solute carrier family 16 member 3 Homo sapiens 57-61 31711985-1 2020 Endothelial cells (ECs) primarily rely on glycolysis for their energy metabolism, and the final product of glycolysis-lactate-is transferred out of cells via monocarboxylate transporter 4 (MCT4). Lactic Acid 118-125 solute carrier family 16 member 3 Homo sapiens 189-193 32002519-0 2020 MCT4 regulates de novo pyrimidine biosynthesis in GBM in a lactate-independent manner. Lactic Acid 59-66 solute carrier family 16 member 3 Homo sapiens 0-4 32808215-4 2020 By superfusing cultures with increasing lactate concentrations and pharmacological inhibitors, it is possible to estimate the kinetic parameters of monocarboxylate transporter 4 (MCT4) and lactate production. Lactic Acid 40-47 solute carrier family 16 member 3 Homo sapiens 148-177 32808215-4 2020 By superfusing cultures with increasing lactate concentrations and pharmacological inhibitors, it is possible to estimate the kinetic parameters of monocarboxylate transporter 4 (MCT4) and lactate production. Lactic Acid 40-47 solute carrier family 16 member 3 Homo sapiens 179-183 31738978-10 2020 Overexpression of cytoplasmic MCT4 increased the expression of Abeta42, gamma-secretase, and CD147 in the co-culture system; in addition, the growth ability of primary neurons decreased significantly, extracellular lactic acid increased, and neuronal apoptosis increased. Lactic Acid 215-226 solute carrier family 16 member 3 Homo sapiens 30-34 32416791-3 2020 We hypothesized that the expression levels of the major signaling molecules that control lactate metabolism, including lactate dehydrogenases (LDHA and LDHB) and monocarboxylate transporters (MCT1 and MCT4), were altered in WB. Lactic Acid 89-96 solute carrier family 16 member 3 Homo sapiens 201-205 32416791-15 2020 Our current findings suggest the potential roles of LDHB and MCT4 on lactate metabolism and provide a unique molecular elucidation for altered lactate homeostasis in WB muscles of broilers. Lactic Acid 69-76 solute carrier family 16 member 3 Homo sapiens 61-65 31530214-7 2019 Both parameters were increased in hypoxia together with increased abundance of Glut1 (glucose transporter), of the monocarboxylic transporter Mct4 (lactate efflux mediator) and of Pfkfb3 (key regulator of glycolytic rate). Lactic Acid 148-155 solute carrier family 16 member 3 Homo sapiens 142-146 31719150-10 2019 Numerical simulation using revised kinetic parameters revealed that MCT4, but not the related transporters MCT1 and MCT2, endows cells with the ability to export lactate in high-lactate microenvironments. Lactic Acid 178-185 solute carrier family 16 member 3 Homo sapiens 68-72 31719150-11 2019 In conclusion, MCT4 is a high-affinity lactate transporter with physiologically relevant affinity for pyruvate. Lactic Acid 39-46 solute carrier family 16 member 3 Homo sapiens 15-19 31719150-0 2019 Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments. Lactic Acid 89-96 solute carrier family 16 member 3 Homo sapiens 0-29 31719150-0 2019 Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments. Lactic Acid 89-96 solute carrier family 16 member 3 Homo sapiens 31-35 31719150-0 2019 Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments. Lactic Acid 105-112 solute carrier family 16 member 3 Homo sapiens 0-29 31719150-0 2019 Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments. Lactic Acid 105-112 solute carrier family 16 member 3 Homo sapiens 31-35 31719150-3 2019 Intriguingly, at 30-40 mm, the reported Km of MCT4 for lactate is more than 1 order of magnitude higher than physiological or even pathological lactate levels. Lactic Acid 55-62 solute carrier family 16 member 3 Homo sapiens 46-50 31719150-3 2019 Intriguingly, at 30-40 mm, the reported Km of MCT4 for lactate is more than 1 order of magnitude higher than physiological or even pathological lactate levels. Lactic Acid 144-151 solute carrier family 16 member 3 Homo sapiens 46-50 31719150-7 2019 Respective Km values for lactate uptake were 1.7, 1.2, and 0.7 mm in MDA-MB-231 cells, macrophages, and HEK293 cells expressing recombinant MCT4. Lactic Acid 25-32 solute carrier family 16 member 3 Homo sapiens 140-144 31719150-10 2019 Numerical simulation using revised kinetic parameters revealed that MCT4, but not the related transporters MCT1 and MCT2, endows cells with the ability to export lactate in high-lactate microenvironments. Lactic Acid 162-169 solute carrier family 16 member 3 Homo sapiens 68-72 31479685-2 2019 In adaptation to the enhanced lactate stress, lactate-effusing monocarboxylate transporter 4(MCT4) is usually overexpressed in a broad range of HCC subtypes. Lactic Acid 30-37 solute carrier family 16 member 3 Homo sapiens 63-92 31479685-2 2019 In adaptation to the enhanced lactate stress, lactate-effusing monocarboxylate transporter 4(MCT4) is usually overexpressed in a broad range of HCC subtypes. Lactic Acid 30-37 solute carrier family 16 member 3 Homo sapiens 93-97 31479685-2 2019 In adaptation to the enhanced lactate stress, lactate-effusing monocarboxylate transporter 4(MCT4) is usually overexpressed in a broad range of HCC subtypes. Lactic Acid 46-53 solute carrier family 16 member 3 Homo sapiens 63-92 31479685-2 2019 In adaptation to the enhanced lactate stress, lactate-effusing monocarboxylate transporter 4(MCT4) is usually overexpressed in a broad range of HCC subtypes. Lactic Acid 46-53 solute carrier family 16 member 3 Homo sapiens 93-97 31479685-3 2019 In this study, the MCT4-mediated lactate efflux in HCC was blocked using microRNA-145(miR-145), which would force the endogenously generated lactate to accumulate within tumor cells in a self-regulated manner, resulting in the acidification of the cytoplasmic compartment as well as partial neutralization for pH in the tumor extracellular environment. Lactic Acid 33-40 solute carrier family 16 member 3 Homo sapiens 19-23 31479685-3 2019 In this study, the MCT4-mediated lactate efflux in HCC was blocked using microRNA-145(miR-145), which would force the endogenously generated lactate to accumulate within tumor cells in a self-regulated manner, resulting in the acidification of the cytoplasmic compartment as well as partial neutralization for pH in the tumor extracellular environment. Lactic Acid 141-148 solute carrier family 16 member 3 Homo sapiens 19-23 31297034-2 2019 We aimed to explore the role of monocarboxylate transporter 1 (MCT1) and MCT4, two essential transporters of lactate, in renal cancer progression during cancer-endothelial cell co-culturing. Lactic Acid 109-116 solute carrier family 16 member 3 Homo sapiens 73-77 31271899-1 2019 Overexpressed Solute Carrier Family 16 Member 3 (SLC16A3, also called MCT4) plays a critical role in hypoxic cancer cell growth and proliferation, by expelling glycolysis-derived lactate across the plasma membrane. Lactic Acid 179-186 solute carrier family 16 member 3 Homo sapiens 14-47 31271899-1 2019 Overexpressed Solute Carrier Family 16 Member 3 (SLC16A3, also called MCT4) plays a critical role in hypoxic cancer cell growth and proliferation, by expelling glycolysis-derived lactate across the plasma membrane. Lactic Acid 179-186 solute carrier family 16 member 3 Homo sapiens 49-56 31271899-1 2019 Overexpressed Solute Carrier Family 16 Member 3 (SLC16A3, also called MCT4) plays a critical role in hypoxic cancer cell growth and proliferation, by expelling glycolysis-derived lactate across the plasma membrane. Lactic Acid 179-186 solute carrier family 16 member 3 Homo sapiens 70-74 31271899-12 2019 While transcriptional repression of SLC16A3 by FBI-1 inhibited lactate efflux, repression of ZBTB7A and activation of lactate efflux by NF-kappaB, increased colon cancer cell growth and proliferation. Lactic Acid 63-70 solute carrier family 16 member 3 Homo sapiens 36-43 31271899-12 2019 While transcriptional repression of SLC16A3 by FBI-1 inhibited lactate efflux, repression of ZBTB7A and activation of lactate efflux by NF-kappaB, increased colon cancer cell growth and proliferation. Lactic Acid 118-125 solute carrier family 16 member 3 Homo sapiens 36-43 30809511-5 2019 The latter evasion tactic provides a therapeutic target for cancer, as shown by our recent finding that patient-derived cancer xenografts can be growth-arrested, without major host toxicity, by inhibiting their lactic acid secretion (as mediated by the MCT4 transporter)-with evidence of host immunity restoration. Lactic Acid 211-222 solute carrier family 16 member 3 Homo sapiens 253-257 31217781-4 2019 It has recently been reported that MCT4 is a plasma membrane transporter that mediates the secretion of lactic acid from aerobic glycolysis by cancer cells. Lactic Acid 104-115 solute carrier family 16 member 3 Homo sapiens 35-39 30270512-1 2019 AIM: Monocarboxylate transporter 4 (MCT4) is a proton pump that exchanges lactate through the plasma membrane. Lactic Acid 74-81 solute carrier family 16 member 3 Homo sapiens 5-34 30270512-1 2019 AIM: Monocarboxylate transporter 4 (MCT4) is a proton pump that exchanges lactate through the plasma membrane. Lactic Acid 74-81 solute carrier family 16 member 3 Homo sapiens 36-40 30540938-1 2018 Highly glycolytic cancer cells prevent intracellular acidification by excreting the glycolytic end-products lactate and H+ via the monocarboxylate transporters 1 (MCT1) and 4 (MCT4). Lactic Acid 108-115 solute carrier family 16 member 3 Homo sapiens 176-180 30262589-11 2018 MCT4 inhibition resulted in intracellular accumulation of lactate. Lactic Acid 58-65 solute carrier family 16 member 3 Homo sapiens 0-4 30540938-2 2018 We report that syrosingopine, an anti-hypertensive drug, is a dual MCT1 and MCT4 inhibitor (with 60-fold higher potency on MCT4) that prevents lactate and H+ efflux. Lactic Acid 143-150 solute carrier family 16 member 3 Homo sapiens 76-80 30540938-2 2018 We report that syrosingopine, an anti-hypertensive drug, is a dual MCT1 and MCT4 inhibitor (with 60-fold higher potency on MCT4) that prevents lactate and H+ efflux. Lactic Acid 143-150 solute carrier family 16 member 3 Homo sapiens 123-127 30262589-14 2018 Inhibition of MCT4 results in decreased tumor growth in vitro and in vivo Targeting lactate metabolism via MCT4 therefore provides a promising therapeutic approach for invasive urothelial carcinoma, especially in the basal subtype. Lactic Acid 84-91 solute carrier family 16 member 3 Homo sapiens 14-18 30262589-14 2018 Inhibition of MCT4 results in decreased tumor growth in vitro and in vivo Targeting lactate metabolism via MCT4 therefore provides a promising therapeutic approach for invasive urothelial carcinoma, especially in the basal subtype. Lactic Acid 84-91 solute carrier family 16 member 3 Homo sapiens 107-111 30177396-2 2018 MCT1 and MCT4 transport pH-related monocarboxylates, such as lactate and pyruvate. Lactic Acid 61-68 solute carrier family 16 member 3 Homo sapiens 9-13 28923861-3 2017 In this study, we assessed the impact of the MCT1 inhibitor AZD3965 on cancer cell metabolism in vitro and in vivo Exposing human lymphoma and colon carcinoma cells to AZD3965 increased MCT4-dependent accumulation of intracellular lactate, inhibiting monocarboxylate influx and efflux. Lactic Acid 231-238 solute carrier family 16 member 3 Homo sapiens 186-190 29854024-1 2018 Background: Monocarboxylate transporter 4 (MCT4), encoded by SLC16A3 gene, is responsible for exporting lactic acid into the extracellular microenvironment, and an acidic microenvironment promotes cytokine production and remodels chronic inflammation, providing a link from glycolysis to inflammatory bowel disease (IBD). Lactic Acid 104-115 solute carrier family 16 member 3 Homo sapiens 12-41 29854024-1 2018 Background: Monocarboxylate transporter 4 (MCT4), encoded by SLC16A3 gene, is responsible for exporting lactic acid into the extracellular microenvironment, and an acidic microenvironment promotes cytokine production and remodels chronic inflammation, providing a link from glycolysis to inflammatory bowel disease (IBD). Lactic Acid 104-115 solute carrier family 16 member 3 Homo sapiens 43-47 29854024-1 2018 Background: Monocarboxylate transporter 4 (MCT4), encoded by SLC16A3 gene, is responsible for exporting lactic acid into the extracellular microenvironment, and an acidic microenvironment promotes cytokine production and remodels chronic inflammation, providing a link from glycolysis to inflammatory bowel disease (IBD). Lactic Acid 104-115 solute carrier family 16 member 3 Homo sapiens 61-68 29854024-5 2018 Results: Lactate level was increased in the forty-three of 54 patients (79.6%) with IBD by blood gas analysis compared with normal level (P < 0.001), in line with the result that showed increased MCT4 expression in inflamed colonic mucosa analyzed by immunohistochemistry. Lactic Acid 9-16 solute carrier family 16 member 3 Homo sapiens 199-203 29854024-7 2018 Conclusion: The data suggested that increased lactate level in blood was possibly due to highly expressed MCT4 expression caused by inflammation in intestinal mucosal epithelial tissue, which could be a prognosis indicator of IBD in children. Lactic Acid 46-53 solute carrier family 16 member 3 Homo sapiens 106-110 28846107-0 2018 Nuclear factor E2-related factor-2 has a differential impact on MCT1 and MCT4 lactate carrier expression in colonic epithelial cells: a condition favoring metabolic symbiosis between colorectal cancer and stromal cells. Lactic Acid 78-85 solute carrier family 16 member 3 Homo sapiens 73-77 28846107-2 2018 These include Warburg- and reverse Warburg phenotypes depending on differential distribution of the lactate carrier proteins monocarboxylate transporter-4 and -1 (MCT4 and MCT1). Lactic Acid 100-107 solute carrier family 16 member 3 Homo sapiens 125-161 28846107-2 2018 These include Warburg- and reverse Warburg phenotypes depending on differential distribution of the lactate carrier proteins monocarboxylate transporter-4 and -1 (MCT4 and MCT1). Lactic Acid 100-107 solute carrier family 16 member 3 Homo sapiens 163-167 29299023-5 2017 The aim of this study was to evaluate the expression of the lactate/proton monocarboxylate transporters MCT1 and MCT4 and their chaperone CD147 in EC, with the ultimate aim of directing future drug development. Lactic Acid 60-67 solute carrier family 16 member 3 Homo sapiens 113-117 29905005-0 2018 Targeting MCT4 to reduce lactic acid secretion and glycolysis for treatment of neuroendocrine prostate cancer. Lactic Acid 25-36 solute carrier family 16 member 3 Homo sapiens 10-14 29905005-6 2018 Specific inhibition of expression of MCT4 (a plasma membrane lactic acid transporter) by antisense oligonucleotides led to reduced lactic acid secretion as well as reduced glucose metabolism and NEPC cell proliferation. Lactic Acid 61-72 solute carrier family 16 member 3 Homo sapiens 37-41 29905005-7 2018 Taken together, our results indicate that elevated glycolysis coupled to excessive MCT4-mediated lactic acid secretion is clinically relevant and functionally important to NEPC. Lactic Acid 97-108 solute carrier family 16 member 3 Homo sapiens 83-87 29113201-1 2017 Monocarboxylate transporter 4 (MCT-4) serves a key function in transporting lactate across the plasma membrane in various types of human cancer. Lactic Acid 76-83 solute carrier family 16 member 3 Homo sapiens 0-29 29113201-1 2017 Monocarboxylate transporter 4 (MCT-4) serves a key function in transporting lactate across the plasma membrane in various types of human cancer. Lactic Acid 76-83 solute carrier family 16 member 3 Homo sapiens 31-36 28385782-4 2017 AZD3965 treatment led to a rapid accumulation of intracellular lactate in a panel of lymphoma cell lines with low monocarboxylate transporter 4 protein expression and potently inhibited their proliferation. Lactic Acid 63-70 solute carrier family 16 member 3 Homo sapiens 114-143 29248133-14 2017 Monocarboxylate transporter 4 (MCT4) is the main lactate exporter out of cells and is a marker of glycolysis. Lactic Acid 49-56 solute carrier family 16 member 3 Homo sapiens 0-29 27859555-3 2017 The pyruvate-to-lactate conversion rate monitored by dissolution dynamic nuclear polarization-NMR in carcinoma cells featuring native MCT4 expression level was lower than the rate observed for cells in which the human MCT4 gene was overexpressed. Lactic Acid 16-23 solute carrier family 16 member 3 Homo sapiens 134-138 27859555-3 2017 The pyruvate-to-lactate conversion rate monitored by dissolution dynamic nuclear polarization-NMR in carcinoma cells featuring native MCT4 expression level was lower than the rate observed for cells in which the human MCT4 gene was overexpressed. Lactic Acid 16-23 solute carrier family 16 member 3 Homo sapiens 218-222 29248133-14 2017 Monocarboxylate transporter 4 (MCT4) is the main lactate exporter out of cells and is a marker of glycolysis. Lactic Acid 49-56 solute carrier family 16 member 3 Homo sapiens 31-35 28107190-5 2017 MCT4 is the main facilitator of lactate export by glycolytic cancer cells, and MCT1 is adapted for lactate uptake by oxidative cancer cells. Lactic Acid 32-39 solute carrier family 16 member 3 Homo sapiens 0-4 28107190-5 2017 MCT4 is the main facilitator of lactate export by glycolytic cancer cells, and MCT1 is adapted for lactate uptake by oxidative cancer cells. Lactic Acid 99-106 solute carrier family 16 member 3 Homo sapiens 0-4 27224918-10 2016 Most importantly, MCT4 was highly overexpressed in malignant cells of acsites and its silencing resulted in reduced tumor cell proliferation and lactate uptake in malignant ascites. Lactic Acid 145-152 solute carrier family 16 member 3 Homo sapiens 18-22 28222424-3 2017 As glycolysis is highly sensitive to cytosolic pH, maintenance of glycolysis requires export of H+ ions and lactate, which is in part accomplished by Na+/H+ exchangers, such as NHE1 and monocarboxylate transporters, such as MCT4. Lactic Acid 108-115 solute carrier family 16 member 3 Homo sapiens 224-228 29521223-0 2017 Effects of a Series of Acidic Drugs on L-Lactic Acid Transport by the Monocarboxylate Transporters MCT1 and MCT4. Lactic Acid 39-52 solute carrier family 16 member 3 Homo sapiens 108-112 29521223-7 2017 The efflux transport was next examined: loratadine (IC50: 10 and 61 microM) and atorvastatin (IC50: 78 and 41 microM) demonstrated the greatest potency for inhibition of L-lactic acid efflux by MCT1 and MCT4, respectively. Lactic Acid 170-183 solute carrier family 16 member 3 Homo sapiens 203-207 26765963-5 2016 Lactate influx capacity was highest in AsPC-1 cells and lowest in HPDE cells and was inhibited by the MCT inhibitor alpha-cyano-4-hydroxycinnamate (4-CIN), MCT1/MCT2 inhibitor AR-C155858, or knockdown of MCT1 or MCT4. Lactic Acid 0-7 solute carrier family 16 member 3 Homo sapiens 212-216 26765963-8 2016 CONCLUSIONS: Human PDAC cells exhibit robust MCT1 and MCT4 expression and partially MCT1- and MCT4-dependent lactate flux. Lactic Acid 109-116 solute carrier family 16 member 3 Homo sapiens 94-98 26858311-10 2016 Lactate efflux mediated by MCT4 was associated with, and required for, the selective conversion of myeloid cells. Lactic Acid 0-7 solute carrier family 16 member 3 Homo sapiens 27-31 27437179-5 2016 In particular, mutant IDH1 gliomas are associated with low levels of lactate dehydrogenase A (LDHA) and monocarboxylate transporters 1 and 4 (MCT1, MCT4), three proteins involved in pyruvate metabolism to lactate. Lactic Acid 69-76 solute carrier family 16 member 3 Homo sapiens 148-152 26996298-4 2016 Leptin action was effective in both low and high glycolytic cancer cell lines, and determined the up-regulation of lactate exporter MCT4 and its associated protein CD147. Lactic Acid 115-122 solute carrier family 16 member 3 Homo sapiens 132-136 27375499-10 2016 These findings suggest that the lactate exchange ability is highly dependent on the milieu so that the importance of the muscle MCT1 and MCT4 content in gamma1 was hidden in the present study. Lactic Acid 32-39 solute carrier family 16 member 3 Homo sapiens 137-141 27375499-11 2016 Our results also suggest that during recovery following all-out supramaximal exercise in well-trained rowers, MCT4 might play a significant role in the distribution and delivery of lactate for its subsequent removal. Lactic Acid 181-188 solute carrier family 16 member 3 Homo sapiens 110-114 27375499-0 2016 Muscle MCT4 Content Is Correlated with the Lactate Removal Ability during Recovery Following All-Out Supramaximal Exercise in Highly-Trained Rowers. Lactic Acid 43-50 solute carrier family 16 member 3 Homo sapiens 7-11 27375499-1 2016 The purpose of this study was to test if the lactate exchange (gamma1) and removal (gamma2) abilities during recovery following short all-out supramaximal exercise correlate with the muscle content of MCT1 and MCT4, the two isoforms of the monocarboxylate transporters family involved in lactate and H(+) co-transport in skeletal muscle. Lactic Acid 45-52 solute carrier family 16 member 3 Homo sapiens 210-214 26048031-0 2016 Androgens enhance the glycolytic metabolism and lactate export in prostate cancer cells by modulating the expression of GLUT1, GLUT3, PFK, LDH and MCT4 genes. Lactic Acid 48-55 solute carrier family 16 member 3 Homo sapiens 147-151 27134168-6 2016 Moreover, tumors establish metabolic symbiosis, illustrated by the differential expression of MCT1 and MCT4, monocarboxylate transporters active in lactate exchange in glycolytic tumors. Lactic Acid 148-155 solute carrier family 16 member 3 Homo sapiens 103-107 26048031-8 2016 Although LDH enzymatic activity decreased in LNCaP cells treated with DHT, the expression of MCT4 was significantly increased with androgenic treatment, which sustains the increase on lactate export. Lactic Acid 184-191 solute carrier family 16 member 3 Homo sapiens 93-97 26755530-4 2016 Cellular lactic acid secretion is thought to be predominantly mediated by MCT4, a plasma membrane transporter protein. Lactic Acid 9-20 solute carrier family 16 member 3 Homo sapiens 74-78 26755530-9 2016 The treatment of PC-3, DU145, and C4-2 CRPC cultures with candidate MCT4 ASOs led to marked inhibition of MCT4 expression, lactic acid secretion, to increased intracellular lactic acid levels, and markedly reduced aerobic glycolysis and cell proliferation. Lactic Acid 123-134 solute carrier family 16 member 3 Homo sapiens 68-72 26755530-9 2016 The treatment of PC-3, DU145, and C4-2 CRPC cultures with candidate MCT4 ASOs led to marked inhibition of MCT4 expression, lactic acid secretion, to increased intracellular lactic acid levels, and markedly reduced aerobic glycolysis and cell proliferation. Lactic Acid 173-184 solute carrier family 16 member 3 Homo sapiens 68-72 26755530-11 2016 CONCLUSIONS: MCT4-targeting ASOs that inhibit lactic acid secretion may be useful for therapy of CRPC and other cancers, as they can interfere with reprogrammed energy metabolism of cancers, an emerging hallmark of cancer. Lactic Acid 46-57 solute carrier family 16 member 3 Homo sapiens 13-17 26363456-6 2015 Knockdown of MCT4 blocks lactate efflux to result in lactic acid accumulation and pH dropping, which is involved in triggering apoptosis in HUVECs. Lactic Acid 25-32 solute carrier family 16 member 3 Homo sapiens 13-17 27557533-9 2016 The expression level of monocarboxylate transporter-4 (MCT4) was positively correlated with the tumor lactate concentration and may thus contribute to high lactate tumors being associated with a high degree of malignancy. Lactic Acid 102-109 solute carrier family 16 member 3 Homo sapiens 24-53 27557533-9 2016 The expression level of monocarboxylate transporter-4 (MCT4) was positively correlated with the tumor lactate concentration and may thus contribute to high lactate tumors being associated with a high degree of malignancy. Lactic Acid 102-109 solute carrier family 16 member 3 Homo sapiens 55-59 26213210-9 2015 MCT4 exported intracellular lactate into the extracellular space. Lactic Acid 28-35 solute carrier family 16 member 3 Homo sapiens 0-4 26363456-6 2015 Knockdown of MCT4 blocks lactate efflux to result in lactic acid accumulation and pH dropping, which is involved in triggering apoptosis in HUVECs. Lactic Acid 53-64 solute carrier family 16 member 3 Homo sapiens 13-17 26384349-4 2015 Lactate export was substantially suppressed to induce death along with lowering intracellular pH in MM cells by blockade of all three MCT molecules with alpha-cyano-4-hydroxy cinnamate (CHC) or the MCT1 and MCT2 inhibitor AR-C155858 in combination with MCT4 knockdown, although only partially by knockdown of each MCT. Lactic Acid 0-7 solute carrier family 16 member 3 Homo sapiens 253-257 25965974-5 2015 MCT4 supports pH maintenance, lactate secretion and non-oxidative glucose metabolism in breast cancer cells. Lactic Acid 30-37 solute carrier family 16 member 3 Homo sapiens 0-4 26284589-2 2015 BASIGIN controls tumour metabolism, particularly glycolysis by facilitating lactic acid export through the two monocarboxylate transporters MCT1 and hypoxia-inducible MCT4. Lactic Acid 76-87 solute carrier family 16 member 3 Homo sapiens 167-171 26117655-7 2015 This new technique revealed decreased conversion of lactate-to-pyruvate with high expression of monocarboxylate transporter 4 (MCT4), known to correlate with aggressive cancer phenotypes. Lactic Acid 52-59 solute carrier family 16 member 3 Homo sapiens 127-131 25406319-2 2015 Enhanced glycolysis leads to increased formation of intracellular lactate that is exported to the extracellular environment by monocarboxylate transporter 4 (MCT4). Lactic Acid 66-73 solute carrier family 16 member 3 Homo sapiens 127-156 25406319-2 2015 Enhanced glycolysis leads to increased formation of intracellular lactate that is exported to the extracellular environment by monocarboxylate transporter 4 (MCT4). Lactic Acid 66-73 solute carrier family 16 member 3 Homo sapiens 158-162 25406319-7 2015 Mechanistically, we found that MCT4 knockdown leads to enhanced intracellular accumulation of lactate and decreased glycolysis in LPS-treated macrophages. Lactic Acid 94-101 solute carrier family 16 member 3 Homo sapiens 31-35 25456395-0 2015 Expression of lactate/H+ symporters MCT1 and MCT4 and their chaperone CD147 predicts tumor progression in clear cell renal cell carcinoma: immunohistochemical and The Cancer Genome Atlas data analyses. Lactic Acid 14-21 solute carrier family 16 member 3 Homo sapiens 45-49 25403912-2 2015 To further explore and validate the blockade of lactic acid export as an anticancer strategy, we disrupted, via zinc finger nucleases, MCT4 and BASIGIN genes in colon adenocarcinoma (LS174T) and glioblastoma (U87) human cell lines. Lactic Acid 48-59 solute carrier family 16 member 3 Homo sapiens 135-139 25403912-4 2015 Second, we demonstrated that knockout of BSG leads to a decrease in lactate transport activity of MCT1 and MCT4 by 10- and 6-fold, respectively. Lactic Acid 68-75 solute carrier family 16 member 3 Homo sapiens 107-111 23780984-1 2013 BACKGROUND: In tumor cells, monocarboxylate transporter (MCT)-4 regulates the excretion of lactate produced by glycolysis from the cell. Lactic Acid 91-98 solute carrier family 16 member 3 Homo sapiens 28-63 25009968-3 2014 MCT-1 and MCT-4 are the main protein isoforms expressed in human skeletal muscle, with MCT-1 showing a higher affinity (lower Km) for lactate than MCT-4. Lactic Acid 134-141 solute carrier family 16 member 3 Homo sapiens 10-15 24464262-1 2014 Efflux of monocaroxylates like lactate, pyruvate, and ketone bodies from astrocytes through monocarboxylate transporter 4 (MCT4) supplies the local neuron population with metabolic intermediates to meet energy requirements under conditions of increased demand. Lactic Acid 31-38 solute carrier family 16 member 3 Homo sapiens 92-121 24464262-1 2014 Efflux of monocaroxylates like lactate, pyruvate, and ketone bodies from astrocytes through monocarboxylate transporter 4 (MCT4) supplies the local neuron population with metabolic intermediates to meet energy requirements under conditions of increased demand. Lactic Acid 31-38 solute carrier family 16 member 3 Homo sapiens 123-127 24077291-0 2014 Inhibition of monocarboxylate transporter-4 depletes stem-like glioblastoma cells and inhibits HIF transcriptional response in a lactate-independent manner. Lactic Acid 129-136 solute carrier family 16 member 3 Homo sapiens 14-43 24077291-10 2014 Interestingly, whereas MCT4 is a well-characterized lactate exporter, we found that both intracellular and extracellular lactate levels did not change following MCT4 silencing, suggesting a novel lactate export-independent mechanism for growth inhibition in GBMs. Lactic Acid 52-59 solute carrier family 16 member 3 Homo sapiens 23-27 25058459-7 2014 MCT4, the hypoxia-inducible lactate/H(+) symporter demonstrated the strongest deleterious impact on survival. Lactic Acid 28-35 solute carrier family 16 member 3 Homo sapiens 0-4 23881922-1 2013 PURPOSE: The monocarboxylate transporter 4 (MCT4) is a metabolic target in tumor biology because it mediates lactate transport across membranes resulting in antiapoptotic effects. Lactic Acid 109-116 solute carrier family 16 member 3 Homo sapiens 13-42 23881922-1 2013 PURPOSE: The monocarboxylate transporter 4 (MCT4) is a metabolic target in tumor biology because it mediates lactate transport across membranes resulting in antiapoptotic effects. Lactic Acid 109-116 solute carrier family 16 member 3 Homo sapiens 44-48 25277190-5 2014 By real time PCR and immunofluorescence, in MSC we detected the expression of MCT-4, the transporter for lactate efflux, whereas MCT-1, responsible for lactate uptake, was expressed in OS cells. Lactic Acid 105-112 solute carrier family 16 member 3 Homo sapiens 78-83 24498219-1 2014 Monocarboxylate transporter 4 (MCT4) is a cell membrane transporter of lactate. Lactic Acid 71-78 solute carrier family 16 member 3 Homo sapiens 0-29 24498219-1 2014 Monocarboxylate transporter 4 (MCT4) is a cell membrane transporter of lactate. Lactic Acid 71-78 solute carrier family 16 member 3 Homo sapiens 31-35 24265240-9 2013 MCT4 has properties that make it especially suited for lactic acid export by glycolytic cells and is upregulated by hypoxia. Lactic Acid 55-66 solute carrier family 16 member 3 Homo sapiens 0-4 22850421-5 2012 Intercellular contact activated the stromal fibroblasts, triggering increased expression of glucose transporter GLUT1, lactate production, and extrusion of lactate by de novo expressed monocarboxylate transporter-4 (MCT4). Lactic Acid 156-163 solute carrier family 16 member 3 Homo sapiens 185-214 23204238-5 2013 Furthermore, a key feature distinguishing the localized from the metastatic RCC cells is the lactate efflux rate, mediated by the monocarboxylate transporter 4 (MCT4). Lactic Acid 93-100 solute carrier family 16 member 3 Homo sapiens 130-159 23204238-5 2013 Furthermore, a key feature distinguishing the localized from the metastatic RCC cells is the lactate efflux rate, mediated by the monocarboxylate transporter 4 (MCT4). Lactic Acid 93-100 solute carrier family 16 member 3 Homo sapiens 161-165 22964025-7 2012 This increase in lactate production was concomitant with higher levels of MCT4 protein, increased LDH activity and higher lactate/alanine ratio, also suggesting increased levels of oxidative stress in PC3 cells. Lactic Acid 17-24 solute carrier family 16 member 3 Homo sapiens 74-78 22850421-5 2012 Intercellular contact activated the stromal fibroblasts, triggering increased expression of glucose transporter GLUT1, lactate production, and extrusion of lactate by de novo expressed monocarboxylate transporter-4 (MCT4). Lactic Acid 156-163 solute carrier family 16 member 3 Homo sapiens 216-220 22065843-5 2011 In tumors, MCT4 is largely involved in hypoxia-driven lactate release, whereas the uptake of lactate into both tumor cells and tumor endothelial cells occurs via MCT1. Lactic Acid 54-61 solute carrier family 16 member 3 Homo sapiens 11-15 22362593-4 2012 MCT4 silencing impaired secretion of lactate generated through glycolysis and induced cell cycle arrest and apoptosis. Lactic Acid 37-44 solute carrier family 16 member 3 Homo sapiens 0-4 22426323-3 2012 In parallel to an increase in lactic acid release from RD cells, the level of MCT4 mRNA and protein were also significantly increased in RD cells. Lactic Acid 30-41 solute carrier family 16 member 3 Homo sapiens 78-82 22473315-1 2012 Vegran and colleagues proposed a model in which the lactate released from tumor cells through MCT4 would be taken up by endothelial cells via the MCT1 transporter and stimulate angiogenesis, using human umbilical vein endothelial cells (HUVECs) as model of tumor endothelial cells. Lactic Acid 52-59 solute carrier family 16 member 3 Homo sapiens 94-98 22146232-7 2012 In insulin-deprived cells, transcript levels of genes associated to lactate metabolism (LDHA and MCT4) were decreased. Lactic Acid 68-75 solute carrier family 16 member 3 Homo sapiens 97-101 22407107-2 2012 MCT1-MCT4 are proton symporters, which mediate the transmembrane transport of pyruvate, lactate and ketone bodies. Lactic Acid 88-95 solute carrier family 16 member 3 Homo sapiens 5-9 22012699-9 2012 Regulation of skeletal muscle MCT1 and MCT4 content by a variety of stimuli inducing an elevation of lactate level (exercise, hypoxia, nutrition, metabolic perturbations) has been demonstrated. Lactic Acid 101-108 solute carrier family 16 member 3 Homo sapiens 39-43 22969839-2 2012 Monocarboxylate transporter 4 (MCT4) is one of the proton pumps exchanging the lactate through the plasma membrane. Lactic Acid 79-86 solute carrier family 16 member 3 Homo sapiens 0-29 22969839-2 2012 Monocarboxylate transporter 4 (MCT4) is one of the proton pumps exchanging the lactate through the plasma membrane. Lactic Acid 79-86 solute carrier family 16 member 3 Homo sapiens 31-35 22360558-8 2012 The monocarboxylate transporters MCT1 and MCT4 have now been confirmed as prominent facilitators of lactate exchanges between cancer cells with different metabolic behaviors and between cancer and stromal cells. Lactic Acid 100-107 solute carrier family 16 member 3 Homo sapiens 42-46 22240841-1 2012 MCT4 (SLC16A3) is the third member of the monocarboxylate transporter (MCT) family and is involved in the transportation of metabolically important monocarboxylates such as lactate, pyruvate, acetate and ketone bodies. Lactic Acid 173-180 solute carrier family 16 member 3 Homo sapiens 0-4 22240841-1 2012 MCT4 (SLC16A3) is the third member of the monocarboxylate transporter (MCT) family and is involved in the transportation of metabolically important monocarboxylates such as lactate, pyruvate, acetate and ketone bodies. Lactic Acid 173-180 solute carrier family 16 member 3 Homo sapiens 6-13 21074987-4 2011 HIF-1 also ensures survival by correcting tumour acidosis via increased expression of the carbonic anhydrase CA IX and the lactate/H+ symporter MCT4. Lactic Acid 123-130 solute carrier family 16 member 3 Homo sapiens 144-148 21558814-0 2011 Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts. Lactic Acid 35-42 solute carrier family 16 member 3 Homo sapiens 69-73 21558814-4 2011 A prediction of this hypothesis is that cancer-associated fibroblasts should express MCT4, a mono-carboxylate transporter that has been implicated in lactate efflux from glycolytic muscle fibers and astrocytes in the brain. Lactic Acid 150-157 solute carrier family 16 member 3 Homo sapiens 85-89 21930917-0 2011 CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors. Lactic Acid 17-24 solute carrier family 16 member 3 Homo sapiens 66-70 21930917-2 2011 Lactic acid is mainly transported by two H(+)/lactate symporters, MCT1/MCT4, that require the ancillary protein CD147/Basigin for their functionality. Lactic Acid 0-11 solute carrier family 16 member 3 Homo sapiens 71-75 21930917-2 2011 Lactic acid is mainly transported by two H(+)/lactate symporters, MCT1/MCT4, that require the ancillary protein CD147/Basigin for their functionality. Lactic Acid 46-53 solute carrier family 16 member 3 Homo sapiens 71-75 21300765-7 2011 Finally, we documented in mouse xenograft models of human colorectal and breast cancer that lactate release from tumor cells through the MCT4 (and not MCT1) transporter is sufficient to stimulate IL-8-dependent angiogenesis and tumor growth. Lactic Acid 92-99 solute carrier family 16 member 3 Homo sapiens 137-141 19505879-5 2009 MCT1 and MCT4 are the natural transporters of lactate, and MiaPaCa2 cells exhibited a high rate of lactate production, which is characteristic for the Warburg effect, an early hallmark of cancer that confers a significant growth advantage. Lactic Acid 46-53 solute carrier family 16 member 3 Homo sapiens 9-13 19505879-5 2009 MCT1 and MCT4 are the natural transporters of lactate, and MiaPaCa2 cells exhibited a high rate of lactate production, which is characteristic for the Warburg effect, an early hallmark of cancer that confers a significant growth advantage. Lactic Acid 99-106 solute carrier family 16 member 3 Homo sapiens 9-13 19505879-6 2009 Further induction of lactate production by sodium azide in MiaPaCa2 cells increased MCT1 as well as MCT4 expression. Lactic Acid 21-28 solute carrier family 16 member 3 Homo sapiens 100-104 16873599-8 2006 Since the transport of lactate across the sarcolemma is mediated mainly by the lactate-H+ cotransport via the monocarboxylate transporters MCT1 and MCT4, an elevated lactate transport capacity delays both muscle lactate accumulation and intracellular pH decrease and seems to favor muscle activity. Lactic Acid 23-30 solute carrier family 16 member 3 Homo sapiens 148-152 17218064-3 2007 In skeletal muscle, it is well established that glycolytic fast twitch muscle fibers produce lactate, which is transported out of the cell through the monocarboxylate transporter (MCT) 4. Lactic Acid 93-100 solute carrier family 16 member 3 Homo sapiens 151-186 18079261-12 2008 The strong tendency for elevated expression of muscle MCT4 could reflect the need to release greater amounts of muscle lactate in the obese state, a situation that would be normalized with weight loss as indicated by decreased MCT4 levels. Lactic Acid 119-126 solute carrier family 16 member 3 Homo sapiens 54-58 18056982-8 2008 It is concluded that an exercise protocol designed to strain muscle carbohydrate reserves and to result in large increases in lactic acid results in a rapid upregulation of both GLUT-4 and MCT-4. Lactic Acid 126-137 solute carrier family 16 member 3 Homo sapiens 189-194 16621368-1 2006 Human MCT4 (SLC16A3) is responsible for the efflux of L-lactic acid from skeletal muscle cells and is essential for muscle homeostasis. Lactic Acid 54-67 solute carrier family 16 member 3 Homo sapiens 6-10 16621368-1 2006 Human MCT4 (SLC16A3) is responsible for the efflux of L-lactic acid from skeletal muscle cells and is essential for muscle homeostasis. Lactic Acid 54-67 solute carrier family 16 member 3 Homo sapiens 12-19 16621368-2 2006 However, the effects of monocarboxylate drugs, such as statins on the MCT4-mediated transport of L-lactic acid have not been elucidated. Lactic Acid 97-110 solute carrier family 16 member 3 Homo sapiens 70-74 16621368-3 2006 Inhibition of L-lactic acid transport mediated by MCT4 might to lead to collapse of muscle homeostasis. Lactic Acid 14-27 solute carrier family 16 member 3 Homo sapiens 50-54 16621368-4 2006 The aim of this study was to establish an MCT4 transfected cell line and to clarify the transport mechanism of L-lactic acid and the effects of statins on this transport system. Lactic Acid 111-124 solute carrier family 16 member 3 Homo sapiens 42-46 16873599-8 2006 Since the transport of lactate across the sarcolemma is mediated mainly by the lactate-H+ cotransport via the monocarboxylate transporters MCT1 and MCT4, an elevated lactate transport capacity delays both muscle lactate accumulation and intracellular pH decrease and seems to favor muscle activity. Lactic Acid 79-86 solute carrier family 16 member 3 Homo sapiens 148-152 16862226-6 2006 These genes are of special interest, because their products have important roles in cellular glucose metabolism, from glucose uptake (GLUT1) to glycolysis (PFKP) and lactate export (MCT4). Lactic Acid 166-173 solute carrier family 16 member 3 Homo sapiens 182-186 16452478-1 2006 The monocarboxylate transporter MCT4 mediates lactic acid efflux from most tissues that are dependent on glycolysis for their ATP production. Lactic Acid 46-57 solute carrier family 16 member 3 Homo sapiens 32-36 16873599-8 2006 Since the transport of lactate across the sarcolemma is mediated mainly by the lactate-H+ cotransport via the monocarboxylate transporters MCT1 and MCT4, an elevated lactate transport capacity delays both muscle lactate accumulation and intracellular pH decrease and seems to favor muscle activity. Lactic Acid 79-86 solute carrier family 16 member 3 Homo sapiens 148-152 16873599-8 2006 Since the transport of lactate across the sarcolemma is mediated mainly by the lactate-H+ cotransport via the monocarboxylate transporters MCT1 and MCT4, an elevated lactate transport capacity delays both muscle lactate accumulation and intracellular pH decrease and seems to favor muscle activity. Lactic Acid 79-86 solute carrier family 16 member 3 Homo sapiens 148-152 16260747-1 2005 Proton-coupled monocarboxylate transporters (MCT) MCT1, MCT3, and MCT4 form heterodimeric complexes with the cell surface glycoprotein CD147 and exhibit tissue-specific polarized distributions that are essential for maintaining lactate and pH homeostasis. Lactic Acid 228-235 solute carrier family 16 member 3 Homo sapiens 56-60 16260747-1 2005 Proton-coupled monocarboxylate transporters (MCT) MCT1, MCT3, and MCT4 form heterodimeric complexes with the cell surface glycoprotein CD147 and exhibit tissue-specific polarized distributions that are essential for maintaining lactate and pH homeostasis. Lactic Acid 228-235 solute carrier family 16 member 3 Homo sapiens 66-70 12115955-6 2002 In contrast, MCT4 expression was low to absent in the membrane of most type 1 fibers, but high in most 2a and in all 2b fibers, favoring the view that their high lactate levels during work may be channeled in part to neighboring type 1 (and perhaps 2a) fibers for oxidation, thereby delaying fatigue. Lactic Acid 162-169 solute carrier family 16 member 3 Homo sapiens 13-17 15997097-10 2005 Accordingly, MCT2 or MCT4 is responsible for L-lactic acid efflux by RD cells. Lactic Acid 45-58 solute carrier family 16 member 3 Homo sapiens 21-25 15997097-12 2005 We conclude that MCT1 is responsible for L-lactic acid uptake and L-lactic acid efflux is mediated by MCT4 in RD cells. Lactic Acid 66-79 solute carrier family 16 member 3 Homo sapiens 102-106 14724187-1 2004 UNLABELLED: Lactate is released from skeletal muscle in proportion to glucose uptake rates, and it leaves the cells via simple diffusion and two monocarboxylate transporter proteins, MCT1 and MCT4. Lactic Acid 12-19 solute carrier family 16 member 3 Homo sapiens 192-196 12739169-1 2004 The monocarboxylate cotransporter (MCT) family now comprises 14 members, of which only the first four (MCT1-MCT4) have been demonstrated experimentally to catalyse the proton-linked transport of metabolically important monocarboxylates such as lactate, pyruvate and ketone bodies. Lactic Acid 244-251 solute carrier family 16 member 3 Homo sapiens 108-112 15531559-8 2005 However, greater MCT1 and MCT4 contents were negatively related with a reduction of blood lactate concentration at the end of 1-min all-out exercise (r = -0.56, and r = -0.61, P < 0.05, respectively). Lactic Acid 90-97 solute carrier family 16 member 3 Homo sapiens 26-30 15586354-8 2005 Lactate uptake is fast in astrocytes, which express powerful, low-affinity MCTs, i.e., MCT1 and MCT4. Lactic Acid 0-7 solute carrier family 16 member 3 Homo sapiens 96-100 11353425-8 2001 These findings support previous work suggesting that the major role of MCT4 is to defend intracellular pH by extruding lactate and H(+) to the interstitium. Lactic Acid 119-126 solute carrier family 16 member 3 Homo sapiens 71-75 34843897-8 2022 Stroke stimulation could prevent neurodegeneration through the strong enhancement of lactate production, as well as upregulation of MCT4 expression to accelerate lactate supply. Lactic Acid 162-169 solute carrier family 16 member 3 Homo sapiens 132-136 10751188-8 2000 Sarcolemmal MCT1 and MCT4 contents correlated positively to net leg lactate release at 5 min of exercise at 65% VO(2 peak) (r = 0.76, P < 0.03 and r = 0. Lactic Acid 68-75 solute carrier family 16 member 3 Homo sapiens 21-25 10510291-4 1999 Direct demonstration of proton-linked lactate and pyruvate transport has been demonstrated for mammalian MCT1-MCT4, but only for MCT1 and MCT2 have detailed analyses of substrate and inhibitor kinetics been described following heterologous expression in Xenopus oocytes. Lactic Acid 38-45 solute carrier family 16 member 3 Homo sapiens 110-114 10510291-6 1999 By contrast, MCT4 is most evident in white muscle and other cells with a high glycolytic rate, such as tumour cells and white blood cells, suggesting it is expressed where lactic acid efflux predominates. Lactic Acid 172-183 solute carrier family 16 member 3 Homo sapiens 13-17 11101640-0 2000 Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. Lactic Acid 82-93 solute carrier family 16 member 3 Homo sapiens 26-55 11101640-1 2000 Monocarboxylate transporter (MCT) 4 is the major monocarboxylate transporter isoform present in white skeletal muscle and is responsible for the efflux of lactic acid produced by glycolysis. Lactic Acid 155-166 solute carrier family 16 member 3 Homo sapiens 0-35 11101640-11 2000 The properties of MCT4 are consistent with published data on giant sarcolemmal vesicles in which MCT4 is the dominant MCT isoform, and are appropriate for the proposed role of MCT4 in mediating the efflux from the cell of glycolytically derived lactic acid but not pyruvate. Lactic Acid 245-256 solute carrier family 16 member 3 Homo sapiens 18-22 10921872-2 2000 Here we use co-immunoprecipitation and chemical cross-linking to demonstrate that CD147 specifically interacts with MCT1 and MCT4, two members of the proton-linked monocarboxylate (lactate) transporter family that play a fundamental role in metabolism, but not with MCT2. Lactic Acid 181-188 solute carrier family 16 member 3 Homo sapiens 125-129 34472101-5 2022 Interestingly, blockade of lactate transporters, monocarboxylate transporter-1 and -4 (MCT1 and MCT4), attenuated the intracellular level of GO6983, and its inhibitory effect on PKC activity, suggesting that lactic acid promotes the resistance to PKC inhibitors by competing for the uptake through these transporters rather than by activating its receptor, GPR81. Lactic Acid 208-219 solute carrier family 16 member 3 Homo sapiens 96-100 34710950-5 2022 The nanoassemblies could be activated by the elevated ROS levels in tumor intracellular environment and readily release the incorporated therapeutic contents, afterwards DEM could directly conjugate to GSH to disrupt the glutathione peroxidase 4 (GPX4)-mediated antioxidant defense while siMCT4 could block the MCT4-mediated efflux of lactic acid and acidify the intracellular milieu, both of which could improve the ferrocene-catalyzed lipid peroxidation and induce pronounced ferroptotic damage. Lactic Acid 335-346 solute carrier family 16 member 3 Homo sapiens 311-315 34513685-3 2021 Monocarboxylate transporter 4 (MCT4), encoded by SLC16A3 gene, is a potential biomarker for bladder cancer because of its crucial role in the lactate efflux in the aerobic glycolysis process. Lactic Acid 142-149 solute carrier family 16 member 3 Homo sapiens 0-29 34822124-2 2022 Astrocyte-specific MCT4 is a key component of the astrocyte-neuron lactate shuttle (ANLS) and is important for neuroplasticity and learning of the hippocampus. Lactic Acid 67-74 solute carrier family 16 member 3 Homo sapiens 19-23 34671407-14 2021 Rescue experiments found SLC16A3 overexpression resisting to LINC00035 knockdown on SKOV3 and A2780 cell viability, migration, invasion, apoptosis, glucose uptake, lactate release, and ATP production. Lactic Acid 164-171 solute carrier family 16 member 3 Homo sapiens 25-32 34513685-3 2021 Monocarboxylate transporter 4 (MCT4), encoded by SLC16A3 gene, is a potential biomarker for bladder cancer because of its crucial role in the lactate efflux in the aerobic glycolysis process. Lactic Acid 142-149 solute carrier family 16 member 3 Homo sapiens 31-35 34513685-3 2021 Monocarboxylate transporter 4 (MCT4), encoded by SLC16A3 gene, is a potential biomarker for bladder cancer because of its crucial role in the lactate efflux in the aerobic glycolysis process. Lactic Acid 142-149 solute carrier family 16 member 3 Homo sapiens 49-56