PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32767829-6	2020	Moreover, targeting DRP1 not only reduces HSP90 expression but also enhances ROS-induced HSP90 cleavage, thus inhibiting activation of the MAPK and PI3K pathways and leading to suppressed lactate utilization and increased ROS-induced cell death.	Lactic Acid	188-195	dynamin 1 like	Homo sapiens	20-24	
32767829-7	2020	Taken together, these results suggest that DRP1 is a crucial regulator of lactate metabolism and redox homeostasis in KRAS-mutant lung cancer, and targeting lactate utilization by modulating DRP1 activity might be an effective treatment for lung cancer.	Lactic Acid	74-81	dynamin 1 like	Homo sapiens	43-47	
32767829-7	2020	Taken together, these results suggest that DRP1 is a crucial regulator of lactate metabolism and redox homeostasis in KRAS-mutant lung cancer, and targeting lactate utilization by modulating DRP1 activity might be an effective treatment for lung cancer.	Lactic Acid	157-164	dynamin 1 like	Homo sapiens	43-47	
32767829-7	2020	Taken together, these results suggest that DRP1 is a crucial regulator of lactate metabolism and redox homeostasis in KRAS-mutant lung cancer, and targeting lactate utilization by modulating DRP1 activity might be an effective treatment for lung cancer.	Lactic Acid	157-164	dynamin 1 like	Homo sapiens	191-195	
32767829-0	2020	DRP1 promotes lactate utilization in KRAS-mutant non-small cell lung cancer cells.	Lactic Acid	14-21	dynamin 1 like	Homo sapiens	0-4	
32767829-3	2020	We developed a lactate-dependent cell proliferation assay and found that dynamin-related protein (DRP1), which is highly expressed in KRAS-mutant NSCLC, is required for tumor cells to proliferate and uses lactate as fuel, demonstrating the critical role of DRP1 in the metabolic reprogramming of NSCLC.	Lactic Acid	15-22	dynamin 1 like	Homo sapiens	98-102	
32767829-3	2020	We developed a lactate-dependent cell proliferation assay and found that dynamin-related protein (DRP1), which is highly expressed in KRAS-mutant NSCLC, is required for tumor cells to proliferate and uses lactate as fuel, demonstrating the critical role of DRP1 in the metabolic reprogramming of NSCLC.	Lactic Acid	15-22	dynamin 1 like	Homo sapiens	257-261	
32767829-3	2020	We developed a lactate-dependent cell proliferation assay and found that dynamin-related protein (DRP1), which is highly expressed in KRAS-mutant NSCLC, is required for tumor cells to proliferate and uses lactate as fuel, demonstrating the critical role of DRP1 in the metabolic reprogramming of NSCLC.	Lactic Acid	205-212	dynamin 1 like	Homo sapiens	98-102	
32767829-3	2020	We developed a lactate-dependent cell proliferation assay and found that dynamin-related protein (DRP1), which is highly expressed in KRAS-mutant NSCLC, is required for tumor cells to proliferate and uses lactate as fuel, demonstrating the critical role of DRP1 in the metabolic reprogramming of NSCLC.	Lactic Acid	205-212	dynamin 1 like	Homo sapiens	257-261	
32767829-4	2020	Metabolic and transcriptional profiling suggests that DRP1 orchestrates a supportive metabolic network to promote lactate utilization and redox homeostasis in lung cancer cells.	Lactic Acid	114-121	dynamin 1 like	Homo sapiens	54-58	
32767829-5	2020	DRP1 suppresses the production of reactive oxygen species (ROS) and protects cells against oxidative damage by enhancing lactate utilization.	Lactic Acid	121-128	dynamin 1 like	Homo sapiens	0-4	
31587467-2	2019	We report the case of an 8-month-old female with autosomal dominant, de novo DNM1L c. 1228G>A (p. E410K) mutation and mitochondrial disorder, septo-optic dysplasia, hypotonia, developmental delay, elevated blood lactate, and severe mitochondrial cardiomyopathy leading to nonischemic congestive heart failure and cardiogenic shock resulting in death.	Lactic Acid	212-219	dynamin 1 like	Homo sapiens	77-82