PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33177492-5 2020 Additionally, the stromal fibroblasts secrete IL6 as the major cytokine, increases glycolytic flux in the pancreatic tumor cells, and increases lactate efflux in the microenvironment via activation of the STAT signaling pathway. Lactic Acid 144-151 interleukin 6 Homo sapiens 46-49 32290188-7 2020 In vitro validation experiments revealed that co-incubation with lactate and pyruvate enhances IL-10 production and attenuates the release of pro-inflammatory IL-1beta and IL-6 by LPS-stimulated leukocytes. Lactic Acid 65-72 interleukin 6 Homo sapiens 172-176 33123172-5 2020 Our results show that lactate significantly attenuates LPS stimulated macrophage TNF-alpha and IL-6 production. Lactic Acid 22-29 interleukin 6 Homo sapiens 95-99 32821126-0 2020 Tumor-Derived Exosome-Educated Hepatic Stellate Cells Regulate Lactate Metabolism of Hypoxic Colorectal Tumor Cells via the IL-6/STAT3 Pathway to Confer Drug Resistance. Lactic Acid 63-70 interleukin 6 Homo sapiens 124-128 32821126-10 2020 Furthermore, the conditioned medium of activated HSCs enhanced the lactate metabolism of hypoxic tumor cells by activating the IL-6/STAT3 pathway and upregulating the downstream MCT1 and LDHB, in order to confer the resistance of SN38, which is the active metabolite of irinotecan. Lactic Acid 67-74 interleukin 6 Homo sapiens 127-131 32821126-11 2020 Conclusion: Taken together, the cultured supernatant of normoxic exosome-educated HSCs enhances the lactate metabolism of hypoxic tumor cells via the IL-6/STAT3 pathway, in order to confer the SN38 resistance in a mimic liver metastatic microenvironment. Lactic Acid 100-107 interleukin 6 Homo sapiens 150-154 32563931-2 2020 IL-6 is known as an exercise-inducible myokine, and in rodents it was identified that a lactate-dependent increase in protease activity mediates IL-6 release from skeletal muscle, which acts in both an autocrine and paracrine roles. Lactic Acid 88-95 interleukin 6 Homo sapiens 0-4 32563931-2 2020 IL-6 is known as an exercise-inducible myokine, and in rodents it was identified that a lactate-dependent increase in protease activity mediates IL-6 release from skeletal muscle, which acts in both an autocrine and paracrine roles. Lactic Acid 88-95 interleukin 6 Homo sapiens 145-149 30811636-8 2019 Lactate mediated part of the crosstalk between tumor cells and Mphis, promoting secretion of IL-1beta, IL-10, IL-6, and up-regulation of hypoxia induced factor-1alpha expression, and down-regulation of p65-NFkappaB phosphorylation in Mphis. Lactic Acid 0-7 interleukin 6 Homo sapiens 110-114 30779630-3 2019 Using interval-based cycling in healthy young men, swimming exercise in mice, and electrical stimulation of primary human muscle cells, we explored the role of lactate production in muscular IL-6 release during exercise. Lactic Acid 160-167 interleukin 6 Homo sapiens 191-195 27262815-9 2016 The enhanced lactate contributed to TLR4 signaling activation, IL-6 and IL-8 generation, and cell viability promotion in MCF-7 cells. Lactic Acid 13-20 interleukin 6 Homo sapiens 63-67 29932015-6 2019 Moreover, in vitro, we treated cells with IL-6 to simulate inflammatory microenvironment and found that glucose uptake, lactate production, and lactate dehydrogenase activity increased dramatically, mirroring what were observed in vivo. Lactic Acid 120-127 interleukin 6 Homo sapiens 42-46 29932015-8 2019 With the inhibition of STAT3/c-Myc signaling, meanwhile, the upregulation of both cell glucose uptake and lactate production by IL-6 pretreatment was reduced simultaneously. Lactic Acid 106-113 interleukin 6 Homo sapiens 128-132 30390336-12 2018 IL-6 treatment induced the phosphorylation of Stat3 and Bmi-1 expression, increased cell viability, as well as elevated glucose consumption, lactate production, and HK2 expression; however, the effects of IL-6 were attenuated by icaritin or S3I-201 treatment. Lactic Acid 141-148 interleukin 6 Homo sapiens 0-4 30390336-12 2018 IL-6 treatment induced the phosphorylation of Stat3 and Bmi-1 expression, increased cell viability, as well as elevated glucose consumption, lactate production, and HK2 expression; however, the effects of IL-6 were attenuated by icaritin or S3I-201 treatment. Lactic Acid 141-148 interleukin 6 Homo sapiens 205-209 29964299-0 2018 Catechol derived from aronia juice through lactic acid bacteria fermentation inhibits breast cancer stem cell formation via modulation Stat3/IL-6 signaling pathway. Lactic Acid 43-54 interleukin 6 Homo sapiens 141-145 31158931-12 2018 A weak positive correlation was found between COHb and lactate levels in patients (P=0.013; r=0.390).This study shows that IL-6 level increases in CO-poisoned patients, but it is not correlated with the severity of the intoxication. Lactic Acid 55-62 interleukin 6 Homo sapiens 123-127 30044000-10 2018 The main determinants for IL-6 level were intragraft lactate level, cold ischemia time, and anhepatic phase duration (P = 0.005). Lactic Acid 53-60 interleukin 6 Homo sapiens 26-30 29567956-6 2018 These results indicate that functional lactic acid bacteria induce IL-6 and IL-10 production by dendritic cells, which contribute to upregulating the sIgA concentration at mucosal sites in humans. Lactic Acid 39-50 interleukin 6 Homo sapiens 67-71 28044237-7 2017 D-lactates and LPS levels were weakly associated with IL6 (R = 0.175; p = 0.03, and R = 0.241; p = 0.003). Lactic Acid 0-10 interleukin 6 Homo sapiens 54-57 28044237-10 2017 CONCLUSION: The weak association between plasma D-lactate, LPS and IL6 levels indicates that intestinal flora overgrowth or increased intestinal permeability contributes very slightly to the chronic inflammation development in HD patients. Lactic Acid 48-57 interleukin 6 Homo sapiens 67-70 25844698-16 2015 The interleukin-6/interleukin-10 ratio directly correlated with plasma lactate. Lactic Acid 71-78 interleukin 6 Homo sapiens 4-17 24559521-5 2014 IL-6 >= 30,750 pg/ml and lactate >= 10 mmol/l make a PJI very likely, IL-6 <10,000pg/ml or lactate <4.3 mmol/l makes a PJI very unlikely. Lactic Acid 28-35 interleukin 6 Homo sapiens 76-80 22713513-8 2012 Pearson correlation analysis revealed that D-lactate was positively correlated to IL-6 and L-lactate (r=0.727, 0.789 and P=0.000, 0.000, respectively). Lactic Acid 43-52 interleukin 6 Homo sapiens 82-86 22302924-0 2012 Intraperitoneal IL-6 signaling in incident patients treated with icodextrin and glucose bicarbonate/lactate-based peritoneal dialysis solutions. Lactic Acid 100-107 interleukin 6 Homo sapiens 16-20 22085740-4 2011 Ringer"s lactate solution (RLS) has been shown to increase serum TNF-alpha and IL-6 in patients and experimental animals; in addition, RLS also provides lactate, which can be used as an alternative metabolic fuel to meet the higher energy demand by liver regeneration. Lactic Acid 9-16 interleukin 6 Homo sapiens 79-83 19560161-9 2011 In patients with sepsis, levels of IL-6 correlated with syndecan-1, ICAM-1, VCAM-1, and lactate, while ICAM-1 furthermore correlated with CRP and lactate levels. Lactic Acid 88-95 interleukin 6 Homo sapiens 35-39 19560161-9 2011 In patients with sepsis, levels of IL-6 correlated with syndecan-1, ICAM-1, VCAM-1, and lactate, while ICAM-1 furthermore correlated with CRP and lactate levels. Lactic Acid 146-153 interleukin 6 Homo sapiens 35-39 16022097-9 2005 Whereas lactate-incubated cells did not respond to IL-1beta stimulation, bicarbonate/lactate-treated cells adequately increased IL-6 release after stimulation (p < 0.0005). Lactic Acid 85-92 interleukin 6 Homo sapiens 128-132 20725805-6 2010 In all compartments, IL-6 levels appeared to be higher in symptomatic patients, accompanied also by a higher ECF lactate-pyruvate ratio (P = 0.04). Lactic Acid 113-120 interleukin 6 Homo sapiens 21-25 19930761-9 2010 However, systemic inflammation (CRP and IL-6) was correlated with the faecal concentrations of phenolics and lactic acid (P < 0.05 and 0.05, and P < 0.01 and 0.05, respectively). Lactic Acid 109-120 interleukin 6 Homo sapiens 40-44 19019580-9 2009 CSF lactate was correlated with CSF concentrations of IL-1beta, IL-6, GM-CSF, G-CSF, IFN-gamma and MIP-1beta. Lactic Acid 4-11 interleukin 6 Homo sapiens 64-68 18273635-13 2008 In particular, lactate up-regulates the expression of interleukin-6 (3 days, 4.11-fold), of heat shock protein 70 (3 days, 2.36-fold) and of hypoxia-inducible factor-1alpha (3 days, 2.09-fold). Lactic Acid 15-22 interleukin 6 Homo sapiens 54-67 16723241-1 2006 OBJECTIVE: Lactate levels after cardiac surgery are influenced by different proinflammatory (TNF, IL-6, IL-8) and anti-inflammatory (IL-10) cytokines. Lactic Acid 11-18 interleukin 6 Homo sapiens 98-102 16945991-4 2006 IL-6 increased glucose incorporation into glycogen, glucose uptake, lactate production, and fatty acid uptake and oxidation, concomitant with increased phosphorylation of AMP-activated protein kinase (AMPK), signal transducer and activator of transcription 3, and ERK1/2. Lactic Acid 68-75 interleukin 6 Homo sapiens 0-4 12556067-0 2002 Generation of TNFalpha and interleukin-6 by peritoneal macrophages after overnight dwells with bicarbonate- or lactate-buffered dialysis fluid. Lactic Acid 111-118 interleukin 6 Homo sapiens 27-40 15496611-6 2004 IL-1 beta, IL-6, IL-8 and TNF-alpha were significantly associated with lactate/choline in the DGN (p = 0.03, 0.02, 0.03, and 0.01 respectively), but not in the WS (all p > 0.1). Lactic Acid 71-78 interleukin 6 Homo sapiens 11-15 15934951-0 2005 Lactate induces tumour necrosis factor-alpha, interleukin-6 and interleukin-1beta release in microglial- and astroglial-enriched primary cultures. Lactic Acid 0-7 interleukin 6 Homo sapiens 46-59 15934951-9 2005 Lactate, but not NH4Cl, induced release of TNF-alpha and IL-6 in both astroglial- and microglial-enriched cultures, while IL-1beta was released only in microglial cultures. Lactic Acid 0-7 interleukin 6 Homo sapiens 57-61 34838662-8 2022 Long time to return of spontaneous circulation and high lactate level at admission were associated with increased complement activation (TCC and C3bc), pro-inflammatory cytokines (IL-6, IL-8) and endothelial injury (syndecan-1) at admission. Lactic Acid 56-63 interleukin 6 Homo sapiens 180-184 11233396-7 2001 There was no correlation between the levels of these cytokines in the serum and the length of cardiopulmonary bypass, although there was a positive relation between levels of interleukin-6 and lactate in samples withdrawn at two hours of the end of bypass, and the measured levels of the cytokines correlated with the extent of inotropic drugs employed in the postoperative period. Lactic Acid 193-200 interleukin 6 Homo sapiens 175-188 11394246-1 2001 In the present study we investigated the possibility that exercise-induced increases in plasma levels of interleukin (IL)-6 are associated with plasma lactate levels. Lactic Acid 151-158 interleukin 6 Homo sapiens 105-123 11394246-9 2001 Furthermore, plasma IL-6 was negatively correlated to plasma lactate at rest (r = -0.786, P = 0.05). Lactic Acid 61-68 interleukin 6 Homo sapiens 20-24 11394246-10 2001 Given that IL-6 is a cytokine with growth-promoting potential, the results of this study suggest that high lactate production contributes to the decreased muscle function observed in MM patients by inhibiting the production of IL-6. Lactic Acid 107-114 interleukin 6 Homo sapiens 11-15 11394246-10 2001 Given that IL-6 is a cytokine with growth-promoting potential, the results of this study suggest that high lactate production contributes to the decreased muscle function observed in MM patients by inhibiting the production of IL-6. Lactic Acid 107-114 interleukin 6 Homo sapiens 227-231 11887802-0 2001 Interleukin-6 levels decrease in effluent from patients dialyzed with bicarbonate/lactate-based peritoneal dialysis solutions. Lactic Acid 82-89 interleukin 6 Homo sapiens 0-13 10513071-7 1999 A positive gradient for interleukin 6 levels was detected throughout the study period with normal intramucosal pH, lactate and oxygen/lactate ratio. Lactic Acid 115-122 interleukin 6 Homo sapiens 24-37 10513071-7 1999 A positive gradient for interleukin 6 levels was detected throughout the study period with normal intramucosal pH, lactate and oxygen/lactate ratio. Lactic Acid 134-141 interleukin 6 Homo sapiens 24-37 9853285-7 1998 RESULTS: While short (30 min) pre-exposure to lactate buffered PDF significantly reduced the IL-1 beta-stimulated IL-6 release from HPMC during a subsequent recovery period (24 hr), a significant decrease in HPMC IL-6 secretion with bicarbonate buffered PDF was only observed after prolonged (> or = 60 min) exposure. Lactic Acid 46-53 interleukin 6 Homo sapiens 114-118 9853285-7 1998 RESULTS: While short (30 min) pre-exposure to lactate buffered PDF significantly reduced the IL-1 beta-stimulated IL-6 release from HPMC during a subsequent recovery period (24 hr), a significant decrease in HPMC IL-6 secretion with bicarbonate buffered PDF was only observed after prolonged (> or = 60 min) exposure. Lactic Acid 46-53 interleukin 6 Homo sapiens 213-217 9593038-3 1998 The combination of GBS and lactate also enhanced the secretion of interleukin (IL)-1beta and IL-6. Lactic Acid 27-34 interleukin 6 Homo sapiens 93-97 8945595-0 1996 Production of human tumor necrosis factor alpha, interleukin-6, and interleukin-10 is induced by lactic acid bacteria. Lactic Acid 97-108 interleukin 6 Homo sapiens 49-62 7731159-0 1995 Effect of lactate-buffered peritoneal dialysis fluids on human peritoneal mesothelial cell interleukin-6 and prostaglandin synthesis. Lactic Acid 10-17 interleukin 6 Homo sapiens 91-104 8286509-8 1993 The preoperative APACHE II score correlated with the increased TNF alpha concentration (r = 0.5, p < 0.001) and plasma lactate concentration with that of IL-6 (r = 0.7, p = 0.003). Lactic Acid 122-129 interleukin 6 Homo sapiens 157-161 2289988-6 1990 Lactate correlated with C3a and C4a, with elastase, and in particular, with IL-6, whereas it did not correlate with either factor XII or prekallikrein. Lactic Acid 0-7 interleukin 6 Homo sapiens 76-80 9041915-11 1997 The responses of IL-6 and IL-1 beta in group 1 were striking compared with those in group 2, and they were accompanied by an elevation of the endotoxin concentration and a subsequent elevation of the concentrations of hepatocyte growth factor, hyaluronic acid, lactate, and other factors that reflected graft viability. Lactic Acid 261-268 interleukin 6 Homo sapiens 17-21 34547109-8 2021 Moreover, in MS patients, significant correlations were found between L-Glu and both CSF levels of lactate and the inflammatory molecules interleukin (IL)-2, IL-6, and IL-1 receptor antagonist. Lactic Acid 99-106 interleukin 6 Homo sapiens 158-162 2790194-5 1989 In addition, IL-6 significantly correlated with plasma lactate (P less than .0001), heart rate (P = .05) and, inversely, with mean arterial pressure (P = .01) and platelet counts (P = .0002). Lactic Acid 55-62 interleukin 6 Homo sapiens 13-17 34400170-4 2021 A growing number of studies have demonstrated that lactic acid regulates the degradation of collagen IV, collagen VII, and glycoprotein; the synthesis of collagen I; and multiple signaling pathways, including TGF-beta/Smad, Wnt/beta-catenin, IL-6/STAT3, and HGF/MET, which are associated with basement membrane (BM) remodeling and epithelial-mesenchymal transition (EMT), two hallmarks of the tumor invasive process. Lactic Acid 51-62 interleukin 6 Homo sapiens 242-246 34459125-8 2021 Subsequently, TNF-alpha, IL-1beta, and lactate activated CAFs, and facilitated the secretion of IL-6, IL-7, IL-8, CCL5, and transforming growth factor-beta1 from CAFs. Lactic Acid 39-46 interleukin 6 Homo sapiens 96-100 35264090-3 2022 Unlike what is observed in inflammation, IL-6 produced by skeletal muscle is not preceded by the release of other pro-inflammatory cytokines, but is seems to be dependent on the lactate produced during exercise, thus causing different effects from those of seen in inflammatory state. Lactic Acid 178-185 interleukin 6 Homo sapiens 41-45 35155394-4 2022 We engineered a model lactic acid bacterium, Lactococcus lactis, to co-display on its surface a protein ligand for tumor antigens (EpCAM-binding affitin; HER2-binding affibody) and a ligand for pro-inflammatory cytokines (IL-8-binding evasin; IL-6-binding affibody). Lactic Acid 22-33 interleukin 6 Homo sapiens 243-247