PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32179636-10	2020	Furthermore, Pfkfb3 overexpression not only rescued the reduction of macrophage glycolysis caused by Zhx2 deficiency, displaying as extracellular acidification rates and lactate production but also destroyed the resistance of mice to LPS-induced sepsis initiated by transfer of bone marrow-derived macrophages from MKO mice.	Lactic Acid	170-177	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Mus musculus	13-19	
31779643-10	2019	Interestingly, additional administration of moderate lactate, which may block the transport function of MCT1, decreased LPS-induced classical activation and expression of PFKFB3 in BV2 cells.	Lactic Acid	53-60	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Mus musculus	171-177	
24700124-9	2014	A lower level of phosphorylated protein kinase B was observed in PFKFB3-knockdown endothelial cells, which was accompanied by a decrease in intracellular lactate.	Lactic Acid	154-161	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Mus musculus	65-71	
28061878-10	2017	Targeting PFKFB3 via PFK15 significantly reduced the glucose uptake, lactate production and ATP generation in HNSCC cell lines.	Lactic Acid	69-76	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Mus musculus	10-16	
24700124-10	2014	The addition of lactate to PFKFB3-knockdown cells rescued the suppression of endothelial proliferation and migration.	Lactic Acid	16-23	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Mus musculus	27-33	
22591674-10	2012	We then found that exposure to the PFKFB3 small molecule antagonist, 3PO (1-10 muM), markedly attenuated the stimulation of F2,6BP synthesis, 2-[1-14C]-deoxy-D-glucose uptake, lactate secretion, TNF-alpha secretion and T cell aggregation and proliferation.	Lactic Acid	176-183	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Mus musculus	35-41	
21860432-7	2012	PFKFB3 was required for JAK2V617F-dependent lactate production, oxidative metabolic activity and glucose uptake.	Lactic Acid	44-51	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Mus musculus	0-6	
16715124-6	2006	Moreover, despite co-expression of all four mRNA species (PFKFB1-4), heterozygotic genomic deletion of the inducible PFKFB3 gene in ras-transformed mouse lung fibroblasts suppresses F2,6BP production, glycolytic flux to lactate, and growth as soft agar colonies or tumors in athymic mice.	Lactic Acid	220-227	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Mus musculus	117-123