PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24700124-9 2014 A lower level of phosphorylated protein kinase B was observed in PFKFB3-knockdown endothelial cells, which was accompanied by a decrease in intracellular lactate. Lactic Acid 154-161 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Mus musculus 65-71 24700124-10 2014 The addition of lactate to PFKFB3-knockdown cells rescued the suppression of endothelial proliferation and migration. Lactic Acid 16-23 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Mus musculus 27-33 22591674-10 2012 We then found that exposure to the PFKFB3 small molecule antagonist, 3PO (1-10 muM), markedly attenuated the stimulation of F2,6BP synthesis, 2-[1-14C]-deoxy-D-glucose uptake, lactate secretion, TNF-alpha secretion and T cell aggregation and proliferation. Lactic Acid 176-183 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Mus musculus 35-41 32179636-10 2020 Furthermore, Pfkfb3 overexpression not only rescued the reduction of macrophage glycolysis caused by Zhx2 deficiency, displaying as extracellular acidification rates and lactate production but also destroyed the resistance of mice to LPS-induced sepsis initiated by transfer of bone marrow-derived macrophages from MKO mice. Lactic Acid 170-177 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Mus musculus 13-19 21860432-7 2012 PFKFB3 was required for JAK2V617F-dependent lactate production, oxidative metabolic activity and glucose uptake. Lactic Acid 44-51 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Mus musculus 0-6 16715124-6 2006 Moreover, despite co-expression of all four mRNA species (PFKFB1-4), heterozygotic genomic deletion of the inducible PFKFB3 gene in ras-transformed mouse lung fibroblasts suppresses F2,6BP production, glycolytic flux to lactate, and growth as soft agar colonies or tumors in athymic mice. Lactic Acid 220-227 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Mus musculus 117-123 31779643-10 2019 Interestingly, additional administration of moderate lactate, which may block the transport function of MCT1, decreased LPS-induced classical activation and expression of PFKFB3 in BV2 cells. Lactic Acid 53-60 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Mus musculus 171-177 28061878-10 2017 Targeting PFKFB3 via PFK15 significantly reduced the glucose uptake, lactate production and ATP generation in HNSCC cell lines. Lactic Acid 69-76 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Mus musculus 10-16