PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27559047-0	2016	Lactic Acid Suppresses IL-33-Mediated Mast Cell Inflammatory Responses via Hypoxia-Inducible Factor-1alpha-Dependent miR-155 Suppression.	Lactic Acid	0-11	hypoxia inducible factor 1, alpha subunit	Mus musculus	75-106	
28642579-6	2017	Glucose consumption, lactate export and glycolytic capacity were reduced in brown adipocytes depleted of Hif-1alpha.	Lactic Acid	21-28	hypoxia inducible factor 1, alpha subunit	Mus musculus	105-115	
25019241-4	2014	Knockdown of PKM2, HIF1alpha and glycolysis-related genes uniformly decreases lactate production and HMGB1 release.	Lactic Acid	78-85	hypoxia inducible factor 1, alpha subunit	Mus musculus	19-28	
26271607-0	2015	Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1alpha pathway in chondrocytes.	Lactic Acid	86-93	hypoxia inducible factor 1, alpha subunit	Mus musculus	94-103	
26271607-4	2015	We found that stearic acid potentiated LDH-a-dependent production of lactate, which further stabilized HIF1alpha protein and increased VEGF and proinflammatory cytokine expression in primary mouse chondrocytes.	Lactic Acid	69-76	hypoxia inducible factor 1, alpha subunit	Mus musculus	103-112	
26271607-7	2015	In conclusion, saturated free fatty acid induced proinflammatory cytokine production partly through activation of a novel lactate-HIF1alpha pathway in chondrocytes.	Lactic Acid	122-129	hypoxia inducible factor 1, alpha subunit	Mus musculus	130-139	
26178372-8	2015	Hif1alpha activation is required for lactate-dependent proliferation of the undifferentiated cells.	Lactic Acid	37-44	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-9	
34552205-10	2021	Exogenous lactate supplementation increased the stability of HIF1alpha and promoted adipogenesis.	Lactic Acid	10-17	hypoxia inducible factor 1, alpha subunit	Mus musculus	61-70	
19276158-6	2009	Because lactate dehydrogenase-A (LDH-A), also a HIF-1alpha target, promotes fermentative glycolysis (conversion of pyruvate to lactate), a step essential for regenerating NAD+, we asked whether FH-deficient cells would be exquisitely sensitive to LDH-A blockade.	Lactic Acid	8-15	hypoxia inducible factor 1, alpha subunit	Mus musculus	48-58	
21775648-9	2011	Overall, our results point to a novel mechanism in muscle where the HIF-1alpha pathway is desensitized in the transition from acute to chronic hypoxia, leading to a reestablishment of PDH activity and a reduction in lactate production by the exercising muscles.	Lactic Acid	216-223	hypoxia inducible factor 1, alpha subunit	Mus musculus	68-78	
15132980-5	2004	Cardiac myocyte-specific HIF-1alpha gene deletion in the hearts of genetically engineered mice caused reductions in contractility, vascularization, high-energy phosphate content, and lactate production.	Lactic Acid	183-190	hypoxia inducible factor 1, alpha subunit	Mus musculus	25-35	
34552205-11	2021	PDK1/2 overexpression-mediated adipogenesis was abolished by HIF1alpha inhibition, suggesting a role for the PDK-lactate-HIF1alpha axis during adipogenesis.	Lactic Acid	113-120	hypoxia inducible factor 1, alpha subunit	Mus musculus	61-70	
34552205-11	2021	PDK1/2 overexpression-mediated adipogenesis was abolished by HIF1alpha inhibition, suggesting a role for the PDK-lactate-HIF1alpha axis during adipogenesis.	Lactic Acid	113-120	hypoxia inducible factor 1, alpha subunit	Mus musculus	121-130	
32251993-5	2020	Furthermore, upon S6K1 loss, induction of both mRNA and protein levels of Hif-1alpha and those of the downstream target, Vegf, was compromised in bone marrow-derived macrophages stimulated with lactate.	Lactic Acid	194-201	hypoxia inducible factor 1, alpha subunit	Mus musculus	74-84	
33732648-12	2021	We further revealed that DPT-induced cell growth inhibition and increased glucose and lactate levels could be reversed by overexpressing HIF-1alpha.	Lactic Acid	86-93	hypoxia inducible factor 1, alpha subunit	Mus musculus	137-147	
30548595-5	2019	Hypoxia or HIF-1alpha could enhanced osteoclastogenesis, bone absorption, and lactic acid concentration in receptor activator of nuclear factor kappaBeta ligand-induced RAW264.7 cells.	Lactic Acid	78-89	hypoxia inducible factor 1, alpha subunit	Mus musculus	11-21	
30813322-3	2019	The hypoxic tumor microenvironment in high-grade tumors, as measured by significantly decreased HP 13C-urea perfusion and increased PIM staining, played a key role in increasing lactate production through increased Hif1alpha and then Ldha expression.	Lactic Acid	178-185	hypoxia inducible factor 1, alpha subunit	Mus musculus	215-224