PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10333080-4	1999	Lactate at a concentration of 10 mmol/l activated both the K(ATP) and KCa channels, not only in cell-attached, but also in inside-out patch configurations, indicating that the increase in [Ca2+](i) and secretion of insulin by lactate cannot be explained by the blocking of the K+ channels.	Lactic Acid	226-233	insulin	Mesocricetus auratus	215-222	
10333080-0	1999	Lactate stimulates insulin secretion without blocking the K+ channels in HIT-T15 insulinoma cells.	Lactic Acid	0-7	insulin	Mesocricetus auratus	19-26	
1346395-6	1992	Other insulin secretagogues such as glutamine, lactate, and isobutylmethylxanthine are also found to activate HIT ACC.	Lactic Acid	47-54	insulin	Mesocricetus auratus	6-13	
10333080-1	1999	To clarify the mechanism by which lactate affects insulin secretion, we investigated the effect of lactate on insulin secretion, cytosolic free Ca2+ ([Ca2+](i), the ATP sensitive K+ channel (K(ATP)) and the Ca2+-activated K+ channel (K(Ca)) in HIT-T15 cells, and the results were compared with those of glucose and glibenclamide.	Lactic Acid	34-41	insulin	Mesocricetus auratus	50-57	
10333080-4	1999	Lactate at a concentration of 10 mmol/l activated both the K(ATP) and KCa channels, not only in cell-attached, but also in inside-out patch configurations, indicating that the increase in [Ca2+](i) and secretion of insulin by lactate cannot be explained by the blocking of the K+ channels.	Lactic Acid	0-7	insulin	Mesocricetus auratus	215-222	
3545948-1	1987	Insulin secretion by monolayer cultures of HIT T-15 cells was measured in response to various fuel molecules (glucose, dihydroxyacetone, lactate, glutamine, alpha-ketoisocaproic acid, alpha-ketoisovaleric acid) and a nonmetabolized glucose analogue (3-O-methylglucose).	Lactic Acid	137-144	insulin	Mesocricetus auratus	0-7