PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33268383-6 2021 Finally, we demonstrated that significant lactate import through MCT1 occurs even when glucose is not limiting, that feeds the oxidative metabolism of beige adipocytes. Lactic Acid 42-49 modifier of curly tail 1 Mus musculus 65-69 32738449-9 2021 We show the tumor suppressor role of miR-342-3p is executed partly by modulating the lactate transport function of MCT1. Lactic Acid 85-92 modifier of curly tail 1 Mus musculus 115-119 33268383-5 2021 We also observed that MCT1 mediates bidirectional and simultaneous inward and outward lactate fluxes which were required for efficient utilization of glucose by beige adipocytes activated by the canonical beta3-adrenergic signaling pathway. Lactic Acid 86-93 modifier of curly tail 1 Mus musculus 22-26 30561869-6 2019 We found that the most likely explanation for our finding that hyperpolarized lactate is reduced in treated cells is a 30% reduction in intracellular lactate levels that occurs as a result of increased expression of both MCT1 and MCT4 in vorinostat-treated cells. Lactic Acid 78-85 modifier of curly tail 1 Mus musculus 221-225 31073907-4 2019 Among the family of MCTs, MCT1 is at least partly responsible for lactate uptake by the germ cells. Lactic Acid 66-73 modifier of curly tail 1 Mus musculus 26-30 32362817-1 2020 The monocarboxylate transporters (MCTs) MCT1, MCT2, and MCT4 are essential components of the astrocyte-neuron lactate shuttle (ANLS), which is a fundamental element of brain energetics. Lactic Acid 110-117 modifier of curly tail 1 Mus musculus 40-44 30561869-6 2019 We found that the most likely explanation for our finding that hyperpolarized lactate is reduced in treated cells is a 30% reduction in intracellular lactate levels that occurs as a result of increased expression of both MCT1 and MCT4 in vorinostat-treated cells. Lactic Acid 150-157 modifier of curly tail 1 Mus musculus 221-225 29026134-7 2017 Adipocyte differentiation was accompanied by increased plasma membrane lactate flux capacity, which was reduced by MCT inhibition and by MCT1 knockdown. Lactic Acid 71-78 modifier of curly tail 1 Mus musculus 137-141 29092796-7 2017 It is proposed that reduced hepatic lactate metabolism is responsible for the protection against hepatic steatosis in MCT1 haploinsufficient mice via a constitutive activation of AMPK and repression of several major elements involved in hepatic lipid metabolism. Lactic Acid 36-43 modifier of curly tail 1 Mus musculus 118-122 29026134-9 2017 We suggest that upregulation of MCT1- and MCT4-mediated lactate flux capacity and NBCe1-mediated HCO3-/pH homeostasis are important for the physiological function of mature adipocytes. Lactic Acid 56-63 modifier of curly tail 1 Mus musculus 32-36 24573205-1 2014 The monocarboxylate transporter (MCT)-1 plays an important role in the transfer of monocarboxylate metabolites such as lactate, ketone bodies, and acetic acid. Lactic Acid 119-126 modifier of curly tail 1 Mus musculus 4-39 26203664-4 2015 In this study, we performed siRNA knockdown of MCT1 and MCT4 in basal-like breast cancer cells in both normoxia and hypoxia conditions to validate the potential of lactate transport inhibition in breast cancer treatment. Lactic Acid 164-171 modifier of curly tail 1 Mus musculus 47-51 26059436-1 2015 Lactic acid generated by highly glycolytic tumours is exported by the MonoCarboxylate Transporters, MCT1 and MCT4, to maintain pHi and energy homeostasis. Lactic Acid 0-11 modifier of curly tail 1 Mus musculus 100-104 26178372-7 2015 Besides, lactate exporter monocarboxylate transporter 4 (Mct4) is induced in newly formed decidual cells, whereas lactate importer Mct1 and proliferation marker Ki-67 are complementarily located in the surrounding undifferentiated cells, which are supposed to consume lactate for proliferation. Lactic Acid 114-121 modifier of curly tail 1 Mus musculus 131-135 26178372-7 2015 Besides, lactate exporter monocarboxylate transporter 4 (Mct4) is induced in newly formed decidual cells, whereas lactate importer Mct1 and proliferation marker Ki-67 are complementarily located in the surrounding undifferentiated cells, which are supposed to consume lactate for proliferation. Lactic Acid 114-121 modifier of curly tail 1 Mus musculus 131-135 19048272-7 2009 Since the secretions from these glands contain fat as a major product, the cellular localization of MCT1 suggests the involvement of the transporter in the uptake of lactate, acetate, and other monocarboxylates for production of medium- and long-chain fatty acids. Lactic Acid 166-173 modifier of curly tail 1 Mus musculus 100-104 24376811-10 2013 In conclusion, RVI in skeletal muscle exposed to raised tonicity and [lactate-] is facilitated by inward flux of solute by NKCC- and MCT1-dependent mechanisms. Lactic Acid 70-77 modifier of curly tail 1 Mus musculus 133-137 24367518-1 2013 The monocarboxylate transporter 1 (MCT1 or SLC16A1) is a carrier of short-chain fatty acids, ketone bodies, and lactate in several tissues. Lactic Acid 112-119 modifier of curly tail 1 Mus musculus 35-39 22451434-4 2012 The augmentation of lactate transport is independent of the enzyme"s catalytic activity, but requires direct binding of CAII to the C-terminal of the monocarboxylate transporter MCT1, one of the major lactate/proton cotransporters in astrocytes and most tissues. Lactic Acid 20-27 modifier of curly tail 1 Mus musculus 178-182 22451434-5 2012 By employing its intramolecular proton shuttle, CAII, bound to MCT1, can act as a "proton collecting antenna" for the transporter, suppressing the formation of proton microdomains at the transporter-pore and thereby enhancing lactate flux. Lactic Acid 226-233 modifier of curly tail 1 Mus musculus 63-67 21792931-6 2012 We propose that basigin interacts with MCT1 and MCT2 to locate them properly in the membrane of spermatogenic cells and that this may enable sperm to utilize lactate as an energy substrate contributing to cell survival. Lactic Acid 158-165 modifier of curly tail 1 Mus musculus 39-43 24303150-15 2013 MCT1 but not MCT4 expression is altered at the onset of skeletal muscle regeneration possibly in an attempt to regulate lactate uptake and use by skeletal muscle cells. Lactic Acid 120-127 modifier of curly tail 1 Mus musculus 0-4 21704401-2 2011 However, recently it was suggested that lactate produced in hypoxic tumor areas may be taken up by the monocarboxylate transporter MCT1 and oxidized in well-oxygenated tumor parts. Lactic Acid 40-47 modifier of curly tail 1 Mus musculus 131-135 21704401-3 2011 Furthermore, it was shown that inhibition of lactate oxidation using the MCT1 inhibitor alpha-cyano-hydroxycinnamate (CHC) can radio-sensitize tumors possibly by forcing a switch from lactate oxidization to glycolysis in oxygenated cells, which in turn improves tumor oxygenation and indirectly kills radio-resistant hypoxic tumor cells from glucose starvation. Lactic Acid 45-52 modifier of curly tail 1 Mus musculus 73-77 21704401-3 2011 Furthermore, it was shown that inhibition of lactate oxidation using the MCT1 inhibitor alpha-cyano-hydroxycinnamate (CHC) can radio-sensitize tumors possibly by forcing a switch from lactate oxidization to glycolysis in oxygenated cells, which in turn improves tumor oxygenation and indirectly kills radio-resistant hypoxic tumor cells from glucose starvation. Lactic Acid 184-191 modifier of curly tail 1 Mus musculus 73-77 21141497-8 2010 Moreover, MCT1 and MCT2 upregulated accompanied with the increase of lactate, MCT2 mRNA enhanced in brazilein 5 mg x kg(-1) group (P < 0.05) while both the two factors increased in brazilein 10 mg x kg(-1) group (P < 0.01). Lactic Acid 69-76 modifier of curly tail 1 Mus musculus 10-14 19604494-5 2009 Immortalized cardiomyocytes (HL-1 cells) were injured with hydrogen peroxide, and cell death in the presence or absence of the competitive inhibitor of MCT1, d-lactate, was evaluated by Trypan blue exclusion. Lactic Acid 158-167 modifier of curly tail 1 Mus musculus 152-156 19604494-14 2009 Increased MCT1 expression after ischemia and reperfusion is likely to restore cardiac pH through lactate export. Lactic Acid 97-104 modifier of curly tail 1 Mus musculus 10-14 15121743-1 2004 We sought to test the hypothesis that monocarboxylate transporter isoform 1 (MCT1) is the inner mitochondrial membrane lactate/pyruvate transporter, and, as such, contributes to functioning of the intracellular lactate shuttle. Lactic Acid 119-126 modifier of curly tail 1 Mus musculus 77-81 18379211-5 2008 Subsequently, the presence of a mitochondrial lactate oxidation complex (composed of mMCT1, CD147 (basigin), mLDH, and cytochrome oxidase (COX)) was discovered, which lends support to the presence of the ILS. Lactic Acid 46-53 modifier of curly tail 1 Mus musculus 85-90 16514190-3 2006 In the case of lactate and pyruvate, this occurs via H+-monocarboxylate cotransporter (MCT) proteins. Lactic Acid 15-22 modifier of curly tail 1 Mus musculus 56-86 15121743-1 2004 We sought to test the hypothesis that monocarboxylate transporter isoform 1 (MCT1) is the inner mitochondrial membrane lactate/pyruvate transporter, and, as such, contributes to functioning of the intracellular lactate shuttle. Lactic Acid 211-218 modifier of curly tail 1 Mus musculus 77-81 34676828-4 2021 Abolishment of MCT1 in the plasma membrane was achieved by Bsg depletion, which led to gluconeogenesis impairment via preventing the influx of lactate and pyruvate into the cell, consequently suppressing the TCA cycle. Lactic Acid 143-150 modifier of curly tail 1 Mus musculus 15-19 11098125-9 2000 In conclusion, these observations are consistent with the possibility that lactate, produced and released by astrocytes (via MCT1), could be taken up (via MCT2) and used by neurons as an energy substrate. Lactic Acid 75-82 modifier of curly tail 1 Mus musculus 125-129