PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10417314-2 1999 The rat monocarboxylate transporter isoform MCT2 was analysed by expression in Xenopus laevis oocytes and the results were compared with the known characteristics of lactate transport in heart and brain. Lactic Acid 166-173 solute carrier family 16 member 7 Rattus norvegicus 44-48 15749979-1 2005 MCT2 is the main neuronal monocarboxylate transporter needed by neurons if they are to use lactate as an additional energy substrate. Lactic Acid 91-98 solute carrier family 16 member 7 Rattus norvegicus 0-4 12773420-13 2003 Together with previous studies, the present data reinforce the concept that among the key functions of the endocrine/paracrine systems in the testis is the control of the energy metabolism occurring in the context of Sertoli cell-germ cell metabolic cooperation where lactate is produced in somatic cells and transported to germ cells via, at least, MCT2. Lactic Acid 268-275 solute carrier family 16 member 7 Rattus norvegicus 350-354 12943996-8 2003 Lactate is transported from Sertoli cells to germ cells via MCT1 and MCT2. Lactic Acid 0-7 solute carrier family 16 member 7 Rattus norvegicus 69-73 12943996-10 2003 In the adult testis exposed in utero to flutamide, MCT1 (53 +/- 8%, P<0.02) and MCT2 (52 +/- 9%, P<0.02) mRNA levels were significantly reduced indicating that lactate transport to germ cells could be also altered. Lactic Acid 166-173 solute carrier family 16 member 7 Rattus norvegicus 83-87 10417314-10 1999 It is suggested that cells which express MCT2 preferentially use lactate and ketone bodies as energy sources. Lactic Acid 65-72 solute carrier family 16 member 7 Rattus norvegicus 41-45 9458768-14 1998 These interactions suggest that MCT2, the monocarboxylate transporter that mediates the hepatic uptake of lactate and other monocarboxylic acids, may be involved in HA transport. Lactic Acid 106-113 solute carrier family 16 member 7 Rattus norvegicus 32-36 10392858-11 1999 The location of monocarboxylate transporter-2 on glial foot processes surrounding retinal vessels suggests that this transporter is also important in blood-retinal lactate exchange. Lactic Acid 164-171 solute carrier family 16 member 7 Rattus norvegicus 16-45 31667814-6 2019 Prolonged exhaustive exercise also increased MCT2 protein in the brain, which takes up lactate in neurons, just as muscle MCTs are increased. Lactic Acid 87-94 solute carrier family 16 member 7 Rattus norvegicus 45-49 34957860-5 2022 Significant hippocampal-dependent memory dysfunction was observed in the pre-symptomatic stage of OLETF rats, accompanied by downregulated levels of hippocampal monocarboxylate transporter 2 (MCT2), a neuronal lactate-transporter, without alteration in hippocampal glycogen levels. Lactic Acid 210-217 solute carrier family 16 member 7 Rattus norvegicus 192-196 28515312-6 2017 The levels of MCT2, which takes up lactate in neurons, increased in the brain, as did muscle MCTs. Lactic Acid 35-42 solute carrier family 16 member 7 Rattus norvegicus 14-18 27987117-1 2018 Astrocyte-neuron lactate shuttle (ANLS) is a pathway that supplies glycogen-derived lactate to active neurons via monocarboxylate transporter 2 (MCT2), and is important for maintaining brain functions. Lactic Acid 17-24 solute carrier family 16 member 7 Rattus norvegicus 114-143 27987117-1 2018 Astrocyte-neuron lactate shuttle (ANLS) is a pathway that supplies glycogen-derived lactate to active neurons via monocarboxylate transporter 2 (MCT2), and is important for maintaining brain functions. Lactic Acid 17-24 solute carrier family 16 member 7 Rattus norvegicus 145-149 23638108-9 2013 Thus, MCT2 distribution coupled with lactate uptake by hypothalamic neurons suggests that hypothalamic neurons control food intake using lactate to reflect changes in glucose levels. Lactic Acid 137-144 solute carrier family 16 member 7 Rattus norvegicus 6-10 28388627-0 2017 A neuronal MCT2 knockdown in the rat somatosensory cortex reduces both the NMR lactate signal and the BOLD response during whisker stimulation. Lactic Acid 79-86 solute carrier family 16 member 7 Rattus norvegicus 11-15 28388627-8 2017 These data not only demonstrate that glucose-derived lactate is locally produced following neuronal activation but also suggest that its use by neurons via MCT2 is probably essential to maintain synaptic activity within the barrel cortex. Lactic Acid 53-60 solute carrier family 16 member 7 Rattus norvegicus 156-160 27928614-6 2017 However, OLETF rats expressed lower levels of hippocampal monocarboxylate transporter 2 (MCT2, a transporter for lactate to neurons). Lactic Acid 113-120 solute carrier family 16 member 7 Rattus norvegicus 58-87 26299481-3 2015 Monocarboxylate transporter (MCT), responsible for the transport of lactate and other monocarboxylates via the cell membrane, is abundant in the testes and sperm (MCT1, MCT2, and MCT4). Lactic Acid 68-75 solute carrier family 16 member 7 Rattus norvegicus 169-173 24260123-7 2013 MCT2 plays a key role in providing lactate as an energy source to neurons. Lactic Acid 35-42 solute carrier family 16 member 7 Rattus norvegicus 0-4 24260123-12 2013 CONCLUSIONS: These data strongly suggest that neuroplastins act as key ancillary proteins for MCT2 cell surface localisation and activity in some neuronal populations, thus playing an important role in facilitating the uptake of lactate for use as a respiratory fuel. Lactic Acid 229-236 solute carrier family 16 member 7 Rattus norvegicus 94-98 27928614-6 2017 However, OLETF rats expressed lower levels of hippocampal monocarboxylate transporter 2 (MCT2, a transporter for lactate to neurons). Lactic Acid 113-120 solute carrier family 16 member 7 Rattus norvegicus 89-93 25827488-9 2015 However, neuronal cell death in co-cultures was increased by exposure to MCT4- or MCT2-specific siRNA, and this effect was attenuated by the addition of lactate into the extracellular medium of neuronal cultures prior to OGD. Lactic Acid 153-160 solute carrier family 16 member 7 Rattus norvegicus 82-86 23201632-6 2013 Astroglial monocarboxylates transporters MCT1 and MCT4 isoforms transfer lactate from blood to astrocytes and release lactate to the extracellular space, whilst the neuronal MCT2 isoform permits neuronal lactate uptake. Lactic Acid 73-80 solute carrier family 16 member 7 Rattus norvegicus 174-178 17941059-4 2008 Estradiol (E) enhances expression of the neuronal monocarboxylate transporter MCT2 in the DVC during insulin-induced hypoglycemia (IIH), evidence that this hormone may promote local lactate utilization during systemic glucose shortages. Lactic Acid 182-189 solute carrier family 16 member 7 Rattus norvegicus 78-82 21376239-4 2011 Disrupting the expression of the neuronal lactate transporter MCT2 also leads to amnesia that is unaffected by either L-lactate or glucose, suggesting that lactate import into neurons is necessary for long-term memory. Lactic Acid 42-49 solute carrier family 16 member 7 Rattus norvegicus 62-66 17941059-6 2008 Insulin-induced decrements in circulating glucose were significantly augmented by lactate, albeit to a greater extent in the presence of E. DVC MCT2, GLUT3, GLUT4, glucokinase (GCK), and sulfonylurea receptor-1 (SUR1) mRNA levels did not differ between saline-injected OVX + E and OVX + O rats. Lactic Acid 82-89 solute carrier family 16 member 7 Rattus norvegicus 144-148 17941059-9 2008 Expression of the SUR1 subunit of the energy-dependent potassium channel K(ATP) was significantly decreased by IIH in both E- and O-treated rats and further suppressed in response to lactate delivery during hypoglycemia in OVX + E. These data reveal that E does not control baseline DVC substrate fuel transporter or energy transducer gene profiles or local MCT2, GLUT3, or SUR1 transcriptional responses to IIH but prevents IIH-associated decreases in GLUT4 and GCK mRNA in this brain site. Lactic Acid 183-190 solute carrier family 16 member 7 Rattus norvegicus 358-362 17941059-10 2008 The results also show that, in the presence of E, intensifying effects of CV4 lactate infusion on hypoglycemia are correlated with reversal of IIH enhancement of DVC MCT2 gene expression, augmented IIH inhibition of SUR1 transcripts, and reductions in GLUT4 and GCK mRNA levels relative to baseline. Lactic Acid 78-85 solute carrier family 16 member 7 Rattus norvegicus 166-170 18084728-2 2008 Neuronal glucose (GLUT3, GLUT4) and monocarboxylate (MCT2) transporter genes are expressed in both sites, suggesting that glucose and lactate, a product of astrocytic glycolysis, may fuel aerobic respiration in local neurons. Lactic Acid 134-141 solute carrier family 16 member 7 Rattus norvegicus 53-57 18084728-8 2008 CV4 lactate infusion in hypoglycemic OVX + EB animals suppressed each mRNA profile, but reversed IIH-associated reductions in MCT2, GLUT3, and GLUT4 gene expression in OVX + O. VMH: IIH increased MCT2 and GLUT4 transcripts in OVX + EB, but not OVX + O rats and decreased GCK mRNA in both groups. Lactic Acid 4-11 solute carrier family 16 member 7 Rattus norvegicus 126-130 18084728-8 2008 CV4 lactate infusion in hypoglycemic OVX + EB animals suppressed each mRNA profile, but reversed IIH-associated reductions in MCT2, GLUT3, and GLUT4 gene expression in OVX + O. VMH: IIH increased MCT2 and GLUT4 transcripts in OVX + EB, but not OVX + O rats and decreased GCK mRNA in both groups. Lactic Acid 4-11 solute carrier family 16 member 7 Rattus norvegicus 196-200 16604139-17 2006 In conclusion, this study suggests that in skeletal muscle, as well as other tissues, lactate and pyruvate transport rates may not only involve MCT1 and -4, as other monocarboxylate transporters are also expressed in rat (MCT2, -5, -6) and human skeletal muscle (MCT2, -5, -6, -7). Lactic Acid 86-93 solute carrier family 16 member 7 Rattus norvegicus 222-226 16597615-7 2006 Conversely, severe hypoxia increased transcripts involved in extracellular matrix remodeling, those of muscle-type myosins, and others involved in creatine phosphate synthesis and lactate transport (Slc16a7). Lactic Acid 180-187 solute carrier family 16 member 7 Rattus norvegicus 199-206