PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24694247-0	2014	Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase beta.	O-(6)-methylguanine	90-106	DNA polymerase beta	Homo sapiens	116-135	
24694247-1	2014	Human DNA polymerase beta (polbeta) inserts, albeit slowly, T opposite the carcinogenic lesion O6-methylguanine (O6MeG) ~30-fold more frequently than C. To gain insight into this promutagenic process, we solved four ternary structures of polbeta with an incoming dCTP or dTTP analogue base-paired with O6MeG in the presence of active-site Mg(2+) or Mn(2+).	O-(6)-methylguanine	95-111	DNA polymerase beta	Homo sapiens	6-25	
24694247-1	2014	Human DNA polymerase beta (polbeta) inserts, albeit slowly, T opposite the carcinogenic lesion O6-methylguanine (O6MeG) ~30-fold more frequently than C. To gain insight into this promutagenic process, we solved four ternary structures of polbeta with an incoming dCTP or dTTP analogue base-paired with O6MeG in the presence of active-site Mg(2+) or Mn(2+).	O-(6)-methylguanine	113-118	DNA polymerase beta	Homo sapiens	6-25	
24694247-1	2014	Human DNA polymerase beta (polbeta) inserts, albeit slowly, T opposite the carcinogenic lesion O6-methylguanine (O6MeG) ~30-fold more frequently than C. To gain insight into this promutagenic process, we solved four ternary structures of polbeta with an incoming dCTP or dTTP analogue base-paired with O6MeG in the presence of active-site Mg(2+) or Mn(2+).	O-(6)-methylguanine	302-307	DNA polymerase beta	Homo sapiens	6-25	
9649318-4	1998	This study was done to understand how Cr(III), in the presence of physiological concentrations of magnesium, affects the kinetic parameters of steady-state DNA synthesis in vitro across site-specific O6-methylguanine (m6dG) residues by DNA polymerase beta (pol beta).	O-(6)-methylguanine	200-216	DNA polymerase beta	Homo sapiens	236-255	
9649318-4	1998	This study was done to understand how Cr(III), in the presence of physiological concentrations of magnesium, affects the kinetic parameters of steady-state DNA synthesis in vitro across site-specific O6-methylguanine (m6dG) residues by DNA polymerase beta (pol beta).	O-(6)-methylguanine	200-216	DNA polymerase beta	Homo sapiens	257-265	
8910463-0	1996	Replication across O6-methylguanine by human DNA polymerase beta in vitro.	O-(6)-methylguanine	19-35	DNA polymerase beta	Homo sapiens	45-64	
8910463-2	1996	Replication in vivo across unrepaired O6-methylguanine (m6dG) lesions by mammalian DNA polymerase beta (pol beta) during short patch repair may contribute to the cytotoxicity and mutagenesis of m6dG.	O-(6)-methylguanine	38-54	DNA polymerase beta	Homo sapiens	83-102	
8910463-2	1996	Replication in vivo across unrepaired O6-methylguanine (m6dG) lesions by mammalian DNA polymerase beta (pol beta) during short patch repair may contribute to the cytotoxicity and mutagenesis of m6dG.	O-(6)-methylguanine	38-54	DNA polymerase beta	Homo sapiens	104-112