PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28694081-11	2017	Treatment of cartilage explants with 12/15-LOX metabolites, suppressed IL-1alpha-induced production of MMP-13, NO and PGE2, with LXA4 being the most potent.	lipoxin A4	129-133	interleukin 1 alpha	Mus musculus	71-80	
33221976-9	2021	CIA mice treated with LXA4 and SB203580 had lower levels of TNF-alpha, IL-6, IL-1beta, and IFN-gamma, accompanying decreased MDA as well as increased SOD, CAT,and GPx.	lipoxin A4	22-26	interleukin 1 alpha	Mus musculus	77-85	
21501589-3	2011	In this study, we investigated the inhibitory effect and the molecular mechanism of the lipoxin A(4) (LXA(4)) on the production of interleukin-1beta (IL-1beta) and tumor necrosis factoralpha (TNFalpha) induced by beta-amyloid in the cortex and hippocampus of mice, and in Abeta-stimulated BV2 cells, a mouse microglial cell line.	lipoxin A4	88-97	interleukin 1 alpha	Mus musculus	150-158	
21501589-5	2011	Our findings suggest that LXA(4) inhibits the production of IL-1beta and TNFalpha induced by beta-amyloid in the cortex and hippocampus of mice, and in BV2 microglial cells via the NF-kappaB signal pathway.	lipoxin A4	26-32	interleukin 1 alpha	Mus musculus	60-68	
35235107-4	2022	In cultured macrophages, LXA4 inhibited LPS-induced inflammatory polarization, thereby decreasing the release of proinflammatory cell factors (IL-1beta, IL-6, TNF-alpha) and increasing the release of anti-inflammatory cytokines (IL-4 and IL-10).	lipoxin A4	25-29	interleukin 1 alpha	Mus musculus	143-151