PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20650112-3 1995 Benz[a]anthracene (BA, 1 or 10 mum), used as a positive control, induced CYP1A1 mRNA in two out of three human leukaemic haemopoietic stem cell lines (positive: KG-1, U937; negative: HL-60), as well as in long-term bone marrow cultures established from healthy volunteers. benz(a)anthracene 0-17 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 73-79 9592188-3 1998 The effect of benzanthracene (Ba) as inducer was tested on the mRNA level of cytochrome P450 1A1. benz(a)anthracene 14-28 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 77-96 9592188-3 1998 The effect of benzanthracene (Ba) as inducer was tested on the mRNA level of cytochrome P450 1A1. benz(a)anthracene 30-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 77-96 20650112-3 1995 Benz[a]anthracene (BA, 1 or 10 mum), used as a positive control, induced CYP1A1 mRNA in two out of three human leukaemic haemopoietic stem cell lines (positive: KG-1, U937; negative: HL-60), as well as in long-term bone marrow cultures established from healthy volunteers. benz(a)anthracene 19-21 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 73-79 20650112-8 1995 In conclusion, CYP1A1 mRNA induction was demonstrated in haemopoietic cells; inducers for CYP1A1 were not only a polycyclic aromatic hydrocarbon (BA), but also, unexpectedly, hydroxylated metabolites of benzene. benz(a)anthracene 146-148 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 15-21 20650112-8 1995 In conclusion, CYP1A1 mRNA induction was demonstrated in haemopoietic cells; inducers for CYP1A1 were not only a polycyclic aromatic hydrocarbon (BA), but also, unexpectedly, hydroxylated metabolites of benzene. benz(a)anthracene 146-148 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 90-96 1521541-6 1992 After benzanthracene treatment, a protein tentatively identified as isozyme CYP1A1 was detected by Western-blot analysis and a concommitant increase in CYP1A mRNA expression was observed. benz(a)anthracene 6-20 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 76-82 7581497-2 1995 Here, the application of rat and human CYP1A1 and CYP1A2 is demonstrated for comparative studies on the oxidation of polycyclic aromatic hydrocarbons, such as phenanthrene, benz[a]anthracene, and benzo[a]pyrene. benz(a)anthracene 173-190 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 39-45 2555530-5 1989 CYP1A1 mRNA was detected in 14 of 15 (93%) of the non-small cell lung carcinoma cell lines examined following 24-hour treatment with benz[a]anthracene (BA) and in nine of 15 (60%) of the non-small cell lines cultured without an inducer in the medium. benz(a)anthracene 133-150 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 1700499-0 1990 Induction of cytochrome P(1)450 RNA and benzo[a]pyrene metabolism in primary human hepatocyte cultures with benzanthracene. benz(a)anthracene 108-122 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 24-31 1700499-2 1990 We have examined the steady-state level of RNA from the P(1)450 gene and the metabolism of benzo[a]pyrene (BP) in primary cultures of human hepatocytes exposed for up to 4 days to 12.5 microM benzanthracene (BA), and in uninduced control cultures. benz(a)anthracene 192-206 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 56-63 1700499-3 1990 While the steady-state levels of RNA from the P(1)450 gene were nondetectable in uninduced (DMSO only) human hepatocytes, 12.5 microM BA-induced AHH activity, BP metabolism, and/or P(1)450-specific RNA in hepatocytes from seven human cases were investigated. benz(a)anthracene 134-136 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 145-148 1700499-3 1990 While the steady-state levels of RNA from the P(1)450 gene were nondetectable in uninduced (DMSO only) human hepatocytes, 12.5 microM BA-induced AHH activity, BP metabolism, and/or P(1)450-specific RNA in hepatocytes from seven human cases were investigated. benz(a)anthracene 134-136 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 181-188 1700499-11 1990 Exposure of human hepatocytes in vitro to BA leads to a large increase in the steady-state level of the RNA specific for the P(1)450 gene and an increase metabolism of BP. benz(a)anthracene 42-44 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 125-132 2555530-5 1989 CYP1A1 mRNA was detected in 14 of 15 (93%) of the non-small cell lung carcinoma cell lines examined following 24-hour treatment with benz[a]anthracene (BA) and in nine of 15 (60%) of the non-small cell lines cultured without an inducer in the medium. benz(a)anthracene 152-154 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 2555530-7 1989 A positive correlation was noted between BA-induced CYP1A1 mRNA levels and the corresponding aryl hydrocarbon hydroxylase activity expressed as absolute BA-induced enzyme activity (r = 0.74; P less than .01; n = 24), which further demonstrated that CYP1A1 mRNA expression reflects CYP1A1 enzyme activity in the individual cell lines. benz(a)anthracene 41-43 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 52-58 2555530-7 1989 A positive correlation was noted between BA-induced CYP1A1 mRNA levels and the corresponding aryl hydrocarbon hydroxylase activity expressed as absolute BA-induced enzyme activity (r = 0.74; P less than .01; n = 24), which further demonstrated that CYP1A1 mRNA expression reflects CYP1A1 enzyme activity in the individual cell lines. benz(a)anthracene 41-43 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 249-255 2555530-7 1989 A positive correlation was noted between BA-induced CYP1A1 mRNA levels and the corresponding aryl hydrocarbon hydroxylase activity expressed as absolute BA-induced enzyme activity (r = 0.74; P less than .01; n = 24), which further demonstrated that CYP1A1 mRNA expression reflects CYP1A1 enzyme activity in the individual cell lines. benz(a)anthracene 41-43 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 249-255 32730838-6 2020 3-Methylcholanthrene (3-MC), benz[a]anthracene (B[a]A), benzo[a]pyrene (B[a]P), and valproic acid (VPA) increased the expression of CYP1B1 and CYP1A1. benz(a)anthracene 29-46 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 143-149 3697986-5 1986 Treatment of lymphocytes with benzanthracene increased the amount of mRNA hybridized to the cloned cytochrome P1-450 gene. benz(a)anthracene 30-44 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 110-116 3839750-5 1985 The isolated human P1-450 genomic clone hybridizes to 3-methylcholanthrene-induced mRNA from monkey liver, benzanthracene and 3-methylcholanthrene-treated human mammary tumor cells (MCF-7), but not to isosafrole-treated human cells. benz(a)anthracene 107-121 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 19-25 2990496-5 1985 P1-450 mRNA was induced markedly by TCDD and benzo[a] anthracene, whereas P3-450 mRNA was induced negligibly. benz(a)anthracene 45-64 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 6809007-0 1982 Stereoselective formation of benz[a]anthracene (+)-(5S,6R)-oxide and (+)-(8R,9S)-oxide by a highly purified and reconstituted system containing cytochrome P-450c. benz(a)anthracene 29-46 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 144-161 26613509-7 2016 CYP1A1 but not CYP1B1 and IL-1beta expression was increased by benzo[a]anthracene in these cell lines except for U937 cells. benz(a)anthracene 63-81 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 12495659-8 2003 After induction with 1,2-benzanthracene, the CYP1A1 selective inhibitor, alpha-naphthoflavone, and the CYP1A2 selective inhibitor, furafylline, effectively inhibited enzyme activities with IC(50)s of 2.4 microM and 12.8 microM, respectively, in microsomes from both trophoblasts culture systems. benz(a)anthracene 21-39 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 45-51 11286621-5 2001 The expression of cytochrome 1A1 was enhanced on the mRNA level after induction with benzanthracene. benz(a)anthracene 85-99 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 18-32 11513080-6 2001 Expression of CYP 1A1 and 1A2 messenger ribonucleic acid by the cells was induced by treatment with benz[a]pyrene, 3-methylcholanthrene, and benz[a]anthracene. benz(a)anthracene 141-158 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-21