PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27289145-8	2016	Induction by cAMP and dexamethasone was repressed 50% by 100 nM insulin.	Cyclic AMP	13-17	insulin	Bos taurus	64-71	
26947295-4	2016	The induction of PCK1 mRNA by propionate or cAMP was eliminated by addition of 100 nM insulin.	Cyclic AMP	44-48	insulin	Bos taurus	86-93	
2550445-5	1989	The actions of the cGMP- and insulin-stimulated enzymes to hydrolyze labeled cAMP were inhibited in an identical manner by cilostamide (Ki = 0.10 microM), griseolic acid (Ki = 0.19 microM), unlabeled cAMP (Km = 0.20 microM), and cGMP (Ki = 0.16 microM), all added to the assay system.	Cyclic AMP	77-81	insulin	Bos taurus	29-36	
1370906-12	1992	The effect of insulin to inhibit ACTH-stimulated steroid secretion was accompanied by a reduction in cAMP accumulation as well as an apparent inhibition of adenylate cyclase activation.	Cyclic AMP	101-105	insulin	Bos taurus	14-21	
1370906-13	1992	These data indicate that the effect of insulin to attenuate ACTH-stimulated corticosteroid secretion results from both an inhibition of ACTH-stimulated adenylate cyclase activity and an antagonism of the intracellular actions of cAMP.	Cyclic AMP	229-233	insulin	Bos taurus	39-46	
15072575-4	2004	The mode of action of insulin in blowflies did not involve cAMP, but triggered a specific and well-conserved transduction cascade.	Cyclic AMP	59-63	insulin	Bos taurus	22-29	
1846114-6	1991	As previously demonstrated for 11 beta-hydroxylase,21-hydroxylase mRNA induction by cholera toxin or cAMP analogs was dependent on the presence of insulin-like growth factor-I or insulin in the culture medium.	Cyclic AMP	101-105	insulin	Bos taurus	147-154	
2169396-4	1990	When cultures were incubated with cholera toxin, cAMP analogs, forskolin, ACTH, or prostaglandin E1 in defined medium with insulin, all agents increased the mRNA levels for 11 beta-hydroxylase and 17 alpha-hydroxylase.	Cyclic AMP	49-53	insulin	Bos taurus	123-130	
2558936-0	1989	Cyclic AMP-mediated cytoskeletal effects in adrenal cells are modified by serum, insulin, insulin-like growth factor-I, and an antibody against urokinase plasminogen activator.	Cyclic AMP	0-10	insulin	Bos taurus	81-88	
2550445-5	1989	The actions of the cGMP- and insulin-stimulated enzymes to hydrolyze labeled cAMP were inhibited in an identical manner by cilostamide (Ki = 0.10 microM), griseolic acid (Ki = 0.19 microM), unlabeled cAMP (Km = 0.20 microM), and cGMP (Ki = 0.16 microM), all added to the assay system.	Cyclic AMP	200-204	insulin	Bos taurus	29-36	
2820812-3	1987	In the present study, dibutyryl cAMP at concentration 0-1.0 mM decreased insulin binding in bovine aortic smooth muscle cells but had no effect on endothelial cells.	Cyclic AMP	32-36	insulin	Bos taurus	73-80	
2820812-8	1987	Thus the differential effect of insulin on arterial endothelial and smooth muscle cells is similar to the effect of cAMP on insulin binding in these cells.	Cyclic AMP	116-120	insulin	Bos taurus	124-131	
2555233-1	1989	The present study shows that pretreatment of BAC cells with insulin or insulin-like growth factor-I (IGF-I) enhances the cAMP response to maximal concentrations of ACTH and cholera toxin.	Cyclic AMP	121-125	insulin	Bos taurus	60-67	
2836166-7	1988	Adrenal cells cultured in a serum-free medium containing transferrin, ascorbic acid, and insulin (5 micrograms/ml) maintained fairly constant angiotensin-II (A-II) receptor concentration per cell and increased cAMP release on response to ACTH and their steroidogenic response to both ACTH and A-II.	Cyclic AMP	210-214	insulin	Bos taurus	89-96	
6321139-0	1984	Permissive effect of insulin on the adenosine 3",5"-monophosphate-dependent up-regulation of low density lipoprotein receptors and the stimulation of steroid release in bovine adrenal cortical cells.	Cyclic AMP	36-65	insulin	Bos taurus	21-28	
6321139-10	1984	The results of these studies suggest that in bovine adrenal cortex cells grown in chemically defined medium, insulin modulates steroidogenic cAMP-induced response by increasing both the LDL receptor pathway activity and 11 DOC release.	Cyclic AMP	141-145	insulin	Bos taurus	109-116