PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12920193-8 2003 The neuroprotective and antiproliferative actions of cAMP, however, were closely mimicked by olomoucine and roscovitine, potent inhibitors of the cyclin-dependent kinase CDK1 that are structurally related to cAMP. Cyclic AMP 53-57 cyclin dependent kinase 1 Homo sapiens 170-174 23814058-0 2013 Cyclin-dependent kinase 1-dependent phosphorylation of cAMP response element-binding protein decreases chromatin occupancy. Cyclic AMP 55-59 cyclin dependent kinase 1 Homo sapiens 0-25 19223768-2 2009 Cyclic AMP (cAMP)-mediated Protein Kinase A (PKA) activity sustains prophase arrest by inhibiting Cdk1. Cyclic AMP 0-10 cyclin dependent kinase 1 Homo sapiens 98-102 19223768-2 2009 Cyclic AMP (cAMP)-mediated Protein Kinase A (PKA) activity sustains prophase arrest by inhibiting Cdk1. Cyclic AMP 12-16 cyclin dependent kinase 1 Homo sapiens 98-102 16551631-6 2006 Studies with PTHrP peptides 1-34 and 67-86, forskolin, and a PTH1 receptor (PTH1R)-specific siRNA showed that PTHrP regulates CDC2 and CDC25B, at least in part, via PTH1R in a cAMP-independent manner. Cyclic AMP 176-180 cyclin dependent kinase 1 Homo sapiens 126-130 21063390-4 2011 CAMP localizes to chromosomes and the spindle including kinetochores, and undergoes CDK1-dependent phosphorylation at multiple sites during mitosis. Cyclic AMP 0-4 cyclin dependent kinase 1 Homo sapiens 84-88 12920193-8 2003 The neuroprotective and antiproliferative actions of cAMP, however, were closely mimicked by olomoucine and roscovitine, potent inhibitors of the cyclin-dependent kinase CDK1 that are structurally related to cAMP. Cyclic AMP 208-212 cyclin dependent kinase 1 Homo sapiens 170-174 12920193-9 2003 Measurement of CDK1 activity confirmed that neuroprotection was closely correlated with inhibition of this kinase by cAMP. Cyclic AMP 117-121 cyclin dependent kinase 1 Homo sapiens 15-19 11933169-0 2002 Roles of cAMP in regulation of both MAP kinase and p34(cdc2) kinase activity during meiotic progression, especially beyond the MI stage. Cyclic AMP 9-13 cyclin dependent kinase 1 Homo sapiens 55-59 27662514-7 2017 Reduction of intraoocyte cAMP level modulates phosphorylation status of cyclin-dependent kinase 1 (Cdk1) and triggers cyclin B1 degradation that destabilizes maturation promoting factor (MPF) and/or increases Cdk1 activity. Cyclic AMP 25-29 cyclin dependent kinase 1 Homo sapiens 72-97 8720436-2 1995 The association of the cAMP-dependent protein kinase type II and the mitotic kinase p34cdc2 with centrosomes from human lymphoblast cells has previously been shown (Keryer et al, 1993, Exp Cell Res 204, 230-240; Bailly et al, 1989, EMBO J 8, 3985-3995). Cyclic AMP 23-27 cyclin dependent kinase 1 Homo sapiens 84-91 8341696-8 1993 DNA binding also reduces phosphorylation of Jun by casein kinase II, p34cdc2 (cdc2) kinase, and protein kinase C. Phosphorylation of Fos by cAMP-dependent protein kinase and cdc2 is relatively insensitive to dimerization and DNA binding, whereas phosphorylation of Fos and Jun by DNA-dependent protein kinase is dramatically stimulated by binding to the AP-1 site. Cyclic AMP 140-144 cyclin dependent kinase 1 Homo sapiens 69-76 8341696-8 1993 DNA binding also reduces phosphorylation of Jun by casein kinase II, p34cdc2 (cdc2) kinase, and protein kinase C. Phosphorylation of Fos by cAMP-dependent protein kinase and cdc2 is relatively insensitive to dimerization and DNA binding, whereas phosphorylation of Fos and Jun by DNA-dependent protein kinase is dramatically stimulated by binding to the AP-1 site. Cyclic AMP 140-144 cyclin dependent kinase 1 Homo sapiens 72-76 8341696-8 1993 DNA binding also reduces phosphorylation of Jun by casein kinase II, p34cdc2 (cdc2) kinase, and protein kinase C. Phosphorylation of Fos by cAMP-dependent protein kinase and cdc2 is relatively insensitive to dimerization and DNA binding, whereas phosphorylation of Fos and Jun by DNA-dependent protein kinase is dramatically stimulated by binding to the AP-1 site. Cyclic AMP 140-144 cyclin dependent kinase 1 Homo sapiens 78-82 1918018-7 1991 All these experiments gave concordant results and demonstrate that at least at G0/G1, human fibroblasts contain a complex of active type II cAMP-dependent protein kinase associated through its RII alpha subunit with p34cdc2. Cyclic AMP 140-144 cyclin dependent kinase 1 Homo sapiens 216-223 35072590-2 2022 These arrests are strictly regulated by follicular cells temporally producing the secondary messengers, cAMP and cGMP, and other factors to regulate maturation promoting factor (composed of cyclin B1 and cyclin-dependent kinase 1) levels in the oocytes. Cyclic AMP 104-108 cyclin dependent kinase 1 Homo sapiens 204-229 10537037-5 1999 Cyclic AMP strongly inhibited cdk1 and cdk2 expression. Cyclic AMP 0-10 cyclin dependent kinase 1 Homo sapiens 30-34 10537037-13 1999 We conclude that cyclic AMP inhibits progression of the cell cycle in astrocytes at least by preventing the expression of the regulatory subunits, cyclins D1 and A, and catalytic subunits, cdk1 and cdk2, of cyclin-regulated protein kinases. Cyclic AMP 17-27 cyclin dependent kinase 1 Homo sapiens 189-193 1668090-0 1991 Negative control of cdc2 kinase activation by cAMP in starfish oocytes. Cyclic AMP 46-50 cyclin dependent kinase 1 Homo sapiens 20-24 27662514-7 2017 Reduction of intraoocyte cAMP level modulates phosphorylation status of cyclin-dependent kinase 1 (Cdk1) and triggers cyclin B1 degradation that destabilizes maturation promoting factor (MPF) and/or increases Cdk1 activity. Cyclic AMP 25-29 cyclin dependent kinase 1 Homo sapiens 99-103 27662514-7 2017 Reduction of intraoocyte cAMP level modulates phosphorylation status of cyclin-dependent kinase 1 (Cdk1) and triggers cyclin B1 degradation that destabilizes maturation promoting factor (MPF) and/or increases Cdk1 activity. Cyclic AMP 25-29 cyclin dependent kinase 1 Homo sapiens 209-213 25994054-6 2015 Increased levels of cAMP and/or ROS trigger accumulation of Thr-14/Tyr-15 phosphorylated cyclin-dependent kinase 1 (Cdk1) on one hand and degradation of cyclin B1 through ubiquitin-mediated proteolysis on the other hand to destabilize maturation promoting factor (MPF). Cyclic AMP 20-24 cyclin dependent kinase 1 Homo sapiens 89-114 25994054-6 2015 Increased levels of cAMP and/or ROS trigger accumulation of Thr-14/Tyr-15 phosphorylated cyclin-dependent kinase 1 (Cdk1) on one hand and degradation of cyclin B1 through ubiquitin-mediated proteolysis on the other hand to destabilize maturation promoting factor (MPF). Cyclic AMP 20-24 cyclin dependent kinase 1 Homo sapiens 116-120