PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6097776-0 1982 Modulation of interferon-induced NK cells by interleukin 2 and cAMP. Cyclic AMP 63-67 interferon alpha 1 Homo sapiens 14-24 6188204-4 1983 The sites of action for cAMP-induced NK suppression and interferon (IFN)-induced NK enhancement are demonstrated to be distinct, since IFN acts by increasing the lytic efficiency and the recycling capacity without influencing target binding. Cyclic AMP 24-28 interferon alpha 1 Homo sapiens 135-138 22152193-6 2012 Promoter-based bioinformatic analyses linked IFN-alpha-related transcriptional alterations to transcription factors involved in myeloid differentiation, IFN-alpha signaling, activator protein-1 (AP1) and cAMP responsive element binding protein/activation transcription factor (CREB/ATF) pathways, which were derived primarily from monocytes and plasmacytoid dendritic cells. Cyclic AMP 204-208 interferon alpha 1 Homo sapiens 45-54 6175278-1 1981 Treatment of murine and human cells with homologous interferon (IFN) resulted in an elevation of the cellular cyclic adenosine monophosphate (cAMP) levels in a time- and dose-dependent manner. Cyclic AMP 110-140 interferon alpha 1 Homo sapiens 64-67 6175278-1 1981 Treatment of murine and human cells with homologous interferon (IFN) resulted in an elevation of the cellular cyclic adenosine monophosphate (cAMP) levels in a time- and dose-dependent manner. Cyclic AMP 142-146 interferon alpha 1 Homo sapiens 64-67 30482227-11 2018 RESULTS: IFN-alpha down-regulated the cyclooxygenase-2 (COX-2) expression in bladder cancer cells through the inhibition of TPL2/NF-kappaB pathway; IFN-alpha also inhibited COX-2 expression by suppressing cAMP signaling through TPL2-ERK mediated PDE4D activity. Cyclic AMP 205-209 interferon alpha 1 Homo sapiens 9-18 30482227-11 2018 RESULTS: IFN-alpha down-regulated the cyclooxygenase-2 (COX-2) expression in bladder cancer cells through the inhibition of TPL2/NF-kappaB pathway; IFN-alpha also inhibited COX-2 expression by suppressing cAMP signaling through TPL2-ERK mediated PDE4D activity. Cyclic AMP 205-209 interferon alpha 1 Homo sapiens 148-157 30482227-12 2018 Reduction of the intracellular cAMP level by PDE4D potentiated the antitumor effect of IFN-alpha against bladder cancer in vitro and in vivo. Cyclic AMP 31-35 interferon alpha 1 Homo sapiens 87-96 30482227-15 2018 The antitumor effects of IFN-alpha and MEK inhibition also depend on the PDE4D-mediated cAMP level in bladder cancer cells. Cyclic AMP 88-92 interferon alpha 1 Homo sapiens 25-34 30482227-16 2018 Suppression of the TPL2 phosphorylation and intracellular cAMP level may be possible therapeutic strategies for enhancing the effectiveness of IFN-alpha and MEK inhibitors in bladder cancer treatment. Cyclic AMP 58-62 interferon alpha 1 Homo sapiens 143-152 23878189-3 2013 Here, we show that IFN-alpha deactivates the suppressive function of human Treg by downregulating their intracellular cAMP level. Cyclic AMP 118-122 interferon alpha 1 Homo sapiens 19-28 23878189-5 2013 Mechanistically, repression of cAMP in Treg was caused by IFN-alpha-induced MAP-ERK kinase (MEK)/extracellular signal-regulated kinase (ERK)-mediated phosphodiesterase 4 (PDE4) activation and accompanied by downregulation of IFN receptor (IFNAR)-2 and negative regulation of T-cell receptor signaling. Cyclic AMP 31-35 interferon alpha 1 Homo sapiens 58-67 6175278-4 1981 Pretreatment with an inhibitor of adenyl cyclase, N-ethylmaleimide, prevented the effect of IFN on cAMP levels, but did not influence tis antiviral activity. Cyclic AMP 99-103 interferon alpha 1 Homo sapiens 92-95 24628847-7 2014 IFN-alpha reduces cAMP in Tregs via ERK/phosphodiesterase-mediated pathways. Cyclic AMP 18-22 interferon alpha 1 Homo sapiens 0-9 24628847-8 2014 Since cAMP is essentially involved in suppression by nTregs, the IFN-alpha-dependent reduction of cAMP levels abolishes the suppressive capacity of nTregs. Cyclic AMP 6-10 interferon alpha 1 Homo sapiens 65-74 24628847-8 2014 Since cAMP is essentially involved in suppression by nTregs, the IFN-alpha-dependent reduction of cAMP levels abolishes the suppressive capacity of nTregs. Cyclic AMP 98-102 interferon alpha 1 Homo sapiens 65-74 17316140-0 2007 Adenylate cyclase/cAMP pathway downmodulation counteracts apoptosis induced by IFN-alpha in human epidermoid cancer cells. Cyclic AMP 18-22 interferon alpha 1 Homo sapiens 79-88 21798341-8 2011 Taken together, these findings suggest that inhibition of GR signaling by mIFN-alpha and STAT5 can be reversed by activation of cAMP-PKA pathways, whereas decreased PKA activity increases the inhibitory effect of IFN-alpha on GR function. Cyclic AMP 128-132 interferon alpha 1 Homo sapiens 75-84 19508175-3 2009 In this regard, we have shown that IFN-a, at growth inhibitory concentrations, enhances the EGF-dependent Ras-->Erk signalling and decreases the adenylate cyclase/cAMP pathway activity in cancer cells; both effects represent escape mechanisms to the growth inhibition and apoptosis induced by IFN-a. Cyclic AMP 166-170 interferon alpha 1 Homo sapiens 35-40 17316140-3 2007 A decrease in the intracellular cAMP levels was recorded in KB cells treated with IFN-alpha, whereas forskolin induced an increase in the production of cAMP that was reduced in the presence of IFN-alpha, suggesting a reduction in the activity of adenylate cyclase (AC) induced by IFN-alpha. Cyclic AMP 32-36 interferon alpha 1 Homo sapiens 82-91 17316140-3 2007 A decrease in the intracellular cAMP levels was recorded in KB cells treated with IFN-alpha, whereas forskolin induced an increase in the production of cAMP that was reduced in the presence of IFN-alpha, suggesting a reduction in the activity of adenylate cyclase (AC) induced by IFN-alpha. Cyclic AMP 152-156 interferon alpha 1 Homo sapiens 193-202 17316140-3 2007 A decrease in the intracellular cAMP levels was recorded in KB cells treated with IFN-alpha, whereas forskolin induced an increase in the production of cAMP that was reduced in the presence of IFN-alpha, suggesting a reduction in the activity of adenylate cyclase (AC) induced by IFN-alpha. Cyclic AMP 152-156 interferon alpha 1 Homo sapiens 193-202 17316140-8 2007 In conclusion, these data suggest that the decrease in AC/cAMP pathway activity is a survival response to the apoptosis induced by IFN-alpha. Cyclic AMP 58-62 interferon alpha 1 Homo sapiens 131-140 2169479-6 1990 Although gamma IFN alone was devoid of any effect on cAMP accumulation, it enhanced forskolin-stimulated (as well as TSH-activated) cAMP in the presence of 3-isobutyl-1-methylxanthine, an inhibitor of cAMP degradation. Cyclic AMP 132-136 interferon alpha 1 Homo sapiens 15-18 9641464-10 1998 Morphine and anandamide stimulation of ECs did not stimulate cyclic adenosine monophosphate (cAMP) accumulation, whereas a marked increase in cAMP was observed in ECs treated with LPS + IFN (8.2 to 33 pmol/mg protein). Cyclic AMP 142-146 interferon alpha 1 Homo sapiens 186-189 15465601-7 2004 It showed that IFNalpha and 129Ser-IFNalpha decreased cAMP production, induced the fever, and stimulated PGE2 to release from the hypothalamus slices, which could be blocked by naloxone, but 38Leu-IFNalpha failed. Cyclic AMP 54-58 interferon alpha 1 Homo sapiens 15-23 15465601-7 2004 It showed that IFNalpha and 129Ser-IFNalpha decreased cAMP production, induced the fever, and stimulated PGE2 to release from the hypothalamus slices, which could be blocked by naloxone, but 38Leu-IFNalpha failed. Cyclic AMP 54-58 interferon alpha 1 Homo sapiens 35-43 15465601-7 2004 It showed that IFNalpha and 129Ser-IFNalpha decreased cAMP production, induced the fever, and stimulated PGE2 to release from the hypothalamus slices, which could be blocked by naloxone, but 38Leu-IFNalpha failed. Cyclic AMP 54-58 interferon alpha 1 Homo sapiens 35-43 10676852-6 2000 IFN alpha could significantly inhibit the production of the cAMP stimulated by forskolin in SK-N-SH cells expressing the mu-opioid receptor, not in NG108-15 cells expressing the delta-opioid receptor uniformly. Cyclic AMP 60-64 interferon alpha 1 Homo sapiens 0-9 10570944-4 1999 Using 5"-deletion constructs in combination with mutational analysis of the proximal CgA core promoter, a cyclic AMP response element (CRE) at -71 to -64 bp was identified as the IFN-alpha response element of the CgA gene. Cyclic AMP 106-116 interferon alpha 1 Homo sapiens 179-188 9831080-4 1998 Receptor-mediated signals such as ATP, IFN-alpha, or PGE1, which can trigger cAMP-dependent magnesium efflux, were ineffective in undifferentiated HL-60 cells but induced 60-70% increase of magnesium efflux in neutrophyl-like HL-60 cells. Cyclic AMP 77-81 interferon alpha 1 Homo sapiens 39-48 9737342-6 1998 IFN-alpha also decreased cAMP response to PTH(1-34) in a dose-dependent manner and significantly depressed expression of the receptor protein. Cyclic AMP 25-29 interferon alpha 1 Homo sapiens 0-9 9458327-5 1998 PKC activator, phorbol 12-myristate 13-acetate (PMA) and PKA activator, dibutyryl cAMP could replace LPS in priming the cells for IFN- stimulation but 8-bromo-cGMP did not. Cyclic AMP 82-86 interferon alpha 1 Homo sapiens 130-133 8383027-8 1993 In conclusion, (a) deficient cAMP-inducible, PKA-dependent phosphorylation in SLE T cells is not reversible by culturing cells in vitro; (b) there is no evidence to support the concept that serum factors, including IC and IFN-alpha, can induce a defect of PKA-dependent protein phosphorylation in normal T cells. Cyclic AMP 29-33 interferon alpha 1 Homo sapiens 222-231 1337276-7 1992 IFN-alpha (0.1-10 ng/ml) reduced cAMP generation in response to FSH by as much as 80%, although its effect was not concentration-dependent. Cyclic AMP 33-37 interferon alpha 1 Homo sapiens 0-9 1846325-0 1991 Modulation of IFN-mediated Ly-6E antigen induction by cAMP in a T cell lymphoma: opposite effects on the responses to IFN-gamma and IFN-alpha/beta. Cyclic AMP 54-58 interferon alpha 1 Homo sapiens 14-17 1846325-4 1991 However, treatment with cAMP analogs, but not with cGMP analogs, markedly altered Ly-6E expression triggered by IFN, both at the mRNA and at the cell surface protein levels. Cyclic AMP 24-28 interferon alpha 1 Homo sapiens 112-115 1846325-12 1991 However, a rise of cAMP modulates in an opposite fashion the Ly-6E-inducing actions of IFN-gamma and IFN-alpha/beta, which suggests that the two types of IFN utilize separate biochemical pathways to regulate Ly-6E expression. Cyclic AMP 19-23 interferon alpha 1 Homo sapiens 101-110 1846325-12 1991 However, a rise of cAMP modulates in an opposite fashion the Ly-6E-inducing actions of IFN-gamma and IFN-alpha/beta, which suggests that the two types of IFN utilize separate biochemical pathways to regulate Ly-6E expression. Cyclic AMP 19-23 interferon alpha 1 Homo sapiens 87-90 1846237-1 1991 Participation of growth factors and intracellular cAMP in direct antiproliferative action of interferon alpha (IFN-alpha) was investigated in PC-3 human prostate carcinoma cell line. Cyclic AMP 50-54 interferon alpha 1 Homo sapiens 93-120 1846237-6 1991 On the other hand, IFN-alpha increased intracellular cAMP concentration about 20-fold. Cyclic AMP 53-57 interferon alpha 1 Homo sapiens 19-28 1846237-8 1991 These indicated that direct antiproliferative effect of IFN-alpha on PC-3 cells was at least partly mediated by cAMP, and that neither growth factors nor a growth inhibitor participated in the action of IFN-alpha. Cyclic AMP 112-116 interferon alpha 1 Homo sapiens 56-65 2169479-6 1990 Although gamma IFN alone was devoid of any effect on cAMP accumulation, it enhanced forskolin-stimulated (as well as TSH-activated) cAMP in the presence of 3-isobutyl-1-methylxanthine, an inhibitor of cAMP degradation. Cyclic AMP 132-136 interferon alpha 1 Homo sapiens 15-18 2169479-7 1990 Thus, it would seem that gamma IFN also exerts an influence on cAMP formation (rather than degradation) at a step subsequent to TSH binding to its receptor. Cyclic AMP 63-67 interferon alpha 1 Homo sapiens 31-34 6319493-7 1984 On the other hand, IFN or poly I:C diminished the accumulation of intracellular cAMP levels in NK cells in response to PGE2 stimulation. Cyclic AMP 80-84 interferon alpha 1 Homo sapiens 19-22 2502045-5 1989 Unlike Hu-IFN-alpha A, but similar to Hu-IFN-gamma, the hybrid Hu-IFN-alpha A/gamma can be phosphorylated by [gamma 32P]ATP and cAMP-dependent protein kinase. Cyclic AMP 128-132 interferon alpha 1 Homo sapiens 66-75 6319493-9 1984 A possible mechanism for the IFN-induced unresponsiveness to PGE2 may be a compartmentalized loss of cAMP responsiveness. Cyclic AMP 101-105 interferon alpha 1 Homo sapiens 29-32 6319493-3 1984 In this study we demonstrated that human NK cells activated by IFN or poly I:C were partially resistant to suppression by PGE2, PGD2, PGA2, PGI2, dibutyryl cAMP, isoproterenol, and theophylline. Cyclic AMP 156-160 interferon alpha 1 Homo sapiens 63-66