PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11467832-3	2001	Therefore, we assessed a possibility of involvement of protein tyrosine kinase (PTK)-dependent pathway as a PKA-independent pathway in the cAMP activation by applying a PTK inhibitor, tyrphostin A23 (AG18).	Cyclic AMP	139-143	protein tyrosine kinase 2 beta	Homo sapiens	80-83	
11467832-5	2001	Further, forskolin increased phosphorylation of protein tyrosine, suggesting that cAMP activates PTK.	Cyclic AMP	82-86	protein tyrosine kinase 2 beta	Homo sapiens	97-100	
11467832-6	2001	These observations suggest that cAMP activates the Cl- channel and the Na+/K+/2Cl- cotransporter by activating PTK.	Cyclic AMP	32-36	protein tyrosine kinase 2 beta	Homo sapiens	111-114	
34374467-8	2021	Furthermore, the effect of TMP on increasing the release of BDNF from BM-MSCs was blocked by inhibiting the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (AKT)/cAMP-response element binding protein (CREB) pathway.	Cyclic AMP	185-189	protein tyrosine kinase 2 beta	Homo sapiens	162-178	
10373549-2	1999	In this report, we show that PKB can also be activated by PKA (cyclic AMP [cAMP]-dependent protein kinase) through a PI3-kinase-independent pathway.	Cyclic AMP	63-73	protein tyrosine kinase 2 beta	Homo sapiens	29-32	
10373549-2	1999	In this report, we show that PKB can also be activated by PKA (cyclic AMP [cAMP]-dependent protein kinase) through a PI3-kinase-independent pathway.	Cyclic AMP	75-79	protein tyrosine kinase 2 beta	Homo sapiens	29-32	
10373549-6	1999	Moreover, phosphopeptide maps of overexpressed PKB from COS cells showed differences between insulin- and forskolin-stimulated cells that pointed to distinct activation mechanisms of PKB depending on whether insulin or cAMP was used.	Cyclic AMP	219-223	protein tyrosine kinase 2 beta	Homo sapiens	47-50	
10373549-6	1999	Moreover, phosphopeptide maps of overexpressed PKB from COS cells showed differences between insulin- and forskolin-stimulated cells that pointed to distinct activation mechanisms of PKB depending on whether insulin or cAMP was used.	Cyclic AMP	219-223	protein tyrosine kinase 2 beta	Homo sapiens	183-186	
9202156-0	1997	cAMP stimulates protein kinase B in a Wortmannin-insensitive manner.	Cyclic AMP	0-4	protein tyrosine kinase 2 beta	Homo sapiens	16-32	
9202156-2	1997	Here, we show that agents which raise intracellular cAMP can also stimulate PKB.	Cyclic AMP	52-56	protein tyrosine kinase 2 beta	Homo sapiens	76-79	
9202156-5	1997	In addition, the activation pathway of PKB by cAMP seems to be linked to that of growth factors, albeit downstream of PI3-kinase.	Cyclic AMP	46-50	protein tyrosine kinase 2 beta	Homo sapiens	39-42	
9202156-6	1997	Evidence for this is that a constitutive active PKB, T308D, S473D, containing activating mutations in the serine and threonine residues which are phosphorylated subsequent to PI3-kinase activation, cannot be further stimulated by cAMP elevations.	Cyclic AMP	230-234	protein tyrosine kinase 2 beta	Homo sapiens	48-51	
9202156-7	1997	Hence, these data suggest that, in addition to growth factors, cAMP can also lead to activation of PKB.	Cyclic AMP	63-67	protein tyrosine kinase 2 beta	Homo sapiens	99-102	
9202156-8	1997	This cAMP stimulatory action appears to require phosphorylation of T308 and S473, and hence would indicate that cAMP modulates the phosphorylation event of these PKB regulatory sites.	Cyclic AMP	5-9	protein tyrosine kinase 2 beta	Homo sapiens	162-165	
9202156-8	1997	This cAMP stimulatory action appears to require phosphorylation of T308 and S473, and hence would indicate that cAMP modulates the phosphorylation event of these PKB regulatory sites.	Cyclic AMP	112-116	protein tyrosine kinase 2 beta	Homo sapiens	162-165	
1330643-4	1992	A maximum of 50% inhibition of forskolin stimulated cAMP production was obtained with 5-HT1 receptor agonists which was blocked by the non-selective 5-HT receptor antagonist methiothepin (pKB = 100 nM).	Cyclic AMP	52-56	protein tyrosine kinase 2 beta	Homo sapiens	188-191	
10601311-1	1999	Protein kinase B and p70 S6 kinase are members of the cyclic AMP-dependent/cyclic GMP-dependent/protein kinase C subfamily of protein kinases and are activated by a phosphatidylinositol 3-kinase-dependent pathway when cells are stimulated with insulin or growth factors.	Cyclic AMP	54-64	protein tyrosine kinase 2 beta	Homo sapiens	0-16	
8047842-7	1994	In addition, our results are compatible with a model where cAMP, through activation of cAKI, eliminates both the PTK and PKC activating capability of the T-cell receptor at a site(s) proximal to PKC activation.	Cyclic AMP	59-63	protein tyrosine kinase 2 beta	Homo sapiens	113-116	
22497928-3	2012	The pro-adipogenic and anti-osteogenic effect of 8-pCPT-2"-O-Me-cAMP was attributed to that 8-pCPT-2"-O-Me-cAMP led to the activation of protein kinase B (PKB) and cAMP response element-binding protein (CREB) as well as the inhibition of Ras homolog gene family member A (RhoA), focal adhesion kinase (FAK), extracellular-signal-regulated kinase (ERK) and runt-related transcription factor 2 (Runx2) activities.	Cyclic AMP	64-68	protein tyrosine kinase 2 beta	Homo sapiens	137-153	
34867807-11	2021	The loss in steroidogenic proteins at high midazolam levels may be mediated in part by the inactivation of protein kinase B/cAMP response element-binding protein (AKT/CREB) signaling pathway.	Cyclic AMP	124-128	protein tyrosine kinase 2 beta	Homo sapiens	107-123	
23584706-4	2013	Our immunohistochemistry approach has shown that the insulin receptor, insulin receptor substrate 1 (IRS1), protein kinase B (PKB) and insulin-sensitive glucose transporter (GLUT4) are expressed in the sensory epithelium of the human saccule, which also exhibits expression of a calcium-sensitive cAMP/cGMP phosphodiesterase 1C (PDE1C) and the vasopressin type 2 receptor.	Cyclic AMP	297-301	protein tyrosine kinase 2 beta	Homo sapiens	108-124	
23584706-4	2013	Our immunohistochemistry approach has shown that the insulin receptor, insulin receptor substrate 1 (IRS1), protein kinase B (PKB) and insulin-sensitive glucose transporter (GLUT4) are expressed in the sensory epithelium of the human saccule, which also exhibits expression of a calcium-sensitive cAMP/cGMP phosphodiesterase 1C (PDE1C) and the vasopressin type 2 receptor.	Cyclic AMP	297-301	protein tyrosine kinase 2 beta	Homo sapiens	126-129	
22497928-3	2012	The pro-adipogenic and anti-osteogenic effect of 8-pCPT-2"-O-Me-cAMP was attributed to that 8-pCPT-2"-O-Me-cAMP led to the activation of protein kinase B (PKB) and cAMP response element-binding protein (CREB) as well as the inhibition of Ras homolog gene family member A (RhoA), focal adhesion kinase (FAK), extracellular-signal-regulated kinase (ERK) and runt-related transcription factor 2 (Runx2) activities.	Cyclic AMP	107-111	protein tyrosine kinase 2 beta	Homo sapiens	137-153	
22497928-3	2012	The pro-adipogenic and anti-osteogenic effect of 8-pCPT-2"-O-Me-cAMP was attributed to that 8-pCPT-2"-O-Me-cAMP led to the activation of protein kinase B (PKB) and cAMP response element-binding protein (CREB) as well as the inhibition of Ras homolog gene family member A (RhoA), focal adhesion kinase (FAK), extracellular-signal-regulated kinase (ERK) and runt-related transcription factor 2 (Runx2) activities.	Cyclic AMP	107-111	protein tyrosine kinase 2 beta	Homo sapiens	155-158	
22497928-3	2012	The pro-adipogenic and anti-osteogenic effect of 8-pCPT-2"-O-Me-cAMP was attributed to that 8-pCPT-2"-O-Me-cAMP led to the activation of protein kinase B (PKB) and cAMP response element-binding protein (CREB) as well as the inhibition of Ras homolog gene family member A (RhoA), focal adhesion kinase (FAK), extracellular-signal-regulated kinase (ERK) and runt-related transcription factor 2 (Runx2) activities.	Cyclic AMP	64-68	protein tyrosine kinase 2 beta	Homo sapiens	155-158	
19182531-0	2009	Pyk2 and Cyr61 at the cross-road of cAMP-dependent signalling in invasiveness and neuroendocrine differentiation of prostate cancer.	Cyclic AMP	36-40	protein tyrosine kinase 2 beta	Homo sapiens	0-4	
19106639-3	2009	The aim of this study was to investigate the interaction between cAMP and Pyk2 in the prostate.	Cyclic AMP	65-69	protein tyrosine kinase 2 beta	Homo sapiens	74-78	
19106639-5	2009	cAMP inhibited cell growth in both prostate cell lines, and activated Pyk2, but not ERK1/2, in EPN cells.	Cyclic AMP	0-4	protein tyrosine kinase 2 beta	Homo sapiens	70-74	
15833736-9	2005	Finally, AEBSF- and PKB-dependent induction of HO-1 promoter activity was reduced by simultaneous mutation of an E-box motif (-47/-42) and a cAMP response element/AP-1 element (-664/-657) of the proximal HO-1 gene promoter.	Cyclic AMP	141-145	protein tyrosine kinase 2 beta	Homo sapiens	20-23	
16839743-4	2007	Interestingly, insulin- and CL316243-induced PKB phosphorylation was found to be inhibited by pools of cAMP controlled by PDE3B and PDE4 (mainly in the context of insulin), whereas a cAMP pool controlling protein kinase A appeared to mediate stimulation of PKB phosphorylation (mainly in the context of CL316243).	Cyclic AMP	103-107	protein tyrosine kinase 2 beta	Homo sapiens	257-260	
16839743-4	2007	Interestingly, insulin- and CL316243-induced PKB phosphorylation was found to be inhibited by pools of cAMP controlled by PDE3B and PDE4 (mainly in the context of insulin), whereas a cAMP pool controlling protein kinase A appeared to mediate stimulation of PKB phosphorylation (mainly in the context of CL316243).	Cyclic AMP	183-187	protein tyrosine kinase 2 beta	Homo sapiens	45-48	
16839743-5	2007	Furthermore, an Epac (exchange protein directly activated by cAMP) agonist (8-pCPT-2"-O-Me-cAMP) mimicked the effect of the PDE inhibitors, giving evidence that Epac has an inhibitory effect on PKB phosphorylation in adipocytes.	Cyclic AMP	61-65	protein tyrosine kinase 2 beta	Homo sapiens	194-197	
16839743-5	2007	Furthermore, an Epac (exchange protein directly activated by cAMP) agonist (8-pCPT-2"-O-Me-cAMP) mimicked the effect of the PDE inhibitors, giving evidence that Epac has an inhibitory effect on PKB phosphorylation in adipocytes.	Cyclic AMP	91-95	protein tyrosine kinase 2 beta	Homo sapiens	194-197	
16839743-2	2007	Whilst Protein kinase B (PKB) is a pivotal mediator of insulin action, in some cells regulation of PKB by cAMP has also been demonstrated.	Cyclic AMP	106-110	protein tyrosine kinase 2 beta	Homo sapiens	7-23	
16839743-2	2007	Whilst Protein kinase B (PKB) is a pivotal mediator of insulin action, in some cells regulation of PKB by cAMP has also been demonstrated.	Cyclic AMP	106-110	protein tyrosine kinase 2 beta	Homo sapiens	99-102	
16839743-4	2007	Interestingly, insulin- and CL316243-induced PKB phosphorylation was found to be inhibited by pools of cAMP controlled by PDE3B and PDE4 (mainly in the context of insulin), whereas a cAMP pool controlling protein kinase A appeared to mediate stimulation of PKB phosphorylation (mainly in the context of CL316243).	Cyclic AMP	103-107	protein tyrosine kinase 2 beta	Homo sapiens	45-48	
12034724-3	2002	Both cAMP and cell swelling stimulated p38 mitogen-activated protein (MAP) kinase as well as PKB activity.	Cyclic AMP	5-9	protein tyrosine kinase 2 beta	Homo sapiens	93-96	
12034724-10	2002	Taken together, these results strongly suggest that cell swelling and cAMP-mediated stimulation of hepatic Na+/TC cotransport and Ntcp translocation requires activation of PKB and is mediated at least in part via a phosphoinositide 3-kinase/PKB-signaling pathway.	Cyclic AMP	70-74	protein tyrosine kinase 2 beta	Homo sapiens	172-175	
12034724-10	2002	Taken together, these results strongly suggest that cell swelling and cAMP-mediated stimulation of hepatic Na+/TC cotransport and Ntcp translocation requires activation of PKB and is mediated at least in part via a phosphoinositide 3-kinase/PKB-signaling pathway.	Cyclic AMP	70-74	protein tyrosine kinase 2 beta	Homo sapiens	241-244	
12034724-7	2002	Cyclic AMP and cell swelling increased TC uptake by 50-100% and PKB activity 2-4-fold in HuH-Ntcp cells transfected with the empty vector and failed to increase PKB activity, TC uptake, and Ntcp translocation in DN-PKB-transfected HuH-Ntcp cells.	Cyclic AMP	0-10	protein tyrosine kinase 2 beta	Homo sapiens	64-67	
12095540-4	2002	These observations suggest that: 1) tyrphostin A23 and A63 stimulate the cAMP-activated CFTR Cl(-) channel via a PTK-independent, structure-dependent mechanism, and 2) tyrphostin A23 and A63 do not stimulate the basal CFTR Cl(-) channel.	Cyclic AMP	73-77	protein tyrosine kinase 2 beta	Homo sapiens	113-116	
12119281-5	2002	It helps more to view PKA as a central hub that interacts with a variety of other signaling pathways in endocrine cells, not only mediating but also communicating cAMP effects to the mitogen-activated protein kinase (MAPK), protein kinase C and B (PKC and PKB/Akt, respectively).	Cyclic AMP	163-167	protein tyrosine kinase 2 beta	Homo sapiens	224-246