PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28994166-8 2017 PDE4 inhibits cAMP, which reduces the inflammatory response of the pathway of Th helper lymphocytes, Th17, and type 1 interferon which modulates the production of anti-inflammatory cytokines such as IL-10 interleukins. Cyclic AMP 14-18 interleukin 10 Homo sapiens 199-204 20586615-7 2010 Inhibition by 8-pCPT-2"-O-Me-cAMP of IL-10 production was confirmed using purified monocytes. Cyclic AMP 29-33 interleukin 10 Homo sapiens 37-42 27709605-1 2017 Cyclic AMP regulatory element binding protein and signal transducer and activator of transcription 3 (STAT3) may control inflammation by several mechanisms, one of the best characterized is the induction of the expression of the anti-inflammatory cytokine interleukin-10 (IL-10). Cyclic AMP 0-10 interleukin 10 Homo sapiens 256-270 27709605-1 2017 Cyclic AMP regulatory element binding protein and signal transducer and activator of transcription 3 (STAT3) may control inflammation by several mechanisms, one of the best characterized is the induction of the expression of the anti-inflammatory cytokine interleukin-10 (IL-10). Cyclic AMP 0-10 interleukin 10 Homo sapiens 272-277 26206993-9 2015 In the course of the inflammatory response, the increase in cAMP level may lead to an increase in IL-10 expression, inhibition of TNF-alpha, IL-12, and MIP-1beta release, as well as to a reduction inthe permeability of blood vessels. Cyclic AMP 60-64 interleukin 10 Homo sapiens 98-103 23878315-8 2013 High production of IL-10 in PKCI-treated DCs was due to not only an increase of intracellular cAMP, but also a synergistic effect of increased cAMP and NF-kappaB inhibition. Cyclic AMP 94-98 interleukin 10 Homo sapiens 19-24 23878315-8 2013 High production of IL-10 in PKCI-treated DCs was due to not only an increase of intracellular cAMP, but also a synergistic effect of increased cAMP and NF-kappaB inhibition. Cyclic AMP 143-147 interleukin 10 Homo sapiens 19-24 20938210-9 2011 The lymphocyte cAMP level was negatively correlated with the IFN-gamma/IL-10 ratio (p < 0.01). Cyclic AMP 15-19 interleukin 10 Homo sapiens 71-76 21084670-3 2010 Several immune-related genes possess this cAMP-responsive element, including IL-2, IL-6, IL-10, and TNF-alpha. Cyclic AMP 42-46 interleukin 10 Homo sapiens 89-94 24652540-6 2014 When cAMP-treated monocytes are exposed to proinflammatory stimuli, they exhibit an increased production of IL-6 and IL-10 and a lower amount of TNF-alpha and IL-12 compared with control cells, resembling the features of the alternative-activated macrophages or M2 macrophages. Cyclic AMP 5-9 interleukin 10 Homo sapiens 117-122 24149807-5 2013 The pro-inflammatory cytokines IL-1beta and TNFalpha decreased, whereas anti-inflammatory cytokines IL-6 and IL-10 increased after 3d rest and 14d camp. Cyclic AMP 147-151 interleukin 10 Homo sapiens 109-114 20586615-9 2010 In conclusion, cAMP stimulates IL-10 production via PKA in activated B cells, but inhibits IL-10 production in activated monocytes through EPAC. Cyclic AMP 15-19 interleukin 10 Homo sapiens 31-36 20586615-9 2010 In conclusion, cAMP stimulates IL-10 production via PKA in activated B cells, but inhibits IL-10 production in activated monocytes through EPAC. Cyclic AMP 15-19 interleukin 10 Homo sapiens 91-96 19058854-6 2009 In this study using normal peripheral T lymphocytes stimulated either through the TCR-CD3 complex or the TCR-CD3 and the CD28 molecule, we show that IL-10 is produced mainly by memory T lymphocytes after either way of stimulation and is drastically inhibited (70-90%) by cAMP elevating agents. Cyclic AMP 271-275 interleukin 10 Homo sapiens 149-154 19852851-12 2009 A two-gene model involving IL10 and VDR was replicated in CAMP, but not in the other populations. Cyclic AMP 58-62 interleukin 10 Homo sapiens 27-31 19058854-9 2009 Transfection of a luciferase reporter plasmid carrying the IL-10 promoter in T cells, revealed that TCR/CD28-induced activation was inhibited by 60% by cAMP elevation. Cyclic AMP 152-156 interleukin 10 Homo sapiens 59-64 19058854-0 2009 cAMP regulates IL-10 production by normal human T lymphocytes at multiple levels: a potential role for MEF2. Cyclic AMP 0-4 interleukin 10 Homo sapiens 15-20 19058854-4 2009 Elevation of cAMP has been shown to increase IL-10 production by monocytes. Cyclic AMP 13-17 interleukin 10 Homo sapiens 45-50 19058854-13 2009 These results suggest that the inhibitory effect of cAMP on IL-10 production by normal peripheral T lymphocytes is cell type and stimulus specific, exerted on multiple levels and involves MEF2 transcription factor. Cyclic AMP 52-56 interleukin 10 Homo sapiens 60-65 19058854-5 2009 However, the mechanism of cAMP mediated regulation of IL-10 production by T lymphocytes remains unclear. Cyclic AMP 26-30 interleukin 10 Homo sapiens 54-59 18263767-0 2008 Activation of cyclic-AMP response element binding protein contributes to adiponectin-stimulated interleukin-10 expression in RAW 264.7 macrophages. Cyclic AMP 14-24 interleukin 10 Homo sapiens 96-110 18263767-4 2008 Deletion of the sequences from -416 and -369 in the IL-10 promoter, containing a cyclic AMP-response element (CRE), decreased gAcrp-induced IL-10 promoter activation. Cyclic AMP 81-91 interleukin 10 Homo sapiens 52-57 18263767-4 2008 Deletion of the sequences from -416 and -369 in the IL-10 promoter, containing a cyclic AMP-response element (CRE), decreased gAcrp-induced IL-10 promoter activation. Cyclic AMP 81-91 interleukin 10 Homo sapiens 140-145 18160064-8 2007 Experiments with the cell line and fresh isolated mononuclear cells with pharmacological inhibitors showed that induction of necrosis involved calcium and cAMP signals resulting in IL-10 production. Cyclic AMP 155-159 interleukin 10 Homo sapiens 181-186 18336664-10 2008 gAcrp-stimulated IL-10 expression was also dependent on the phosphorylation of cAMP response element-binding protein and the cAMP response element in the IL-10 promoter. Cyclic AMP 79-83 interleukin 10 Homo sapiens 17-22 18336664-10 2008 gAcrp-stimulated IL-10 expression was also dependent on the phosphorylation of cAMP response element-binding protein and the cAMP response element in the IL-10 promoter. Cyclic AMP 125-129 interleukin 10 Homo sapiens 17-22 18336664-10 2008 gAcrp-stimulated IL-10 expression was also dependent on the phosphorylation of cAMP response element-binding protein and the cAMP response element in the IL-10 promoter. Cyclic AMP 125-129 interleukin 10 Homo sapiens 154-159 17469457-1 2007 BACKGROUND: Prostaglandins modulate cytokine release though increases in cAMP, regulating interleukin-6 and interleukin-10. Cyclic AMP 73-77 interleukin 10 Homo sapiens 108-122 17261591-5 2007 As expected with this type of mechanism, the AAT-mediated rise in cAMP and the impact on endotoxin-stimulated tumor necrosis factor-alpha and interleukin-10 was enhanced when the catabolism of cAMP was blocked by the phosphodiesterase inhibitor rolipram. Cyclic AMP 66-70 interleukin 10 Homo sapiens 142-156 17261591-5 2007 As expected with this type of mechanism, the AAT-mediated rise in cAMP and the impact on endotoxin-stimulated tumor necrosis factor-alpha and interleukin-10 was enhanced when the catabolism of cAMP was blocked by the phosphodiesterase inhibitor rolipram. Cyclic AMP 193-197 interleukin 10 Homo sapiens 142-156 16917108-0 2006 C-reactive protein decreases interleukin-10 secretion in activated human monocyte-derived macrophages via inhibition of cyclic AMP production. Cyclic AMP 120-130 interleukin 10 Homo sapiens 29-43 16917108-9 2006 cAMP agonists reversed CRP-mediated IL-10 inhibition. Cyclic AMP 0-4 interleukin 10 Homo sapiens 36-41 16818766-8 2006 Pretreatment with dibutyryl cAMP augmented IL-10-induced, but did not change IL-6-induced STAT3 phosphorylation. Cyclic AMP 28-32 interleukin 10 Homo sapiens 43-48 16859503-7 2006 Adhered monocytes, after 3-day preincubation with IL-10 and M-CSF, could produce more IL-1beta and IL-6 in response to TNF-alpha in the presence of dibutyryl cAMP, as compared with the cells preincubated with or without IL-10 or M-CSF alone. Cyclic AMP 158-162 interleukin 10 Homo sapiens 50-55 15683856-3 2005 Since cyclic adenosine monophosphate (cAMP) production is stimulated by some antidepressants, and since cAMP inhibits IFN-gamma and stimulates IL-10 production, we postulate that the negative immunoregulatory effects of antidepressants result from their effects on the cAMP-dependent protein kinase A (PKA) pathway. Cyclic AMP 104-108 interleukin 10 Homo sapiens 143-148 15096183-4 2004 In this report, we have investigated the involvement of PKC and cAMP in the production of TNF-alpha and IL-10 by peripheral blood monocyte-derived macrophages. Cyclic AMP 64-68 interleukin 10 Homo sapiens 104-109 15096183-8 2004 Cyclic-AMP augmented IL-10 production and cAMP response element binding protein activation upon stimulation by PMA/ionomycin. Cyclic AMP 0-10 interleukin 10 Homo sapiens 21-26 15096183-9 2004 In addition, cAMP activated PKCzeta; inhibition of which, by a dominant negative adenovirus construct, selectively suppressed IL-10 production. Cyclic AMP 13-17 interleukin 10 Homo sapiens 126-131 15096183-10 2004 These observations suggest that pro-inflammatory and anti-inflammatory cytokines are differentially regulated by PKC isoforms; TNF-alpha being dependent on conventional PKCs (alpha and beta) whereas IL-10 is regulated by the cAMP-regulated atypical PKCzeta. Cyclic AMP 225-229 interleukin 10 Homo sapiens 199-204 12493739-2 2003 Recently, we provided evidence that stress-induced IL-10 promoter activation in monocytic cells is mediated by catecholamines via a cAMP-dependent signaling pathway including CREB/ATF (cAMP-responsive element binding protein/activating transcription factor) binding to two CRE motifs. Cyclic AMP 132-136 interleukin 10 Homo sapiens 51-56 12967650-2 2003 In the present study, we investigated the production of tumor necrosis factor-alpha (TNF-alpha), IL-6 and IL-10 by UVB-irradiated human keratinocytes NCTC 2544 cell line in the presence of cAMP-elevating agents and we attempted to determine the implication of cyclic AMP/PKA pathway in the regulation of cytokine gene expression. Cyclic AMP 189-193 interleukin 10 Homo sapiens 106-111 12967650-4 2003 Treatment of UVB-irradiated NCTC 2544 cells with drugs known to enhance cAMP concentration [dibutyryl cAMP, PGE(2) and cholera toxin] results in a significant decrease of TNF-alpha mRNA expression whereas IL-6 and IL-10 mRNAs were enhanced. Cyclic AMP 72-76 interleukin 10 Homo sapiens 214-219 12967650-4 2003 Treatment of UVB-irradiated NCTC 2544 cells with drugs known to enhance cAMP concentration [dibutyryl cAMP, PGE(2) and cholera toxin] results in a significant decrease of TNF-alpha mRNA expression whereas IL-6 and IL-10 mRNAs were enhanced. Cyclic AMP 102-106 interleukin 10 Homo sapiens 214-219 12967650-7 2003 Taken together our results showed: (i) a differential regulation of TNF-alpha, IL-6 and IL-10 in UVB-irradiated human keratinocytes via cyclic AMP/protein kinase A pathway, and (ii) a possible reduction of deleterious inflammatory effects of cytokine following UVB-irradiation by using pharmacological agents that regulate both the intracellular cAMP levels and the cellular PKA activity. Cyclic AMP 346-350 interleukin 10 Homo sapiens 88-93 12493739-3 2003 However, the mutation of these sites diminished cAMP responsiveness by only 50%, suggesting a role for additional transcription factors and elements in the cAMP-dependent regulation of the human IL-10 promoter. Cyclic AMP 156-160 interleukin 10 Homo sapiens 195-200 12493739-5 2003 We show that the level of basal as well as cAMP-stimulated IL-10 transcription depends on the expression of C/EBP alpha and beta and their binding to three motifs in the promoter/enhancer region. Cyclic AMP 43-47 interleukin 10 Homo sapiens 59-64 12493739-6 2003 The C/EBP5 motif, which is located between the TATA-box and the translation start point, is essential for the C/EBP-mediated constitutive and most of the cAMP-stimulated expression as its mutation nearly abolished IL-10 promoter activity. Cyclic AMP 154-158 interleukin 10 Homo sapiens 214-219 12493739-3 2003 However, the mutation of these sites diminished cAMP responsiveness by only 50%, suggesting a role for additional transcription factors and elements in the cAMP-dependent regulation of the human IL-10 promoter. Cyclic AMP 48-52 interleukin 10 Homo sapiens 195-200 12493739-2 2003 Recently, we provided evidence that stress-induced IL-10 promoter activation in monocytic cells is mediated by catecholamines via a cAMP-dependent signaling pathway including CREB/ATF (cAMP-responsive element binding protein/activating transcription factor) binding to two CRE motifs. Cyclic AMP 185-189 interleukin 10 Homo sapiens 51-56 14680506-0 2003 Impact of VIP and cAMP on the regulation of TNF-alpha and IL-10 production: implications for rheumatoid arthritis. Cyclic AMP 18-22 interleukin 10 Homo sapiens 58-63 14680506-9 2003 Interestingly, macrophages stimulated with phorbol 12-myristate 13-acetate/ionomycin displayed an augmented IL-10 response upon addition of dibutyryl cAMP, with corresponding downregulation in TNF-alpha, suggesting a complex interaction between protein kinase C and protein kinase A in cytokine regulation. Cyclic AMP 150-154 interleukin 10 Homo sapiens 108-113 12136890-11 2002 Experiments using inducers and an inhibitor of cyclic AMP (cAMP) suggest that a major intracellular signal mediates the regulatory effect of PGE2 on the production of IL-15 and IL-10. Cyclic AMP 47-57 interleukin 10 Homo sapiens 177-182 12133935-8 2002 In addition, cAMP-primed CD45RA cells produce considerable amounts of the Th2 cytokines, IL-4, IL-10, and IL-13, whereas the production of IFN-gamma and TNF-alpha was nearly undetectable. Cyclic AMP 13-17 interleukin 10 Homo sapiens 95-100 12136890-11 2002 Experiments using inducers and an inhibitor of cyclic AMP (cAMP) suggest that a major intracellular signal mediates the regulatory effect of PGE2 on the production of IL-15 and IL-10. Cyclic AMP 59-63 interleukin 10 Homo sapiens 177-182 12173196-1 2002 BACKGROUND: Prostaglandins modulate cytokine release though increases in cAMP, regulating interleukin (IL) 6 and IL-10. Cyclic AMP 73-77 interleukin 10 Homo sapiens 113-118 12034038-7 2002 Prostaglandin (PGE) and other cAMP agonists had subset-specific effects on IL-10 production opposite to IFN-beta. Cyclic AMP 30-34 interleukin 10 Homo sapiens 75-80 10713361-3 2000 Using reporter gene assays we demonstrated that catecholamines in monocytic cells directly stimulate the IL-10 promoter/enhancer via a cAMP/protein kinase A-dependent pathway. Cyclic AMP 135-139 interleukin 10 Homo sapiens 105-110 11817607-10 2002 Agonists of cAMP displayed an additive effect on the changes produced in the IL-10, IL-15, and TNFalpha levels by CSA, while a cAMP antagonist almost completely abrogated the effect of CSA, suggesting that cAMP is the major intracellular signal that mediates cytokine regulation by CSA. Cyclic AMP 12-16 interleukin 10 Homo sapiens 77-82 11956020-2 2002 Herein, we identify cAMP-elevating agents such as prostaglandin E2 (PGE2), PGE1, forskolin, dibutyryl cAMP (dbcAMP) and cholera toxin as a novel class of agonists able to induce SOCS-3 mRNA and protein expression in human leukocytes, cooperating with interleukin-10 (IL-10) in such activities. Cyclic AMP 20-24 interleukin 10 Homo sapiens 251-265 11956020-2 2002 Herein, we identify cAMP-elevating agents such as prostaglandin E2 (PGE2), PGE1, forskolin, dibutyryl cAMP (dbcAMP) and cholera toxin as a novel class of agonists able to induce SOCS-3 mRNA and protein expression in human leukocytes, cooperating with interleukin-10 (IL-10) in such activities. Cyclic AMP 20-24 interleukin 10 Homo sapiens 267-272 11956020-3 2002 While PGE2 or dbcAMP prolonged the stability of SOCS-3 mRNA isolated from IL-10-treated leukocytes, inhibitors of cAMP-dependent protein kinase A (H89, KT5720, and St-Ht31 peptide) did not influence the action of PGE2/dbcAMP and/or IL-10 on SOCS-3 mRNA and protein expression, implying that their effect are mediated through a PKA-independent pathway. Cyclic AMP 16-20 interleukin 10 Homo sapiens 74-79 11108135-3 2000 In vitro and in vivo studies in experimental models suggest that catecholamines induce IL-10 release via a cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) dependent pathway. Cyclic AMP 156-160 interleukin 10 Homo sapiens 87-92 11108135-7 2000 Recently, we demonstrated that catecholamines directly stimulate the IL-10 promoter/enhancer via a cAMP/PKA pathway in monocytic cells. Cyclic AMP 99-103 interleukin 10 Homo sapiens 69-74 11108135-10 2000 In contrast to monocytic cells, in T-cells cAMP-induced PKA-dependent phosphorylation of the CRE-binding protein 1 (CREB-1) seems to play a marginal role in IL-10 induction, which was reflected by a low cAMP-dependent IL-10-promoter/enhancer stimulation in reporter gene assays. Cyclic AMP 43-47 interleukin 10 Homo sapiens 157-162 11108135-10 2000 In contrast to monocytic cells, in T-cells cAMP-induced PKA-dependent phosphorylation of the CRE-binding protein 1 (CREB-1) seems to play a marginal role in IL-10 induction, which was reflected by a low cAMP-dependent IL-10-promoter/enhancer stimulation in reporter gene assays. Cyclic AMP 43-47 interleukin 10 Homo sapiens 218-223 10929069-8 2000 In response to ionomycin and dibutyryl cAMP, cord blood cells were more prone than adult lymphocytes to secrete the T helper type 2-derived immunosuppressive cytokines IL-4 and IL-10. Cyclic AMP 39-43 interleukin 10 Homo sapiens 177-182 10540320-0 1999 Cyclic adenosine monophosphate-responsive elements are involved in the transcriptional activation of the human IL-10 gene in monocytic cells. Cyclic AMP 0-30 interleukin 10 Homo sapiens 111-116 10540320-2 1999 We and others have demonstrated recently that cyclic adenosine monophosphate (cAMP)-elevating substances up-regulate monocytic IL-10 expression in vitro and in vivo. Cyclic AMP 46-76 interleukin 10 Homo sapiens 127-132 9818793-8 1998 Finally, elevation of intracellular cAMP levels by dbcAMP treatment consistently inhibited IL-12 as well as IL-10 production in monocytes induced by IFN-gamma or IFN-gamma plus 25 mM ethanol. Cyclic AMP 36-40 interleukin 10 Homo sapiens 108-113 10089566-3 1999 In this study, we examined whether gp41-induced IL-10 up-regulation is mediated by the previously described synergistic activation of cAMP and NF-kappaB pathways. Cyclic AMP 134-138 interleukin 10 Homo sapiens 48-53 9878122-0 1998 Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway. Cyclic AMP 68-78 interleukin 10 Homo sapiens 35-40 9301524-0 1997 Differential regulation of IFN-gamma, IL-10 and inducible nitric oxide synthase in human T cells by cyclic AMP-dependent signal transduction pathway. Cyclic AMP 100-110 interleukin 10 Homo sapiens 38-43 9717082-1 1998 The aim of the present study was to investigate the role of cAMP in enhanced IL-10 synthesis in human mononuclear cells. Cyclic AMP 60-64 interleukin 10 Homo sapiens 77-82 9717082-3 1998 The effects of cAMP elevation on IL-10 synthesis were studied at the protein level by ELISA and at the level of mRNA by RT/PCR. Cyclic AMP 15-19 interleukin 10 Homo sapiens 33-38 9469479-0 1998 Anti-inflammatory activities of cAMP-elevating agents: enhancement of IL-10 synthesis and concurrent suppression of TNF production. Cyclic AMP 32-36 interleukin 10 Homo sapiens 70-75 9469479-2 1998 In this study we investigated (1) the potency of different cAMP-elevating agents in enhancing IL-10 synthesis, (2) the involvement of protein kinase A in this enhancement, and (3) the mutual dependence of cAMP-enhanced IL-10 formation and cAMP-suppressed TNF synthesis. Cyclic AMP 205-209 interleukin 10 Homo sapiens 219-224 9469479-2 1998 In this study we investigated (1) the potency of different cAMP-elevating agents in enhancing IL-10 synthesis, (2) the involvement of protein kinase A in this enhancement, and (3) the mutual dependence of cAMP-enhanced IL-10 formation and cAMP-suppressed TNF synthesis. Cyclic AMP 205-209 interleukin 10 Homo sapiens 219-224 9469479-11 1998 These results demonstrate that (1) cAMP-elevating agents enhance IL-10 synthesis and suppress TNF production; (2) these regulative functions of cAMP-elevating agents are mediated by activation of protein kinases A; (3) suppression of TNF synthesis by cAMP in the early phase is not mediated by endogenous IL-10. Cyclic AMP 35-39 interleukin 10 Homo sapiens 65-70 9469479-11 1998 These results demonstrate that (1) cAMP-elevating agents enhance IL-10 synthesis and suppress TNF production; (2) these regulative functions of cAMP-elevating agents are mediated by activation of protein kinases A; (3) suppression of TNF synthesis by cAMP in the early phase is not mediated by endogenous IL-10. Cyclic AMP 35-39 interleukin 10 Homo sapiens 305-310 9469479-11 1998 These results demonstrate that (1) cAMP-elevating agents enhance IL-10 synthesis and suppress TNF production; (2) these regulative functions of cAMP-elevating agents are mediated by activation of protein kinases A; (3) suppression of TNF synthesis by cAMP in the early phase is not mediated by endogenous IL-10. Cyclic AMP 144-148 interleukin 10 Homo sapiens 65-70 9469479-11 1998 These results demonstrate that (1) cAMP-elevating agents enhance IL-10 synthesis and suppress TNF production; (2) these regulative functions of cAMP-elevating agents are mediated by activation of protein kinases A; (3) suppression of TNF synthesis by cAMP in the early phase is not mediated by endogenous IL-10. Cyclic AMP 144-148 interleukin 10 Homo sapiens 305-310 9469479-11 1998 These results demonstrate that (1) cAMP-elevating agents enhance IL-10 synthesis and suppress TNF production; (2) these regulative functions of cAMP-elevating agents are mediated by activation of protein kinases A; (3) suppression of TNF synthesis by cAMP in the early phase is not mediated by endogenous IL-10. Cyclic AMP 144-148 interleukin 10 Homo sapiens 65-70 9469479-11 1998 These results demonstrate that (1) cAMP-elevating agents enhance IL-10 synthesis and suppress TNF production; (2) these regulative functions of cAMP-elevating agents are mediated by activation of protein kinases A; (3) suppression of TNF synthesis by cAMP in the early phase is not mediated by endogenous IL-10. Cyclic AMP 144-148 interleukin 10 Homo sapiens 305-310 9550368-0 1997 Induction of IL-10 synthesis by human keratinocytes through CD23 ligation: a cyclic adenosine 3",5"-monophosphate-dependent mechanism. Cyclic AMP 77-113 interleukin 10 Homo sapiens 13-18 9550368-4 1997 Here, our data show that CD23 ligation induces significant IL-10 synthesis in HK, a phenomenon inhibited by cAMP antagonists, but not by inhibitors of the nitric oxide pathway. Cyclic AMP 108-112 interleukin 10 Homo sapiens 59-64 9550368-5 1997 Accordingly, cAMP agonist induced significant IL-10 synthesis by HK, while nitric oxide-releasing chemical did not. Cyclic AMP 13-17 interleukin 10 Homo sapiens 46-51 8964081-3 1996 On the other hand, N6,O2-dibutyryl cAMP enhanced the production of IL-10 but not IFN-gamma when the low doses of Con A or A23187 coexisted. Cyclic AMP 35-39 interleukin 10 Homo sapiens 67-72 9063693-0 1997 Suppression of tumor necrosis factor-alpha production by interleukin-10 is enhanced by cAMP-elevating agents. Cyclic AMP 87-91 interleukin 10 Homo sapiens 57-71 7547677-0 1995 Up-regulation of monocytic IL-10 by tumor necrosis factor-alpha and cAMP elevating drugs. Cyclic AMP 68-72 interleukin 10 Homo sapiens 27-32 8647222-3 1996 In the presence of Rp-cAMP, the CD23-induced production of IL-10 and of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) was totally abrogated, whereas, in the presence of L-NMMA, IL-10 production was enhanced and TNF-alpha production was suppressed. Cyclic AMP 22-26 interleukin 10 Homo sapiens 59-64 8647222-3 1996 In the presence of Rp-cAMP, the CD23-induced production of IL-10 and of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) was totally abrogated, whereas, in the presence of L-NMMA, IL-10 production was enhanced and TNF-alpha production was suppressed. Cyclic AMP 22-26 interleukin 10 Homo sapiens 201-206 8647222-5 1996 Such an inducing effect was observed with different anti-CD23 mAb (clone 135, MHM6 and 25), indicating that the triggering of the CD23 molecule at the surface of human macrophages induced the generation of IL-10 through a cAMP-dependent mechanism. Cyclic AMP 222-226 interleukin 10 Homo sapiens 206-211 8917629-6 1996 In monocyte/macrophages the formation of IL-1 beta, IL-12 and tumor necrosis factor alpha is decreased by cAMP or through the increased formation of IL-10, which is up-regulated by cAMP. Cyclic AMP 181-185 interleukin 10 Homo sapiens 149-154 8555492-10 1996 Moreover, it appeared that the sensitivity for cAMP-mediated downregulation could not be blocked by stimulation T lymphocytes with alpha CD3/alpha CD28 in the presence of IL-2, IL-7, IL-10, IL-12, or a combination of these cytokines. Cyclic AMP 47-51 interleukin 10 Homo sapiens 183-188 8579753-2 1995 Here, Soichi Haraguchi, Robert Good and Noorbibi Day propose that induction of intracellular cAMP by a synthetic, immunosuppressive, retroviral envelope peptide causes a shift in the cytokine balance, leading to suppression of cell-mediated immunity by upregulation of interleukin 10 (IL-10) and downregulation of IL-2, IL-12 and tumor necrosis factor alpha production. Cyclic AMP 93-97 interleukin 10 Homo sapiens 269-283 8579753-2 1995 Here, Soichi Haraguchi, Robert Good and Noorbibi Day propose that induction of intracellular cAMP by a synthetic, immunosuppressive, retroviral envelope peptide causes a shift in the cytokine balance, leading to suppression of cell-mediated immunity by upregulation of interleukin 10 (IL-10) and downregulation of IL-2, IL-12 and tumor necrosis factor alpha production. Cyclic AMP 93-97 interleukin 10 Homo sapiens 285-290 32240179-6 2020 However, IL10 has also been described to induce the activation of the cyclic adenosine monophosphate (cAMP) regulated protein kinase A (PKA). Cyclic AMP 70-100 interleukin 10 Homo sapiens 9-13 33807944-3 2021 PDE4 blocking can lead to increased levels of intracellular cAMP, which results in down-regulation of inflammatory responses by reducing the expression of tumor necrosis factor (TNF), interleukin (IL)-23, IL-17, interferon-gamma, while increasing regulatory cytokines, such as IL-10. Cyclic AMP 60-64 interleukin 10 Homo sapiens 277-282 32240179-6 2020 However, IL10 has also been described to induce the activation of the cyclic adenosine monophosphate (cAMP) regulated protein kinase A (PKA). Cyclic AMP 102-106 interleukin 10 Homo sapiens 9-13 32240179-11 2020 The coordination between IL10R and EP4 signalling also provides an explanation for why cAMP elevating agents synergize with IL10 to elicit anti-inflammatory responses. Cyclic AMP 87-91 interleukin 10 Homo sapiens 25-29