PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2553385-4 1989 Stimulatory effects on erythropoietin response are observed with the addition of compounds affecting the cAMP level such as forskolin, phosphodiesterase inhibitor and cholera toxin only in the presence of erythropoietin. Cyclic AMP 105-109 erythropoietin Mus musculus 23-37 2465166-6 1989 In initial experiments, cAMP levels in cells stimulated with either recombinant Epo or recombinant IL-3 were monitored. Cyclic AMP 24-28 erythropoietin Mus musculus 80-83 2465166-10 1989 The regulatory effects of cAMP on Epo- and IL-3-stimulated cell growth were next examined. Cyclic AMP 26-30 erythropoietin Mus musculus 34-37 2465166-11 1989 It was found that whereas Epo-stimulated growth was markedly inhibited by cAMP-enhancing agents, IL-3-stimulated growth was relatively resistant and inhibited only by high doses of these agents. Cyclic AMP 74-78 erythropoietin Mus musculus 26-29 25500291-0 2015 Erythropoietin activates the phosporylated cAMP [adenosine 3"5" cyclic monophosphate] response element-binding protein pathway and attenuates delayed paraplegia after ischemia-reperfusion injury. Cyclic AMP 43-47 erythropoietin Mus musculus 0-14 25500291-0 2015 Erythropoietin activates the phosporylated cAMP [adenosine 3"5" cyclic monophosphate] response element-binding protein pathway and attenuates delayed paraplegia after ischemia-reperfusion injury. Cyclic AMP 49-84 erythropoietin Mus musculus 0-14 25500291-3 2015 We hypothesized that EPO induces the CREB (cAMP [adenosine 3"5" cyclic monophosphate] response element-binding protein) pathway and neurotrophin production in the murine spinal cord, attenuating functional and cellular injury. Cyclic AMP 43-47 erythropoietin Mus musculus 21-24 25500291-3 2015 We hypothesized that EPO induces the CREB (cAMP [adenosine 3"5" cyclic monophosphate] response element-binding protein) pathway and neurotrophin production in the murine spinal cord, attenuating functional and cellular injury. Cyclic AMP 49-84 erythropoietin Mus musculus 21-24 18621143-3 2008 The blood plasma erythropoietin level increased after the injection of N6-2-O-dibutyladenosine-3",5"-cyclic monophosphate into adenosine 3",5"-cyclic monophosphate (cAMP) at a dose of 500 mg/kg. Cyclic AMP 127-163 erythropoietin Mus musculus 17-31 18621143-3 2008 The blood plasma erythropoietin level increased after the injection of N6-2-O-dibutyladenosine-3",5"-cyclic monophosphate into adenosine 3",5"-cyclic monophosphate (cAMP) at a dose of 500 mg/kg. Cyclic AMP 165-169 erythropoietin Mus musculus 17-31 18621143-4 2008 A peak of erythropoietin induction was observed 3 h after the injection of cAMP. Cyclic AMP 75-79 erythropoietin Mus musculus 10-24 9364843-0 1997 [Establishment and characterization of a renal carcinoma cell line producing erythropoietin (effects of cyclic AMP on erythropoietin production in vitro)]. Cyclic AMP 104-114 erythropoietin Mus musculus 77-91 9364843-0 1997 [Establishment and characterization of a renal carcinoma cell line producing erythropoietin (effects of cyclic AMP on erythropoietin production in vitro)]. Cyclic AMP 104-114 erythropoietin Mus musculus 118-132 2171931-3 1990 cAMP-elevating agents, such as forskolin and 3-isobutyl-1-methyl-xanthine, caused spontaneous erythroid differentiation, and these agents showed the stimulatory effects on erythropoietin- or Me2SO-induced differentiation. Cyclic AMP 0-4 erythropoietin Mus musculus 172-186 2171931-5 1990 The intracellular cAMP level was rapidly increased by addition of erythropoietin but not by Me2SO. Cyclic AMP 18-22 erythropoietin Mus musculus 66-80 2171931-6 1990 These observations suggest that erythroid differentiation induced by erythropoietin is mediated, at least in part, through the cAMP-dependent pathway. Cyclic AMP 127-131 erythropoietin Mus musculus 69-83 2553385-4 1989 Stimulatory effects on erythropoietin response are observed with the addition of compounds affecting the cAMP level such as forskolin, phosphodiesterase inhibitor and cholera toxin only in the presence of erythropoietin. Cyclic AMP 105-109 erythropoietin Mus musculus 205-219 2553385-5 1989 cAMP analogues themselves show no stimulatory effect on TSA8 cells, nor does erythropoietin increase cAMP level in the cells. Cyclic AMP 101-105 erythropoietin Mus musculus 77-91 2553385-6 1989 Thus, it is suggested that cAMP does not act as a direct second messenger for signal transduction through erythropoietin receptors, but as a stimulator of the erythropoietin receptor pathway and/or as a second messenger in combination with the receptor pathway. Cyclic AMP 27-31 erythropoietin Mus musculus 106-120 2553385-6 1989 Thus, it is suggested that cAMP does not act as a direct second messenger for signal transduction through erythropoietin receptors, but as a stimulator of the erythropoietin receptor pathway and/or as a second messenger in combination with the receptor pathway. Cyclic AMP 27-31 erythropoietin Mus musculus 159-173 163577-0 1975 The role of renal adenosine 3",5"-monophosphate in the control of erythropoietin production. Cyclic AMP 18-47 erythropoietin Mus musculus 66-80 163577-2 1975 Studies in rates reveal a temporal relationship between renal cyclic AMP levels and plasma titers of erythropoietin. Cyclic AMP 62-72 erythropoietin Mus musculus 101-115 163577-3 1975 In addition, cobalt increases the activity of an erythropoietin-generating enzyme (renal erythropoietic factor) with maximal enzyme activity occurring after the rise in cyclic AMP levels but before the increase in erythropoietin titers. Cyclic AMP 169-179 erythropoietin Mus musculus 49-63 163577-9 1975 These results suggest that cyclic AMP plays a significant role in the renal production of erythropoietin following cobalt administration. Cyclic AMP 27-37 erythropoietin Mus musculus 90-104 163577-11 1975 Cyclic AMP then activates a protein kinase which subsequently stimulates renal erythropoietic factor to generate erythropoietin. Cyclic AMP 0-10 erythropoietin Mus musculus 113-127 164670-3 1975 These studies confirm earlier reports of the effects of cyclic AMP in increasing radioactive iron incorporation into red cells and further indicate that this change is associated with an absolute increase renal cyclic AMP concentrations probably stimulate erythropoiesis as a consequence of increased kidney production of erythropoietin. Cyclic AMP 211-221 erythropoietin Mus musculus 322-336