PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29602907-3 2018 Previous investigations into the activation mechanisms of PKG I isoforms have been largely influenced by structures of the cAMP-dependent protein kinase (PKA). Cyclic AMP 123-127 protein kinase cGMP-dependent 1 Homo sapiens 58-61 28405029-11 2017 Localization of cAK and cGK in close relation to key mediators of the cyclic AMP (PDE4, VIP) and cyclic GMP (CGRP) pathways indicate that both signaling systems may synergistically work together in human vaginal tissue. Cyclic AMP 70-80 protein kinase cGMP-dependent 1 Homo sapiens 24-27 28668721-2 2017 Consequently, subcellular compartmentalization allows for spatiotemporal control of cAMP/cGMP metabolism and subsequent regulation of their respective effector kinases PKA or PKG is most important for cardiac function in health and disease. Cyclic AMP 84-88 protein kinase cGMP-dependent 1 Homo sapiens 175-178 25783887-8 2015 Here we present an improved chemical proteomics method involving in-solution competition with low doses of different free cyclic nucleotides to segregate the cAMP/PKA- and cGMP/PKG-based signaling nodes, allowing the purification and subsequent identification of new scaffold proteins for PKG. Cyclic AMP 158-162 protein kinase cGMP-dependent 1 Homo sapiens 289-292 26773602-3 2016 As a result, PDEs facilitate communication between the beta-adrenergic and Nitric Oxide (NO)/cGMP/Protein Kinase G (PKG) signaling pathways, which regulate the synthesis of cAMP and cGMP respectively. Cyclic AMP 173-177 protein kinase cGMP-dependent 1 Homo sapiens 116-119 27959381-2 2017 Vasodilator-stimulated phosphoprotein (VASP) is a common substrate for cyclic AMP and cyclic GMP-regulated protein kinases [i.e., cyclic AMP-dependent protein kinase (PKA; also known as protein kinase A) and cyclic GMP-dependent protein kinase (PKG; also known as protein kinase G)] and it has been shown to be directly phosphorylated by protein kinase C (PKC). Cyclic AMP 71-81 protein kinase cGMP-dependent 1 Homo sapiens 245-248 26370085-0 2015 Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG). Cyclic AMP 13-17 protein kinase cGMP-dependent 1 Homo sapiens 37-53 26370085-0 2015 Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG). Cyclic AMP 13-17 protein kinase cGMP-dependent 1 Homo sapiens 55-58 26370085-2 2015 Hence, the selective activation of PKG by cGMP versus cAMP is critical. Cyclic AMP 54-58 protein kinase cGMP-dependent 1 Homo sapiens 35-38 26370085-4 2015 Although the C-terminal cyclic nucleotide-binding domain B of PKG binds cGMP with higher affinity than cAMP, the intracellular concentrations of cAMP are typically higher than those of cGMP, suggesting that the cGMP-versus-cAMP selectivity of PKG is not controlled uniquely through affinities. Cyclic AMP 103-107 protein kinase cGMP-dependent 1 Homo sapiens 62-65 26370085-4 2015 Although the C-terminal cyclic nucleotide-binding domain B of PKG binds cGMP with higher affinity than cAMP, the intracellular concentrations of cAMP are typically higher than those of cGMP, suggesting that the cGMP-versus-cAMP selectivity of PKG is not controlled uniquely through affinities. Cyclic AMP 145-149 protein kinase cGMP-dependent 1 Homo sapiens 62-65 26370085-4 2015 Although the C-terminal cyclic nucleotide-binding domain B of PKG binds cGMP with higher affinity than cAMP, the intracellular concentrations of cAMP are typically higher than those of cGMP, suggesting that the cGMP-versus-cAMP selectivity of PKG is not controlled uniquely through affinities. Cyclic AMP 145-149 protein kinase cGMP-dependent 1 Homo sapiens 62-65 26370085-5 2015 Here, we show that cAMP is a partial agonist for PKG, and we elucidate the mechanism for cAMP partial agonism through the comparative NMR analysis of the apo, cGMP-, and cAMP-bound forms of the PKG cyclic nucleotide-binding domain B. Cyclic AMP 19-23 protein kinase cGMP-dependent 1 Homo sapiens 49-52 26370085-5 2015 Here, we show that cAMP is a partial agonist for PKG, and we elucidate the mechanism for cAMP partial agonism through the comparative NMR analysis of the apo, cGMP-, and cAMP-bound forms of the PKG cyclic nucleotide-binding domain B. Cyclic AMP 19-23 protein kinase cGMP-dependent 1 Homo sapiens 194-197 26370085-5 2015 Here, we show that cAMP is a partial agonist for PKG, and we elucidate the mechanism for cAMP partial agonism through the comparative NMR analysis of the apo, cGMP-, and cAMP-bound forms of the PKG cyclic nucleotide-binding domain B. Cyclic AMP 89-93 protein kinase cGMP-dependent 1 Homo sapiens 194-197 26370085-5 2015 Here, we show that cAMP is a partial agonist for PKG, and we elucidate the mechanism for cAMP partial agonism through the comparative NMR analysis of the apo, cGMP-, and cAMP-bound forms of the PKG cyclic nucleotide-binding domain B. Cyclic AMP 89-93 protein kinase cGMP-dependent 1 Homo sapiens 194-197 24813825-0 2014 Improved long-term memory via enhancing cGMP-PKG signaling requires cAMP-PKA signaling. Cyclic AMP 68-72 protein kinase cGMP-dependent 1 Homo sapiens 45-48 25783887-1 2015 The chemically quite similar cyclic nucleotides cAMP and cGMP are two second messengers that activate the homologous cAMP- and cGMP-dependent protein kinases (PKA and PKG, respectively). Cyclic AMP 48-52 protein kinase cGMP-dependent 1 Homo sapiens 167-170 25783887-1 2015 The chemically quite similar cyclic nucleotides cAMP and cGMP are two second messengers that activate the homologous cAMP- and cGMP-dependent protein kinases (PKA and PKG, respectively). Cyclic AMP 117-121 protein kinase cGMP-dependent 1 Homo sapiens 167-170 25783887-5 2015 We have shown the utility of immobilized cAMP and cGMP to enrich for PKA and PKG and their associated proteins. Cyclic AMP 41-45 protein kinase cGMP-dependent 1 Homo sapiens 77-80 23014861-2 2012 cAMP and cGMP increase in platelets as a consequence of prostacyclin and nitric oxide production by endothelial cells and act through PKA and PKG, respectively. Cyclic AMP 0-4 protein kinase cGMP-dependent 1 Homo sapiens 142-145 24244663-4 2013 Cyclic AMP- and cyclic GMP-dependent kinases (PKA, PKG) inhibit the interaction of RGS18 and 14-3-3 by phosphorylating S216. Cyclic AMP 0-10 protein kinase cGMP-dependent 1 Homo sapiens 51-54 23849862-2 2013 This type of oxidative modification can occur within the cAMP- and cGMP-dependent protein kinases often referred to as PKA and PKG, which have important roles in regulating cardiac contractility and systemic blood pressure. Cyclic AMP 57-61 protein kinase cGMP-dependent 1 Homo sapiens 127-130 19997608-4 2009 Our data implicate a number of classic signal transduction pathways in the response and provide a model for the sequence of events, where the tmAC-cAMP-PKA pathway is activated first, followed by protein tyrosine phosphorylation (equatorial band and flagellum) and calcium mobilization (through IP(3)R and SOC channels), whereas the sGC-cGMP-PKG cascade, is activated later. Cyclic AMP 147-151 protein kinase cGMP-dependent 1 Homo sapiens 342-345 21526164-0 2011 Co-crystal structures of PKG Ibeta (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding. Cyclic AMP 58-62 protein kinase cGMP-dependent 1 Homo sapiens 25-28 22692928-7 2012 In these discrete compartments, PDEs control cyclic nucleotide levels and regulate specific physiological processes as components of individual signalosomes which are tethered at specific locations and which contain PDEs together with cyclic nucleotide-dependent protein kinases (PKA and PKG), adenylyl cyclases, Epacs (guanine nucleotide exchange proteins activated by cAMP), phosphoprotein phosphatases, A-Kinase anchoring proteins (AKAPs), and pathway-specific regulators and effectors. Cyclic AMP 370-374 protein kinase cGMP-dependent 1 Homo sapiens 288-291 22136590-7 2012 An emerging principle of cyclic nucleotide signaling in platelets is the high degree of interconnection between activating and cAMP/cGMP-dependent inhibitory signaling pathways at all levels, including cAMP/cGMP synthesis and breakdown, and PKA/PKG-mediated substrate phosphorylation. Cyclic AMP 127-131 protein kinase cGMP-dependent 1 Homo sapiens 245-248 22074826-1 2011 The cyclic purine nucleotides cAMP and cGMP are well-characterized second messengers and activators of PKA and PKG, respectively. Cyclic AMP 30-34 protein kinase cGMP-dependent 1 Homo sapiens 111-114 22363980-1 2011 Protein kinase C (PKC) belongs to the AGC (cAMP-dependent protein kinase/PKG/PKC) protein kinase family which plays an important role in the morphine-induced desensitization of R-opioid receptors. Cyclic AMP 43-47 protein kinase cGMP-dependent 1 Homo sapiens 73-76 20869365-3 2011 It can be phosphorylated at Ser-16 by both cAMP- and cGMP-dependent protein kinases (PKA/PKG). Cyclic AMP 43-47 protein kinase cGMP-dependent 1 Homo sapiens 89-92 21597619-9 2011 Our data reveal that within a few minutes several specific PKA and PKG signaling nodes respond significantly to the activating signal, whereas others do not, suggesting a rapid adaption of specific localized cAMP and cGMP pools to the stimulus. Cyclic AMP 208-212 protein kinase cGMP-dependent 1 Homo sapiens 67-70 20487500-2 2010 cAMP- and cGMP-dependent protein kinases (cAK, cGKI) have been identified as important receptors for cyclic nucleotides downstream the signaling cascades. Cyclic AMP 0-4 protein kinase cGMP-dependent 1 Homo sapiens 47-51 18208372-5 2008 HPCs contained high concentrations of cyclic guanosine monophosphate (cGMP)-dependent and cyclic adenosine monophosphate (cAMP)-dependent protein kinases G and A (PKG and PKA, respectively). Cyclic AMP 90-120 protein kinase cGMP-dependent 1 Homo sapiens 163-166 18064650-7 2008 Using pharmacological and molecular activation and inhibition of cAMP-and cGMP-dependent protein kinases (PKA and PKG), Epac, Rap1, Tiam1, Vav2, and Rac we linked ANP-mediated protective effects to the activation of Epac/Rap and PKA signaling cascades, which dramatically inhibited the Rho pathway of thrombin-induced EC hyper-permeability. Cyclic AMP 65-69 protein kinase cGMP-dependent 1 Homo sapiens 114-117 12524425-6 2003 Cloning and functional analysis of the human rhoA promoter revealed that the effect of NO/PKG involved phosphorylation of ATF-1 and subsequent binding to the cAMP-response element. Cyclic AMP 158-162 protein kinase cGMP-dependent 1 Homo sapiens 90-93 16959250-0 2006 PGI2 opens potassium channels in retinal pericytes by cyclic AMP-stimulated, cross-activation of PKG. Cyclic AMP 54-64 protein kinase cGMP-dependent 1 Homo sapiens 97-100 16959250-12 2006 Interestingly, this response appears to involve cAMP-stimulated cross-activation of PKG, and not PKA. Cyclic AMP 48-52 protein kinase cGMP-dependent 1 Homo sapiens 84-87 16460276-10 2006 PKA and PKG, which mediate relaxation, act upstream to desensitize the receptors (VPAC2 and NPR-C), inhibit adenylyl and guanylyl cyclase activities, and stimulate cAMP-specific PDE3 and PDE4 and cGMP-specific PDE5 activities. Cyclic AMP 164-168 protein kinase cGMP-dependent 1 Homo sapiens 8-11 14722776-10 2004 NO inhibits the AVT-induced increase of water flow at least partly by activation of PKG, which interferes with the hydroosmotic effect of AVT probably at (a) post-cAMP step(s). Cyclic AMP 163-167 protein kinase cGMP-dependent 1 Homo sapiens 84-87 14985234-9 2004 However, CPT-cAMP was more effective than CPT-cGMP in decreasing PKG mRNA levels. Cyclic AMP 13-17 protein kinase cGMP-dependent 1 Homo sapiens 65-68 12566973-8 2002 Furthermore, cAMP-stimulated PKG activity mimicked the effect of PGE(2). Cyclic AMP 13-17 protein kinase cGMP-dependent 1 Homo sapiens 29-32 12574812-5 2003 Inhibition of PKA with H-89 reversed cAMP-induced inhibition of P-selectin while cGMP-dependent protein kinase (PKG) inhibition with KT5823 significantly potentiated cAMP-dependent inhibition of P-selectin. Cyclic AMP 166-170 protein kinase cGMP-dependent 1 Homo sapiens 112-115 12574812-8 2003 PKG appears to be solicited for P-selectin expression when cAMP levels are elevated which suggest a cAMP/PKG-dependent pathway of platelet activation. Cyclic AMP 59-63 protein kinase cGMP-dependent 1 Homo sapiens 0-3 12574812-8 2003 PKG appears to be solicited for P-selectin expression when cAMP levels are elevated which suggest a cAMP/PKG-dependent pathway of platelet activation. Cyclic AMP 100-104 protein kinase cGMP-dependent 1 Homo sapiens 0-3 12082174-1 2002 The human protein kinase X gene (PRKX) is a member of an ancient family of cAMP-dependent serine/threonine kinases here shown to be phylogenetically distinct from the classical PKA, PKB/Akt, PKC, SGK, and PKG gene families. Cyclic AMP 75-79 protein kinase cGMP-dependent 1 Homo sapiens 205-208 11884369-5 2002 Cyclic nucleotide analogues also suppressed PKG-Ialpha promoter activity with cAMP being more potent than cGMP. Cyclic AMP 78-82 protein kinase cGMP-dependent 1 Homo sapiens 44-47 11884369-9 2002 These results indicate that PKG-Ialpha gene expression is driven by an Sp1 transcription mechanism, and that NO and cAMP inhibit Sp1-mediated PKG-Ialpha gene expression through separate mechanisms. Cyclic AMP 116-120 protein kinase cGMP-dependent 1 Homo sapiens 142-145 11832336-1 2002 Regulation of adenylyl cyclase type V/VI and cAMP-specific, cGMP-inhibited phosphodiesterase (PDE) 3 and cAMP-specific PDE4 by cAMP-dependent protein kinase (PKA) and cGMP-dependent protein kinase (PKG) was examined in gastric smooth muscle cells. Cyclic AMP 45-49 protein kinase cGMP-dependent 1 Homo sapiens 198-201 11313394-7 2001 Evidence suggested that cGK regulated neutrophil spreading, as both VASP phosphorylation and neutrophil spreading were inhibited by Rp-8-pCPT-cGMPS (cGK inhibitor), but not KT5720 (cAMP-dependent protein kinase inhibitor). Cyclic AMP 181-185 protein kinase cGMP-dependent 1 Homo sapiens 24-27 11668033-0 2001 cAMP inhibits IP(3)-dependent Ca(2+) release by preferential activation of cGMP-primed PKG. Cyclic AMP 0-4 protein kinase cGMP-dependent 1 Homo sapiens 87-90 11668033-2 2001 In permeabilized muscle cells, exogenous cAMP and cGMP inhibited inositol 1,4,5-trisphosphate (IP(3))-induced Ca(2+) release and muscle contraction via PKA and PKG, respectively. Cyclic AMP 41-45 protein kinase cGMP-dependent 1 Homo sapiens 160-163 11668033-3 2001 A combination of cAMP and cGMP caused synergistic inhibition that was exclusively mediated by PKG and attenuated by PKA. Cyclic AMP 17-21 protein kinase cGMP-dependent 1 Homo sapiens 94-97 10547076-8 1999 These findings demonstrate that activation of DA-1 receptors causes stimulation of BKCa channel activity by a mechanism involving cyclic AMP-dependent stimulation of PKG, but not PKA, and further suggest that this cross-reactivity mediates dopamine-induced coronary vasodilation. Cyclic AMP 130-140 protein kinase cGMP-dependent 1 Homo sapiens 166-169 10922374-1 2000 Many signal transduction pathways are mediated by the second messengers cGMP and cAMP, cGMP- and cAMP-dependent protein kinases (cGK and PKA), phosphodiesterases, and ion channels. Cyclic AMP 97-101 protein kinase cGMP-dependent 1 Homo sapiens 129-132 10785513-2 2000 In the present study we demonstrate that cAMP-stimulating agents enhance the activity of the large-conductance, calcium-activated potassium (BK(Ca)) channel in single myocytes from coronary arteries by "cross-activation" of the cGMP-dependent protein kinase (protein kinase G, PKG). Cyclic AMP 41-45 protein kinase cGMP-dependent 1 Homo sapiens 277-280 10785513-3 2000 Single-channel patch-clamp data revealed that 10 micromol/L isoproterenol, forskolin, or dopamine opens BK(Ca) channels in coronary myocytes and that this effect is attenuated by inhibitors of PKG (KT5823; Rp-8-pCPT-cGMPS), but not by inhibiting the cAMP-dependent protein kinase (protein kinase A, PKA). Cyclic AMP 250-254 protein kinase cGMP-dependent 1 Homo sapiens 193-196 10785513-6 2000 Finally, the stimulatory effect of cAMP on BK(Ca) channels was reconstituted in a cell-free, inside-out patch by addition of purified PKG activated by either cGMP or cAMP. Cyclic AMP 35-39 protein kinase cGMP-dependent 1 Homo sapiens 134-137 10785513-6 2000 Finally, the stimulatory effect of cAMP on BK(Ca) channels was reconstituted in a cell-free, inside-out patch by addition of purified PKG activated by either cGMP or cAMP. Cyclic AMP 166-170 protein kinase cGMP-dependent 1 Homo sapiens 134-137 10785513-8 2000 In summary, findings from on-cell and cell-free patch-clamp experiments provide direct evidence that cAMP-dependent vasodilators open BK(Ca) channels in coronary myocytes by cross-activation of PKG (but not via PKA). Cyclic AMP 101-105 protein kinase cGMP-dependent 1 Homo sapiens 194-197 11074350-12 2000 The present observations suggest the involvement of cGMP and PKG in control of the production of steroid, nonapeptide hormone, growth factor, cAMP and cAMP-dependent PKA, as well as the induction of apoptosis in porcine ovarian cells. Cyclic AMP 142-146 protein kinase cGMP-dependent 1 Homo sapiens 61-64 11074350-12 2000 The present observations suggest the involvement of cGMP and PKG in control of the production of steroid, nonapeptide hormone, growth factor, cAMP and cAMP-dependent PKA, as well as the induction of apoptosis in porcine ovarian cells. Cyclic AMP 151-155 protein kinase cGMP-dependent 1 Homo sapiens 61-64 8550555-2 1996 The cAMP-dependent (PKA) and cGMP-dependent protein kinases (PKG) share a strong primary sequence homology within their respective active site regions. Cyclic AMP 4-8 protein kinase cGMP-dependent 1 Homo sapiens 61-64 10085070-2 1999 Although both the type Ibeta cGMP-dependent protein kinase (cGKIbeta) and the type II cAMP-dependent protein kinase (cAKII) phosphorylated the cytoplasmic substrate VASP (vasodilator- and A kinase-stimulated phosphoprotein) to a similar extent, cyclic nucleotide regulation of CRE-dependent transcription was at least 10-fold higher in cAKII-transfected cells than in cGKIbeta-transfected cells. Cyclic AMP 86-90 protein kinase cGMP-dependent 1 Homo sapiens 368-376 8719784-21 1995 The results obtained indicate that (Rp)-8-bromo-PET-cyclic GMPS presently is the most potent and selective inhibitor of PKG and is helpful in distinguishing between cyclic GMP and cyclic AMP messenger pathways activation. Cyclic AMP 180-190 protein kinase cGMP-dependent 1 Homo sapiens 120-123 7589570-1 1995 To study the fluctuations of cGMP in living cells through changes of energy transfer of dissociable fluorescence labeled subunits, we constructed a cGMP-sensitive probe by combining the N-terminus of the type I regulatory subunit of cAMP-dependent protein kinase (PKA) with the cGMP binding sites of cGMP-dependent protein kinase I alpha (PKG). Cyclic AMP 233-237 protein kinase cGMP-dependent 1 Homo sapiens 339-342 34864165-4 2022 This study aimed to explore the role of BCAA catabolism in the pathogenesis of AF and to further evaluate the therapeutic effect of melatonin with a focus on protein kinase G (PKG)-cAMP response element binding protein (CREB)-Kruppel-like factor 15 (KLF15) signaling. Cyclic AMP 181-185 protein kinase cGMP-dependent 1 Homo sapiens 158-174 1653962-2 1991 The cyclic-nucleotide dependent protein kinases, cAMP-dependent protein kinase (PKA) and cGMP-dependent protein kinase (PKG), are the major intracellular receptors of cAMP and cGMP. Cyclic AMP 49-53 protein kinase cGMP-dependent 1 Homo sapiens 120-123 7654713-1 1995 An iterative approach to the a priori determination of the substrate specificity of cAMP- and cGMP-dependent protein kinases (PKA and PKG) by the use of peptide libraries on cellulose paper is described. Cyclic AMP 84-88 protein kinase cGMP-dependent 1 Homo sapiens 134-137 34864165-4 2022 This study aimed to explore the role of BCAA catabolism in the pathogenesis of AF and to further evaluate the therapeutic effect of melatonin with a focus on protein kinase G (PKG)-cAMP response element binding protein (CREB)-Kruppel-like factor 15 (KLF15) signaling. Cyclic AMP 181-185 protein kinase cGMP-dependent 1 Homo sapiens 176-179 32085646-0 2020 The Cell Cycle Checkpoint System MAST(L)-ENSA/ARPP19-PP2A is Targeted by cAMP/PKA and cGMP/PKG in Anucleate Human Platelets. Cyclic AMP 73-77 protein kinase cGMP-dependent 1 Homo sapiens 91-94 35427632-1 2022 The cAMP- and cGMP-dependent protein kinases (PKA and PKG) are canonically activated by the corresponding cyclic nucleotides. Cyclic AMP 4-8 protein kinase cGMP-dependent 1 Homo sapiens 54-57 33503999-10 2021 In 661W cells, the results suggest that PKG activators cause minor activation of PKG, but a prominent increase in the activity of cAMP-dependent protein kinase (PKA). Cyclic AMP 130-134 protein kinase cGMP-dependent 1 Homo sapiens 40-43 32715279-2 2020 cAMP/protein kinase A (PKA) and cGMP/protein kinase G (PKG) signaling are disrupted in AD. Cyclic AMP 0-4 protein kinase cGMP-dependent 1 Homo sapiens 55-58 34845961-1 2021 Cyclic nucleotides (cAMP and cGMP) and corresponding protein kinases, protein kinase A (PKA) and protein kinase G (PKG), are the main intracellular mediators of endothelium-derived platelet inhibitors. Cyclic AMP 20-24 protein kinase cGMP-dependent 1 Homo sapiens 97-113 34400180-0 2021 Mutual Protein-Ligand Conformational Selection Drives cGMP vs. cAMP Selectivity in Protein Kinase G. Cyclic AMP 63-67 protein kinase cGMP-dependent 1 Homo sapiens 83-99 34400180-2 2021 However, the contributions of the two substituents that differentiate cGMP from cAMP (i.e. 6-oxo and 2-NH2) to the cGMP-versus-cAMP selectivity of PKG remain unclear. Cyclic AMP 80-84 protein kinase cGMP-dependent 1 Homo sapiens 147-150 34400180-2 2021 However, the contributions of the two substituents that differentiate cGMP from cAMP (i.e. 6-oxo and 2-NH2) to the cGMP-versus-cAMP selectivity of PKG remain unclear. Cyclic AMP 127-131 protein kinase cGMP-dependent 1 Homo sapiens 147-150 34400180-6 2021 Therefore, understanding the conformational dynamics of both the protein and ligand is essential to explain the cGMP-versus-cAMP selectivity of PKG. Cyclic AMP 124-128 protein kinase cGMP-dependent 1 Homo sapiens 144-147 29769318-3 2018 Here we determined co-crystal structures of the PKG Ialpha C-domain and cAMP-dependent protein kinase (PKA) Calpha, each bound with N46, at 1.98 A and 2.65 A, respectively. Cyclic AMP 72-76 protein kinase cGMP-dependent 1 Homo sapiens 48-51