PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23542062-6 2013 In addition, in order to ascertain the receptors involved, the levels of cyclic AMP in cells were measured in monocytes and THP-1 cells in response to PGE2-EA and directly compared to those of PGE2. Cyclic AMP 73-83 GLI family zinc finger 2 Homo sapiens 124-129 29146892-6 2017 In vitro, IMD increased intracellular cAMP concentration in a dose-dependent manner in THP-1 and RAW264.7 cell lines, which enhanced the expression of ABCA1 and increased cholesterol efflux rate. Cyclic AMP 38-42 GLI family zinc finger 2 Homo sapiens 87-92 25829542-8 2015 Shh promotes cytosolic over nuclear localization of Gli2, induces Gli2 and Gli3 processing into repressor forms, and activates cAMP-responsive element binding protein that in turn represses gli1 transcription. Cyclic AMP 127-131 GLI family zinc finger 2 Homo sapiens 52-56 17938542-8 2007 Intracellular concentration of cAMP was significantly increased after cilostazol treatment, and treatment with Forskolin and Dibutyryl-cAMP, potent inducers of cAMP, dramatically increased THP-1 adhesion to HUVECs. Cyclic AMP 31-35 GLI family zinc finger 2 Homo sapiens 189-194 21801332-4 2011 The balance between M-MITF and GLI2 expression did not correlate with the presence or absence of BRAF-activating mutations, but rather was controlled by two distinct pathways: the TGF-beta pathway, which favors GLI2 expression, and the protein kinase A (PKA)/cAMP pathway, which pushes the balance toward high M-MITF expression. Cyclic AMP 259-263 GLI family zinc finger 2 Homo sapiens 31-35 20625316-10 2010 These results provide evidence that D4-F enhances ABCA1 serine phosphorylation and ABCA1-dependent cholesterol efflux through Cdc42/cAMP/PKA pathway in THP-1 macrophage-derived foam cells. Cyclic AMP 132-136 GLI family zinc finger 2 Homo sapiens 152-157 18496024-7 2008 In PMA-treated THP-1 cells, intracellular cAMP levels increased after stimulation with forskolin, in a dose-dependent manner. Cyclic AMP 42-46 GLI family zinc finger 2 Homo sapiens 15-20 22609331-0 2012 Norepinephrine differentially modulates the innate inflammatory response provoked by amyloid-beta peptide via action at beta-adrenoceptors and activation of cAMP/PKA pathway in human THP-1 macrophages. Cyclic AMP 157-161 GLI family zinc finger 2 Homo sapiens 183-188 22382002-0 2012 Activation of phospholipase A(2) by low levels of fluoride in THP1 macrophages via altered Ca(2+) and cAMP concentration. Cyclic AMP 102-106 GLI family zinc finger 2 Homo sapiens 62-66 17938542-8 2007 Intracellular concentration of cAMP was significantly increased after cilostazol treatment, and treatment with Forskolin and Dibutyryl-cAMP, potent inducers of cAMP, dramatically increased THP-1 adhesion to HUVECs. Cyclic AMP 135-139 GLI family zinc finger 2 Homo sapiens 189-194 12080031-4 2002 Tammar relaxin bound with high affinity to rat cortical relaxin receptors and stimulated cAMP production in the human monocytic cell line, THP-1, which expresses the relaxin receptor. Cyclic AMP 89-93 GLI family zinc finger 2 Homo sapiens 139-144 17307163-8 2007 Our findings suggest that activation of the prostanoid DP receptor on THP-1 cells enhances TNF-alpha-induced MCP-1 and IL-8 production via the cAMP/PKA signaling pathway. Cyclic AMP 143-147 GLI family zinc finger 2 Homo sapiens 70-75 16274952-6 2006 Finally, bioactivity of the conditioned media was tested using the human monocyte cell line, THP-1, which exhibits a rapid and dose-dependent increase in the accumulation of cAMP upon binding relaxin. Cyclic AMP 174-178 GLI family zinc finger 2 Homo sapiens 93-98 16274952-9 2006 THP-1 cells incubated with conditioned media (5x) from transfected cells, in the presence of forskolin (1 microM) and isobutylmethylxanthine (50 microM), showed an increase in cAMP production over media from mock-transfected cells alone. Cyclic AMP 176-180 GLI family zinc finger 2 Homo sapiens 0-5 16303766-9 2006 These responses in THP-1 and peripheral blood mononuclear cells are relaxin dose-dependent and proportional to cAMP accumulation. Cyclic AMP 111-115 GLI family zinc finger 2 Homo sapiens 19-24 15956717-0 2005 Relaxin stimulates multiple signaling pathways: activation of cAMP, PI3K, and PKCzeta in THP-1 cells. Cyclic AMP 62-66 GLI family zinc finger 2 Homo sapiens 89-94 15956717-10 2005 In summary, relaxin has pleiotropic signaling effects in THP-1 cells activating ERK1/2, cAMP, PI3K, and PKCzeta. Cyclic AMP 88-92 GLI family zinc finger 2 Homo sapiens 57-62 11359835-7 2001 Pretreatment of THP-1 cells or mutant THP-1 cells with cAMP analog or forskolin followed by treatment with CKS-17 showed no activation of MEK or ERK1/2. Cyclic AMP 55-59 GLI family zinc finger 2 Homo sapiens 38-43 11785950-3 2002 We show that rolipram and cilomilast, inhibitors of cAMP-specific PDE4, increase apolipoprotein A-I (apoA-I)-mediated cholesterol efflux up to 80 and 140% in human THP-1 and mouse J774.A1 macrophages, respectively, concomitant with an elevation of cAMP levels. Cyclic AMP 52-56 GLI family zinc finger 2 Homo sapiens 164-169 11879578-3 2002 Here, we show that cAMP treatment of several cell types, including mouse liver-derived BNL CL.2, human monocyte-derived THP-1, and a primary culture of vascular smooth muscle cells from porcine aorta, activated cellular SAF"s ability to bind DNA. Cyclic AMP 19-23 GLI family zinc finger 2 Homo sapiens 120-125 11517286-5 2001 The specific tyrphostins AG 1478, AG 527 and AG 879 inhibited the RLX-stimulated cAMP response in human ESC and THP-1 cells in a dose-dependent manner, though the potent broad range tyrphostin AG 213 had no effect. Cyclic AMP 81-85 GLI family zinc finger 2 Homo sapiens 112-117 11517286-6 2001 Also, treatment of THP-1 cells with the potent phosphotyrosine phosphatase inhibitors bpV(phen) and mpV(pic) increased RLX-stimulated cAMP accumulation in a dose-dependent manner. Cyclic AMP 134-138 GLI family zinc finger 2 Homo sapiens 19-24 11164949-4 2001 The bioassay systems used were (a) cAMP production by human endometrial stromal cells and (b) cAMP production by the human monocyte cell line THP-1. Cyclic AMP 94-98 GLI family zinc finger 2 Homo sapiens 142-147 11331250-3 2001 To that end, we have examined the binding activity on activation protein-1 (AP-1) and cyclic AMP responsive element (CRE) target sequences in human THP-1 myeloid cells after treatment with the beta-chemokine macrophage inflammatory protein (MIP-1alpha). Cyclic AMP 86-96 GLI family zinc finger 2 Homo sapiens 148-153 9614222-10 1998 Exposure of microglia and THP1 monocytes to Abeta resulted in the activation of RSK1 and RSK2 and phosphorylation of cAMP response element-binding protein at Ser133, providing a mechanism for Abeta-induced changes in gene expression. Cyclic AMP 117-121 GLI family zinc finger 2 Homo sapiens 26-30 7594450-9 1995 In addition, an increase in CREB phosphorylation was observed when THP-1 5A cells were treated with dibutyryl cAMP, LPS, or both. Cyclic AMP 110-114 GLI family zinc finger 2 Homo sapiens 67-72 9528941-14 1998 On the other hand, dibutyryl cAMP suppressed PMA-stimulated expression of exon I.6 in THP-1 cells and adipose stromal cells. Cyclic AMP 29-33 GLI family zinc finger 2 Homo sapiens 86-91 8384124-1 1993 The activation of the cAMP signaling pathway by vasoactive intestinal peptide (VIP), pituitary adenylate cyclase-activating peptide (PACAP) and related peptides was studied (i) in normal peripheral human monocytes and THP-1 leukemic human monocytes, (ii) in their derived macrophage counterparts respectively obtained after spontaneous differentiation or retinoic acid (RA) treatment, and (iii) in human bronchoalveolar macrophages. Cyclic AMP 22-26 GLI family zinc finger 2 Homo sapiens 218-223 7915087-1 1994 Spontaneous and all-trans-retinoic acid (RA)-induced differentiation of normal human monocytes and of leukemic THP-1 monocytes into macrophages resulted in a progressive loss of adenosine 3",5"-cyclic monophosphate production induced by histamine via typical H2 receptors (H2R). Cyclic AMP 178-214 GLI family zinc finger 2 Homo sapiens 111-116 7948429-9 1994 In addition, dibutyryl cAMP alone stimulated the release of both receptors but only in THP-1 cells. Cyclic AMP 23-27 GLI family zinc finger 2 Homo sapiens 87-92 8413264-3 1993 In U937 and THP-1 cells, maximum stimulation of both the endogenous IL-1 beta gene and pIL1(4.0kb)-CAT transfectants was observed following treatment with the combination of inducing agents lipopolysaccharide-phorbol myristate acetate-dibutyryl cyclic AMP. Cyclic AMP 245-255 GLI family zinc finger 2 Homo sapiens 12-17 7608561-3 1995 Here we report that in human PBMC and in a stable transfectant of the promonocytic cell line, THP-1, TNF-alpha indeed appears to be an inducer of IL-1 beta production, but only in the presence of dibutyryl cAMP or agents such as the PG that elevate intracellular cAMP levels. Cyclic AMP 206-210 GLI family zinc finger 2 Homo sapiens 94-99 7608561-3 1995 Here we report that in human PBMC and in a stable transfectant of the promonocytic cell line, THP-1, TNF-alpha indeed appears to be an inducer of IL-1 beta production, but only in the presence of dibutyryl cAMP or agents such as the PG that elevate intracellular cAMP levels. Cyclic AMP 263-267 GLI family zinc finger 2 Homo sapiens 94-99 2548077-1 1989 Transcription of the low-density lipoprotein receptor (LDL-R) gene in the human monocytic leukemic cell line THP-1 and in the human hepatocarcinoma cell line Hep-G2 is regulated by second messengers of the diacylglycerol-protein kinase C (DAG-PKC), inositol 1,4,5-triphosphate-Ca2+, and cyclic AMP pathways. Cyclic AMP 287-297 GLI family zinc finger 2 Homo sapiens 109-114 1797949-2 1991 A selective inhibitor, MDL 29,152 (4-propyl-5-(4-quinolinyl)-2(3H)-oxazolone) was used to show that this induction required activation of protein kinase C. MDL 29,152 acts in the catalytic domain of protein kinase C and is at least 200-fold selective for protein kinase C over cAMP-dependent protein kinase in THP-1 cells. Cyclic AMP 277-281 GLI family zinc finger 2 Homo sapiens 310-315 1375507-0 1992 Prostacyclin analogues inhibit tissue factor expression in the human monocytic cell line THP-1 via a cyclic AMP-dependent mechanism. Cyclic AMP 101-111 GLI family zinc finger 2 Homo sapiens 89-94 33741928-3 2021 We identify alterations within the cAMP dependent pathway (GNAS, PRKAR1A) which converge on GLI2 activity and show that 18% of tumors have a genetic event that directly targets the abundance and/or stability of MYCN. Cyclic AMP 35-39 GLI family zinc finger 2 Homo sapiens 92-96 29444935-9 2018 Together, our results show that AC1 is a major isoform for apoA-1-activated cAMP signaling to promote cholesterol transport and exocytosis to the surface of THP-1 macrophage foam cells. Cyclic AMP 76-80 GLI family zinc finger 2 Homo sapiens 157-162 32371475-8 2020 Mechanistically, PGE1 inhibited HH signaling through the EP4 receptor, enhancing cAMP-PKA activity, which promoted phosphorylation and degradation of GLI2 via the ubiquitination pathway. Cyclic AMP 81-85 GLI family zinc finger 2 Homo sapiens 150-154