PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16870702-0 2006 Nonadaptive regulation of ERK2 in Dictyostelium: implications for mechanisms of cAMP relay. Cyclic AMP 80-84 mitogen-activated protein kinase 1 Homo sapiens 26-30 16870702-4 2006 We argue that the net result of these two regulatory actions is a persistently active ERK2 pathway when the extracellular ligand (i.e., cAMP) concentration is held constant and that oscillatory production/destruction of secreted cAMP in chemotaxing cells accounts for the observed oscillatory activity of ERK2. Cyclic AMP 136-140 mitogen-activated protein kinase 1 Homo sapiens 86-90 16870702-4 2006 We argue that the net result of these two regulatory actions is a persistently active ERK2 pathway when the extracellular ligand (i.e., cAMP) concentration is held constant and that oscillatory production/destruction of secreted cAMP in chemotaxing cells accounts for the observed oscillatory activity of ERK2. Cyclic AMP 229-233 mitogen-activated protein kinase 1 Homo sapiens 86-90 16870702-4 2006 We argue that the net result of these two regulatory actions is a persistently active ERK2 pathway when the extracellular ligand (i.e., cAMP) concentration is held constant and that oscillatory production/destruction of secreted cAMP in chemotaxing cells accounts for the observed oscillatory activity of ERK2. Cyclic AMP 229-233 mitogen-activated protein kinase 1 Homo sapiens 305-309 16870702-5 2006 We also show that pathways controlling seven-transmembrane receptor (7-TMR) ERK2 activation/deactivation function independently of G proteins and ligand-induced production of intracellular cAMP and the consequent activation of PKA. Cyclic AMP 189-193 mitogen-activated protein kinase 1 Homo sapiens 76-80 16926362-8 2006 Cross-talk between the key cAMP and ERK signaling pathways provides a mechanism that, along with distinct mechanisms of both positive and negative attenuation provided by Raf and PDE4 isoforms, can be tailored on a cell type-specific basis. Cyclic AMP 27-31 mitogen-activated protein kinase 1 Homo sapiens 36-39 16807403-2 2006 Arginine vasopressin (AVP) stimulates the proliferation of human PKD cells in vitro via cAMP-dependent activation of the B-Raf/MEK (MAPK/ERK kinase/extracellular signal-regulated kinase (ERK) pathway. Cyclic AMP 88-92 mitogen-activated protein kinase 1 Homo sapiens 187-190 16458997-4 2006 Both the cyclooxygenase inhibitor, indomethacin and the ERK inhibitors, UO126 and PD980589 reverse the hypoxia-induced increase in intracellular cAMP levels back to those seen in normoxic hPASM cells. Cyclic AMP 145-149 mitogen-activated protein kinase 1 Homo sapiens 56-59 16458997-8 2006 We propose that the hypoxia-induced activation of ERK initiates a phospholipase A(2)/COX-driven autocrine effect whereupon PGE(2) is generated, causing the activation of adenylyl cyclase and increase in intracellular cAMP. Cyclic AMP 217-221 mitogen-activated protein kinase 1 Homo sapiens 50-53 16700004-5 2006 After interacting with a specific binding site on breast cancer cell membranes, SHBG activates a specific pathway, and by cAMP induction, inhibits estradiol-mediated activation of ERK. Cyclic AMP 122-126 mitogen-activated protein kinase 1 Homo sapiens 180-183 16470843-0 2006 Cyclic AMP synergistically enhances neuregulin-dependent ERK and Akt activation and cell cycle progression in Schwann cells. Cyclic AMP 0-10 mitogen-activated protein kinase 1 Homo sapiens 57-60 16470843-2 2006 To better understand this mechanism, we investigated the effect of cAMP on the activation of the extracellular signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3-K)-Akt (PKB) pathways by heregulin, a member of the neuregulin family. Cyclic AMP 67-71 mitogen-activated protein kinase 1 Homo sapiens 97-134 16470843-2 2006 To better understand this mechanism, we investigated the effect of cAMP on the activation of the extracellular signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3-K)-Akt (PKB) pathways by heregulin, a member of the neuregulin family. Cyclic AMP 67-71 mitogen-activated protein kinase 1 Homo sapiens 136-139 16470843-4 2006 When cAMP levels were increased, using either forskolin or a cell permeable analogue of cAMP, the heregulin-induced phosphorylation of ERK was converted from transient to sustained and the heregulin-induced phosphorylation of Akt was synergistically increased. Cyclic AMP 5-9 mitogen-activated protein kinase 1 Homo sapiens 135-138 16470843-4 2006 When cAMP levels were increased, using either forskolin or a cell permeable analogue of cAMP, the heregulin-induced phosphorylation of ERK was converted from transient to sustained and the heregulin-induced phosphorylation of Akt was synergistically increased. Cyclic AMP 88-92 mitogen-activated protein kinase 1 Homo sapiens 135-138 16470843-6 2006 Overall, these novel results indicate that in neuregulin-stimulated SCs the activation of cAMP-mediated pathways accelerates G1-S progression by prolonging ERK activation and concurrently enhancing Akt activation. Cyclic AMP 90-94 mitogen-activated protein kinase 1 Homo sapiens 156-159 16731514-4 2006 We report that kinase suppressor of Ras (KSR1) functions biochemically in the hippocampus to scaffold the components of the ERK cascade, specifically regulating the cascade when a membrane fraction of ERK is activated via a PKC-dependent pathway but not via a cAMP/PKA-dependent pathway. Cyclic AMP 260-264 mitogen-activated protein kinase 1 Homo sapiens 124-127 16731514-4 2006 We report that kinase suppressor of Ras (KSR1) functions biochemically in the hippocampus to scaffold the components of the ERK cascade, specifically regulating the cascade when a membrane fraction of ERK is activated via a PKC-dependent pathway but not via a cAMP/PKA-dependent pathway. Cyclic AMP 260-264 mitogen-activated protein kinase 1 Homo sapiens 201-204 16319189-3 2006 cAMP stimulates the B-Raf/MEK/extracellular signal-regulated kinase (B-Raf/MEK/ERK) pathway and accelerates the proliferation of cells that are cultured from PKD cysts. Cyclic AMP 0-4 mitogen-activated protein kinase 1 Homo sapiens 79-82 16414357-5 2006 We also found that the down-regulation of TIMP-2 expression and extracellular signal-regulated kinase (ERK)1/2 activation by sPLA2 were blocked by increasing the intracellular cAMP level. Cyclic AMP 176-180 mitogen-activated protein kinase 1 Homo sapiens 64-110 16332989-10 2006 These results indicate that CRH induces VEGF release in human mast cells via selective activation of the cAMP/protein kinase A/p38 MAPK signaling pathway, thereby providing further insight into the molecular mechanism of how CRH affects the release of a key proinflammatory mediator. Cyclic AMP 105-109 mitogen-activated protein kinase 1 Homo sapiens 131-135 16319189-5 2006 Previously, it was found that a sustained reduction of intracellular Ca2+ levels in NHK and M-1 cells that were treated with Ca2+ entry blockers allowed cAMP activation of the B-Raf/MEK/ERK pathway, switching the cells to a cAMP-growth stimulated phenotype. Cyclic AMP 153-157 mitogen-activated protein kinase 1 Homo sapiens 186-189 16319189-5 2006 Previously, it was found that a sustained reduction of intracellular Ca2+ levels in NHK and M-1 cells that were treated with Ca2+ entry blockers allowed cAMP activation of the B-Raf/MEK/ERK pathway, switching the cells to a cAMP-growth stimulated phenotype. Cyclic AMP 224-228 mitogen-activated protein kinase 1 Homo sapiens 186-189 16319189-9 2006 Elevation of intracellular Ca2+ levels in ADPKD cells increased Akt activity and blocked cAMP-dependent B-Raf and ERK activation. Cyclic AMP 89-93 mitogen-activated protein kinase 1 Homo sapiens 114-117 16214133-10 2005 Taken together, these results demonstrate a novel pathway in ES cells that 8-Br-cAMP activate PLD through PKA and ERK1/2 and this ERK/PLD activation by 8-Br-cAMP is mediated by Src and Ras, separately. Cyclic AMP 80-84 mitogen-activated protein kinase 1 Homo sapiens 114-117 16214133-8 2005 H-89 and Rp-cAMPs completely blocked 8-Br-cAMP-mediated PLD and ERK activation, implying the involvement of PKA in this PLD activation. Cyclic AMP 12-16 mitogen-activated protein kinase 1 Homo sapiens 64-67 15838308-2 2004 In this study, we showed that the molar potency of ET-1 to induce Erk activation was two orders of magnitude higher in dibutyryl cAMP (DBcAMP)-treated astrocytes than in quiescent astrocytes. Cyclic AMP 129-133 mitogen-activated protein kinase 1 Homo sapiens 66-69 16214133-9 2005 In addition, transfection of ES cells with DN-Src, or DN-Ras partially inhibited 8-Br-cAMP-induced ERK1/2 and consequently PLD activation, whereas cotransfection of DN-Src and DN-Ras completely inhibited ERK1/2 and PLD activation, suggesting that Src and Ras independently regulate ERK/PLD activation. Cyclic AMP 86-90 mitogen-activated protein kinase 1 Homo sapiens 99-102 16008550-0 2005 Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways. Cyclic AMP 28-32 mitogen-activated protein kinase 1 Homo sapiens 53-56 16008550-3 2005 Clearly cAMP has cell type specific effects and the outcome on proliferation is largely attributed to crosstalk from cAMP to the RAS/RAF/mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK pathway. Cyclic AMP 8-12 mitogen-activated protein kinase 1 Homo sapiens 220-223 16008550-3 2005 Clearly cAMP has cell type specific effects and the outcome on proliferation is largely attributed to crosstalk from cAMP to the RAS/RAF/mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK pathway. Cyclic AMP 8-12 mitogen-activated protein kinase 1 Homo sapiens 238-241 16008550-3 2005 Clearly cAMP has cell type specific effects and the outcome on proliferation is largely attributed to crosstalk from cAMP to the RAS/RAF/mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK pathway. Cyclic AMP 117-121 mitogen-activated protein kinase 1 Homo sapiens 220-223 16008550-3 2005 Clearly cAMP has cell type specific effects and the outcome on proliferation is largely attributed to crosstalk from cAMP to the RAS/RAF/mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK pathway. Cyclic AMP 117-121 mitogen-activated protein kinase 1 Homo sapiens 238-241 15689414-10 2005 In summary, we show a dual mechanism of isoproterenol-induced ERK phosphorylation in HSY cells-one pathway mediated by EGF receptor transactivation and the other by an EGF receptor-independent pathway possibly mediated by cAMP. Cyclic AMP 222-226 mitogen-activated protein kinase 1 Homo sapiens 62-65 15280158-2 2004 Although it is widely accepted that cAMP inhibits mitogenesis through PKA-mediated phosphorylation of Raf-1, recent studies have indicated that cAMP-mediated inhibition of mitogenesis may occur independently of Raf-1 phosphorylation or without inhibiting ERK activity. Cyclic AMP 144-148 mitogen-activated protein kinase 1 Homo sapiens 255-258 15689414-8 2005 The stimulatory effects of isoproterenol and cAMP on ERK phosphorylation were not reduced by the PKA inhibitor H-89, whereas the Src family inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidase (PP2) and transfection of a dominant-negative Src construct diminished isoproterenol-induced ERK activation. Cyclic AMP 45-49 mitogen-activated protein kinase 1 Homo sapiens 53-56 15689414-8 2005 The stimulatory effects of isoproterenol and cAMP on ERK phosphorylation were not reduced by the PKA inhibitor H-89, whereas the Src family inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidase (PP2) and transfection of a dominant-negative Src construct diminished isoproterenol-induced ERK activation. Cyclic AMP 45-49 mitogen-activated protein kinase 1 Homo sapiens 307-310 15615708-0 2005 Prostaglandin E2 induces MUC8 gene expression via a mechanism involving ERK MAPK/RSK1/cAMP response element binding protein activation in human airway epithelial cells. Cyclic AMP 86-90 mitogen-activated protein kinase 1 Homo sapiens 72-75 15615708-5 2005 Here, we show that ERK mitogen-activated protein kinase is essential for PGE2-induced MUC8 gene expression in normal human nasal epithelial cells and that p90 ribosomal S 6 protein kinase 1 (RSK1) mediates the PGE2-induced phosphorylation of cAMP-response element binding protein. Cyclic AMP 242-246 mitogen-activated protein kinase 1 Homo sapiens 19-22 15557324-4 2005 Conversion of sustained ERK phosphorylation to transient, by means of cholera toxin-induced activation of the adenylate cyclase/cAMP/protein kinase A pathway, abrogated the pro-apoptotic effect of 17beta-estradiol on osteoclasts. Cyclic AMP 128-132 mitogen-activated protein kinase 1 Homo sapiens 24-27 15988067-0 2005 Investigation of extracellular signal-regulated kinase 2 mitogen-activated protein kinase phosphorylation and regulation of activity of PDE4 cyclic adenosine monophosphate-specific phosphodiesterases. Cyclic AMP 141-171 mitogen-activated protein kinase 1 Homo sapiens 17-56 15988067-1 2005 Recently, it has been shown that enzymes of the cyclic adenosine monophosphate (cAMP)-specific phosphodiesterase (PDE) family 4 can be directly phosphorylated by extracellular signal-regulated kinase 2 (ERK2). Cyclic AMP 48-78 mitogen-activated protein kinase 1 Homo sapiens 162-201 15988067-1 2005 Recently, it has been shown that enzymes of the cyclic adenosine monophosphate (cAMP)-specific phosphodiesterase (PDE) family 4 can be directly phosphorylated by extracellular signal-regulated kinase 2 (ERK2). Cyclic AMP 48-78 mitogen-activated protein kinase 1 Homo sapiens 203-207 15988067-1 2005 Recently, it has been shown that enzymes of the cyclic adenosine monophosphate (cAMP)-specific phosphodiesterase (PDE) family 4 can be directly phosphorylated by extracellular signal-regulated kinase 2 (ERK2). Cyclic AMP 80-84 mitogen-activated protein kinase 1 Homo sapiens 162-201 15988067-1 2005 Recently, it has been shown that enzymes of the cyclic adenosine monophosphate (cAMP)-specific phosphodiesterase (PDE) family 4 can be directly phosphorylated by extracellular signal-regulated kinase 2 (ERK2). Cyclic AMP 80-84 mitogen-activated protein kinase 1 Homo sapiens 203-207 15988067-4 2005 We detail some of the methods that have been crucial in elucidating these important discoveries that represent a novel point of cross talk between the cAMP signaling system and the ERK mitogen-activated protein kinase cascade. Cyclic AMP 151-155 mitogen-activated protein kinase 1 Homo sapiens 181-184 15452854-2 2004 The mitogen-activated protein kinase / extracellular signal-regulated kinase (MAPK/ERK) pathway participates in regulating diverse neuronal processes such as proliferation, differentiation, survival, synaptic efficacy, and long-term potentiation by inducing cAMP-response element (CRE)-mediated gene transcription. Cyclic AMP 258-262 mitogen-activated protein kinase 1 Homo sapiens 78-82 15452854-2 2004 The mitogen-activated protein kinase / extracellular signal-regulated kinase (MAPK/ERK) pathway participates in regulating diverse neuronal processes such as proliferation, differentiation, survival, synaptic efficacy, and long-term potentiation by inducing cAMP-response element (CRE)-mediated gene transcription. Cyclic AMP 258-262 mitogen-activated protein kinase 1 Homo sapiens 83-86 15278365-0 2004 Cyclic AMP differentially regulates cell proliferation of normal human keratinocytes through ERK activation depending on the expression pattern of B-Raf. Cyclic AMP 0-10 mitogen-activated protein kinase 1 Homo sapiens 93-96 15278365-3 2004 Recent studies have revealed that cAMP signaling regulates cell proliferation by modulating mitogen-activated protein kinase (MAPK) activity. Cyclic AMP 34-38 mitogen-activated protein kinase 1 Homo sapiens 126-130 15278365-6 2004 In confluent NHK, cyclic AMP decreased extracellular regulated kinase (ERK) phosphorylation and cell proliferation in a Ras-independent and Rap1-dependent manner. Cyclic AMP 18-28 mitogen-activated protein kinase 1 Homo sapiens 39-69 15278365-6 2004 In confluent NHK, cyclic AMP decreased extracellular regulated kinase (ERK) phosphorylation and cell proliferation in a Ras-independent and Rap1-dependent manner. Cyclic AMP 18-28 mitogen-activated protein kinase 1 Homo sapiens 71-74 15278365-8 2004 In contrast, in subconfluent NHK, cAMP increased ERK phosphorylation and cell proliferation. Cyclic AMP 34-38 mitogen-activated protein kinase 1 Homo sapiens 49-52 15278365-11 2004 Transfection of 95 kDa B-Raf into confluent NHK resulted in a cAMP-dependent increase in ERK phosphorylation and cell proliferation. Cyclic AMP 62-66 mitogen-activated protein kinase 1 Homo sapiens 89-92 15278365-12 2004 These findings indicate that differential expression of B-Raf isoforms is critical for cAMP-dependent regulation of NHK proliferation that depends on phosphorylation of ERK. Cyclic AMP 87-91 mitogen-activated protein kinase 1 Homo sapiens 169-172 15163698-3 2004 Here, we show that the contact with a nonphysiological postsynaptic target inhibits neurotransmitter release from axonal terminals of the Helix serotonergic neuron C1 by means of an active mechanism requiring ongoing protein synthesis and leading to the inhibition of cAMP-dependent protein kinase (PKA) and mitogen-activated protein kinase (MAPK)-extracellular signal-related kinase (Erk) pathways. Cyclic AMP 268-272 mitogen-activated protein kinase 1 Homo sapiens 385-388 15131307-3 2004 We have observed spontaneous oscillations in activation of the mitogen-activated protein (MAP) kinase ERK2 that occur in phase with peaks of cAMP, and we show that ERK2 modulates cAMP levels through the phosphodiesterase RegA. Cyclic AMP 141-145 mitogen-activated protein kinase 1 Homo sapiens 102-106 15131307-3 2004 We have observed spontaneous oscillations in activation of the mitogen-activated protein (MAP) kinase ERK2 that occur in phase with peaks of cAMP, and we show that ERK2 modulates cAMP levels through the phosphodiesterase RegA. Cyclic AMP 141-145 mitogen-activated protein kinase 1 Homo sapiens 164-168 15131307-3 2004 We have observed spontaneous oscillations in activation of the mitogen-activated protein (MAP) kinase ERK2 that occur in phase with peaks of cAMP, and we show that ERK2 modulates cAMP levels through the phosphodiesterase RegA. Cyclic AMP 179-183 mitogen-activated protein kinase 1 Homo sapiens 102-106 15131307-3 2004 We have observed spontaneous oscillations in activation of the mitogen-activated protein (MAP) kinase ERK2 that occur in phase with peaks of cAMP, and we show that ERK2 modulates cAMP levels through the phosphodiesterase RegA. Cyclic AMP 179-183 mitogen-activated protein kinase 1 Homo sapiens 164-168 15030385-7 2004 Taken together the results imply that neuronal CCK gene transcription is regulated by the cumulative action of calcium and cAMP via stimulation of the PKA and ERK signalling pathways and that synergy is accomplished by the coordinate activation of CREB and CBP. Cyclic AMP 123-127 mitogen-activated protein kinase 1 Homo sapiens 159-162 14744867-0 2004 Cyclic AMP activation of the extracellular signal-regulated kinases 1 and 2: implications for intestinal cell survival through the transient inhibition of apoptosis. Cyclic AMP 0-10 mitogen-activated protein kinase 1 Homo sapiens 29-75 14744867-3 2004 We have examined the ability of cAMP to transiently inhibit apoptosis via the extracellular signal-regulated kinases 1 and 2 (ERK1/2), in T84 cells, an intestinal crypt-like cell line. Cyclic AMP 32-36 mitogen-activated protein kinase 1 Homo sapiens 78-124 14641023-0 2003 The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways. Cyclic AMP 53-57 mitogen-activated protein kinase 1 Homo sapiens 12-16 15361692-8 2004 While cAMP inhibits Ras-Raf-1-stimulated phosphorylation of ERK in normal kidney cells, it markedly increases B-Raf kinase activity and ERK phosphorylation in polycystic kidney cells. Cyclic AMP 6-10 mitogen-activated protein kinase 1 Homo sapiens 60-63 15361692-8 2004 While cAMP inhibits Ras-Raf-1-stimulated phosphorylation of ERK in normal kidney cells, it markedly increases B-Raf kinase activity and ERK phosphorylation in polycystic kidney cells. Cyclic AMP 6-10 mitogen-activated protein kinase 1 Homo sapiens 136-139 14684879-0 2003 Neurotrophins elevate cAMP to reach a threshold required to overcome inhibition by MAG through extracellular signal-regulated kinase-dependent inhibition of phosphodiesterase. Cyclic AMP 22-26 mitogen-activated protein kinase 1 Homo sapiens 95-132 14684879-5 2003 We also show that activation of extracellular signal-regulated kinase (Erk) by BDNF is required to overcome inhibition by MAG, and that activated Erk transiently inhibits phosphodiesterase 4 (PDE4), the enzyme that hydrolyzes cAMP. Cyclic AMP 226-230 mitogen-activated protein kinase 1 Homo sapiens 32-69 14684879-5 2003 We also show that activation of extracellular signal-regulated kinase (Erk) by BDNF is required to overcome inhibition by MAG, and that activated Erk transiently inhibits phosphodiesterase 4 (PDE4), the enzyme that hydrolyzes cAMP. Cyclic AMP 226-230 mitogen-activated protein kinase 1 Homo sapiens 71-74 14684879-5 2003 We also show that activation of extracellular signal-regulated kinase (Erk) by BDNF is required to overcome inhibition by MAG, and that activated Erk transiently inhibits phosphodiesterase 4 (PDE4), the enzyme that hydrolyzes cAMP. Cyclic AMP 226-230 mitogen-activated protein kinase 1 Homo sapiens 146-149 14684879-7 2003 Furthermore, we also show that basal levels of Erk activation and basal cAMP levels contribute to the effects of db-cAMP by pushing the combined levels of cAMP above a threshold required to overcome inhibition. Cyclic AMP 116-120 mitogen-activated protein kinase 1 Homo sapiens 47-50 14684879-8 2003 Together, these results not only show how NGF-like neurotrophins can elevate cAMP and overcome inhibition but also point to a novel mechanism of cross talk in neurons from the Erk to the cAMP signaling pathways. Cyclic AMP 77-81 mitogen-activated protein kinase 1 Homo sapiens 176-179 14684879-8 2003 Together, these results not only show how NGF-like neurotrophins can elevate cAMP and overcome inhibition but also point to a novel mechanism of cross talk in neurons from the Erk to the cAMP signaling pathways. Cyclic AMP 187-191 mitogen-activated protein kinase 1 Homo sapiens 176-179 14641023-0 2003 The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways. Cyclic AMP 121-125 mitogen-activated protein kinase 1 Homo sapiens 12-16 14641023-0 2003 The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways. Cyclic AMP 121-125 mitogen-activated protein kinase 1 Homo sapiens 12-15 14641023-6 2003 ERK inhibition of long isoforms is regulated by a unique feedback control whereby elevated cAMP levels cause PKA (protein kinase A) to phosphorylate UCR1 and ablate the inhibitory action of ERK. Cyclic AMP 91-95 mitogen-activated protein kinase 1 Homo sapiens 0-3 14641023-6 2003 ERK inhibition of long isoforms is regulated by a unique feedback control whereby elevated cAMP levels cause PKA (protein kinase A) to phosphorylate UCR1 and ablate the inhibitory action of ERK. Cyclic AMP 91-95 mitogen-activated protein kinase 1 Homo sapiens 190-193 14512869-5 2003 In addition, activity of cyclic-AMP and serum responsive element, downstream pathways of p38 MAPK and ERK, was also increased. Cyclic AMP 25-35 mitogen-activated protein kinase 1 Homo sapiens 102-105 14516797-6 2003 Inhibition of cAMP-dependent protein kinase (PKA) using H89 (N-[2-((p-bromocinnamyl)amino)ethyl]-5-isoquinolinesulfonamide)) blocked phosphorylation of the cAMP response element-binding protein (CREB) and p38, but did not decrease NECA-induced ERK1/2 phosphorylation. Cyclic AMP 14-18 mitogen-activated protein kinase 1 Homo sapiens 205-208 14516797-10 2003 Thus, stimulation of adenosine A(2B) receptors activates both ERK1/2 and p38 via cAMP, but the downstream pathways are markedly different. Cyclic AMP 81-85 mitogen-activated protein kinase 1 Homo sapiens 73-76 14516797-12 2003 p38 activation by NECA was instead independent of PI3K but required cAMP and PKA. Cyclic AMP 68-72 mitogen-activated protein kinase 1 Homo sapiens 0-3 14592419-0 2003 Possible involvement of a cyclic AMP-dependent mechanism in PACAP-induced proliferation and ERK activation in astrocytes. Cyclic AMP 26-36 mitogen-activated protein kinase 1 Homo sapiens 92-95 14592419-7 2003 Dibutyryl cyclic AMP maximally stimulated the incorporation of thymidine and activation of ERK at 10(-10)M. These results suggest that PACAP-mediated stimulation of ERK activity and proliferation of astrocytes may involve a cyclic AMP-dependent, but PKA-independent, pathway. Cyclic AMP 10-20 mitogen-activated protein kinase 1 Homo sapiens 91-94 14592419-7 2003 Dibutyryl cyclic AMP maximally stimulated the incorporation of thymidine and activation of ERK at 10(-10)M. These results suggest that PACAP-mediated stimulation of ERK activity and proliferation of astrocytes may involve a cyclic AMP-dependent, but PKA-independent, pathway. Cyclic AMP 10-20 mitogen-activated protein kinase 1 Homo sapiens 165-168 12826611-2 2003 In contrast to ERK1 and ERK2, which are activated by neurotrophins (NTs), cAMP, and neuronal activity in cortical neurons, ERK5 is activated only by NTs. Cyclic AMP 74-78 mitogen-activated protein kinase 1 Homo sapiens 24-28 12753285-0 2003 Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys. Cyclic AMP 0-10 mitogen-activated protein kinase 1 Homo sapiens 31-34 12798950-0 2003 Immature human osteoblastic MG63 cells predominantly express a subtype 1-like CGRP receptor that inactivates extracellular signal response kinase by a cAMP-dependent mechanism. Cyclic AMP 151-155 mitogen-activated protein kinase 1 Homo sapiens 109-145 12753285-5 2003 We determined the effects of cAMP and epidermal growth factor (EGF) on the activation of ERK, B-Raf and Raf-1 in ADPKD and HKC cells by immune kinase assay and Western blot. Cyclic AMP 29-33 mitogen-activated protein kinase 1 Homo sapiens 89-92 12753285-10 2003 8-Br-cAMP and EGF conjointly increased ERK activation above that of either agonist alone in ADPKD cells, and this combined effect was abolished by PD98059, indicating that ERK was activated by EGF- and cAMP-responsive cascades that converge at MAPK. Cyclic AMP 5-9 mitogen-activated protein kinase 1 Homo sapiens 39-42 12753285-7 2003 Inhibition of PKA by H89 strikingly decreased cAMP-stimulated phosphorylation of ERK and B-Raf, and MAPK inhibition by PD98059 blocked the effect of the nucleotide to activate ERK. Cyclic AMP 46-50 mitogen-activated protein kinase 1 Homo sapiens 81-84 12753285-10 2003 8-Br-cAMP and EGF conjointly increased ERK activation above that of either agonist alone in ADPKD cells, and this combined effect was abolished by PD98059, indicating that ERK was activated by EGF- and cAMP-responsive cascades that converge at MAPK. Cyclic AMP 5-9 mitogen-activated protein kinase 1 Homo sapiens 172-175 12753285-11 2003 CONCLUSION: cAMP activates ERK and increases proliferation of ADPKD epithelial cells, but not cells from normal human kidney cortex, through the sequential phosphorylation of PKA, B-Raf and MAPK in a pathway separate from, but complementary to, the classical receptor tyrosine kinase cascade. Cyclic AMP 12-16 mitogen-activated protein kinase 1 Homo sapiens 27-30 12753285-7 2003 Inhibition of PKA by H89 strikingly decreased cAMP-stimulated phosphorylation of ERK and B-Raf, and MAPK inhibition by PD98059 blocked the effect of the nucleotide to activate ERK. Cyclic AMP 46-50 mitogen-activated protein kinase 1 Homo sapiens 176-179 12540838-9 2003 These data provide evidence that CBP.RSK complex formation in response to persistent ERK phosphorylation by Cpd 5 down-regulates CREB activity, leading to inhibition of both cAMP response element-mediated gene expression and cell growth. Cyclic AMP 174-178 mitogen-activated protein kinase 1 Homo sapiens 85-88 12679459-5 2003 Increasing cAMP by forskolin caused a protein kinase A-dependent increase of ERK activity (287 +/- 37%) in GH-omas and had no effect in NFPA. Cyclic AMP 11-15 mitogen-activated protein kinase 1 Homo sapiens 77-80 12479852-2 2003 The present study was designed to assess the regulation of the extracellular signal-regulated kinase (ERK) pathway by cAMP and its association with differentiation in HL-60 cells. Cyclic AMP 118-122 mitogen-activated protein kinase 1 Homo sapiens 63-100 12479852-2 2003 The present study was designed to assess the regulation of the extracellular signal-regulated kinase (ERK) pathway by cAMP and its association with differentiation in HL-60 cells. Cyclic AMP 118-122 mitogen-activated protein kinase 1 Homo sapiens 102-105 12479852-5 2003 These data suggest that cAMP-induced ERK activation is essential for the differentiation of HL-60 cells, independently of B-Raf. Cyclic AMP 24-28 mitogen-activated protein kinase 1 Homo sapiens 37-40 12036966-7 2002 We next employed the GsCT construct to examine the complex role of G(s) in regulation of the ERK mitogen-activated protein kinase cascade, where activation of the cAMP-dependent protein kinase (PKA) pathway reportedly produces both stimulatory and inhibitory effects on heptahelical receptor-mediated ERK activation. Cyclic AMP 163-167 mitogen-activated protein kinase 1 Homo sapiens 93-96 12402047-0 2002 A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Cyclic AMP 22-26 mitogen-activated protein kinase 1 Homo sapiens 84-87 12402047-5 2002 Using this analogue, we tested the widespread model that Rap1 mediates cAMP-induced regulation of the extracellular signal-regulated kinase (ERK). Cyclic AMP 71-75 mitogen-activated protein kinase 1 Homo sapiens 102-139 12402047-5 2002 Using this analogue, we tested the widespread model that Rap1 mediates cAMP-induced regulation of the extracellular signal-regulated kinase (ERK). Cyclic AMP 71-75 mitogen-activated protein kinase 1 Homo sapiens 141-144 12402047-6 2002 However, both in cell lines in which cAMP inhibits growth-factor-induced ERK activation and in which cAMP activates ERK, 8CPT-2Me-cAMP did not affect ERK activity. Cyclic AMP 37-41 mitogen-activated protein kinase 1 Homo sapiens 73-76 12402047-6 2002 However, both in cell lines in which cAMP inhibits growth-factor-induced ERK activation and in which cAMP activates ERK, 8CPT-2Me-cAMP did not affect ERK activity. Cyclic AMP 101-105 mitogen-activated protein kinase 1 Homo sapiens 116-119 12402047-6 2002 However, both in cell lines in which cAMP inhibits growth-factor-induced ERK activation and in which cAMP activates ERK, 8CPT-2Me-cAMP did not affect ERK activity. Cyclic AMP 101-105 mitogen-activated protein kinase 1 Homo sapiens 116-119 12402047-6 2002 However, both in cell lines in which cAMP inhibits growth-factor-induced ERK activation and in which cAMP activates ERK, 8CPT-2Me-cAMP did not affect ERK activity. Cyclic AMP 101-105 mitogen-activated protein kinase 1 Homo sapiens 116-119 12402047-6 2002 However, both in cell lines in which cAMP inhibits growth-factor-induced ERK activation and in which cAMP activates ERK, 8CPT-2Me-cAMP did not affect ERK activity. Cyclic AMP 101-105 mitogen-activated protein kinase 1 Homo sapiens 116-119 12402047-7 2002 Moreover, in cell lines in which cAMP activates ERK, inhibition of PKA and Ras, but not Rap1, abolished cAMP-mediated ERK activation. Cyclic AMP 33-37 mitogen-activated protein kinase 1 Homo sapiens 48-51 12402047-7 2002 Moreover, in cell lines in which cAMP activates ERK, inhibition of PKA and Ras, but not Rap1, abolished cAMP-mediated ERK activation. Cyclic AMP 33-37 mitogen-activated protein kinase 1 Homo sapiens 118-121 12402047-7 2002 Moreover, in cell lines in which cAMP activates ERK, inhibition of PKA and Ras, but not Rap1, abolished cAMP-mediated ERK activation. Cyclic AMP 104-108 mitogen-activated protein kinase 1 Homo sapiens 48-51 12402047-7 2002 Moreover, in cell lines in which cAMP activates ERK, inhibition of PKA and Ras, but not Rap1, abolished cAMP-mediated ERK activation. Cyclic AMP 104-108 mitogen-activated protein kinase 1 Homo sapiens 118-121 12402047-8 2002 We conclude that cAMP-induced regulation of ERK and activation of Rap1 are independent processes. Cyclic AMP 17-21 mitogen-activated protein kinase 1 Homo sapiens 44-47 12388073-5 2002 Pharmacological analysis of signaling pathways revealed that the inhibition of cAMP-driven epithelial Cl(-) secretion by TGF-beta was blocked by pretreatment with SB-203580, a specific inhibitor of p38 MAPK, but not by inhibitors of JNK, ERK1/2 MAPK, or phosphatidylinositol 3"-kinase. Cyclic AMP 79-83 mitogen-activated protein kinase 1 Homo sapiens 198-201 12203122-14 2002 Moreover, inhibition of the cAMP-activated small G protein Rap1, partially reversed the inhibitory effects of cAMP on cell proliferation and MEK/ERK activation. Cyclic AMP 28-32 mitogen-activated protein kinase 1 Homo sapiens 145-148 12203122-14 2002 Moreover, inhibition of the cAMP-activated small G protein Rap1, partially reversed the inhibitory effects of cAMP on cell proliferation and MEK/ERK activation. Cyclic AMP 110-114 mitogen-activated protein kinase 1 Homo sapiens 145-148 12036966-7 2002 We next employed the GsCT construct to examine the complex role of G(s) in regulation of the ERK mitogen-activated protein kinase cascade, where activation of the cAMP-dependent protein kinase (PKA) pathway reportedly produces both stimulatory and inhibitory effects on heptahelical receptor-mediated ERK activation. Cyclic AMP 163-167 mitogen-activated protein kinase 1 Homo sapiens 301-304 11956184-0 2002 New signaling pathway for parathyroid hormone and cyclic AMP action on extracellular-regulated kinase and cell proliferation in bone cells. Cyclic AMP 50-60 mitogen-activated protein kinase 1 Homo sapiens 71-101 12089357-5 2002 CRH/cAMP stimulated ERK2 activity and increased transcriptional activity of a Gal4-Elk1 protein, which was blocked by overexpression of dominant negative mutants and kinase inhibitors and stimulated by expression of B-Raf. Cyclic AMP 4-8 mitogen-activated protein kinase 1 Homo sapiens 20-24 11956184-3 2002 Recent evidence of a second enzyme target for cAMP suggests divergent effects on extracellular-regulated kinase (ERK) activity depending on Epac/Rap1/B-Raf signaling. Cyclic AMP 46-50 mitogen-activated protein kinase 1 Homo sapiens 81-111 11956184-3 2002 Recent evidence of a second enzyme target for cAMP suggests divergent effects on extracellular-regulated kinase (ERK) activity depending on Epac/Rap1/B-Raf signaling. Cyclic AMP 46-50 mitogen-activated protein kinase 1 Homo sapiens 113-116 11956184-6 2002 cAMP stimulated Ras-independent and Rap1-dependent ERK phosphorylation and cell proliferation in B-Raf-expressing cells, but inhibited growth in B-Raf-lacking cells. Cyclic AMP 0-4 mitogen-activated protein kinase 1 Homo sapiens 51-54 11956184-7 2002 The mitogenic action of cAMP was blocked by the ERK pathway inhibitor PD98059. Cyclic AMP 24-28 mitogen-activated protein kinase 1 Homo sapiens 48-51 11956184-8 2002 In B-Raf-transduced MG63 cells, cAMP stimulated ERK activation and cell proliferation. Cyclic AMP 32-36 mitogen-activated protein kinase 1 Homo sapiens 48-51 11956184-9 2002 Thus, B-Raf is the dominant molecular switch that permits differential cAMP-dependent regulation of ERK with important implications for cell proliferation in bone cells. Cyclic AMP 71-75 mitogen-activated protein kinase 1 Homo sapiens 100-103 11971957-7 2002 cAMP increased Raf-1 serine 259 phosphorylation in a PKA-dependent manner with kinetics that correlated with ERK deactivation. Cyclic AMP 0-4 mitogen-activated protein kinase 1 Homo sapiens 109-112 11997240-4 2002 HS and cAMP-elevating drugs (forskolin and dibutyryl cAMP-acetoxymethyl ester) similarly suppressed extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase activation and superoxide formation in response to N-formylmethionyl-leucyl-phenylalanine (fMLP) stimulation. Cyclic AMP 7-11 mitogen-activated protein kinase 1 Homo sapiens 100-137 11997240-4 2002 HS and cAMP-elevating drugs (forskolin and dibutyryl cAMP-acetoxymethyl ester) similarly suppressed extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase activation and superoxide formation in response to N-formylmethionyl-leucyl-phenylalanine (fMLP) stimulation. Cyclic AMP 7-11 mitogen-activated protein kinase 1 Homo sapiens 139-142 11997240-4 2002 HS and cAMP-elevating drugs (forskolin and dibutyryl cAMP-acetoxymethyl ester) similarly suppressed extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase activation and superoxide formation in response to N-formylmethionyl-leucyl-phenylalanine (fMLP) stimulation. Cyclic AMP 7-11 mitogen-activated protein kinase 1 Homo sapiens 148-151 11997240-7 2002 These findings suggest that HS-activated cAMP/PKA signaling inhibits superoxide formation by intercepting fMLP-induced activation steps upstream of ERK and p38. Cyclic AMP 41-45 mitogen-activated protein kinase 1 Homo sapiens 148-151 11997240-7 2002 These findings suggest that HS-activated cAMP/PKA signaling inhibits superoxide formation by intercepting fMLP-induced activation steps upstream of ERK and p38. Cyclic AMP 41-45 mitogen-activated protein kinase 1 Homo sapiens 156-159 12074885-3 2002 In this review, the cell type-specific effects of cAMP on the mitogen-activated protein (MAP) kinase (also called extracellular signal-regulated kinase, or ERK) cascade and cell proliferation are examined. Cyclic AMP 50-54 mitogen-activated protein kinase 1 Homo sapiens 156-159 12074885-5 2002 First, the capacity of cAMP for either positive or negative regulation of the ERK cascade accounts for many of the cell type-specific actions of cAMP on cell proliferation. Cyclic AMP 23-27 mitogen-activated protein kinase 1 Homo sapiens 78-81 12074885-5 2002 First, the capacity of cAMP for either positive or negative regulation of the ERK cascade accounts for many of the cell type-specific actions of cAMP on cell proliferation. Cyclic AMP 145-149 mitogen-activated protein kinase 1 Homo sapiens 78-81 12074885-6 2002 Second, there are several specific mechanisms involved in the inhibition or activation of ERKs by cAMP. Cyclic AMP 98-102 mitogen-activated protein kinase 1 Homo sapiens 90-94 11410589-2 2001 We demonstrate that cyclic AMP-induced steroid synthesis is dependent upon the phosphorylation and activation of ERKs and that ERK activation results in enhanced phosphorylation of SF-1 and increased steroid production through increased transcription of the StAR gene. Cyclic AMP 20-30 mitogen-activated protein kinase 1 Homo sapiens 113-116 12039071-8 2002 It is suggested that in tilapia the differential regulation of gonadotropin subunit gene expression by GnRH results from a divergent recruitment of signal transduction pathways, activated upon GnRH binding; PKC-ERK cascade is involved in elevating alpha and LHbeta mRNAs, whereas induction of FSHbeta transcript is ERK-independent and is under direct cAMP-PKA regulation or through other MAPK cascades. Cyclic AMP 351-355 mitogen-activated protein kinase 1 Homo sapiens 211-214 11880483-8 2002 BDNF-LTP was further coupled to ERK-dependent phosphorylation of the transcription factor cAMP response element-binding protein. Cyclic AMP 90-94 mitogen-activated protein kinase 1 Homo sapiens 32-35 11410589-7 2001 These observations suggest that the activation of ERK2/1 by increasing cAMP is an obligatory and regulated stage in the stimulation of steroid synthesis by cyclic AMP-generating stimuli. Cyclic AMP 71-75 mitogen-activated protein kinase 1 Homo sapiens 50-56 11410589-7 2001 These observations suggest that the activation of ERK2/1 by increasing cAMP is an obligatory and regulated stage in the stimulation of steroid synthesis by cyclic AMP-generating stimuli. Cyclic AMP 156-166 mitogen-activated protein kinase 1 Homo sapiens 50-56 11466342-8 2001 Although both CD72 and BCR induced Btk-dependent ERK activation, CD72-mediated proliferation is more resistant to blocking of ERK activity than that of BCR, as shown by the proliferation response of B cells treated with PD98059 and dibutyryl cAMP, agents that inhibit ERK activity. Cyclic AMP 242-246 mitogen-activated protein kinase 1 Homo sapiens 126-129 11553671-2 2001 In the present study, we provide evidence that intracellular cAMP determines the proliferation-differentiation decision of astroglia to FGF-2 by either facilitating FGF-2 signalling to extracellular signal-related protein kinase (ERK) or cAMP response element binding protein (CREB). Cyclic AMP 61-65 mitogen-activated protein kinase 1 Homo sapiens 185-228 11553671-2 2001 In the present study, we provide evidence that intracellular cAMP determines the proliferation-differentiation decision of astroglia to FGF-2 by either facilitating FGF-2 signalling to extracellular signal-related protein kinase (ERK) or cAMP response element binding protein (CREB). Cyclic AMP 61-65 mitogen-activated protein kinase 1 Homo sapiens 230-233 11553671-3 2001 Pharmacologically increasing intracellular cAMP levels in cultured cortical astroglia by treatment with dbcAMP or forskolin attenuated FGF-2-induced ERK phosphorylation and glial cell proliferation. Cyclic AMP 43-47 mitogen-activated protein kinase 1 Homo sapiens 149-152 11553671-6 2001 Moreover, the effects of cAMP on the time-course of FGF-2-dependent CREB phosphorylation were mimicked by PD98059, suggesting that the cAMP-induced redirection of FGF-2-signalling is linked to the RAF-MEK-ERK signalling pathway. Cyclic AMP 25-29 mitogen-activated protein kinase 1 Homo sapiens 205-208 11553671-6 2001 Moreover, the effects of cAMP on the time-course of FGF-2-dependent CREB phosphorylation were mimicked by PD98059, suggesting that the cAMP-induced redirection of FGF-2-signalling is linked to the RAF-MEK-ERK signalling pathway. Cyclic AMP 135-139 mitogen-activated protein kinase 1 Homo sapiens 205-208 11500376-4 2001 However, cAMP-induced ERK2 phosphorylation is unaffected in rasC(-) cells, indicating that RasC is not an upstream activator of the mitogen-activated protein kinase required for cAMP relay. Cyclic AMP 9-13 mitogen-activated protein kinase 1 Homo sapiens 22-26 11466342-8 2001 Although both CD72 and BCR induced Btk-dependent ERK activation, CD72-mediated proliferation is more resistant to blocking of ERK activity than that of BCR, as shown by the proliferation response of B cells treated with PD98059 and dibutyryl cAMP, agents that inhibit ERK activity. Cyclic AMP 242-246 mitogen-activated protein kinase 1 Homo sapiens 126-129 11444827-0 2001 cAMP protection of pancreatic cancer cells against apoptosis induced by ERK inhibition. Cyclic AMP 0-4 mitogen-activated protein kinase 1 Homo sapiens 72-75 10828059-0 2000 ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. Cyclic AMP 92-96 mitogen-activated protein kinase 1 Homo sapiens 0-4 11390363-10 2001 We propose that CulA and FbxA regulate multicellular development by targeting RegA for degradation via a pathway that requires ERK2 function, leading to an increase in cAMP and PKA activity. Cyclic AMP 168-172 mitogen-activated protein kinase 1 Homo sapiens 127-131 11359835-8 2001 These results indicate that CKS-17 activates the MEK/ERK cascade and that there is a cross-talk between CKS-17-mediated MEK/ERK cascade and cAMP in that the MEK/ERK cascade is negatively regulated by cAMP. Cyclic AMP 140-144 mitogen-activated protein kinase 1 Homo sapiens 53-56 11359835-8 2001 These results indicate that CKS-17 activates the MEK/ERK cascade and that there is a cross-talk between CKS-17-mediated MEK/ERK cascade and cAMP in that the MEK/ERK cascade is negatively regulated by cAMP. Cyclic AMP 140-144 mitogen-activated protein kinase 1 Homo sapiens 124-127 11359835-8 2001 These results indicate that CKS-17 activates the MEK/ERK cascade and that there is a cross-talk between CKS-17-mediated MEK/ERK cascade and cAMP in that the MEK/ERK cascade is negatively regulated by cAMP. Cyclic AMP 140-144 mitogen-activated protein kinase 1 Homo sapiens 124-127 11359835-8 2001 These results indicate that CKS-17 activates the MEK/ERK cascade and that there is a cross-talk between CKS-17-mediated MEK/ERK cascade and cAMP in that the MEK/ERK cascade is negatively regulated by cAMP. Cyclic AMP 200-204 mitogen-activated protein kinase 1 Homo sapiens 124-127 11359835-8 2001 These results indicate that CKS-17 activates the MEK/ERK cascade and that there is a cross-talk between CKS-17-mediated MEK/ERK cascade and cAMP in that the MEK/ERK cascade is negatively regulated by cAMP. Cyclic AMP 200-204 mitogen-activated protein kinase 1 Homo sapiens 124-127 11139572-2 2001 In this study, we have investigated in striatal primary cultures the mechanism by which activation of the cAMP/PKA-dependent pathway leads to CREB phosphorylation via the extracellular signal-regulated kinase (ERK)-dependent pathway. Cyclic AMP 106-110 mitogen-activated protein kinase 1 Homo sapiens 171-208 11139572-2 2001 In this study, we have investigated in striatal primary cultures the mechanism by which activation of the cAMP/PKA-dependent pathway leads to CREB phosphorylation via the extracellular signal-regulated kinase (ERK)-dependent pathway. Cyclic AMP 106-110 mitogen-activated protein kinase 1 Homo sapiens 210-213 11027949-0 2000 cAMP-dependent protein kinase (PKA) inhibits T cell activation by phosphorylating ser-43 of raf-1 in the MAPK/ERK pathway. Cyclic AMP 0-4 mitogen-activated protein kinase 1 Homo sapiens 105-109 11027949-0 2000 cAMP-dependent protein kinase (PKA) inhibits T cell activation by phosphorylating ser-43 of raf-1 in the MAPK/ERK pathway. Cyclic AMP 0-4 mitogen-activated protein kinase 1 Homo sapiens 110-113 11404397-7 2001 The phosphorylation state of a transcriptional mediator of long-term potentiation and a downstream target of the ERK MAPK cascade, the cAMP-regulatory element binding (CREB) protein, were affected also. Cyclic AMP 135-139 mitogen-activated protein kinase 1 Homo sapiens 113-116 11062237-5 2001 The reduction in basal phospho-ERK2 by 100 microm NMDA was also reflected as a decrease in phospho-cAMP response element-binding protein. Cyclic AMP 99-103 mitogen-activated protein kinase 1 Homo sapiens 31-35 11042208-3 2001 Here we report that odorants stimulate cAMP-response element (CRE)-mediated transcription in OSNs through Ca2+ activation of the ERK/MAPK/p90rsk pathway. Cyclic AMP 39-43 mitogen-activated protein kinase 1 Homo sapiens 129-132 11042208-3 2001 Here we report that odorants stimulate cAMP-response element (CRE)-mediated transcription in OSNs through Ca2+ activation of the ERK/MAPK/p90rsk pathway. Cyclic AMP 39-43 mitogen-activated protein kinase 1 Homo sapiens 133-137 10851231-5 2000 Whereas a prolonged elevation of cAMP in VSMC resulted in a protein kinase A (PKA)-dependent induction of expression of two PDE4D variants (PDE4D1 and PDE4D2), simultaneous activation of both the cAMP-PKA and PKC-Raf-MEK-ERK signaling cascades blunted this cAMP-mediated increase in PDE4D expression. Cyclic AMP 33-37 mitogen-activated protein kinase 1 Homo sapiens 221-224 10851231-6 2000 By using biochemical, molecular biological, and pharmacological approaches, we demonstrate that this PDE4D-selective effect of activators of the PKC-Raf-MEK-ERK cascade was mediated through a mechanism involving altered PDE4D mRNA stability and markedly attenuated the cAMP-mediated desensitization that results from prolonged activation of the cAMP signaling system in cells. Cyclic AMP 269-273 mitogen-activated protein kinase 1 Homo sapiens 157-160 10851231-6 2000 By using biochemical, molecular biological, and pharmacological approaches, we demonstrate that this PDE4D-selective effect of activators of the PKC-Raf-MEK-ERK cascade was mediated through a mechanism involving altered PDE4D mRNA stability and markedly attenuated the cAMP-mediated desensitization that results from prolonged activation of the cAMP signaling system in cells. Cyclic AMP 345-349 mitogen-activated protein kinase 1 Homo sapiens 157-160 10851231-7 2000 The data are presented in the context of activators of the PKC-Raf-MEK-ERK cascade having both short and long term effects on PDE4D activity and expression in cells that may influence cAMP signaling. Cyclic AMP 184-188 mitogen-activated protein kinase 1 Homo sapiens 71-74 10828059-2 2000 The cAMP-specific phosphodiesterase family 4, subfamily D, isoform 3 (PDE4D3) is shown to have FQF and KIM docking sites for extracellular signal-regulated kinase 2 (ERK2) (p42(MAPK)). Cyclic AMP 4-8 mitogen-activated protein kinase 1 Homo sapiens 125-164 10828059-2 2000 The cAMP-specific phosphodiesterase family 4, subfamily D, isoform 3 (PDE4D3) is shown to have FQF and KIM docking sites for extracellular signal-regulated kinase 2 (ERK2) (p42(MAPK)). Cyclic AMP 4-8 mitogen-activated protein kinase 1 Homo sapiens 166-170 10828059-2 2000 The cAMP-specific phosphodiesterase family 4, subfamily D, isoform 3 (PDE4D3) is shown to have FQF and KIM docking sites for extracellular signal-regulated kinase 2 (ERK2) (p42(MAPK)). Cyclic AMP 4-8 mitogen-activated protein kinase 1 Homo sapiens 177-181 10828059-8 2000 The PDE4D gene thus encodes a series of isoenzymes that are either inhibited or activated by ERK2 phosphorylation and thereby offers the potential for ERK2 activation either to increase or decrease cAMP levels in cellular compartments. Cyclic AMP 198-202 mitogen-activated protein kinase 1 Homo sapiens 93-97 10828059-8 2000 The PDE4D gene thus encodes a series of isoenzymes that are either inhibited or activated by ERK2 phosphorylation and thereby offers the potential for ERK2 activation either to increase or decrease cAMP levels in cellular compartments. Cyclic AMP 198-202 mitogen-activated protein kinase 1 Homo sapiens 151-155 10760082-8 2000 cAMP agonists increased the activity of ERK above control levels within five minutes. Cyclic AMP 0-4 mitogen-activated protein kinase 1 Homo sapiens 40-43 10910134-1 2000 Mitogen-activated protein (MAP)-kinase extracellular signal regulated kinase (ERK2) is essential for regulation of the intracellular cyclic adenosine monophosphate (cAMP) level in Dictyostelium. Cyclic AMP 133-163 mitogen-activated protein kinase 1 Homo sapiens 78-82 10910134-1 2000 Mitogen-activated protein (MAP)-kinase extracellular signal regulated kinase (ERK2) is essential for regulation of the intracellular cyclic adenosine monophosphate (cAMP) level in Dictyostelium. Cyclic AMP 165-169 mitogen-activated protein kinase 1 Homo sapiens 78-82 10777769-7 2000 However, incubation of slices with forskolin, an activator of the cAMP-dependent protein kinase (PKA) cascade, did result in increases in active ERK and cAMP response element-binding protein (CREB) phosphorylation in area CA3. Cyclic AMP 66-70 mitogen-activated protein kinase 1 Homo sapiens 145-148 10753954-5 2000 Both cGMP and cAMP activated both ERK and p70(S6k), whereas only selective inhibitors of protein kinase G prevented the activation of the kinases by SNAP. Cyclic AMP 14-18 mitogen-activated protein kinase 1 Homo sapiens 34-37 10760082-10 2000 CONCLUSIONS: : We conclude that cAMP agonists stimulate the proliferation of ADPKD but not HKC epithelial cells through PKA activation of the ERK pathway at a locus distal to receptor tyrosine kinase. Cyclic AMP 32-36 mitogen-activated protein kinase 1 Homo sapiens 142-145 10617116-5 2000 Interestingly, cAMP reduced phosphorylation of extracellular signal-regulated kinase (Erk). Cyclic AMP 15-19 mitogen-activated protein kinase 1 Homo sapiens 47-84 10688975-6 2000 Forskolin, a direct activator of adenylyl cyclase also stimulated ERK and P38 activities in these cells suggesting the invovement of cAMP in this process. Cyclic AMP 133-137 mitogen-activated protein kinase 1 Homo sapiens 66-69 10617116-5 2000 Interestingly, cAMP reduced phosphorylation of extracellular signal-regulated kinase (Erk). Cyclic AMP 15-19 mitogen-activated protein kinase 1 Homo sapiens 86-89 10508738-3 1999 In particular, it has become evident that multiple second messengers, such as cyclic adenosine monophosphate, protein kinase A, calcium, and diacylglycerol, can control ERK signalling via the small G proteins Ras and Rap1. Cyclic AMP 78-108 mitogen-activated protein kinase 1 Homo sapiens 169-172 10022832-1 1999 The extracellular receptor stimulated kinase ERK2 (p42(MAPK))-phosphorylated human cAMP-specific phosphodiesterase PDE4D3 at Ser579 and profoundly reduced ( approximately 75%) its activity. Cyclic AMP 83-87 mitogen-activated protein kinase 1 Homo sapiens 45-49 10092665-3 1999 Inhibitors for cAMP and protein kinase A (PKA) abolished isoproterenol-evoked ERK activation, suggesting that Gs protein is involved in the activation. Cyclic AMP 15-19 mitogen-activated protein kinase 1 Homo sapiens 78-81 10022832-1 1999 The extracellular receptor stimulated kinase ERK2 (p42(MAPK))-phosphorylated human cAMP-specific phosphodiesterase PDE4D3 at Ser579 and profoundly reduced ( approximately 75%) its activity. Cyclic AMP 83-87 mitogen-activated protein kinase 1 Homo sapiens 55-59 10022832-10 1999 We identify a novel means of cross-talk between the cAMP and ERK signalling pathways whereby cell stimuli that lead to ERK2 activation may modulate cAMP signalling. Cyclic AMP 148-152 mitogen-activated protein kinase 1 Homo sapiens 61-64 9843585-2 1998 Previous biochemical assays have shown that when extracellular adenosine 3",5"-cyclic monophosphate (cAMP) binds to the surface receptor CAR1, adenylyl cyclase and the MAP kinase ERK2 are transiently activated. Cyclic AMP 63-99 mitogen-activated protein kinase 1 Homo sapiens 179-183 9843585-2 1998 Previous biochemical assays have shown that when extracellular adenosine 3",5"-cyclic monophosphate (cAMP) binds to the surface receptor CAR1, adenylyl cyclase and the MAP kinase ERK2 are transiently activated. Cyclic AMP 101-105 mitogen-activated protein kinase 1 Homo sapiens 179-183 9843585-3 1998 A rise in the internal concentration of cAMP activates protein kinase A such that it inhibits ERK2 and leads to a loss-of-ligand binding by CAR1. Cyclic AMP 40-44 mitogen-activated protein kinase 1 Homo sapiens 94-98 9843585-4 1998 ERK2 phosphorylates the cAMP phosphodiesterase REG A that reduces the internal concentration of cAMP. Cyclic AMP 24-28 mitogen-activated protein kinase 1 Homo sapiens 0-4 9165004-16 1997 Taken together with the effects of cAMP on IGF-I- and EGF-induced Elk-1 activation, these data suggest that the effect of cAMP on SRE activity occurs distal to ERK activation, possibly via inhibition of an ERK-independent pathway. Cyclic AMP 122-126 mitogen-activated protein kinase 1 Homo sapiens 206-209 9291137-6 1997 However, activation of ERK2 by FGF-2 was not affected by PGE2 whereas that of JNK1 by U46619 was inhibited, suggesting that inhibition of COX-2 expression by cAMP may be downstream of ERK2. Cyclic AMP 158-162 mitogen-activated protein kinase 1 Homo sapiens 23-27 9291137-6 1997 However, activation of ERK2 by FGF-2 was not affected by PGE2 whereas that of JNK1 by U46619 was inhibited, suggesting that inhibition of COX-2 expression by cAMP may be downstream of ERK2. Cyclic AMP 158-162 mitogen-activated protein kinase 1 Homo sapiens 184-188 9165004-3 1997 To determine whether this effect of cAMP on cell growth was mediated by inhibition of the activity of extracellular signal-regulated kinases 1 and 2 (ERK1 and -2), two mitogen-activated protein kinases, the effect of cAMP on growth factor-induced ERK activity in MCF-7 cells was examined. Cyclic AMP 36-40 mitogen-activated protein kinase 1 Homo sapiens 102-148 9165004-3 1997 To determine whether this effect of cAMP on cell growth was mediated by inhibition of the activity of extracellular signal-regulated kinases 1 and 2 (ERK1 and -2), two mitogen-activated protein kinases, the effect of cAMP on growth factor-induced ERK activity in MCF-7 cells was examined. Cyclic AMP 36-40 mitogen-activated protein kinase 1 Homo sapiens 150-153 9551080-1 1998 The Dictyostelium ERK2 protein is transiently activated when cells are treated with the chemotactic agents cAMP or folic acid. Cyclic AMP 107-111 mitogen-activated protein kinase 1 Homo sapiens 18-22 9482941-2 1998 Elevation of cAMP partially inhibited the epidermal growth factor-stimulated DNA synthesis and the intrinsic MAPK (ERK-1 and ERK-2) of serum-starved MCF-7 cells. Cyclic AMP 13-17 mitogen-activated protein kinase 1 Homo sapiens 125-130 9546582-9 1998 Cyclic AMP derivatives or cAMP generating agents such as PTH and forskolin inhibited ERK2 activation by bFGF and PDGF-BB suggesting a "cross-talk" between the two different signalling pathways activated by receptor tyrosine kinases and cAMP-dependent protein kinase. Cyclic AMP 0-10 mitogen-activated protein kinase 1 Homo sapiens 85-89 9295311-1 1997 The Dictyostelium MAP kinase ERK2 is activated by extracellular cAMP in aggregation-competent cells and is required for receptor activation of adenylyl cyclase (Maeda, M., Aubry, L., Insall, R., Gaskins, C., Devreotes, P. N., and Firtel, R. A. Cyclic AMP 64-68 mitogen-activated protein kinase 1 Homo sapiens 29-33 9295311-7 1997 This cAMP-dependent activation of ERK2 is mediated by the serpentine, G protein-coupled cAMP receptors. Cyclic AMP 5-9 mitogen-activated protein kinase 1 Homo sapiens 34-38 9295311-8 1997 However, ERK2 activation by cAMP is at least partially heterotrimeric G protein-independent, with a level of activation in cells lacking the sole Gbeta subunit or the G protein-coupled cAMP receptors-coupled Galpha2 subunit that is approximately 50% that of wild-type cells (Maeda, M., Aubry, L., Insall, R., Gaskins, C., Devreotes, P. N., and Firtel, R. A. Cyclic AMP 28-32 mitogen-activated protein kinase 1 Homo sapiens 9-13 9295311-30 1997 Furthermore, we show that the activation of ERK2 by cAMP is independent of the Galpha4 subunit, while the activation of ERK2 by folate is independent of Galpha2. Cyclic AMP 52-56 mitogen-activated protein kinase 1 Homo sapiens 44-48 9020088-1 1997 The chemoattractant cAMP, acting through serpentine cAMP receptors, results in a rapid and transient stimulation of the Dictyostelium mitogen-activated protein kinase ERK2 activity (). Cyclic AMP 20-24 mitogen-activated protein kinase 1 Homo sapiens 167-171 9148940-2 1997 Activated p38 phosphorylates transcription factors important in the regulation of cell growth and apoptosis, including activating transcription factor 2 (ATF2), Max, cAMP response element-binding protein-homologous protein/growth arrest DNA damage 153 (CHDP/GADD153). Cyclic AMP 166-170 mitogen-activated protein kinase 1 Homo sapiens 10-13 9020088-7 1997 Furthermore, we show that constitutive expression of PKA catalytic subunit bypasses the requirement of ERK2 for aggregation and later development, indicating that PKA lies downstream from ERK2 and that ERK2 may regulate one or more components of the signaling pathway required for mediating PKA function, possibly by directly regulating PKA R or a protein controlling the intracellular level of cAMP. Cyclic AMP 395-399 mitogen-activated protein kinase 1 Homo sapiens 103-107 8910361-5 1996 The relative orientation of the two domains of p38 kinase is different from that observed in the active form of cAMP-dependent protein kinase. Cyclic AMP 112-116 mitogen-activated protein kinase 1 Homo sapiens 47-50 8941662-9 1996 Phorbol 12-myristate 13-acetate, calcium ionophore, and cAMP analogues only increased ERK activity but had no significant effects on JNK or p38. Cyclic AMP 56-60 mitogen-activated protein kinase 1 Homo sapiens 86-89 8631932-4 1996 In this manuscript, we show that the Dictyostelium MAP kinase ERK2 is rapidly and transiently activated in response to the chemoattractant cAMP. Cyclic AMP 139-143 mitogen-activated protein kinase 1 Homo sapiens 62-66 8759733-8 1996 Both PKC-dependent and -independent activation of ERK were sensitive to inhibition by forskolin or a cell-permeable cAMP analogue, dbcAMP. Cyclic AMP 116-120 mitogen-activated protein kinase 1 Homo sapiens 50-53 8645177-9 1996 Therefore, in blocking ceramide-stimulated ERK-2 activity, cyclic AMP may allow the ceramide-dependent activation of JNK to programme cells to opt out of the cell cycle. Cyclic AMP 59-69 mitogen-activated protein kinase 1 Homo sapiens 43-48 8645177-11 1996 ERK-2 can be activated by both cyclic AMP-sensitive c-Raf-1 kinase-dependent and cyclic AMP-insensitive c-Raf-1 kinase-independent pathways in ASM cells. Cyclic AMP 31-41 mitogen-activated protein kinase 1 Homo sapiens 0-5 8645177-11 1996 ERK-2 can be activated by both cyclic AMP-sensitive c-Raf-1 kinase-dependent and cyclic AMP-insensitive c-Raf-1 kinase-independent pathways in ASM cells. Cyclic AMP 81-91 mitogen-activated protein kinase 1 Homo sapiens 0-5 8647130-9 1996 For instance, both ceramide and sphingosine will elicit growth arrest via activation of JNK, whereas sphingosine phosphate will potentiate growth-factor-stimulated DNA synthesis, a consequence of the activation of ERK-2, Furthermore, under certain conditions, sphingosine and ceramide stimulate cAMP formation, a negative modulator of cell growth, whereas sphingosine phosphate depresses cAMP, thereby enhancing its own growth-promoting properties. Cyclic AMP 295-299 mitogen-activated protein kinase 1 Homo sapiens 214-219 8647130-9 1996 For instance, both ceramide and sphingosine will elicit growth arrest via activation of JNK, whereas sphingosine phosphate will potentiate growth-factor-stimulated DNA synthesis, a consequence of the activation of ERK-2, Furthermore, under certain conditions, sphingosine and ceramide stimulate cAMP formation, a negative modulator of cell growth, whereas sphingosine phosphate depresses cAMP, thereby enhancing its own growth-promoting properties. Cyclic AMP 388-392 mitogen-activated protein kinase 1 Homo sapiens 214-219 8107865-2 1994 The two domains of unphosphorylated ERK2 are farther apart than in the active conformation of cAMP-dependent protein kinase and the peptide-binding site is blocked by tyrosine 185, one of the two residues that are phosphorylated in the active enzyme. Cyclic AMP 94-98 mitogen-activated protein kinase 1 Homo sapiens 36-40 8557190-2 1996 erk2 null cells lack cAMP stimulation of adenylyl cyclase and thus cannot relay the cAMP chemotactic signal, although the cells chemotax to cAMP (Segall et al. Cyclic AMP 21-25 mitogen-activated protein kinase 1 Homo sapiens 0-4 7629120-4 1995 Surprisingly, extracellular signal regulated kinase 2 (ERK1, ERK2, and ERK3) of MAP kinase were poorly inhibited by cAMP. Cyclic AMP 116-120 mitogen-activated protein kinase 1 Homo sapiens 14-53 7629120-6 1995 The resistance of ERK and Raf-1 to cAMP clearly distinguishes T cells from fibroblasts. Cyclic AMP 35-39 mitogen-activated protein kinase 1 Homo sapiens 18-21 7702566-4 1995 We have previously demonstrated that, in order to induce full activation of ERK-2 with bradykinin, it is necessary to obliterate PKC-stimulated cyclic AMP formation. Cyclic AMP 144-154 mitogen-activated protein kinase 1 Homo sapiens 76-81 7702566-5 1995 We concluded that the cyclic AMP signal limits the magnitude of ERK-2 activation [Pyne, Moughal, Stevens, Tolan and Pyne (1994) Biochem. Cyclic AMP 22-32 mitogen-activated protein kinase 1 Homo sapiens 64-69 7702566-8 1995 The present study indicates that the bradykinin-stimulated ERK-2 pathway is entirely cyclic AMP-sensitive, and suggests that coincident signal detection by adenylate cyclase may be an important physiological route for the modulation of early mitogenic signalling. Cyclic AMP 85-95 mitogen-activated protein kinase 1 Homo sapiens 59-64 7998998-0 1994 Protein kinase C-dependent cyclic AMP formation in airway smooth muscle: the role of type II adenylate cyclase and the blockade of extracellular-signal-regulated kinase-2 (ERK-2) activation. Cyclic AMP 27-37 mitogen-activated protein kinase 1 Homo sapiens 131-170 7998998-0 1994 Protein kinase C-dependent cyclic AMP formation in airway smooth muscle: the role of type II adenylate cyclase and the blockade of extracellular-signal-regulated kinase-2 (ERK-2) activation. Cyclic AMP 27-37 mitogen-activated protein kinase 1 Homo sapiens 172-177 8573086-4 1996 In the human astrocytic cell line, U-373MG, LPS was found to strongly activate (and cAMP to inhibit) both ERK2 and Raf-1. Cyclic AMP 84-88 mitogen-activated protein kinase 1 Homo sapiens 106-110 7998998-11 1994 Thus the PKC-stimulated cyclic AMP response can limit the activation of ERK-2 in response to bradykinin. Cyclic AMP 24-34 mitogen-activated protein kinase 1 Homo sapiens 72-77 35342363-4 2022 Furthermore, HB-EGF transduced intracellular downstream cAMP-PKA signaling to promote the phosphorylation of JNK and ERK whose blockage impeded the induction of HB-EGF on estrogen secretion. Cyclic AMP 56-60 mitogen-activated protein kinase 1 Homo sapiens 117-120 34774353-5 2022 It is further suggested that low-dose PFOA stimulates steroid hormone synthesis by accelerating fatty acid metabolism and steroidogenic process, which is involved in the repression of p38 and cAMP-dependent ERK signaling pathway. Cyclic AMP 192-196 mitogen-activated protein kinase 1 Homo sapiens 207-210 34512650-8 2021 The catabolic influence of SP and alphaCGRP might be due to activation of ERK signaling that could be counteracted by an increased cAMP response. Cyclic AMP 131-135 mitogen-activated protein kinase 1 Homo sapiens 74-77 34374340-5 2021 We show that calcium and cAMP work synergistically to activate ERK and that stimuli given with large inter-trial intervals activate more ERK than shorter intervals. Cyclic AMP 25-29 mitogen-activated protein kinase 1 Homo sapiens 63-66 34374340-5 2021 We show that calcium and cAMP work synergistically to activate ERK and that stimuli given with large inter-trial intervals activate more ERK than shorter intervals. Cyclic AMP 25-29 mitogen-activated protein kinase 1 Homo sapiens 137-140 35196602-3 2022 Previous studies have provided substantial evidence for crosstalk between cAMP and the MAPK/ERK signaling pathway. Cyclic AMP 74-78 mitogen-activated protein kinase 1 Homo sapiens 92-95 35474595-0 2022 CD55 is upregulated by cAMP/PKA/AKT and modulates human decidualization via Src and ERK pathway and decidualization-related genes. Cyclic AMP 23-27 mitogen-activated protein kinase 1 Homo sapiens 84-87 35566061-7 2022 More importantly, peptides reduce the tyrosinase expression content, primarily through the cAMP/PKA/CREB pathway, with PI3K/AKT/GSK3beta, MEK/ERK/MITF and p38 MAPK/CREB/MITF as side pathways. Cyclic AMP 91-95 mitogen-activated protein kinase 1 Homo sapiens 142-145 35353814-0 2022 Analysis of localized cAMP perturbations within a tissue reveal the effects of a local, dynamic gap junction state on ERK signaling. Cyclic AMP 22-26 mitogen-activated protein kinase 1 Homo sapiens 118-121 35353814-3 2022 The time-dependent ERK responses we observe in the perturbed cells for spatially uniform cAMP perturbations (all cells) can be very different from those due to spatially localized perturbations (a few cells). Cyclic AMP 89-93 mitogen-activated protein kinase 1 Homo sapiens 19-22 33960038-5 2021 Exendin-4/GLP1R-stimulated neuritogenesis was MEK-ERK-dependent (blocked by U0126), indicating its use of the cAMP RapGEF2 ERK neuritogenic signalling pathway previously identified for PACAP/PAC1 signalling in NS-1 cells. Cyclic AMP 110-114 mitogen-activated protein kinase 1 Homo sapiens 123-126 33960038-0 2021 Cyclic AMP-dependent activation of ERK via GLP-1 receptor signalling requires the neuroendocrine cell-specific guanine nucleotide exchanger NCS-RapGEF2. Cyclic AMP 0-10 mitogen-activated protein kinase 1 Homo sapiens 35-38 33960038-1 2021 Cyclic AMP activation of the Rap-Braf-MEK-ERK pathway after signalling initiated by the neuropeptide pituitary adenylate cyclase-activating peptide (PACAP), via the Gs -protein coupled receptor (Gs PCR) PAC1, occurs uniquely through the neuritogenic cAMP sensor Rap guanine nucleotide exchange factor 2 (NCS-RapGEF2) in Neuroscreen-1 (NS-1) neuroendocrine cells. Cyclic AMP 0-10 mitogen-activated protein kinase 1 Homo sapiens 42-45 33960038-1 2021 Cyclic AMP activation of the Rap-Braf-MEK-ERK pathway after signalling initiated by the neuropeptide pituitary adenylate cyclase-activating peptide (PACAP), via the Gs -protein coupled receptor (Gs PCR) PAC1, occurs uniquely through the neuritogenic cAMP sensor Rap guanine nucleotide exchange factor 2 (NCS-RapGEF2) in Neuroscreen-1 (NS-1) neuroendocrine cells. Cyclic AMP 250-254 mitogen-activated protein kinase 1 Homo sapiens 42-45 33693952-6 2021 In GCs, follicle-stimulating hormone (FSH) is dependent on the cyclic adenosine monophosphate (cAMP) pathway to regulate the aromatase activity, and the regulation of this enzyme is related to the activation of signaling pathways, such as phosphatidylinositol 3-kinase (PI3K) and extracellular signal-regulated kinase (ERK). Cyclic AMP 95-99 mitogen-activated protein kinase 1 Homo sapiens 280-317 33693952-6 2021 In GCs, follicle-stimulating hormone (FSH) is dependent on the cyclic adenosine monophosphate (cAMP) pathway to regulate the aromatase activity, and the regulation of this enzyme is related to the activation of signaling pathways, such as phosphatidylinositol 3-kinase (PI3K) and extracellular signal-regulated kinase (ERK). Cyclic AMP 95-99 mitogen-activated protein kinase 1 Homo sapiens 319-322 33995100-3 2021 Agents that increase cAMP have been suggested as alternative therapies, as this second messenger can inhibit the ERK cascade. Cyclic AMP 21-25 mitogen-activated protein kinase 1 Homo sapiens 113-116 33995100-9 2021 This suggests that sustained elevation of cAMP in the nucleus is necessary for efficient inhibition of PDGF-induced nuclear ERK and fibroblast proliferation. Cyclic AMP 42-46 mitogen-activated protein kinase 1 Homo sapiens 124-127 32827681-11 2020 Most of these genes were related to cancer development processes, cAMP, and the ERK cell signaling pathway. Cyclic AMP 66-70 mitogen-activated protein kinase 1 Homo sapiens 80-83 33730343-8 2021 Both the JNK and the ERK inhibitors potentiated the phototherapy effect on IL-8 as well as on cAMP secretion from BEAS. Cyclic AMP 94-98 mitogen-activated protein kinase 1 Homo sapiens 21-24 33292089-5 2021 SN induced expression of the cAMP/PKA pathway genes ADCY3 and MAPK1 in MNP01 cells and MAPK1, GNAS, PRKACA, and PRKAR2A in Caco-2 cells, as well as modulated the transcription of genes related to cell proliferation (JUN; AKT1) and inflammation (RELA; TNF) in both cell lines. Cyclic AMP 29-33 mitogen-activated protein kinase 1 Homo sapiens 62-67 31063758-6 2019 Furthermore, we identify lysosome-mediated cAMP-PKA/EPAC-dependent activation of RAF-MEK-ERK signaling as a resistance mechanism to YAP/TAZ inhibition. Cyclic AMP 43-47 mitogen-activated protein kinase 1 Homo sapiens 89-92 32830375-0 2020 Protein kinase A inhibitor proteins (PKIs) divert GPCR-Galphas-cAMP signaling toward EPAC and ERK activation and are involved in tumor growth. Cyclic AMP 63-67 mitogen-activated protein kinase 1 Homo sapiens 94-97 32094002-6 2020 Then, cell ultrastructure, expression and localization of GPER, ERRbeta, PPARgamma together with the molecular receptor mechanism, through cyclic AMP and Raf/Ras/extracellular signal activated kinases (ERK), in the control of cholesterol concentration and estrogen production by Leydig cells were studied. Cyclic AMP 139-149 mitogen-activated protein kinase 1 Homo sapiens 202-205 31215069-6 2020 Nqo1 ablation also induced the expression of phosphatase and tensin homolog, a dual protein/lipid phosphatase that blocks PI3K/Akt signaling, through the ERK/cAMP-responsive element-binding protein/c-Jun pathway. Cyclic AMP 158-162 mitogen-activated protein kinase 1 Homo sapiens 154-157 31730032-2 2020 Epistasis analysis in the soil amoeba Dictyostelium discoideum suggests the atypical MAPK Erk2 downregulates the function of the cAMP-specific phosphodiesterase RegA to regulate progression of the developmental life cycle. Cyclic AMP 129-133 mitogen-activated protein kinase 1 Homo sapiens 90-94 31807022-5 2019 Related proteins of the extracellular signal-regulated kinase/cAMP response element binding protein (ERK/CREB) pathway were detected by Western blotting analysis. Cyclic AMP 62-66 mitogen-activated protein kinase 1 Homo sapiens 101-104 31202858-3 2019 StAR is phosphorylated by mitochondrial ERK in a cAMP-dependent transduction pathway to achieve maximal steroid production. Cyclic AMP 49-53 mitogen-activated protein kinase 1 Homo sapiens 40-43 30884895-0 2019 Roles of Cyclic AMP Response Element Binding Activation in the ERK1/2 and p38 MAPK Signalling Pathway in Central Nervous System, Cardiovascular System, Osteoclast Differentiation and Mucin and Cytokine Production. Cyclic AMP 9-19 mitogen-activated protein kinase 1 Homo sapiens 74-77 29574069-11 2018 Altogether, our data indicate that forskolin sensitizes TNBC cells to doxorubicin via a mechanism depending on the cAMP/PKA-mediated ERK inhibition. Cyclic AMP 115-119 mitogen-activated protein kinase 1 Homo sapiens 133-136 30711170-10 2019 CONCLUSIONS: This study showed that cAMP signaling exerts its up-regulating effects on the odonto/osteogenic differentiation of SCAPs by interfering with TGF-beta1 signaling via inhibiting Smad3 and ERK phosphorylation. Cyclic AMP 36-40 mitogen-activated protein kinase 1 Homo sapiens 199-202 30711170-6 2019 The effect of cAMP on the phosphorylation of Smad2/Smad3 and extracellular-regulated kinase (ERK)/P38 induced by TGF-beta1 was analyzed by Western blotting. Cyclic AMP 14-18 mitogen-activated protein kinase 1 Homo sapiens 61-91 29728647-4 2019 Combining-conditioned place preference (CPP) with molecular analyses, we investigated the DA D1 receptor (D1R) and extracellular signal-regulated kinase (ERK)-cAMP-response element binding protein (CREB) signaling, as well as DA D2 receptor (D2R) and protein kinase B (PKB or Akt)/glycogen synthase kinase 3 (GSK3) signaling in the ventral hippocampus (vHip) and medial prefrontal cortex (mPFC) during the formation of opiate-related associative memories. Cyclic AMP 159-163 mitogen-activated protein kinase 1 Homo sapiens 154-157 30262435-5 2018 In addition, we found MEK/Erk is the signaling pathway that triggers the cAMP- and IL-6-mediated NED induction in radioresistant lung cancer cells. Cyclic AMP 73-77 mitogen-activated protein kinase 1 Homo sapiens 26-29 30420637-7 2018 Furthermore, ectopic expression of MUC15 activated extracellular signal-regulated kinase (ERK) signaling via G-protein-coupled receptor (GPCR)/cyclic AMP (cAMP) and integrin/focal adhesion kinase pathways. Cyclic AMP 143-153 mitogen-activated protein kinase 1 Homo sapiens 51-88 30420637-7 2018 Furthermore, ectopic expression of MUC15 activated extracellular signal-regulated kinase (ERK) signaling via G-protein-coupled receptor (GPCR)/cyclic AMP (cAMP) and integrin/focal adhesion kinase pathways. Cyclic AMP 143-153 mitogen-activated protein kinase 1 Homo sapiens 90-93 30420637-7 2018 Furthermore, ectopic expression of MUC15 activated extracellular signal-regulated kinase (ERK) signaling via G-protein-coupled receptor (GPCR)/cyclic AMP (cAMP) and integrin/focal adhesion kinase pathways. Cyclic AMP 155-159 mitogen-activated protein kinase 1 Homo sapiens 51-88 30420637-7 2018 Furthermore, ectopic expression of MUC15 activated extracellular signal-regulated kinase (ERK) signaling via G-protein-coupled receptor (GPCR)/cyclic AMP (cAMP) and integrin/focal adhesion kinase pathways. Cyclic AMP 155-159 mitogen-activated protein kinase 1 Homo sapiens 90-93 29769519-4 2018 Upon stimulation with visible light, we identify activation of canonical cell signaling pathways, including cAMP-, Ca2+-, MAPK/ERK-, and Rho-dependent pathways, downstream of the engineered receptors. Cyclic AMP 108-112 mitogen-activated protein kinase 1 Homo sapiens 127-130 29551366-2 2018 Reduced levels of Erk2 expression have been shown previously to restrict cAMP production during development but still allow for chemotactic movement. Cyclic AMP 73-77 mitogen-activated protein kinase 1 Homo sapiens 18-22 29551366-4 2018 The absence of Erk2 resulted in a complete loss of folate and cAMP chemotaxis suggesting that this MAPK plays an integral role in the signaling mechanisms involved with this cellular response. Cyclic AMP 62-66 mitogen-activated protein kinase 1 Homo sapiens 15-19 28162907-0 2017 beta2-receptor agonists salbutamol and terbutaline attenuated cytokine production by suppressing ERK pathway through cAMP in macrophages. Cyclic AMP 117-121 mitogen-activated protein kinase 1 Homo sapiens 97-100 28460186-10 2017 In summary, these results suggest that PKA-mediated suppression of Ang-II-induced Egr-1 expression and phosphorylation of ERK may be among the mechanisms by which cAMP exerts its vasculoprotective effects. Cyclic AMP 163-167 mitogen-activated protein kinase 1 Homo sapiens 122-125 28162907-2 2017 beta2-receptor activation is considered to lead to the activation of ERK pathway through G-protein- and cAMP-independent mechanisms. Cyclic AMP 104-108 mitogen-activated protein kinase 1 Homo sapiens 69-72 28162907-5 2017 A chemical cAMP analog 8-Br-cAMP also inhibited ERK phosphorylation and TNF and MCP-1 release. Cyclic AMP 11-15 mitogen-activated protein kinase 1 Homo sapiens 48-51 28162907-7 2017 In conclusion, we suggest that beta2-receptor agonists salbutamol and terbutaline inhibit inflammatory gene expression partly by a mechanism dependent on cAMP leading to the inhibition of ERK signaling in macrophages. Cyclic AMP 154-158 mitogen-activated protein kinase 1 Homo sapiens 188-191 27977772-0 2016 Inhibition of cAMP-Dependent PKA Activates beta2-Adrenergic Receptor Stimulation of Cytosolic Phospholipase A2 via Raf-1/MEK/ERK and IP3-Dependent Ca2+ Signaling in Atrial Myocytes. Cyclic AMP 14-18 mitogen-activated protein kinase 1 Homo sapiens 125-128 28003362-0 2017 Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP. Cyclic AMP 27-31 mitogen-activated protein kinase 1 Homo sapiens 105-108 28003362-0 2017 Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP. Cyclic AMP 123-127 mitogen-activated protein kinase 1 Homo sapiens 105-108 28003362-1 2017 Cyclic adenosine monophosphate (cAMP) is an important mediator of hormonal stimulation of cell growth and differentiation through its activation of the extracellular signal-regulated kinase (ERK) cascade. Cyclic AMP 0-30 mitogen-activated protein kinase 1 Homo sapiens 152-189 28003362-1 2017 Cyclic adenosine monophosphate (cAMP) is an important mediator of hormonal stimulation of cell growth and differentiation through its activation of the extracellular signal-regulated kinase (ERK) cascade. Cyclic AMP 0-30 mitogen-activated protein kinase 1 Homo sapiens 191-194 28003362-1 2017 Cyclic adenosine monophosphate (cAMP) is an important mediator of hormonal stimulation of cell growth and differentiation through its activation of the extracellular signal-regulated kinase (ERK) cascade. Cyclic AMP 32-36 mitogen-activated protein kinase 1 Homo sapiens 152-189 28003362-1 2017 Cyclic adenosine monophosphate (cAMP) is an important mediator of hormonal stimulation of cell growth and differentiation through its activation of the extracellular signal-regulated kinase (ERK) cascade. Cyclic AMP 32-36 mitogen-activated protein kinase 1 Homo sapiens 191-194 28003362-3 2017 Using HEK293 cells as a model system, we have recently shown that both Ras and Rap1 are required for cAMP signaling to ERKs. Cyclic AMP 101-105 mitogen-activated protein kinase 1 Homo sapiens 119-123 28003362-4 2017 However, cAMP-dependent Ras signaling to ERKs is transient and rapidly terminated by PKA phosphorylation of the Raf isoforms C-Raf and B-Raf. Cyclic AMP 9-13 mitogen-activated protein kinase 1 Homo sapiens 41-45 28003362-5 2017 In contrast, cAMP-dependent Rap1 signaling to ERKs and Rap1 is potentiated by PKA. Cyclic AMP 13-17 mitogen-activated protein kinase 1 Homo sapiens 46-50 26797706-11 2016 In summary, melatonin inhibited the cAMP synthesis through ROS reduction and the phosphorylation of the ERK/GSK-3beta site which is known to be responsible for C/EBPbeta activation for adipogenic differentiation in hMSCs. Cyclic AMP 36-40 mitogen-activated protein kinase 1 Homo sapiens 104-107 27531745-0 2016 Protein Kinase A-independent Ras Protein Activation Cooperates with Rap1 Protein to Mediate Activation of the Extracellular Signal-regulated Kinases (ERK) by cAMP. Cyclic AMP 158-162 mitogen-activated protein kinase 1 Homo sapiens 150-153 27531745-1 2016 Cyclic adenosine monophosphate (cAMP) is an important mediator of hormonal stimulation of cell growth and differentiation through its activation of the extracellular signal-regulated kinase (ERK) cascade. Cyclic AMP 0-30 mitogen-activated protein kinase 1 Homo sapiens 152-189 27531745-1 2016 Cyclic adenosine monophosphate (cAMP) is an important mediator of hormonal stimulation of cell growth and differentiation through its activation of the extracellular signal-regulated kinase (ERK) cascade. Cyclic AMP 0-30 mitogen-activated protein kinase 1 Homo sapiens 191-194 27531745-1 2016 Cyclic adenosine monophosphate (cAMP) is an important mediator of hormonal stimulation of cell growth and differentiation through its activation of the extracellular signal-regulated kinase (ERK) cascade. Cyclic AMP 32-36 mitogen-activated protein kinase 1 Homo sapiens 152-189 27531745-1 2016 Cyclic adenosine monophosphate (cAMP) is an important mediator of hormonal stimulation of cell growth and differentiation through its activation of the extracellular signal-regulated kinase (ERK) cascade. Cyclic AMP 32-36 mitogen-activated protein kinase 1 Homo sapiens 191-194 27531745-3 2016 Using Hek293 cells, we show that both Ras and Rap1 are required for cAMP signaling to ERKs. Cyclic AMP 68-72 mitogen-activated protein kinase 1 Homo sapiens 86-90 27531745-5 2016 Ras was required for the early portion of ERK activation by cAMP and was activated independently of PKA. Cyclic AMP 60-64 mitogen-activated protein kinase 1 Homo sapiens 42-45 27531745-10 2016 This is the first report of a mechanism for the cooperative actions of Ras and Rap1 in cAMP activation of ERKs. Cyclic AMP 87-91 mitogen-activated protein kinase 1 Homo sapiens 106-110 27531745-12 2016 We show that the induction of c-FOS by cAMP required both the early and sustained phases of ERK activation, requiring Ras and Rap1, as well as for each of the Raf isoforms, B-Raf and C-Raf. Cyclic AMP 39-43 mitogen-activated protein kinase 1 Homo sapiens 92-95 26494252-8 2016 Activation of cAMP/Creb pathway by forskolin prevented gstp1-2 expression, whereas U0126 suppressed Creb phosphorylation, thus setting up Creb as a proximal transmitter of Erk inhibitory effect. Cyclic AMP 14-18 mitogen-activated protein kinase 1 Homo sapiens 172-175 26990063-6 2016 Acetate also elicited the activation of ERK and cAMP response element-binding protein, and these responses were sensitive to G(i/o)-type G protein inactivator, Gbetagamma-subunit inhibitor, phospholipase C inhibitor, and MAPK kinase inhibitor, indicating a role for the G(i/o)betagamma/phospholipase C/protein kinase C/MAPK kinase signaling pathway in these responses. Cyclic AMP 48-52 mitogen-activated protein kinase 1 Homo sapiens 221-225 26990063-6 2016 Acetate also elicited the activation of ERK and cAMP response element-binding protein, and these responses were sensitive to G(i/o)-type G protein inactivator, Gbetagamma-subunit inhibitor, phospholipase C inhibitor, and MAPK kinase inhibitor, indicating a role for the G(i/o)betagamma/phospholipase C/protein kinase C/MAPK kinase signaling pathway in these responses. Cyclic AMP 48-52 mitogen-activated protein kinase 1 Homo sapiens 319-323 26853750-7 2016 Mechanistically, HIF2alpha abrogated glucagon-PKA signaling by activating cAMP-phosphodiesterases in a MEK/ERK-dependent manner. Cyclic AMP 74-78 mitogen-activated protein kinase 1 Homo sapiens 107-110 26289612-9 2016 These data suggest that whereas PDE4 is the major PDE isoform involved in the regulation of global intracellular cAMP and Cl(-) secretion, PDE1 specifically affects the cAMP signal to the B-Raf/MEK/ERK pathway and regulates AVP-induced proliferation of ADPKD cells. Cyclic AMP 169-173 mitogen-activated protein kinase 1 Homo sapiens 198-201 25239597-7 2014 These observations suggest that: (1) insulin respectively upregulates mRNA expression of NKCC and CFTR through activation of PI3K and inactivation of ERK; (2) insulin signals on mRNA expression of NKCC and CFTR are not enough to stimulate transepithelial Cl(-) secretion, but enhance the stimulatory action of cAMP on transepithelial Cl(-) secretion. Cyclic AMP 310-314 mitogen-activated protein kinase 1 Homo sapiens 150-153 26596264-0 2016 Calcitonin gene-related peptide mediates an inflammatory response in Schwann cells via cAMP-dependent ERK signaling cascade. Cyclic AMP 87-91 mitogen-activated protein kinase 1 Homo sapiens 102-105 25823818-4 2015 Specifically, shear-induced cAMP and IL-1beta activate PI3-K, ERK1/2 and p38 signaling pathways, which lead to the synthesis of MMP-7 via transactivating NF-kappaB and c-Jun in human chondrosarcoma cells. Cyclic AMP 28-32 mitogen-activated protein kinase 1 Homo sapiens 73-76 26596264-11 2016 CGRP activates the cAMP-PKA-ERK signaling cascade leading to IL-1beta production. Cyclic AMP 19-23 mitogen-activated protein kinase 1 Homo sapiens 28-31 26090315-12 2015 cAMP, the second messenger for PTH1R also inhibits proliferation and activates ERK. Cyclic AMP 0-4 mitogen-activated protein kinase 1 Homo sapiens 79-82 25713071-0 2015 Cyclic AMP signaling reduces sirtuin 6 expression in non-small cell lung cancer cells by promoting ubiquitin-proteasomal degradation via inhibition of the Raf-MEK-ERK (Raf/mitogen-activated extracellular signal-regulated kinase/extracellular signal-regulated kinase) pathway. Cyclic AMP 0-10 mitogen-activated protein kinase 1 Homo sapiens 163-166 25713071-14 2015 It is concluded that cAMP signaling reduces SIRT6 expression by promoting its ubiquitin-proteasome-dependent degradation, a process mediated by the PKA-dependent inhibition of the Raf-MEK-ERK pathway. Cyclic AMP 21-25 mitogen-activated protein kinase 1 Homo sapiens 188-191 24760659-10 2014 Furthermore, PGE2 activates the EP2/EP4-cAMP-PI3K-ERK signaling pathway, which enhanced ERRa transcriptional potentiality by increasing ERRa phosphorylation and nuclear translocation, subsequently promoting the expression of its target genes, such as aromatase. Cyclic AMP 40-44 mitogen-activated protein kinase 1 Homo sapiens 50-53 25365078-7 2014 Upregulation of Noxa was due to a transcriptional increase mediated by cAMP responsive element binding protein, activation of which was also increased by MEK/ERK signaling in melanoma cells. Cyclic AMP 71-75 mitogen-activated protein kinase 1 Homo sapiens 158-161 24626642-5 2014 The treatment of these cells with risperidone induced the activation of extracellular signal-related kinase (ERK) by cellular cyclic adenosine 3-monophosphate (cAMP)-dependent protein kinase (also known as protein kinase A; PKA) and the mechanisms involved include the induction of suppressor of cytokine signaling 3 (SOCS3) and suppressor of cytokine signaling 6 (SOCS6) expression. Cyclic AMP 160-164 mitogen-activated protein kinase 1 Homo sapiens 72-107 25229504-4 2014 In this study, we investigated the relationship between the activation of the cAMP pathway by hCG and subsequent phosphorylation of extracellular signal-regulated kinase1/2 (ERK1/2) or p38 mitogen-activated protein kinase (MAPK) pathways in the regulation of placental HSD11B2 expression in human placental syncytiotrophoblasts. Cyclic AMP 78-82 mitogen-activated protein kinase 1 Homo sapiens 132-172 25229504-8 2014 These data suggest that p38 MAPK is involved in both basal and hCG/cAMP-induced expression of HSD11B2, and ERK1/2 may play a role opposite to p38 MAPK at least in the basal expression of HSD11B2 in human placental syncytiotrophoblasts and that there is complicated cross-talk between hCG/cAMP and MAPK cascades in the regulation of placental HSD11B2 expression. Cyclic AMP 67-71 mitogen-activated protein kinase 1 Homo sapiens 24-27 25229504-8 2014 These data suggest that p38 MAPK is involved in both basal and hCG/cAMP-induced expression of HSD11B2, and ERK1/2 may play a role opposite to p38 MAPK at least in the basal expression of HSD11B2 in human placental syncytiotrophoblasts and that there is complicated cross-talk between hCG/cAMP and MAPK cascades in the regulation of placental HSD11B2 expression. Cyclic AMP 67-71 mitogen-activated protein kinase 1 Homo sapiens 142-145 25229504-8 2014 These data suggest that p38 MAPK is involved in both basal and hCG/cAMP-induced expression of HSD11B2, and ERK1/2 may play a role opposite to p38 MAPK at least in the basal expression of HSD11B2 in human placental syncytiotrophoblasts and that there is complicated cross-talk between hCG/cAMP and MAPK cascades in the regulation of placental HSD11B2 expression. Cyclic AMP 288-292 mitogen-activated protein kinase 1 Homo sapiens 24-27 24853429-0 2014 Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk/MAP kinase pathway mediated by cAMP/PKA signaling. Cyclic AMP 121-125 mitogen-activated protein kinase 1 Homo sapiens 86-89 24853429-10 2014 Hence, we examined the cAMP/PKA pathway, which could inhibit Erk/MAPK transduction in VSMCs. Cyclic AMP 23-27 mitogen-activated protein kinase 1 Homo sapiens 61-64 24853429-11 2014 The results showed that SO2 could stimulate the cAMP/PKA pathway to block c-Raf activation, whereas the Ser259 site on c-Raf had an important role in SO2-induced suppression of Erk/MAPK pathway. Cyclic AMP 48-52 mitogen-activated protein kinase 1 Homo sapiens 177-180 24853429-12 2014 The present study firstly demonstrated that SO2 exerted a negative regulation of VSMC proliferation via suppressing the Erk/MAPK pathway mediated by cAMP/PKA signaling. Cyclic AMP 149-153 mitogen-activated protein kinase 1 Homo sapiens 120-123 24384504-0 2014 Mechanisms of cAMP-induced sustained activation of extracellular signal-regulated kinase in the hippocampus. Cyclic AMP 14-18 mitogen-activated protein kinase 1 Homo sapiens 51-88 24626642-5 2014 The treatment of these cells with risperidone induced the activation of extracellular signal-related kinase (ERK) by cellular cyclic adenosine 3-monophosphate (cAMP)-dependent protein kinase (also known as protein kinase A; PKA) and the mechanisms involved include the induction of suppressor of cytokine signaling 3 (SOCS3) and suppressor of cytokine signaling 6 (SOCS6) expression. Cyclic AMP 160-164 mitogen-activated protein kinase 1 Homo sapiens 109-112 23000456-3 2012 In human melanocytes, ERK activation by MC1R relies on cAMP-independent transactivation of the c-KIT receptor. Cyclic AMP 55-59 mitogen-activated protein kinase 1 Homo sapiens 22-25 24409148-8 2014 Besides the classical cAMP/PKA pathway, downstream of D1R, recent evidence implicates a cAMP-independent crosstalk mechanism by which the D1R potentiates NMDAR-mediated calcium influx and ERK activation. Cyclic AMP 22-26 mitogen-activated protein kinase 1 Homo sapiens 188-191 24409148-8 2014 Besides the classical cAMP/PKA pathway, downstream of D1R, recent evidence implicates a cAMP-independent crosstalk mechanism by which the D1R potentiates NMDAR-mediated calcium influx and ERK activation. Cyclic AMP 88-92 mitogen-activated protein kinase 1 Homo sapiens 188-191 24185007-8 2013 Combined treatment with MAPK-pathway and histone-deacetylase inhibitors suppressed MITF expression and cAMP-mediated resistance. Cyclic AMP 103-107 mitogen-activated protein kinase 1 Homo sapiens 24-28 24151242-0 2013 S49G and R389G polymorphisms of the beta1-adrenergic receptor influence signaling via the cAMP-PKA and ERK pathways. Cyclic AMP 90-94 mitogen-activated protein kinase 1 Homo sapiens 103-106 24100627-4 2013 We used the androgen-independent Du145 cells, for which we demonstrate that adrenomedullin stimulated cell proliferation in vitro through the cAMP/CRAF/MEK/ERK pathway. Cyclic AMP 142-146 mitogen-activated protein kinase 1 Homo sapiens 156-159 23800469-0 2013 Rapgef2 connects GPCR-mediated cAMP signals to ERK activation in neuronal and endocrine cells. Cyclic AMP 31-35 mitogen-activated protein kinase 1 Homo sapiens 47-50 23800469-1 2013 G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor (GPCR)-mediated increases in the second messenger cyclic adenosine monophosphate (cAMP) activate the mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase (ERK), and in neuroendocrine cells, this pathway leads to cAMP-dependent neuritogenesis mediated through Rap1 and B-Raf. Cyclic AMP 129-159 mitogen-activated protein kinase 1 Homo sapiens 214-218 23800469-1 2013 G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor (GPCR)-mediated increases in the second messenger cyclic adenosine monophosphate (cAMP) activate the mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase (ERK), and in neuroendocrine cells, this pathway leads to cAMP-dependent neuritogenesis mediated through Rap1 and B-Raf. Cyclic AMP 129-159 mitogen-activated protein kinase 1 Homo sapiens 220-257 23800469-1 2013 G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor (GPCR)-mediated increases in the second messenger cyclic adenosine monophosphate (cAMP) activate the mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase (ERK), and in neuroendocrine cells, this pathway leads to cAMP-dependent neuritogenesis mediated through Rap1 and B-Raf. Cyclic AMP 129-159 mitogen-activated protein kinase 1 Homo sapiens 259-262 23800469-1 2013 G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor (GPCR)-mediated increases in the second messenger cyclic adenosine monophosphate (cAMP) activate the mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase (ERK), and in neuroendocrine cells, this pathway leads to cAMP-dependent neuritogenesis mediated through Rap1 and B-Raf. Cyclic AMP 161-165 mitogen-activated protein kinase 1 Homo sapiens 214-218 23800469-1 2013 G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor (GPCR)-mediated increases in the second messenger cyclic adenosine monophosphate (cAMP) activate the mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase (ERK), and in neuroendocrine cells, this pathway leads to cAMP-dependent neuritogenesis mediated through Rap1 and B-Raf. Cyclic AMP 161-165 mitogen-activated protein kinase 1 Homo sapiens 220-257 23800469-1 2013 G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor (GPCR)-mediated increases in the second messenger cyclic adenosine monophosphate (cAMP) activate the mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase (ERK), and in neuroendocrine cells, this pathway leads to cAMP-dependent neuritogenesis mediated through Rap1 and B-Raf. Cyclic AMP 161-165 mitogen-activated protein kinase 1 Homo sapiens 259-262 23053667-5 2013 On the other hand, SQ22,536, but not ddAd, inhibited the effects of cAMP analogs 8-Br-cAMP and 8-CPT-cAMP on ERK phosphorylation and neuritogenesis, indicating that it acts not only as an AC blocker, but also as an inhibitor of the NCS. Cyclic AMP 68-72 mitogen-activated protein kinase 1 Homo sapiens 109-112 23893412-8 2013 cAMP inhibited the growth of H1299 cells and Ras-dependent ERK activation via PKA. Cyclic AMP 0-4 mitogen-activated protein kinase 1 Homo sapiens 59-62 23800469-1 2013 G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor (GPCR)-mediated increases in the second messenger cyclic adenosine monophosphate (cAMP) activate the mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase (ERK), and in neuroendocrine cells, this pathway leads to cAMP-dependent neuritogenesis mediated through Rap1 and B-Raf. Cyclic AMP 316-320 mitogen-activated protein kinase 1 Homo sapiens 214-218 23800469-1 2013 G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor (GPCR)-mediated increases in the second messenger cyclic adenosine monophosphate (cAMP) activate the mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase (ERK), and in neuroendocrine cells, this pathway leads to cAMP-dependent neuritogenesis mediated through Rap1 and B-Raf. Cyclic AMP 316-320 mitogen-activated protein kinase 1 Homo sapiens 220-257 23800469-1 2013 G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor (GPCR)-mediated increases in the second messenger cyclic adenosine monophosphate (cAMP) activate the mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase (ERK), and in neuroendocrine cells, this pathway leads to cAMP-dependent neuritogenesis mediated through Rap1 and B-Raf. Cyclic AMP 316-320 mitogen-activated protein kinase 1 Homo sapiens 259-262 23800469-3 2013 With loss-of-function experiments in the rat neuronal cell line Neuroscreen-1 (NS-1) and gain-of-function experiments in human embryonic kidney 293T cells, we demonstrated that Rapgef2 connected GPCR-dependent activation of adenylate cyclase and increased cAMP concentration with the activation of ERK in neurons and endocrine cells. Cyclic AMP 256-260 mitogen-activated protein kinase 1 Homo sapiens 298-301 23800469-5 2013 Our data are consistent with a pathway involving the cAMP-mediated activation of Rapgef2, which then stimulates Rap1, leading to increases in B-Raf, MEK, and ERK activity. Cyclic AMP 53-57 mitogen-activated protein kinase 1 Homo sapiens 158-161 23690594-3 2013 Prosaptide stimulation of cells transfected with GPR37 or GPR37L1 induced the phosphorylation of ERK in a pertussis toxin-sensitive manner, stimulated (35)S-GTPgammaS binding, and promoted the inhibition of forskolin-stimulated cAMP production. Cyclic AMP 228-232 mitogen-activated protein kinase 1 Homo sapiens 97-100 23657011-11 2013 It requires complex formation of both kinases with GTP-Rac1 to unleash cAMP-PKA-boosted activation of Raf-Mek-Erk. Cyclic AMP 71-75 mitogen-activated protein kinase 1 Homo sapiens 110-113 23055509-3 2012 The transcriptome that emerged strongly implicates MAPK signaling and CREB-dependent transcription, with 74% of differentially expressed genes containing a cAMP response element (CRE) in their proximal promoter, more than half of which are conserved. Cyclic AMP 156-160 mitogen-activated protein kinase 1 Homo sapiens 51-55 22230192-4 2012 In addition, 8-Br-cAMP-induced PKA and Epac activation increased phosphorylation of extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase (MAPK), and nuclear factor kappa B (NF-kappaB), which were involved in expressions of SGLTs. Cyclic AMP 18-22 mitogen-activated protein kinase 1 Homo sapiens 84-121 22753408-0 2012 Dopamine- and cAMP-regulated phosphoprotein of 32-kDa (DARPP-32)-dependent activation of extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin complex 1 (mTORC1) signaling in experimental parkinsonism. Cyclic AMP 14-18 mitogen-activated protein kinase 1 Homo sapiens 89-126 22753408-0 2012 Dopamine- and cAMP-regulated phosphoprotein of 32-kDa (DARPP-32)-dependent activation of extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin complex 1 (mTORC1) signaling in experimental parkinsonism. Cyclic AMP 14-18 mitogen-activated protein kinase 1 Homo sapiens 128-131 22753408-4 2012 We also show that mutation of the phosphorylation site for cAMP-dependent protein kinase on DARPP-32 attenuates l-DOPA-induced dyskinesia and reduces the concomitant activations of ERK and mTORC1 signaling. Cyclic AMP 59-63 mitogen-activated protein kinase 1 Homo sapiens 181-184 22532442-0 2012 Signaling through the neuropeptide GPCR PAC1 induces neuritogenesis via a single linear cAMP- and ERK-dependent pathway using a novel cAMP sensor. Cyclic AMP 134-138 mitogen-activated protein kinase 1 Homo sapiens 98-101 22753408-5 2012 These studies demonstrate that, in D1R-expressing MSNs, l-DOPA-induced activation of ERK and mTORC1 requires DARPP-32 and indicates the importance of the cAMP/DARPP-32 signaling cascade in dyskinesia. Cyclic AMP 154-158 mitogen-activated protein kinase 1 Homo sapiens 85-88 22532442-4 2012 Forskolin (25 muM) and cAMP analogs (8-bromo-cAMP, dibutyryl-cAMP, and 8-chlorophenylthio-cAMP) stimulated ERK phosphorylation and neuritogenesis in NS-1 cells. Cyclic AMP 23-27 mitogen-activated protein kinase 1 Homo sapiens 107-110 22532442-8 2012 Thus, PACAP-38 potently stimulated two distinct and independent cAMP pathways leading to CREB or ERK activation in NS-1 cells. Cyclic AMP 64-68 mitogen-activated protein kinase 1 Homo sapiens 97-100 22532442-10 2012 In summary, a novel PKA- and Epac-independent signaling pathway: PACAP adenylate cyclase cAMP ERK neuritogenesis has been identified. Cyclic AMP 93-97 mitogen-activated protein kinase 1 Homo sapiens 100-103 22497928-3 2012 The pro-adipogenic and anti-osteogenic effect of 8-pCPT-2"-O-Me-cAMP was attributed to that 8-pCPT-2"-O-Me-cAMP led to the activation of protein kinase B (PKB) and cAMP response element-binding protein (CREB) as well as the inhibition of Ras homolog gene family member A (RhoA), focal adhesion kinase (FAK), extracellular-signal-regulated kinase (ERK) and runt-related transcription factor 2 (Runx2) activities. Cyclic AMP 64-68 mitogen-activated protein kinase 1 Homo sapiens 347-350 22497928-3 2012 The pro-adipogenic and anti-osteogenic effect of 8-pCPT-2"-O-Me-cAMP was attributed to that 8-pCPT-2"-O-Me-cAMP led to the activation of protein kinase B (PKB) and cAMP response element-binding protein (CREB) as well as the inhibition of Ras homolog gene family member A (RhoA), focal adhesion kinase (FAK), extracellular-signal-regulated kinase (ERK) and runt-related transcription factor 2 (Runx2) activities. Cyclic AMP 107-111 mitogen-activated protein kinase 1 Homo sapiens 347-350 22230192-4 2012 In addition, 8-Br-cAMP-induced PKA and Epac activation increased phosphorylation of extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase (MAPK), and nuclear factor kappa B (NF-kappaB), which were involved in expressions of SGLTs. Cyclic AMP 18-22 mitogen-activated protein kinase 1 Homo sapiens 123-126 22230192-4 2012 In addition, 8-Br-cAMP-induced PKA and Epac activation increased phosphorylation of extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase (MAPK), and nuclear factor kappa B (NF-kappaB), which were involved in expressions of SGLTs. Cyclic AMP 18-22 mitogen-activated protein kinase 1 Homo sapiens 167-171 22341864-4 2012 We found that cAMP inhibited NF-kappaB and ERK pathways through a PKA-dependent mechanism, while Dexamethasone blocked TCR-induced NF-kappaB signaling. Cyclic AMP 14-18 mitogen-activated protein kinase 1 Homo sapiens 43-46 22301787-1 2012 Modulation of MAPK signaling duration by cAMP defines its physiological output by driving cells toward proliferation or differentiation. Cyclic AMP 41-45 mitogen-activated protein kinase 1 Homo sapiens 14-18 21987453-2 2012 In PC2-defective mice, cyclic 3",5"-adenosine monophosphate/ protein kinase A (cAMP/PKA)-dependent activation of extracellular signal-regulated kinase/ mammalian target of rapamycin (ERK-mTOR) signaling stimulates cyst growth. Cyclic AMP 79-83 mitogen-activated protein kinase 1 Homo sapiens 183-186 22301787-8 2012 Because both DARPP-32 levels and function as inhibitor of protein phosphatase 1, a key inhibitor of MAPK kinase activity, are governed by cAMP/protein kinase A, the results may explain why in thyroid cells cAMP signaling downstream from TSH controls the duration of MAPK pathway activity. Cyclic AMP 138-142 mitogen-activated protein kinase 1 Homo sapiens 100-104 21278326-7 2011 We present evidence for a treprostinil/cAMP-induced downstream suppression of extracellular regulated kinase (ERK) that is transmitted via a protein kinase A-independent pathway through Rap proteins, which sequester Ras. Cyclic AMP 39-43 mitogen-activated protein kinase 1 Homo sapiens 78-108 21940623-7 2011 PKA, PI3K, and ERK inhibitors abolished PGE2- and cAMP-induced c-Fos and MMP-9 up-regulation, and ERK activation was required for the binding of activator protein 1 (AP-1) transcription factor to the MMP-9 promoter. Cyclic AMP 50-54 mitogen-activated protein kinase 1 Homo sapiens 15-18 22080750-10 2012 Activation of the cAMP/protein kinase A pathway, followed by p38 activation, is essential for these mechanisms. Cyclic AMP 18-22 mitogen-activated protein kinase 1 Homo sapiens 61-64 21816754-1 2011 In autosomal dominant polycystic kidney disease (ADPKD), arginine vasopressin (AVP) accelerates cyst growth by stimulating cAMP-dependent ERK activity and epithelial cell proliferation and by promoting Cl(-)-dependent fluid secretion. Cyclic AMP 123-127 mitogen-activated protein kinase 1 Homo sapiens 138-141 21278326-7 2011 We present evidence for a treprostinil/cAMP-induced downstream suppression of extracellular regulated kinase (ERK) that is transmitted via a protein kinase A-independent pathway through Rap proteins, which sequester Ras. Cyclic AMP 39-43 mitogen-activated protein kinase 1 Homo sapiens 110-113 21278326-10 2011 Thus our data suggest that treprostinil inhibits the adhesion and differentiation of fibrocytes by limiting the activity of ERK via the cAMP-Rap axis. Cyclic AMP 136-140 mitogen-activated protein kinase 1 Homo sapiens 124-127 21478863-1 2011 Melanocytes use BRAF to activate the MAP kinase (MAPK) pathway because CRAF is inhibited by the cyclic AMP (cAMP) pathway in these cells. Cyclic AMP 96-106 mitogen-activated protein kinase 1 Homo sapiens 49-53 21750416-0 2011 cAMP induces autophagy via a novel pathway involving ERK, cyclin E and Beclin 1. Cyclic AMP 0-4 mitogen-activated protein kinase 1 Homo sapiens 53-56 21750416-4 2011 Our data suggest a model in which cAMP-signaling via ERK-mediated induction of cyclin E leads to enhanced perinuclear recruitment of Beclin 1 and formation of autophagosomes. Cyclic AMP 34-38 mitogen-activated protein kinase 1 Homo sapiens 53-56 21118718-3 2011 This phenotypic difference in the proliferative response to cAMP appears to involve cross-talk between cAMP and Ca(2+) signaling to B-Raf, a kinase upstream of the MEK/ERK pathway. Cyclic AMP 60-64 mitogen-activated protein kinase 1 Homo sapiens 168-171 21118718-3 2011 This phenotypic difference in the proliferative response to cAMP appears to involve cross-talk between cAMP and Ca(2+) signaling to B-Raf, a kinase upstream of the MEK/ERK pathway. Cyclic AMP 103-107 mitogen-activated protein kinase 1 Homo sapiens 168-171 21118718-4 2011 In normal cells, B-Raf is repressed by Akt (protein kinase B), a Ca(2+)-dependent kinase, preventing cAMP activation of ERK and cell proliferation. Cyclic AMP 101-105 mitogen-activated protein kinase 1 Homo sapiens 120-123 21478863-1 2011 Melanocytes use BRAF to activate the MAP kinase (MAPK) pathway because CRAF is inhibited by the cyclic AMP (cAMP) pathway in these cells. Cyclic AMP 108-112 mitogen-activated protein kinase 1 Homo sapiens 49-53 21102438-8 2010 This offers mechanistic insight into cAMP-responsive control of ERK signalling events. Cyclic AMP 37-41 mitogen-activated protein kinase 1 Homo sapiens 64-67 21195128-6 2011 Cyclic AMP-related PKA inhibitors (H89, KI(6-22)) and Rp-cAMPS decreased p44/p42(mapk) phosphorylation but not ACTH-mediated cAMP production. Cyclic AMP 0-10 mitogen-activated protein kinase 1 Homo sapiens 81-85 21429300-3 2011 This study was conducted to determine if cAMP affects the antiapoptotic activity of insulin and the activity of PI3K and ERK in CHO cells expressing human insulin receptors (CHO-IR). Cyclic AMP 41-45 mitogen-activated protein kinase 1 Homo sapiens 121-124 21429300-4 2011 Insulin-stimulated ERK activity was completely suppressed by cAMP-elevating agents like as pertussis toxin (Ptx) and cholera toxin (Ctx) after 4 h treatment. Cyclic AMP 61-65 mitogen-activated protein kinase 1 Homo sapiens 19-22 21429300-8 2011 Taken together, cAMP antagonizes the antiapoptotic activity of insulin and the main target molecule of cAMP in this process is likely ERK, not PI3K-dependent PKB/Akt. Cyclic AMP 16-20 mitogen-activated protein kinase 1 Homo sapiens 134-137 21429300-8 2011 Taken together, cAMP antagonizes the antiapoptotic activity of insulin and the main target molecule of cAMP in this process is likely ERK, not PI3K-dependent PKB/Akt. Cyclic AMP 103-107 mitogen-activated protein kinase 1 Homo sapiens 134-137 21311231-4 2011 AKAP-Lbc associates with the ERK scaffold protein KSR-1 to organize a growth factor and cAMP responsive signaling network. Cyclic AMP 88-92 mitogen-activated protein kinase 1 Homo sapiens 29-32 21044952-6 2011 Pathway and motif activity analyses using transcriptome data additionally suggested that deregulated activation of GSK3beta (glycogen-synthase kinase 3beta) and MAPK1/3 signaling might be associated with altered activation of cAMP-responsive element-binding protein and AP-1 transcription factors in tamoxifen-resistant cells, and this hypothesis was validated by reporter assays. Cyclic AMP 226-230 mitogen-activated protein kinase 1 Homo sapiens 161-166 21429300-0 2011 cAMP antagonizes ERK-dependent antiapoptotic action of insulin. Cyclic AMP 0-4 mitogen-activated protein kinase 1 Homo sapiens 17-20 21084381-6 2011 ERK activation was comparable for wild-type and mutant MC1R and was independent on cAMP because it was neither triggered by stimulation of cAMP synthesis with forskolin nor blocked by the adenylyl cyclase inhibitor 2",5"-dideoxyadenosine. Cyclic AMP 139-143 mitogen-activated protein kinase 1 Homo sapiens 0-3 20357815-0 2010 Cyclic AMP suppresses matrix metalloproteinase-1 expression through inhibition of MAPK and GSK-3beta. Cyclic AMP 0-10 mitogen-activated protein kinase 1 Homo sapiens 82-86 20810616-0 2010 Sorafenib inhibits cAMP-dependent ERK activation, cell proliferation, and in vitro cyst growth of human ADPKD cyst epithelial cells. Cyclic AMP 19-23 mitogen-activated protein kinase 1 Homo sapiens 34-37 20810616-2 2010 cAMP agonists, including arginine vasopressin, accelerate cyst epithelial cell proliferation through protein kinase A activation of the B-Raf/MEK/extracellular signal-regulated kinase (ERK) signaling pathway. Cyclic AMP 0-4 mitogen-activated protein kinase 1 Homo sapiens 185-188 20810616-5 2010 We found that nanomolar concentrations of Sorafenib reduced the basal activity of ERK, inhibited cAMP-dependent activation of B-Raf and MEK/ERK signaling, and caused a concentration-dependent inhibition of cell proliferation induced by cAMP, epidermal growth factor, or the combination of the two agonists. Cyclic AMP 97-101 mitogen-activated protein kinase 1 Homo sapiens 140-143 20810616-5 2010 We found that nanomolar concentrations of Sorafenib reduced the basal activity of ERK, inhibited cAMP-dependent activation of B-Raf and MEK/ERK signaling, and caused a concentration-dependent inhibition of cell proliferation induced by cAMP, epidermal growth factor, or the combination of the two agonists. Cyclic AMP 236-240 mitogen-activated protein kinase 1 Homo sapiens 82-85 20610381-9 2010 We show that expression of Y53A-actin causes a 50% reduction of cell surface cAMP receptors, and inhibits cAMP-induced increases in adenylyl cyclase A activity, phosphorylation of ERK2, and actin polymerization. Cyclic AMP 106-110 mitogen-activated protein kinase 1 Homo sapiens 180-184 20357815-5 2010 cAMP inhibited TNF-alpha-stimulated ERK and JNK activation, which was shown to have an important role in MMP-1 expression. Cyclic AMP 0-4 mitogen-activated protein kinase 1 Homo sapiens 36-39 20357815-8 2010 Taken together, our results suggest that cAMP/PKA pathway can suppress MMP-1 expression through inhibition of multiple signaling pathways, including MAPK and GSK-3beta. Cyclic AMP 41-45 mitogen-activated protein kinase 1 Homo sapiens 149-153 20107853-0 2010 cAMP-induced auditory supporting cell proliferation is mediated by ERK MAPK signaling pathway. Cyclic AMP 0-4 mitogen-activated protein kinase 1 Homo sapiens 67-70 20107853-0 2010 cAMP-induced auditory supporting cell proliferation is mediated by ERK MAPK signaling pathway. Cyclic AMP 0-4 mitogen-activated protein kinase 1 Homo sapiens 71-75 20178980-9 2010 Chromatin immunoprecipitation assays demonstrated that binding of phosphorylated CREB1 and ATF2 to cAMP-response element-like sites was significantly increased with 8-Br-cAMP treatment and that binding was reduced with PKA, PI3K, and ERK inhibition, whereas transfection of Creb1 and Atf2 overexpression constructs enhanced cAMP-driven Cd39 mRNA expression. Cyclic AMP 170-174 mitogen-activated protein kinase 1 Homo sapiens 234-237 20178980-9 2010 Chromatin immunoprecipitation assays demonstrated that binding of phosphorylated CREB1 and ATF2 to cAMP-response element-like sites was significantly increased with 8-Br-cAMP treatment and that binding was reduced with PKA, PI3K, and ERK inhibition, whereas transfection of Creb1 and Atf2 overexpression constructs enhanced cAMP-driven Cd39 mRNA expression. Cyclic AMP 170-174 mitogen-activated protein kinase 1 Homo sapiens 234-237 20178980-9 2010 Chromatin immunoprecipitation assays demonstrated that binding of phosphorylated CREB1 and ATF2 to cAMP-response element-like sites was significantly increased with 8-Br-cAMP treatment and that binding was reduced with PKA, PI3K, and ERK inhibition, whereas transfection of Creb1 and Atf2 overexpression constructs enhanced cAMP-driven Cd39 mRNA expression. Cyclic AMP 99-103 mitogen-activated protein kinase 1 Homo sapiens 234-237 20178980-12 2010 These data identify cAMP as a crucial regulator of macrophage CD39 expression and demonstrate that cAMP acts through the PKA/CREB, PKA/PI3K/ATF2, and PKA/ERK/ATF2 pathways to control a key vascular homeostatic mediator. Cyclic AMP 99-103 mitogen-activated protein kinase 1 Homo sapiens 154-157 19949837-6 2010 These results indicate that high glucose can increase adipogenic and inhibit osteogenic differentiation by activating cAMP/PKA/ERK pathway in MG-63 cells, thereby providing further insight into the molecular mechanism of diabetic osteoporosis. Cyclic AMP 118-122 mitogen-activated protein kinase 1 Homo sapiens 127-130 20196770-0 2010 Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK. Cyclic AMP 31-35 mitogen-activated protein kinase 1 Homo sapiens 144-147 20015475-0 2010 Prostaglandin E2 activates cAMP response element-binding protein in glioma cells via a signaling pathway involving PKA-dependent inhibition of ERK. Cyclic AMP 27-31 mitogen-activated protein kinase 1 Homo sapiens 143-146 19218743-0 2009 [cAMP signaling for ERK activation in neuronal cells]. Cyclic AMP 1-5 mitogen-activated protein kinase 1 Homo sapiens 20-23 19385062-7 2009 The exchange protein directly activated by cAMP (Epac) activator, 8CPT-2Me-cAMP, promoted the Akt/eNOS/NO pathway and ERK phosphorylation,but did not induce CREB phosphorylation and VEGF expression. Cyclic AMP 43-47 mitogen-activated protein kinase 1 Homo sapiens 118-121 19385062-7 2009 The exchange protein directly activated by cAMP (Epac) activator, 8CPT-2Me-cAMP, promoted the Akt/eNOS/NO pathway and ERK phosphorylation,but did not induce CREB phosphorylation and VEGF expression. Cyclic AMP 75-79 mitogen-activated protein kinase 1 Homo sapiens 118-121 19223551-6 2009 Moreover, through the ERK pathway, RET/PTC stimulates cyclic AMP-responsive element binding protein (CREB) phosphorylation and promotes the formation of a beta-catenin-CREB-CREB-binding protein/p300 transcriptional complex. Cyclic AMP 54-64 mitogen-activated protein kinase 1 Homo sapiens 22-25 19725049-7 2009 We conclude that B-Raf/ERK and mTOR signaling play an essential role in cAMP-dependent, but PKA-independent, proliferation of cancer cells. Cyclic AMP 72-76 mitogen-activated protein kinase 1 Homo sapiens 23-26 18751959-8 2009 In particular, the reversed effect of cAMP agonist on cell proliferation was partly prevented by PKC, ERK1/2, and p38 MAPK blockade. Cyclic AMP 38-42 mitogen-activated protein kinase 1 Homo sapiens 114-117 18799465-1 2008 In Schwann cells (SCs), cyclic adenosine monophosphate (cAMP) enhances the action of neuregulin, the most potent known mitogen for SCs, by synergistically increasing the activation of two crucial signaling pathways: ERK and Akt. Cyclic AMP 24-54 mitogen-activated protein kinase 1 Homo sapiens 216-219 19155528-1 2009 Signaling from G(i/o)-coupled G protein-coupled receptors (GPCRs), such as the serotonin 1B, cannabinoid 1, and dopamine D2 receptors, inhibits cAMP production by adenylyl cyclases and activates protein kinases, such as Src, mitogen-activated protein kinases 1 and 2, and Akt. Cyclic AMP 144-148 mitogen-activated protein kinase 1 Homo sapiens 225-266 18799465-1 2008 In Schwann cells (SCs), cyclic adenosine monophosphate (cAMP) enhances the action of neuregulin, the most potent known mitogen for SCs, by synergistically increasing the activation of two crucial signaling pathways: ERK and Akt. Cyclic AMP 56-60 mitogen-activated protein kinase 1 Homo sapiens 216-219 18509114-7 2008 Because ERK is involved in translational control of long-lasting plasticity and memory, our data suggest that Epac is a crucial link between cAMP and ERK during some forms of protein synthesis-dependent LTP. Cyclic AMP 141-145 mitogen-activated protein kinase 1 Homo sapiens 8-11 18684840-7 2008 We found that high levels of cAMP interfered with agonist-activated p38 MAPK phosphorylation. Cyclic AMP 29-33 mitogen-activated protein kinase 1 Homo sapiens 68-71 18403484-7 2008 Using EMSA and a decoy oligonucleotide approach, the transcription factors activator protein-1 (activated by ERK and JNK) and cAMP response element-binding protein (activated by ERK) were found to be involved in the up-regulation of MKP-1 by dexamethasone. Cyclic AMP 126-130 mitogen-activated protein kinase 1 Homo sapiens 109-112 18403484-7 2008 Using EMSA and a decoy oligonucleotide approach, the transcription factors activator protein-1 (activated by ERK and JNK) and cAMP response element-binding protein (activated by ERK) were found to be involved in the up-regulation of MKP-1 by dexamethasone. Cyclic AMP 126-130 mitogen-activated protein kinase 1 Homo sapiens 178-181 18571589-11 2008 The cAMP stimulators forskolin and IBMX abolished TSP-1-induced chemotaxis and ERK and p38 activation. Cyclic AMP 4-8 mitogen-activated protein kinase 1 Homo sapiens 79-82 18571589-11 2008 The cAMP stimulators forskolin and IBMX abolished TSP-1-induced chemotaxis and ERK and p38 activation. Cyclic AMP 4-8 mitogen-activated protein kinase 1 Homo sapiens 87-90 18799615-2 2008 At variance with the cAMP-dependent mitogenesis of normal thyroid epithelial cells, we show here that cAMP and cAMP-dependent protein kinase activation inhibit S-phase entry in four thyroid carcinoma cell lines that harbor a permanent activation of the Raf/ERK pathway by different oncogenes. Cyclic AMP 102-106 mitogen-activated protein kinase 1 Homo sapiens 257-260 18799615-2 2008 At variance with the cAMP-dependent mitogenesis of normal thyroid epithelial cells, we show here that cAMP and cAMP-dependent protein kinase activation inhibit S-phase entry in four thyroid carcinoma cell lines that harbor a permanent activation of the Raf/ERK pathway by different oncogenes. Cyclic AMP 102-106 mitogen-activated protein kinase 1 Homo sapiens 257-260 18799615-3 2008 Only in Ret/PTC1-positive TPC-1 cells did cAMP markedly inhibit the Raf/ERK cascade, leading to mTOR pathway inhibition, repression of cyclin D1 and p21 and p27 accumulation. Cyclic AMP 42-46 mitogen-activated protein kinase 1 Homo sapiens 72-75 18174287-2 2008 Reports that ACTH may stimulate ERK/MAPK in Y1 cells have suggested a role for cAMP in this process. Cyclic AMP 79-83 mitogen-activated protein kinase 1 Homo sapiens 32-35 17995938-11 2008 Activation of exchange protein directly activated by cAMP (Epac) partially mimicked the effects of PACAP-38, and led to the phosphorylation of ERK but not p38 MAP kinase. Cyclic AMP 53-57 mitogen-activated protein kinase 1 Homo sapiens 143-146 18406603-3 2008 Although estrogen"s transcriptional effects occur through classical nuclear steroid receptors (ERs), recent studies reveal the existence of a novel 7-transmembrane G protein-coupled receptor, GPR30, which responds to estrogen and tamoxifen stimulation with rapid cellular signaling including ERK activation, PI3K activation, calcium mobilization and cAMP production. Cyclic AMP 350-354 mitogen-activated protein kinase 1 Homo sapiens 292-295 17995938-0 2008 PACAP-38 induces neuronal differentiation of human SH-SY5Y neuroblastoma cells via cAMP-mediated activation of ERK and p38 MAP kinases. Cyclic AMP 83-87 mitogen-activated protein kinase 1 Homo sapiens 111-114 17396115-5 2007 These cells had an increased sensitivity to IGF-1 and to cyclic AMP, which required phosphatidylinositol-3 (PI3)-kinase and the mitogen-activated protein kinase, extracellular signal-regulated protein kinase (ERK) for enhanced growth. Cyclic AMP 57-67 mitogen-activated protein kinase 1 Homo sapiens 162-207 17956250-6 2007 Functional phenotypes uncovered using these methodologies have shown that beta-arrestin-sequestered PDE4D5 shapes the spatial cAMP gradient around the membrane-bound beta(2)-AR, regulating its phosphorylation by PKA and its ability to activate ERK (extracellular-signal-regulated kinase) through G(i) in cardiomyocytes and HEK-293 (human embryonic kidney)-B2 cells. Cyclic AMP 126-130 mitogen-activated protein kinase 1 Homo sapiens 244-247 17956250-6 2007 Functional phenotypes uncovered using these methodologies have shown that beta-arrestin-sequestered PDE4D5 shapes the spatial cAMP gradient around the membrane-bound beta(2)-AR, regulating its phosphorylation by PKA and its ability to activate ERK (extracellular-signal-regulated kinase) through G(i) in cardiomyocytes and HEK-293 (human embryonic kidney)-B2 cells. Cyclic AMP 126-130 mitogen-activated protein kinase 1 Homo sapiens 249-286 17947509-5 2008 The activated ERKs did not translocate into the nucleus, but phosphorylated 90-kDa ribosomal S6 kinase and induced the activity of transcription factor cAMP response element-binding protein. Cyclic AMP 152-156 mitogen-activated protein kinase 1 Homo sapiens 14-18 17875734-6 2007 Here, we show that PGE(2) or its surrogate hormonal mixture dibutyryl cAMP (Bt(2)cAMP) + phorbol diacetate (PDA) stimulated the p38, c-jun NH(2)-terminal kinase (JNK)-1, and extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase pathways. Cyclic AMP 70-74 mitogen-activated protein kinase 1 Homo sapiens 174-211 17875734-6 2007 Here, we show that PGE(2) or its surrogate hormonal mixture dibutyryl cAMP (Bt(2)cAMP) + phorbol diacetate (PDA) stimulated the p38, c-jun NH(2)-terminal kinase (JNK)-1, and extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase pathways. Cyclic AMP 70-74 mitogen-activated protein kinase 1 Homo sapiens 213-216 17875734-6 2007 Here, we show that PGE(2) or its surrogate hormonal mixture dibutyryl cAMP (Bt(2)cAMP) + phorbol diacetate (PDA) stimulated the p38, c-jun NH(2)-terminal kinase (JNK)-1, and extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase pathways. Cyclic AMP 81-85 mitogen-activated protein kinase 1 Homo sapiens 174-211 17875734-6 2007 Here, we show that PGE(2) or its surrogate hormonal mixture dibutyryl cAMP (Bt(2)cAMP) + phorbol diacetate (PDA) stimulated the p38, c-jun NH(2)-terminal kinase (JNK)-1, and extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase pathways. Cyclic AMP 81-85 mitogen-activated protein kinase 1 Homo sapiens 213-216 17396115-5 2007 These cells had an increased sensitivity to IGF-1 and to cyclic AMP, which required phosphatidylinositol-3 (PI3)-kinase and the mitogen-activated protein kinase, extracellular signal-regulated protein kinase (ERK) for enhanced growth. Cyclic AMP 57-67 mitogen-activated protein kinase 1 Homo sapiens 209-212 17377064-5 2007 Similarly, using pharmacological, genetic, and molecular tools, we observed that 5-HT(4)Rs in human embryonic kidney 293 cells, activated the ERK pathway in a G(s)/cAMP/PKA-independent manner. Cyclic AMP 164-168 mitogen-activated protein kinase 1 Homo sapiens 142-145 17298385-0 2007 (-)Epicatechin stimulates ERK-dependent cyclic AMP response element activity and up-regulates GluR2 in cortical neurons. Cyclic AMP 40-50 mitogen-activated protein kinase 1 Homo sapiens 26-29 17254020-2 2007 In these cells, ERKs are activated by diverse stimuli, including cyclic adenosine monophosphate (cAMP), pituitary adenylate cyclase activating protein (PACAP), depolarization induced by elevated extracellular potassium (KCl), and the neurotrophin brain-derived neurotrophic factor. Cyclic AMP 65-95 mitogen-activated protein kinase 1 Homo sapiens 16-20 17307136-4 2007 We demonstrate that BCP crystals induce c-fos expression primarily through a Ras/ERK-dependent signaling mechanism targeting two highly conserved regulatory binding sites, the serum response element (SRE) and the cAMP response element (CRE). Cyclic AMP 213-217 mitogen-activated protein kinase 1 Homo sapiens 81-84 17254020-0 2007 The requirement of Ras and Rap1 for the activation of ERKs by cAMP, PACAP, and KCl in cerebellar granule cells. Cyclic AMP 62-66 mitogen-activated protein kinase 1 Homo sapiens 54-58 17254020-2 2007 In these cells, ERKs are activated by diverse stimuli, including cyclic adenosine monophosphate (cAMP), pituitary adenylate cyclase activating protein (PACAP), depolarization induced by elevated extracellular potassium (KCl), and the neurotrophin brain-derived neurotrophic factor. Cyclic AMP 97-101 mitogen-activated protein kinase 1 Homo sapiens 16-20 17254020-3 2007 Extensive studies in neuronal cell lines have implicated the small G proteins Ras and Rap1 in the activation of ERKs by cAMP, PACAP, and KCl. Cyclic AMP 120-124 mitogen-activated protein kinase 1 Homo sapiens 112-116 17254020-8 2007 Using both adenoviral and transgenic approaches, we show that Ras plays a major role in ERK activation by cAMP, PACAP, and KCl, while Rap1 also mediates activation of a selective membrane-associated pool of ERKs. Cyclic AMP 106-110 mitogen-activated protein kinase 1 Homo sapiens 88-91 17031853-12 2007 Activation of EP4 receptor resulted in cAMP-mediated phosphorylation of Raf-1 on Ser259, a negative regulatory site, and blocked activation of Raf-1/MEK/ERK cascade. Cyclic AMP 39-43 mitogen-activated protein kinase 1 Homo sapiens 153-156 17426247-7 2007 Transcriptional activation of HIF-1-dependent promoters was dependent on the active ERK pathway, and the association of HIF-1alpha protein with cyclic AMP-responsive element binding protein was enhanced by Id-1. Cyclic AMP 144-154 mitogen-activated protein kinase 1 Homo sapiens 84-87 16959941-0 2006 cAMP inhibits transforming growth factor-beta-stimulated collagen synthesis via inhibition of extracellular signal-regulated kinase 1/2 and Smad signaling in cardiac fibroblasts. Cyclic AMP 0-4 mitogen-activated protein kinase 1 Homo sapiens 94-135