PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2540210-0 1989 Interleukin 1 stimulates prostaglandin synthesis and cyclic AMP accumulation in Swiss 3T3 fibroblasts: interactions between two second messenger systems. Cyclic AMP 53-63 interleukin 1 alpha Homo sapiens 0-13 2540210-3 1989 IL-1 also stimulated cAMP accumulation. Cyclic AMP 21-25 interleukin 1 alpha Homo sapiens 0-4 2540210-4 1989 Indomethacin blocked cAMP accumulation in response to IL-1, suggesting that PGE2 was responsible for the increase. Cyclic AMP 21-25 interleukin 1 alpha Homo sapiens 54-58 2540210-8 1989 PGE2 augmented thymidine incorporation by increasing cAMP accumulation because in the presence of indomethacin addition of exogenous cAMP enhanced thymidine incorporation in response to low concentrations of IL-1. Cyclic AMP 133-137 interleukin 1 alpha Homo sapiens 208-212 2540210-12 1989 PGE2, in turn, stimulates cAMP accumulation which potentiates IL-1-stimulated PGE2 synthesis and thymidine incorporation. Cyclic AMP 26-30 interleukin 1 alpha Homo sapiens 62-66 2484435-4 1989 Other agents that increase intracellular cAMP, such as prostaglandin E (PGE) or isobutyl-methylxanthine (IBMX), also synergized with IL-1 or TNF alpha (but not with FK). Cyclic AMP 41-45 interleukin 1 alpha Homo sapiens 133-137 2826581-8 1987 Dex-mediated inhibition of IL-1 release in prestimulated cells is likely to occur via increased levels of cAMP, which have been shown to block post-transcriptional IL-1 synthesis. Cyclic AMP 106-110 interleukin 1 alpha Homo sapiens 27-31 3261237-7 1988 IL-1 also inhibited hCG-stimulated cAMP formation, as well as 8-bromo-cAMP- and forskolin-stimulated testosterone synthesis. Cyclic AMP 35-39 interleukin 1 alpha Homo sapiens 0-4 2842790-0 1988 Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin 1 in human fibroblasts: role in the induction of interleukin 6. Cyclic AMP 15-19 interleukin 1 alpha Homo sapiens 87-100 2842790-2 1988 Our present study shows that exposure of human FS-4 fibroblasts to TNF or IL-1 caused a rapid accumulation of intracellular cAMP and an increase in protein kinase activity. Cyclic AMP 124-128 interleukin 1 alpha Homo sapiens 74-78 2842790-3 1988 Intracellular cAMP levels peaked 3-5 min after the addition of TNF or IL-1 and returned to basal level by 15 min. Cyclic AMP 14-18 interleukin 1 alpha Homo sapiens 70-74 2826581-8 1987 Dex-mediated inhibition of IL-1 release in prestimulated cells is likely to occur via increased levels of cAMP, which have been shown to block post-transcriptional IL-1 synthesis. Cyclic AMP 106-110 interleukin 1 alpha Homo sapiens 164-168 2826581-9 1987 Our results indicate that glucocorticoids suppress IL-1 synthesis by two distinct mechanisms, blocking transcription of IL-1 mRNA during monocyte activation, and blocking post-transcriptional IL-1 synthesis via cAMP. Cyclic AMP 211-215 interleukin 1 alpha Homo sapiens 51-55 3108877-6 1987 The enhancement of IFN-beta 2 gene expression by diC8, interleukin 1, or tumor necrosis factor was not prevented by H8, a preferential inhibitor of cAMP- and cGMP-dependent protein kinases, but was blocked by H7, an inhibitor of protein kinase C as well as of cyclic nucleotide-dependent protein kinases. Cyclic AMP 148-152 interleukin 1 alpha Homo sapiens 49-94 2828770-3 1987 Antigen-reactive B cells mount a strong immune response in the presence of IL-1 and IL-2 when their cAMP is high, but become unresponsive when their cAMP is low. Cyclic AMP 100-104 interleukin 1 alpha Homo sapiens 75-79 2828770-4 1987 We show here that reagents which raise cAMP concentrations (Prostaglandin E, cholera toxin, forskolin) synergize strongly with IL-1 and IL-2 in the generation of antibody. Cyclic AMP 39-43 interleukin 1 alpha Homo sapiens 127-131 33324330-6 2020 Second messengers, cAMP and calcium, are triggered by TAAR1 activation, which is upregulated by IL-1beta METH-mediated increases in these second messengers and signal transduction pathways have not been shown to directly decrease astrocyte EAAT-2. Cyclic AMP 19-23 interleukin 1 alpha Homo sapiens 96-104 3021848-0 1986 Prostaglandins posttranscriptionally inhibit monocyte expression of interleukin 1 activity by increasing intracellular cyclic adenosine monophosphate. Cyclic AMP 119-149 interleukin 1 alpha Homo sapiens 68-81 3021848-6 1986 Other agents that cause an increase in levels of cellular cAMP, including theophylline, isobutylmethylxanthine, dibutyryl cAMP, or cholera toxin, also reversibly reduced expression of IL 1 by stimulated monocytes. Cyclic AMP 58-62 interleukin 1 alpha Homo sapiens 184-188 3021848-6 1986 Other agents that cause an increase in levels of cellular cAMP, including theophylline, isobutylmethylxanthine, dibutyryl cAMP, or cholera toxin, also reversibly reduced expression of IL 1 by stimulated monocytes. Cyclic AMP 122-126 interleukin 1 alpha Homo sapiens 184-188 3019358-5 1986 These results suggest that the IL-1 induction of synovial cell PA occurs via generation of endogenous PGE2 and cAMP. Cyclic AMP 111-115 interleukin 1 alpha Homo sapiens 31-35 3019358-0 1986 Evidence that interleukin-1 induction of synovial cell plasminogen activator is mediated via prostaglandin E2 and cAMP. Cyclic AMP 114-118 interleukin 1 alpha Homo sapiens 14-27 2857137-5 1985 Opposing these effects of cyclic AMP are those of cyclic GMP and an expanding collection of compounds that increase its levels: acetylcholine (muscarinic), ascorbate, calcium ionophore, hydroperoxides of arachidonic acid, hypoxanthine derivatives, interleukin 1, serotonin, thymic hormones, and plant lectin mitogens. Cyclic AMP 26-36 interleukin 1 alpha Homo sapiens 248-261 24054992-5 2014 Moreover, downregulating IPAF (which was found to be regulated by cAMP response element-binding protein) in astrocytes through silencing to decrease IL-1beta secretion from the astrocytes reduced the generation of amyloid-beta42 by primary neurons. Cyclic AMP 66-70 interleukin 1 alpha Homo sapiens 149-157 32298238-5 2020 The inflammatory cytokine IL-1beta reduced cAMP generation and CREB-mediated transcription of VE-cadherin. Cyclic AMP 43-47 interleukin 1 alpha Homo sapiens 26-34 11368781-1 2001 We have recently reported that interleukin-1alpha (IL-1alpha) can induce human macrophage colony-stimulating factor (M-CSF) expression through nuclear factor kappaB (NF-kappaB) activation, and treatment of human pancreatic MIA PaCa-2 cancer cells with forskolin or cAMP attenuated the NF-kappaB activation as well as M-CSF expression. Cyclic AMP 265-269 interleukin 1 alpha Homo sapiens 31-49 18784253-9 2008 As a physiological activator of CREB, interleukin 1alpha triggered MEKK1-dependent phosphorylation of TORC1 and its consequent recruitment to the cAMP response elements in the interleukin 8 promoter. Cyclic AMP 146-150 interleukin 1 alpha Homo sapiens 38-56 29539150-10 2005 Dibutyryl cAMP, a cAMP analog, and forskolin, an adenylate cyclase activator, significantly inhibited IL-1alpha-stimulated MMP-3 production in PDL cells. Cyclic AMP 10-14 interleukin 1 alpha Homo sapiens 102-111 29539150-10 2005 Dibutyryl cAMP, a cAMP analog, and forskolin, an adenylate cyclase activator, significantly inhibited IL-1alpha-stimulated MMP-3 production in PDL cells. Cyclic AMP 18-22 interleukin 1 alpha Homo sapiens 102-111 29539150-11 2005 CONCLUSIONS: These data suggest that COX-2-dependent PGE2 downregulates IL-1alpha-elicited MMP-3 production by cAMP-dependent pathways via EP2 /EP4 receptors in human PDL cells. Cyclic AMP 111-115 interleukin 1 alpha Homo sapiens 72-81 11564822-7 2001 CGS-21680 stimulated an increase in intracellular cAMP in a time- and dose-dependent manner in IL-1- and TNF-alpha-treated cells but not in control or IFN-gamma-treated cells. Cyclic AMP 50-54 interleukin 1 alpha Homo sapiens 95-99 19210337-12 2009 Exogenous prostaglandin E(2), butaprost (an EP2 receptor agonist) and dibutyryl cAMP abolished the inhibitory effect of indomethacin on interleukin-1alpha-induced vascular endothelial growth factor production. Cyclic AMP 80-84 interleukin 1 alpha Homo sapiens 136-154 15948687-10 2005 Dibutyryl cAMP, a cAMP analog, and forskolin, an adenylate cyclase activator, significantly inhibited IL-1alpha-stimulated MMP-3 production in PDL cells. Cyclic AMP 10-14 interleukin 1 alpha Homo sapiens 102-111 15948687-10 2005 Dibutyryl cAMP, a cAMP analog, and forskolin, an adenylate cyclase activator, significantly inhibited IL-1alpha-stimulated MMP-3 production in PDL cells. Cyclic AMP 18-22 interleukin 1 alpha Homo sapiens 102-111 15948687-11 2005 CONCLUSIONS: These data suggest that COX-2-dependent PGE2 downregulates IL-1alpha-elicited MMP-3 production by cAMP-dependent pathways via EP2/EP4 receptors in human PDL cells. Cyclic AMP 111-115 interleukin 1 alpha Homo sapiens 72-81 15780952-6 2005 The addition of cell-permeable PKI, an inhibitor of the cAMP/PKA signaling pathway, to the cocultures 8 h after the IL-1alpha stimulation inhibited IL-1alpha-induced TRAP+ cell formation. Cyclic AMP 56-60 interleukin 1 alpha Homo sapiens 148-157 12040027-4 2002 IL-1 increased SP-A expression in lung type II cells and had additive stimulatory effects with cAMP. Cyclic AMP 95-99 interleukin 1 alpha Homo sapiens 0-4 12040027-5 2002 Nuclear extracts from cAMP- or IL-1-treated type II cells manifested increased binding to NF-kappaB consensus and TBE probes; cAMP and IL-1 had additive effects. Cyclic AMP 22-26 interleukin 1 alpha Homo sapiens 135-139 12040027-5 2002 Nuclear extracts from cAMP- or IL-1-treated type II cells manifested increased binding to NF-kappaB consensus and TBE probes; cAMP and IL-1 had additive effects. Cyclic AMP 126-130 interleukin 1 alpha Homo sapiens 31-35 11368781-11 2001 Wholly, these studies indicate that elevated cAMP antagonizes IL-1-induced M-CSF transcription by up-regulating IkappaBalpha gene induction and its consequent attenuation of NF-kappaB activation. Cyclic AMP 45-49 interleukin 1 alpha Homo sapiens 62-66 11368781-1 2001 We have recently reported that interleukin-1alpha (IL-1alpha) can induce human macrophage colony-stimulating factor (M-CSF) expression through nuclear factor kappaB (NF-kappaB) activation, and treatment of human pancreatic MIA PaCa-2 cancer cells with forskolin or cAMP attenuated the NF-kappaB activation as well as M-CSF expression. Cyclic AMP 265-269 interleukin 1 alpha Homo sapiens 51-60 9138453-4 1997 RESULTS: Numerous studies indicate that TNF and IL-1 inhibit gonadotropin-stimulated steroidogenesis of undifferentiated ovarian cells due to inhibition of adenylyl cyclase and post-cAMP sites. Cyclic AMP 182-186 interleukin 1 alpha Homo sapiens 48-52 10200497-5 1998 Additionally, IL-1 depresses beta-cell energy production, insulin gene expression and cyclic AMP synthesis, and impacts negatively on different parts of the insulin stimulus-secretion coupling, actions mimicked by NO. Cyclic AMP 86-96 interleukin 1 alpha Homo sapiens 14-18 9769026-8 1998 A strengthening of the cAMP-dependent signaling chains was found to counteract the proliferation rate, the formation of free oxygen radicals, and the stimulated release of TNF-alpha and IL-1beta in cultivated microglia. Cyclic AMP 23-27 interleukin 1 alpha Homo sapiens 186-194 9401927-4 1997 This IL-1 alpha, IL-1 beta, or TNF-alpha-induced IL-6 production was enhanced, but the cAMP accumulation they induced was inhibited by the addition of indomethacin. Cyclic AMP 87-91 interleukin 1 alpha Homo sapiens 5-15 7544275-2 1995 IL-1 blocks human CG-induced cAMP and testosterone formation, as well as cytochrome P450 side-chain cleavage messenger RNA (mRNA) expression. Cyclic AMP 29-33 interleukin 1 alpha Homo sapiens 0-4 8587236-2 1995 The objective of this study was to investigate the role of cAMP in the regulation of IL-6 and IL-8 gene expression and peptide production in IL-1 stimulated human MC. Cyclic AMP 59-63 interleukin 1 alpha Homo sapiens 141-145 8587236-8 1995 Thus our data show that cAMP can potentiate IL-1 induced IL-6 production, while having no effect on IL-8 induction, and PGE2 may operate via a positive feedback loop to up-regulate IL-1 induced IL-6. Cyclic AMP 24-28 interleukin 1 alpha Homo sapiens 44-48 8587236-9 1995 Taken together, our results demonstrate that cAMP differentially regulates IL-6 and IL-8 production in IL-1-stimulated human MC. Cyclic AMP 45-49 interleukin 1 alpha Homo sapiens 103-107 8746788-3 1995 We previously reported that IL-1 upregulates transcription and cell surface molecules of type I IL-1R in TIG-1 cells through induction of prostaglandin (PG) E2 and cAMP accumulation. Cyclic AMP 164-168 interleukin 1 alpha Homo sapiens 28-32 7578979-3 1995 IL-1-induced cAMP was associated with a marked increase in prostacyclin (PGI2) production, and was reversed by indomethacin and tranylcypromine, inhibitors of cyclooxygenase and PGI2 synthetase respectively. Cyclic AMP 13-17 interleukin 1 alpha Homo sapiens 0-4 7578979-0 1995 Interleukin 1 induces prostacyclin-dependent increases in cyclic AMP production and does not affect cyclic GMP production in human vascular smooth muscle cells. Cyclic AMP 58-68 interleukin 1 alpha Homo sapiens 0-13 7578979-4 1995 Furthermore, PGI2, but not PGE2, was a potent inducer of cAMP production in HSVSMC, implicating a role for PGI2 in mediating IL-1-induced cAMP production. Cyclic AMP 138-142 interleukin 1 alpha Homo sapiens 125-129 7578979-2 1995 In the present study, IL-1 markedly increased intracellular levels of the vasodilatory mediator, cAMP, in human saphenous and human aortic VSMC. Cyclic AMP 97-101 interleukin 1 alpha Homo sapiens 22-26 7578979-7 1995 The results implicate prostacyclin-dependent cAMP production as a mediator of the vasodilatory effects of IL-1 in humans. Cyclic AMP 45-49 interleukin 1 alpha Homo sapiens 106-110 8311930-4 1993 RESULTS: HMC were found to specifically bind [125I]IL-1 with an apparent Kd of 2 x 10(-10) M. Incubation of HMC with IL-1 or TNF caused a time-dependent and dose-dependent accumulation of cAMP, as well as a significant potentiation of forskolin-promoted cAMP production. Cyclic AMP 188-192 interleukin 1 alpha Homo sapiens 117-121 7714166-5 1994 TNF alpha and IL-1 significantly suppressed cAMP-stimulated prolactin production by endometrial stromal cells. Cyclic AMP 44-48 interleukin 1 alpha Homo sapiens 14-18 7714166-7 1994 These results indicated that TNF alpha and IL-1 suppress both progesterone-induced and cAMP-mediated prolactin production in endometrial stromal cells, and that this inhibition was not attributable to direct effects on progesterone metabolism or related to Ca(2+)-mediated signal transduction. Cyclic AMP 87-91 interleukin 1 alpha Homo sapiens 43-47 8311930-4 1993 RESULTS: HMC were found to specifically bind [125I]IL-1 with an apparent Kd of 2 x 10(-10) M. Incubation of HMC with IL-1 or TNF caused a time-dependent and dose-dependent accumulation of cAMP, as well as a significant potentiation of forskolin-promoted cAMP production. Cyclic AMP 254-258 interleukin 1 alpha Homo sapiens 117-121 8311930-7 1993 CONCLUSIONS: It is suggested that IL-1 and TNF may activate one or more isoforms of the catalytic component of adenylyl cyclase, raising intracellular cAMP. Cyclic AMP 151-155 interleukin 1 alpha Homo sapiens 34-38 8099911-8 1993 Furthermore, elevation of intracellular cAMP levels by 8-bromo-cAMP, forskolin, or cholera toxin potentiated the effect of suboptimal concentration of colchicine on IL-1 synthesis. Cyclic AMP 40-44 interleukin 1 alpha Homo sapiens 165-169 8144314-1 1993 Cyclic AMP, protein kinase A and NF kappa B have been implicated as second messengers in the interleukin-1 (IL-1) action pathway. Cyclic AMP 0-10 interleukin 1 alpha Homo sapiens 93-106 8381280-3 1993 IL-1 was found to elicit a dose-dependent rise in adenyl cyclase activity in isolated K562 membranes, as well as increasing cAMP concentrations in whole cells. Cyclic AMP 124-128 interleukin 1 alpha Homo sapiens 0-4 8381280-4 1993 cAMP concentrations were found to peak within 3 minutes of IL-1 stimulation. Cyclic AMP 0-4 interleukin 1 alpha Homo sapiens 59-63 8180318-1 1993 The inhibitory effect of interleukin (IL)-1 on thyroid cell functions, including cAMP and thyroglobulin production, is well documented. Cyclic AMP 81-85 interleukin 1 alpha Homo sapiens 25-43 8461522-5 1993 These cytokines also inhibit contractility and nitric oxide release (a vasodilator), and IL-1 and TNF-alpha have been found to reduce adrenergic stimulation of myocardial contractility by reducing intracellular cyclic AMP levels and uncoupling adenylate cyclase from beta receptors. Cyclic AMP 211-221 interleukin 1 alpha Homo sapiens 89-93 8381280-0 1993 Cyclic adenosine 3",5"-monophosphate, a second messenger in interleukin-1 mediated K562 cytostasis. Cyclic AMP 0-36 interleukin 1 alpha Homo sapiens 60-73 8381280-1 1993 This study evaluates intracellular cAMP concentrations, in interleukin-1 (IL-1) mediated cytostasis of K562 cells. Cyclic AMP 35-39 interleukin 1 alpha Homo sapiens 59-72 8381280-1 1993 This study evaluates intracellular cAMP concentrations, in interleukin-1 (IL-1) mediated cytostasis of K562 cells. Cyclic AMP 35-39 interleukin 1 alpha Homo sapiens 74-78 8144314-1 1993 Cyclic AMP, protein kinase A and NF kappa B have been implicated as second messengers in the interleukin-1 (IL-1) action pathway. Cyclic AMP 0-10 interleukin 1 alpha Homo sapiens 108-112 1376256-6 1992 Altogether, our results demonstrate that the activation of a tyrosine kinase(s) is an early and major event that happens after IL-1/IL-1R interaction, leading to an increase in intracellular cAMP which results in c-myb and IL-5 mRNA expression. Cyclic AMP 191-195 interleukin 1 alpha Homo sapiens 127-131 1322303-6 1992 Accumulation of intracellular cAMP generated by IL-1 through the 80-kDa IL-1R negatively regulated c-fos expression which was induced by IL-1 through PKC activation. Cyclic AMP 30-34 interleukin 1 alpha Homo sapiens 48-52 1322303-6 1992 Accumulation of intracellular cAMP generated by IL-1 through the 80-kDa IL-1R negatively regulated c-fos expression which was induced by IL-1 through PKC activation. Cyclic AMP 30-34 interleukin 1 alpha Homo sapiens 72-76 1315688-0 1992 Interleukin-1 up-regulates transcription of its own receptor in a human fibroblast cell line TIG-1: role of endogenous PGE2 and cAMP. Cyclic AMP 128-132 interleukin 1 alpha Homo sapiens 0-13 1315505-5 1992 Dibutyryl-cAMP as well as other cAMP elevating agents such as theophylline and forskolin also suppressed IL-1-induced CSF-1 production, suggesting that cAMP concentrations inversely regulate the biosynthesis of CSF-1. Cyclic AMP 10-14 interleukin 1 alpha Homo sapiens 105-109 1315505-5 1992 Dibutyryl-cAMP as well as other cAMP elevating agents such as theophylline and forskolin also suppressed IL-1-induced CSF-1 production, suggesting that cAMP concentrations inversely regulate the biosynthesis of CSF-1. Cyclic AMP 32-36 interleukin 1 alpha Homo sapiens 105-109 1315505-6 1992 Measurement of cAMP concentration indicated that IL-1 treatment of MIA PaCa-2 cells did not change the cAMP level. Cyclic AMP 15-19 interleukin 1 alpha Homo sapiens 49-53 1315688-2 1992 After 2 h of stimulation with human recombinant IL-1 alpha or IL-1 beta, the levels of T cell/fibroblast-type IL-1R mRNA increased, and the elevation was sustained for at least 72 h. IL-1 also stimulated synthesis of prostaglandin E2 (PGE2) and secondary cAMP accumulation. Cyclic AMP 255-259 interleukin 1 alpha Homo sapiens 48-58 1571831-7 1992 These results suggest that the cytokines, IL-1 and TNF-beta, can increase t-PA activity in G292 cells and that there is both a cAMP-dependent as well as a cAMP-independent pathway involved in the regulation of this osteoblastic cell function. Cyclic AMP 127-131 interleukin 1 alpha Homo sapiens 42-46 1662225-0 1991 Interleukin-1 alpha modulates luteinizing hormone stimulated cyclic AMP and progesterone release from human granulosa cells in vitro. Cyclic AMP 61-71 interleukin 1 alpha Homo sapiens 0-19 1661292-1 1991 The effects of increasing intracellular cAMP levels on IL-1 alpha and IL-1 beta mRNA expression and IL-1 production in human monocytes and nonlymphoid hematopoietic cell lines were examined. Cyclic AMP 40-44 interleukin 1 alpha Homo sapiens 55-65 1661292-3 1991 Dibutyryl cAMP, 8-bromo-cAMP, forskolin, cholera toxin, PGE1, and PGE2 synergized with PMA or LPS to increase the accumulation in cell lines of IL-1 alpha mRNA by up to 50-fold and that of IL-1 beta mRNA by 10- to 20-fold compared to LPS or PMA alone. Cyclic AMP 10-14 interleukin 1 alpha Homo sapiens 144-154 1662225-6 1991 However, at the highest concentration tested (50 IU/ml), IL-1 alpha enhanced cyclic AMP accumulation over that seen with LH alone. Cyclic AMP 77-87 interleukin 1 alpha Homo sapiens 57-67 1571831-7 1992 These results suggest that the cytokines, IL-1 and TNF-beta, can increase t-PA activity in G292 cells and that there is both a cAMP-dependent as well as a cAMP-independent pathway involved in the regulation of this osteoblastic cell function. Cyclic AMP 155-159 interleukin 1 alpha Homo sapiens 42-46 1663075-8 1991 Scavenger receptor-mediated IL-1 production was inhibited by H7, a protein kinase C inhibitor, and enhanced by IBMX, an inhibitor of cyclic AMP degradation, suggesting a synergistic effect of protein kinase C and cyclic AMP-mediated signal transduction pathways in scavenger receptor-mediated IL-1 production. Cyclic AMP 133-143 interleukin 1 alpha Homo sapiens 28-32 1663075-8 1991 Scavenger receptor-mediated IL-1 production was inhibited by H7, a protein kinase C inhibitor, and enhanced by IBMX, an inhibitor of cyclic AMP degradation, suggesting a synergistic effect of protein kinase C and cyclic AMP-mediated signal transduction pathways in scavenger receptor-mediated IL-1 production. Cyclic AMP 213-223 interleukin 1 alpha Homo sapiens 28-32 1663075-8 1991 Scavenger receptor-mediated IL-1 production was inhibited by H7, a protein kinase C inhibitor, and enhanced by IBMX, an inhibitor of cyclic AMP degradation, suggesting a synergistic effect of protein kinase C and cyclic AMP-mediated signal transduction pathways in scavenger receptor-mediated IL-1 production. Cyclic AMP 213-223 interleukin 1 alpha Homo sapiens 293-297 1657905-0 1991 Cyclic adenosine 3",5"-monophosphate suppresses interleukin 1-induced synthesis of matrix metalloproteinases but not of tissue inhibitor of metalloproteinases in human uterine cervical fibroblasts. Cyclic AMP 0-36 interleukin 1 alpha Homo sapiens 48-61 1657905-2 1991 Here, we have examined the exact participation of cAMP in the IL-1-induced production of the precursors of matrix metalloproteinase (MMPs) and their specific inhibitor, tissue inhibitor of metalloproteinases (TIMP) in human uterine cervical fibroblasts. Cyclic AMP 50-54 interleukin 1 alpha Homo sapiens 62-66 1657905-3 1991 IL-1 significantly augmented the production of proMMP-1 (vertebrate procollagenase), proMMP-3 (prostromelysin), and TIMP without detectable changes in the intracellular level of cAMP. Cyclic AMP 178-182 interleukin 1 alpha Homo sapiens 0-4 1874173-2 1991 We have reported that IL-1 inhibited hCG-induced cAMP and testosterone formation. Cyclic AMP 49-53 interleukin 1 alpha Homo sapiens 22-26 1662225-7 1991 At a lower concentration, IL-1 alpha either had no effect or was slightly inhibitory to the LH-induced cyclic AMP accumulation, depending on the culture period. Cyclic AMP 103-113 interleukin 1 alpha Homo sapiens 26-36 2175325-0 1990 cAMP mediates IL-1-induced lymphocyte penetration through endothelial monolayers. Cyclic AMP 0-4 interleukin 1 alpha Homo sapiens 14-18 1645326-8 1991 These results indicate that the binding of IGIV to PEC via Fc gamma receptors (Fc gamma R) induces the elevation of intracellular cAMP levels, resulting in the suppression of LPS-induced TNF-alpha and IL-1 productions. Cyclic AMP 130-134 interleukin 1 alpha Homo sapiens 201-205 1812993-2 1991 Interleukin-1 is a potent inhibitor of thyroglobulin and cAMP production in human thyroid cells and the inhibitory effect is enhanced by tumor necrosis factor-alpha and interferon-gamma. Cyclic AMP 57-61 interleukin 1 alpha Homo sapiens 0-13 2124488-1 1990 Prostaglandin production and cAMP formation are two signaling pathways identified for IL-1, though neither adequately account for the multitude of effects of IL-1. Cyclic AMP 29-33 interleukin 1 alpha Homo sapiens 86-90 2175325-5 1990 Concomitantly we were able to show that IL-1 increased the cytosolic cAMP levels in endothelial cells. Cyclic AMP 69-73 interleukin 1 alpha Homo sapiens 40-44 2175325-6 1990 An inhibitor of adenylate cyclase, ddAdo, decreased both the IL-1-induced cAMP elevation and lymphocyte penetration. Cyclic AMP 74-78 interleukin 1 alpha Homo sapiens 61-65 2175325-9 1990 These data support the view that IL-1 acts via cAMP as a second messenger in regard to lymphocyte penetration through endothelial cells. Cyclic AMP 47-51 interleukin 1 alpha Homo sapiens 33-37 2175325-10 1990 The above data demonstrate that IL-1-induced lymphocyte penetration through endothelial cells and that this IL-1-induced signal is transduced via cAMP in endothelial cells. Cyclic AMP 146-150 interleukin 1 alpha Homo sapiens 32-36 2175325-10 1990 The above data demonstrate that IL-1-induced lymphocyte penetration through endothelial cells and that this IL-1-induced signal is transduced via cAMP in endothelial cells. Cyclic AMP 146-150 interleukin 1 alpha Homo sapiens 108-112 1963325-7 1990 IL-1 also inhibited induction of aromatase activity and LH-stimulated cAMP accumulation induced by dibutyryl cAMP, suggesting that IL-1 also affects the steps distal to cAMP generation. Cyclic AMP 70-74 interleukin 1 alpha Homo sapiens 0-4 1963325-7 1990 IL-1 also inhibited induction of aromatase activity and LH-stimulated cAMP accumulation induced by dibutyryl cAMP, suggesting that IL-1 also affects the steps distal to cAMP generation. Cyclic AMP 70-74 interleukin 1 alpha Homo sapiens 131-135 1963325-2 1990 IL-1 inhibited FSH induction of aromatase activity and of LH-stimulated cAMP accumulation by granulosa cells. Cyclic AMP 72-76 interleukin 1 alpha Homo sapiens 0-4 1963325-7 1990 IL-1 also inhibited induction of aromatase activity and LH-stimulated cAMP accumulation induced by dibutyryl cAMP, suggesting that IL-1 also affects the steps distal to cAMP generation. Cyclic AMP 109-113 interleukin 1 alpha Homo sapiens 0-4 1963325-5 1990 IL-1 also significantly inhibited increases in [125I]iodo-LH binding and progesterone secretion induced by FSH, as well as reducing basal levels of aromatase activity and LH-stimulated cAMP accumulation. Cyclic AMP 185-189 interleukin 1 alpha Homo sapiens 0-4 1963325-6 1990 Studies on the mechanisms of IL-1 actions on FSH-induced differentiation of immature porcine granulosa cells revealed that IL-1 reduced cAMP accumulation by the cells in response to FSH in a time- and concentration-dependent manner. Cyclic AMP 136-140 interleukin 1 alpha Homo sapiens 29-33 1963325-7 1990 IL-1 also inhibited induction of aromatase activity and LH-stimulated cAMP accumulation induced by dibutyryl cAMP, suggesting that IL-1 also affects the steps distal to cAMP generation. Cyclic AMP 109-113 interleukin 1 alpha Homo sapiens 131-135 1963325-6 1990 Studies on the mechanisms of IL-1 actions on FSH-induced differentiation of immature porcine granulosa cells revealed that IL-1 reduced cAMP accumulation by the cells in response to FSH in a time- and concentration-dependent manner. Cyclic AMP 136-140 interleukin 1 alpha Homo sapiens 123-127 1963325-7 1990 IL-1 also inhibited induction of aromatase activity and LH-stimulated cAMP accumulation induced by dibutyryl cAMP, suggesting that IL-1 also affects the steps distal to cAMP generation. Cyclic AMP 109-113 interleukin 1 alpha Homo sapiens 0-4 1963325-7 1990 IL-1 also inhibited induction of aromatase activity and LH-stimulated cAMP accumulation induced by dibutyryl cAMP, suggesting that IL-1 also affects the steps distal to cAMP generation. Cyclic AMP 109-113 interleukin 1 alpha Homo sapiens 131-135 2174073-0 1990 IL-1 regulation of transin/stromelysin transcription in rheumatoid synovial fibroblasts appears to involve two antagonistic transduction pathways, an inhibitory, prostaglandin-dependent pathway mediated by cAMP, and a stimulatory, protein kinase C-dependent pathway. Cyclic AMP 206-210 interleukin 1 alpha Homo sapiens 0-4 2174073-2 1990 cAMP has been shown to inhibit stromelysin transcription in fibroblasts of nonsynovial origin, and is regarded as an important second messenger for IL-1. Cyclic AMP 0-4 interleukin 1 alpha Homo sapiens 148-152 2174073-5 1990 The cAMP agonists forskolin, 3-isobutyl-1-methylxanthine, and PGE2 suppressed the IL-1 induction of stromelysin; conversely, indomethacin superinduced IL-1-elicited stromelysin mRNA. Cyclic AMP 4-8 interleukin 1 alpha Homo sapiens 82-86 2172158-0 1990 IL-1-induced production of IL-2 and IFN-gamma in subclones of human T-cell derived leukaemia HSB.2 cells: regulation by phytohaemagglutinin-mediated (poly)phosphoinositide breakdown and cyclic AMP. Cyclic AMP 186-196 interleukin 1 alpha Homo sapiens 0-4 2174073-5 1990 The cAMP agonists forskolin, 3-isobutyl-1-methylxanthine, and PGE2 suppressed the IL-1 induction of stromelysin; conversely, indomethacin superinduced IL-1-elicited stromelysin mRNA. Cyclic AMP 4-8 interleukin 1 alpha Homo sapiens 151-155 2172158-11 1990 These results indicate that the variation of IL-1-induced production of IL-2 and IFN-gamma in this T-cell line is attributed to the difference in the PHA-mediated signal transduction pathway and, presumably, to the different regulation of intracellular cyclic AMP. Cyclic AMP 253-263 interleukin 1 alpha Homo sapiens 45-49 1972149-6 1990 On the other hand interleukin 1 alpha increases binding within 4 hr and operates via cAMP but not via protein kinase C. These results imply that different mediators of inflammation can activate different signal transduction pathways but lead to similar increases in lymphocyte binding. Cyclic AMP 85-89 interleukin 1 alpha Homo sapiens 18-37 2166110-4 1990 Agents previously shown to stimulate protein kinase C and to inhibit Ca2(+)-dependent, TCR-mediated thymocyte apoptosis, including IL-1, also blocked both DNA fragmentation and cell death in response to cAMP, suggesting interactions ("cross-talk") between the two protein kinase systems. Cyclic AMP 203-207 interleukin 1 alpha Homo sapiens 131-135 2167226-5 1990 Dibutyryl cyclic AMP, which is a cAMP analog able to penetrate into the cytosol, increased lymphocyte binding to the same extent as IL 1. Cyclic AMP 33-37 interleukin 1 alpha Homo sapiens 132-136 2167226-7 1990 IL 1 increased the level of cytosolic cAMP in a time- and dose-dependent manner measured with radioimmunoassay. Cyclic AMP 38-42 interleukin 1 alpha Homo sapiens 0-4 2167226-8 1990 2",5"-Dideoxyadenosine, which is an inhibitor of adenylate cyclase, decreased both the IL 1-induced lymphocyte binding to endothelial cells and elevation in cytosolic cAMP levels. Cyclic AMP 167-171 interleukin 1 alpha Homo sapiens 87-91 2167226-9 1990 Lymphocyte binding increased with cytosolic cAMP levels in accordance with elevation of IL 1 concentration. Cyclic AMP 44-48 interleukin 1 alpha Homo sapiens 88-92 2167226-10 1990 These results suggest that cAMP is essential in signal transduction during IL 1-induced lymphocyte binding to cultured endothelial cell monolayers. Cyclic AMP 27-31 interleukin 1 alpha Homo sapiens 75-79 2165582-8 1990 Furthermore, the quinolone-induced accumulation of intracellular cAMP could explain the extracellular decrease in both IL-1 and TNF production. Cyclic AMP 65-69 interleukin 1 alpha Homo sapiens 119-123 2159204-3 1990 Cyclic AMP levels were stimulated in cells exposed to interleukin 1, however, significantly only after 42 h of pre-incubation, whereas TSH-stimulated cAMP response was inhibited by interleukin 1 already after 18 h of pre-incubation. Cyclic AMP 0-10 interleukin 1 alpha Homo sapiens 54-67 2159204-3 1990 Cyclic AMP levels were stimulated in cells exposed to interleukin 1, however, significantly only after 42 h of pre-incubation, whereas TSH-stimulated cAMP response was inhibited by interleukin 1 already after 18 h of pre-incubation. Cyclic AMP 150-154 interleukin 1 alpha Homo sapiens 181-194 2153178-2 1990 Interaction of IL-1 with its receptor leads to the translocation of protein kinase C (PKC) from the cytosol to the membrane, phosphorylation of the 80-kDa protein that is substrate for PKC, as well as an increase in the level of cAMP. Cyclic AMP 229-233 interleukin 1 alpha Homo sapiens 15-19 2157429-0 1990 IL1 induces proliferation and IL6 mRNA expression in a human astrocytoma cell line: positive and negative modulation by chorela toxin and cAMP. Cyclic AMP 138-142 interleukin 1 alpha Homo sapiens 0-3 2157429-4 1990 Drugs raising cellular cAMP level or cAMP analogues augmented IL1-mediated IL6 mRNA expression but much less. Cyclic AMP 23-27 interleukin 1 alpha Homo sapiens 62-65 2157429-4 1990 Drugs raising cellular cAMP level or cAMP analogues augmented IL1-mediated IL6 mRNA expression but much less. Cyclic AMP 37-41 interleukin 1 alpha Homo sapiens 62-65 2157429-5 1990 Although cAMP is not directly involved in the IL1 action, cAMP thus has a modulatory effect on IL1-mediated IL6 gene activation. Cyclic AMP 9-13 interleukin 1 alpha Homo sapiens 95-98 2157429-5 1990 Although cAMP is not directly involved in the IL1 action, cAMP thus has a modulatory effect on IL1-mediated IL6 gene activation. Cyclic AMP 58-62 interleukin 1 alpha Homo sapiens 95-98 2176076-1 1990 Cultured human periodontal ligament fibroblasts showed synergistic elevations in the synthesis of prostaglandin E and production of cAMP by the administration of parathyroid hormone and cytokines (interleukin 1 alpha, -1 beta, or tumour necrosis factor-alpha). Cyclic AMP 132-136 interleukin 1 alpha Homo sapiens 197-258 34867348-7 2021 We showed that LPS-induced expression of IL-6 and IL-1beta was cAMP dependent, that IL-6 and IL-1beta expression were induced by direct cAMP activation (forskolin) and that RG0216 and deprenyl effectively reduced cAMP-mediated cytokine expression. Cyclic AMP 63-67 interleukin 1 alpha Homo sapiens 50-58 33804447-8 2021 Enhancement of cAMP by forskolin reduced IL-1beta-induced NO release and prevented IL-1beta-induced mitochondrial impairment. Cyclic AMP 15-19 interleukin 1 alpha Homo sapiens 41-49 33804447-8 2021 Enhancement of cAMP by forskolin reduced IL-1beta-induced NO release and prevented IL-1beta-induced mitochondrial impairment. Cyclic AMP 15-19 interleukin 1 alpha Homo sapiens 83-91 33804447-11 2021 Increased intracellular cAMP or inhibition of AMPK prevented both IL-1beta-induced NO release and mitochondrial dysfunction. Cyclic AMP 24-28 interleukin 1 alpha Homo sapiens 66-74 34867348-7 2021 We showed that LPS-induced expression of IL-6 and IL-1beta was cAMP dependent, that IL-6 and IL-1beta expression were induced by direct cAMP activation (forskolin) and that RG0216 and deprenyl effectively reduced cAMP-mediated cytokine expression. Cyclic AMP 136-140 interleukin 1 alpha Homo sapiens 93-101 34867348-8 2021 Targeted protein kinase A (PKA) and Exchange Protein Activated by cAMP (EPAC) activation regulated IL-6 and IL-1beta expression, albeit in different ways, but both cytokines were effectively decreased with RG0216. Cyclic AMP 66-70 interleukin 1 alpha Homo sapiens 108-116 2549546-8 1989 The effects of interleukin 1 and tumor necrosis factor on intracellular cAMP accumulation may be a model for immune modulation of other cellular functions dependent upon cyclic nucleotide metabolism. Cyclic AMP 72-76 interleukin 1 alpha Homo sapiens 15-54 2800921-7 1989 Interleukin 1 also inhibited cAMP analogue 8-bromo-cyclic AMP induced thyroid peroxidase mRNA level. Cyclic AMP 29-33 interleukin 1 alpha Homo sapiens 0-13 2542409-4 1989 The inhibition by PT was associated with a decrease in IL-1-mediated cAMP production. Cyclic AMP 69-73 interleukin 1 alpha Homo sapiens 55-59 2544398-0 1989 Inhibitory effects of interleukin-1 on luteinizing hormone-stimulated adenosine 3",5"-monophosphate accumulation by cultured porcine granulosa cells. Cyclic AMP 70-99 interleukin 1 alpha Homo sapiens 22-35 2544398-2 1989 Pretreatment of the cells for 48 h with IL-1 reduced intra- and extracellular cAMP accumulation in response to LH by 73% and 83%, respectively. Cyclic AMP 78-82 interleukin 1 alpha Homo sapiens 40-44 2544398-5 1989 The lowest concentration of IL-1 used (0.5 pg/ml), in contrast, showed a tendency to stimulate LH-induced cAMP accumulation. Cyclic AMP 106-110 interleukin 1 alpha Homo sapiens 28-32 2544398-7 1989 IL-1 also significantly reduced intra- and extracellular cAMP accumulation by the cells in response to forskolin (50, 150 microM) by 28-46%, indicating that IL-1 can directly inhibit adenylate cyclase activity. Cyclic AMP 57-61 interleukin 1 alpha Homo sapiens 0-4 2544398-7 1989 IL-1 also significantly reduced intra- and extracellular cAMP accumulation by the cells in response to forskolin (50, 150 microM) by 28-46%, indicating that IL-1 can directly inhibit adenylate cyclase activity. Cyclic AMP 57-61 interleukin 1 alpha Homo sapiens 157-161 2544398-9 1989 These results indicate that the inhibitory effect of IL-1 on LH-stimulated progesterone secretion is due to its actions at at least two different sites along the LH-stimulated, cAMP-mediated, progesterone biosynthetic pathway, the LH receptor level and adenylate cyclase systems. Cyclic AMP 177-181 interleukin 1 alpha Homo sapiens 53-57 2542409-5 1989 PT also inhibited IL-1-stimulated cAMP production in crude membrane fractions from 7OZ/3, YT, and 3T3 fibroblasts. Cyclic AMP 34-38 interleukin 1 alpha Homo sapiens 18-22 2539970-7 1989 These findings suggest that PTH-rP and IL-1 alpha produced by the tumor cells were synergistically responsible for the humoral hypercalcemia observed in both the original patient and the tumor-bearing nude mice, and that at least two bone-resorbing factors [PTH-rP and another nonadenylate cyclase-stimulating bone-resorbing factor(s)] are active in patients with malignancy-associated hypercalcemia, in whom nephrogenous cAMP excretion is neither increased nor decreased. Cyclic AMP 422-426 interleukin 1 alpha Homo sapiens 39-49