PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30994454-2	2019	We report that HTT forms a transcription-coupled DNA repair (TCR) complex with RNA polymerase II subunit A (POLR2A), ataxin-3, the DNA repair enzyme polynucleotide-kinase-3"-phosphatase (PNKP), and cyclic AMP-response element-binding (CREB) protein (CBP).	Cyclic AMP	198-208	huntingtin	Mus musculus	15-18	
28263187-3	2017	Here we have demonstrated that HTT forms a ternary protein complex with the scaffolding protein DISC1 and cAMP-degrading phosphodiesterase 4 (PDE4) to regulate PDE4 activity.	Cyclic AMP	106-110	huntingtin	Mus musculus	31-34	
21552328-9	2011	In Dictyostelium, huntingtin deficiency is compatible with survival of the organism but renders cells sensitive to low osmolarity, which produces pleiotropic cell autonomous defects that affect cAMP signaling and as a consequence development.	Cyclic AMP	194-198	huntingtin	Mus musculus	18-28	
16019264-5	2005	The reduction in mHtt was concomitant with a reduction in the size and number of neuronal intranuclear inclusions and a small but significant normalization of the steady-state levels of preproenkephalin and dopamine- and cAMP-responsive phosphoprotein 32 kDa mRNA.	Cyclic AMP	221-225	huntingtin	Mus musculus	17-21	
12588797-4	2003	Furthermore, cAMP levels in Hdh(Q111) striatum declined from an early age (10 weeks), and cAMP was significantly decreased in HD postmortem brain and lymphoblastoid cells, attesting to a chronic deficit in man.	Cyclic AMP	13-17	huntingtin	Mus musculus	28-31	
27811172-2	2017	Impairment of cAMP/cGMP signaling by mutant huntingtin is hypothesized as the molecular mechanism underlying degeneration of MSNs.	Cyclic AMP	14-18	huntingtin	Mus musculus	44-54	
20448484-1	2010	Previous studies have reported that mutant huntingtin (htt) interferes with cyclic AMP response element binding protein binding protein (CBP)-mediated transcription, possibly by inhibiting the acetylation of histones.	Cyclic AMP	76-86	huntingtin	Mus musculus	43-53	
20448484-1	2010	Previous studies have reported that mutant huntingtin (htt) interferes with cyclic AMP response element binding protein binding protein (CBP)-mediated transcription, possibly by inhibiting the acetylation of histones.	Cyclic AMP	76-86	huntingtin	Mus musculus	55-58	
12165554-1	2002	Previous analyses of gene expression in a mouse model of Huntington"s disease (R6/2) indicated that an N-terminal fragment of mutant huntingtin causes downregulation of striatal signaling genes and particularly those normally induced by cAMP and retinoic acid.	Cyclic AMP	237-241	huntingtin	Mus musculus	133-143