PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16168438-3	2005	The histamine receptor H1 antagonist diphenhydramine, the antimalarial drug amodiaquine, the antifolate drug metoprine, and the anticholinesterase drug tacrine (an early drug for Alzheimer"s disease) are surprisingly all potent HNMT inhibitors, having inhibition constants in the range of 10-100nM.	Tacrine	152-159	histamine N-methyltransferase	Homo sapiens	228-232	
15834447-0	2005	Actions of tacrine and galanthamine on histamine-N-methyltransferase.	Tacrine	11-18	histamine N-methyltransferase	Homo sapiens	39-68	
15834447-2	2005	The AD medication tacrine was previously shown to inhibit some forms of rodent histamine-N-methyltransferase (HNMT), but the effects of AD drugs have not been investigated on human HNMT activity.	Tacrine	18-25	histamine N-methyltransferase	Homo sapiens	79-108	
15834447-2	2005	The AD medication tacrine was previously shown to inhibit some forms of rodent histamine-N-methyltransferase (HNMT), but the effects of AD drugs have not been investigated on human HNMT activity.	Tacrine	18-25	histamine N-methyltransferase	Homo sapiens	110-114	
15834447-4	2005	Tacrine (0.01-10 microM) inhibited both human and rat HNMT activity in a concentration-dependent manner, but was less potent on both human embryonic kidney and recombinant human brain HNMT than on rat kidney HNMT (IC50 values were 0.46 and 0.70 microM vs. 0.29 microM, respectively).	Tacrine	0-7	histamine N-methyltransferase	Homo sapiens	184-188