PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8383401-3	1993	Both lidocaine and bupivacaine inhibited the release of the inflammatory mediators leukotriene B4 (LTB4) and interleukin-1 (IL-1) evaluated by radioimmunoassay (RIA).	Lidocaine	5-14	interleukin 1 alpha	Homo sapiens	109-128	
8383401-5	1993	In short-term (24 h) cultures of mononuclear cells the addition of lidocaine or bupivacaine reduced, in a dose-dependent manner, the level of IL-1 detected after stimulation with lipopolysaccharide (LPS).	Lidocaine	67-76	interleukin 1 alpha	Homo sapiens	142-146	
30963625-9	2019	Lidocaine dramatically reduced the protein expression of IL-1alpha, IL-6, THF-alpha, ELAVL1, NLRP3, caspase-1, and IL-1beta in adenovirus-infected thyroid follicular epithelial cells.	Lidocaine	0-9	interleukin 1 alpha	Homo sapiens	57-66	
35482438-5	2022	HYPOTHESIS: Treatment of articular cartilage with IL-1Ra in combination with a clinically relevant concentration of lidocaine (1%) will inhibit the catabolic effects of IL-1alpha in a manner similar to treatment with IL-1Ra alone.	Lidocaine	116-125	interleukin 1 alpha	Homo sapiens	169-178	
35482438-11	2022	RESULTS: The combination of IL-1Ra and lidocaine, premixed at various time points and stored at room temperature or 4 C, was as effective as IL-1Ra alone at inhibiting IL-1alpha-mediated sGAG release.	Lidocaine	39-48	interleukin 1 alpha	Homo sapiens	168-177	
35482438-13	2022	CONCLUSION: Our hypothesis was supported, and results indicated that the combination of IL-1Ra and lidocaine was as efficacious as IL-1Ra treatment alone in acutely mitigating biological cartilage injury due to IL-1alpha in an explant model.	Lidocaine	99-108	interleukin 1 alpha	Homo sapiens	211-220	
27309886-0	2016	Effect of intravenous lidocaine combined with amitriptyline on pain intensity, clinical manifestations and the concentrations of IL-1, IL-6 and IL-8 in patients with fibromyalgia: A randomized double-blind study.	Lidocaine	22-31	interleukin 1 alpha	Homo sapiens	129-133