PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30226584-7 2018 The HIF-1alpha knockout in SMMC-7721 cells significantly suppressed cell invasiveness and migration, and induced cell apoptosis under CoCl2-mimicking hypoxic conditions. smmc 27-31 hypoxia inducible factor 1 subunit alpha Homo sapiens 4-14 25607114-3 2015 Increased levels of hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) were observed when SMMC-7721 cells were exposed to hypoxia, and exposure of tumor cells to hypoxia impaired etoposide-induced DNA damage, as indicated by the failure of upregulation of gammaHA2X. smmc 130-134 hypoxia inducible factor 1 subunit alpha Homo sapiens 20-51 25607114-3 2015 Increased levels of hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) were observed when SMMC-7721 cells were exposed to hypoxia, and exposure of tumor cells to hypoxia impaired etoposide-induced DNA damage, as indicated by the failure of upregulation of gammaHA2X. smmc 130-134 hypoxia inducible factor 1 subunit alpha Homo sapiens 53-63 21950556-5 2011 HIF-1alpha downregulation by siRNA inhibited proliferation, induced apoptosis, and enhanced radiosensitivity in chemical hypoxic SMMC-7721 cells in vitro. smmc 129-133 hypoxia inducible factor 1 subunit alpha Homo sapiens 0-10