PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10960024-15	2000	These effects appear to occur without altering either mRNA or protein levels for these enzymes, supporting a possible mechanism of action that involves the ability of bisphosphonates to chelate cations from the MMPs.	Diphosphonates	167-182	matrix metallopeptidase 1	Homo sapiens	211-215	
11984068-1	2002	Bisphosphonates (clodronate, alendronate, pamidronate and zoledronate) at therapeutically attainable non-cytotoxic concentrations inhibited MMP-3, -12, -13 and -20 as well as MMP-1, -2, -8 and -9, but not urokinase-type plasminogen activator (uPA), a serine proteinase and a pro-MMP activator.	Diphosphonates	0-15	matrix metallopeptidase 1	Homo sapiens	175-195	
11984068-8	2002	Bisphosphonates are broad-spectrum MMP inhibitors and this inhibition involves cation chelation.	Diphosphonates	0-15	matrix metallopeptidase 1	Homo sapiens	35-38	
10620064-10	1999	In conclusion, the apoptosis of myeloma cells and BMSCs and the inhibition of both IL-6 and MMP-1 production induced by bisphosphonates, mainly zoledronate, could have antitumoral effects in patients with MM.	Diphosphonates	120-135	matrix metallopeptidase 1	Homo sapiens	92-97	
10415748-4	1999	We have discovered that various matrix metalloproteinases (MMPs) are inhibited in vitro by several bisphosphonates.	Diphosphonates	99-114	matrix metallopeptidase 1	Homo sapiens	59-63	
9192515-1	1997	Interstitial collagenase present in human jaw cyst extract and purified human fibroblast-type collagenase (MMP-1) were both efficiently inhibited in vitro by clodronate, an osteoactive, antiresorptive bisphosphonate.	Diphosphonates	201-215	matrix metallopeptidase 1	Homo sapiens	0-24	
9192515-1	1997	Interstitial collagenase present in human jaw cyst extract and purified human fibroblast-type collagenase (MMP-1) were both efficiently inhibited in vitro by clodronate, an osteoactive, antiresorptive bisphosphonate.	Diphosphonates	201-215	matrix metallopeptidase 1	Homo sapiens	107-112