PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16100524-3	2005	The aim of the present study was to determine the effect of alendronate, one of the nitrogen-containing bisphosphonates on the phoshoinositide 3-kinase (PI3K)-Akt-NFkappaB pathway, the major cell survival pathway.	Diphosphonates	104-119	AKT serine/threonine kinase 1	Homo sapiens	159-162	
30675875-0	2019	Epidermal Growth Factor Reverses the Inhibitory Effects of the Bisphosphonate, Zoledronic Acid, on Human Oral Keratinocytes and Human Vascular Endothelial Cells In Vitro via the Epidermal Growth Factor Receptor (EGFR)/Akt/Phosphoinositide 3-Kinase (PI3K) Signaling Pathway.	Diphosphonates	63-77	AKT serine/threonine kinase 1	Homo sapiens	218-221	
30675875-10	2019	CONCLUSIONS EGF partially reversed the effects of the bisphosphonate, zoledronic acid, on HOKs and HUVECs in vitro via the EGFR/Akt/PI3K signaling pathway.	Diphosphonates	54-68	AKT serine/threonine kinase 1	Homo sapiens	128-131	
25628928-6	2015	In this study, we found that bisphosphonates and statins inhibited MIP-1alpha mRNA and MIP-1alpha secretion and suppressed extracellular signal-regulated kinase 1/2 (ERK1/2) and Akt phosphorylation by inhibiting Ras prenylation.	Diphosphonates	29-44	AKT serine/threonine kinase 1	Homo sapiens	178-181	
25628928-8	2015	These results indicate that bisphosphonates and statins suppress the Ras/mitogen-activated protein kinase kinase/ERK/AML-1A and Ras/phosphatidylinositol-3 kinase/Akt/AML-1A pathways, thereby inhibiting MIP-1alpha secretion by MM cells.	Diphosphonates	28-43	AKT serine/threonine kinase 1	Homo sapiens	162-165	
19350555-10	2009	We have shown that bisphosphonates could modulate the function of osteoclasts by inhibiting downstream signaling mediated by PTP-PEST/Src, in addition to its effect on the inhibition of the post-translational modification of small GTP-binding proteins such as Rab, Rho, and Rac as shown by others.	Diphosphonates	19-34	AKT serine/threonine kinase 1	Homo sapiens	274-277	
25628928-0	2015	Bisphosphonates and statins inhibit expression and secretion of MIP-1alpha via suppression of Ras/MEK/ERK/AML-1A and Ras/PI3K/Akt/AML-1A pathways.	Diphosphonates	0-15	AKT serine/threonine kinase 1	Homo sapiens	126-129	
19569175-7	2010	In addition, our results indicated that the inhibitory effects of bisphosphonates on the HIF-1alpha/VEGF axis are associated with the inhibition of the phosphoinositide 3-kinase/AKT/mammalian target of rapamycin signaling pathways.	Diphosphonates	66-81	AKT serine/threonine kinase 1	Homo sapiens	178-181	
13679234-12	2003	These results suggest that YM529, the new bisphosphonate, induced apoptosis when inhibit GGPP synthase and consequently decreased the levels of phosphorylated ERK, which is a survival signal; moreover, during this process, there is no influence on NF-kappaB, Akt, p38, and Bcl-2.	Diphosphonates	42-56	AKT serine/threonine kinase 1	Homo sapiens	259-262