PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19903468-7	2010	Urokinase-type plasminogen activator (uPA) is one of the critical proteins in tumor metastasis and decreased in bisphosphonate-treated PC-3 cells.	Diphosphonates	112-126	plasminogen activator, urokinase	Homo sapiens	0-36	
19903468-7	2010	Urokinase-type plasminogen activator (uPA) is one of the critical proteins in tumor metastasis and decreased in bisphosphonate-treated PC-3 cells.	Diphosphonates	112-126	plasminogen activator, urokinase	Homo sapiens	38-41	
19903468-8	2010	We also showed that uPA expression was suppressed by PKC inhibitors (calphostin C and staurosporine) and induced by a PKC activator (PMA) in PC-3 cells, suggesting that the inhibition of uPA by bisphosphonates is involved in PKC inhibition.	Diphosphonates	194-209	plasminogen activator, urokinase	Homo sapiens	20-23	
19903468-8	2010	We also showed that uPA expression was suppressed by PKC inhibitors (calphostin C and staurosporine) and induced by a PKC activator (PMA) in PC-3 cells, suggesting that the inhibition of uPA by bisphosphonates is involved in PKC inhibition.	Diphosphonates	194-209	plasminogen activator, urokinase	Homo sapiens	187-190	
11984068-1	2002	Bisphosphonates (clodronate, alendronate, pamidronate and zoledronate) at therapeutically attainable non-cytotoxic concentrations inhibited MMP-3, -12, -13 and -20 as well as MMP-1, -2, -8 and -9, but not urokinase-type plasminogen activator (uPA), a serine proteinase and a pro-MMP activator.	Diphosphonates	0-15	plasminogen activator, urokinase	Homo sapiens	205-241	
11984068-1	2002	Bisphosphonates (clodronate, alendronate, pamidronate and zoledronate) at therapeutically attainable non-cytotoxic concentrations inhibited MMP-3, -12, -13 and -20 as well as MMP-1, -2, -8 and -9, but not urokinase-type plasminogen activator (uPA), a serine proteinase and a pro-MMP activator.	Diphosphonates	0-15	plasminogen activator, urokinase	Homo sapiens	243-246