PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22723339-1	2012	Statins and bisphosphonates are two distinct classes of isoprenoid pathway inhibitors targeting downstream enzyme to HMG-CoA reductase (upstream enzyme) and farnesyl-pyrophosphate synthase, respectively.	Diphosphonates	12-27	farnesyl diphosphate synthetase	Mus musculus	157-188	
16006204-1	2005	Nitrogen-containing bisphosphonate drugs such as risedronate act by inhibiting farnesyl diphosphate synthase, thereby disrupting protein prenylation in osteoclasts.	Diphosphonates	20-34	farnesyl diphosphate synthetase	Mus musculus	79-108	
23564016-1	2013	Nitrogen-containing bisphosphonates have been well known to be inhibited farnesyl diphosphate synthase (FDPS), an enzyme in mevalonic acid metabolism, resulting in disturbance in polymerization of cytoskeleton structure in bone resorption and promotion of apoptosis in mature osteoclasts.	Diphosphonates	20-35	farnesyl diphosphate synthetase	Mus musculus	73-102	
23564016-1	2013	Nitrogen-containing bisphosphonates have been well known to be inhibited farnesyl diphosphate synthase (FDPS), an enzyme in mevalonic acid metabolism, resulting in disturbance in polymerization of cytoskeleton structure in bone resorption and promotion of apoptosis in mature osteoclasts.	Diphosphonates	20-35	farnesyl diphosphate synthetase	Mus musculus	104-108	
23564016-12	2013	These results suggest that nitrogen-containing bisphosphonates suppress the activity of osteoclastic acid-activated Cl(-) currents through FDPS inhibition, suggesting the inhibition of Cl(-) extrusion activity.	Diphosphonates	47-62	farnesyl diphosphate synthetase	Mus musculus	139-143	
16734383-4	2006	INTRODUCTION: Nitrogen-containing bisphosphonates (N-BPs) are potent inhibitors of bone resorption that act by inhibiting farnesyl diphosphate synthase, thereby indirectly preventing the prenylation of Rho family GTPases that are required for the function and survival of bone-resorbing osteoclasts.	Diphosphonates	34-49	farnesyl diphosphate synthetase	Mus musculus	122-151	
11792566-1	2002	Nitrogen-containing bisphosphonates (NBps) are taken up by osteoclasts and inhibit farnesyl pyrophosphate synthase, an enzyme of the mevalonate pathway.	Diphosphonates	20-35	farnesyl diphosphate synthetase	Mus musculus	83-114	
11581260-1	2001	Nitrogen-containing bisphosphonate drugs inhibit bone resorption by inhibiting FPP synthase and thereby preventing the synthesis of isoprenoid lipids required for protein prenylation in bone-resorbing osteoclasts.	Diphosphonates	20-34	farnesyl diphosphate synthetase	Mus musculus	79-91