PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22750450-0	2012	Bisphosphonates improve trabecular bone mass and normalize cortical thickness in ovariectomized, osteoblast connexin43 deficient mice.	Diphosphonates	0-15	gap junction protein, alpha 1	Mus musculus	108-118	
22750450-2	2012	Cx43 has also been proposed to mediate an anti-apoptotic effect of bisphosphonates, potent inhibitors of bone resorption.	Diphosphonates	67-82	gap junction protein, alpha 1	Mus musculus	0-4	
22750450-3	2012	We studied whether bisphosphonates are effective in protecting mice with a conditional Cx43 gene deletion in osteoblasts and osteocytes (cKO) from the consequences of ovariectomy on bone mass and strength.	Diphosphonates	19-34	gap junction protein, alpha 1	Mus musculus	87-91	
18597631-0	2008	Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo.	Diphosphonates	57-72	gap junction protein, alpha 1	Mus musculus	0-11	
12064622-0	2001	Bisphosphonate-induced, hemichannel-mediated, anti-apoptosis through the Src/ERK pathway: a gap junction-independent action of connexin43.	Diphosphonates	0-14	gap junction protein, alpha 1	Mus musculus	127-137	
12064622-2	2001	We report herein a mechanism by which connexin43 hemichannel opening by bisphosphonates triggers the activation of the kinases Src and ERKs and promotes cell survival.	Diphosphonates	72-87	gap junction protein, alpha 1	Mus musculus	38-48	
12064622-5	2001	The anti-apoptotic effect of bisphosphonates depends on connexin43 expression in mouse embryonic fibroblasts and osteoblastic cells.	Diphosphonates	29-44	gap junction protein, alpha 1	Mus musculus	56-66	
12064622-9	2001	These studies establish a role for connexin43 hemichannels in bisphosphonate action, and a novel function of connexin43--beyond gap junction communication--in the regulation of survival signaling pathways.	Diphosphonates	62-76	gap junction protein, alpha 1	Mus musculus	35-45	
22679450-7	2011	Thus, the preservation of the viability of osteoblasts and osteocytes by the anti-osteoporotic drugs bisphosphonates depends on Cx43 expression in vitro and in vivo.	Diphosphonates	101-116	gap junction protein, alpha 1	Mus musculus	128-132