PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3006732-2 1985 Since interleukin 1 (IL-1)-like activity has been shown to stimulate bone resorption in vitro, we have studied whether bisphosphonates inhibit either the production of IL-1-like activity or its effect on one type of connective tissue cell, chondrocytes. Diphosphonates 119-134 interleukin 1 complex Mus musculus 168-172 3006732-4 1985 Production of IL-1-like activity was unaffected by bisphosphonates, whereas the effect of IL-1-like activity on collagenase and prostaglandin E2 secretion by rabbit chondrocytes was increased rather than inhibited by bisphosphonates. Diphosphonates 217-232 interleukin 1 complex Mus musculus 90-94 3006732-5 1985 Finally, bisphosphonates increased DNA and cell number in chondrocyte cultures, but this effect was blocked when IL-1-like activity was added to the cultures. Diphosphonates 9-24 interleukin 1 complex Mus musculus 113-117