PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24636958-11 2014 In conclusion, bisphosphonates have diverse growth inhibitory effects on osteosarcoma through: (1) activation of apoptosis and inhibition of cell proliferation, (2) inhibition of VEGF-A and VEGFR1 expression by tumor cells, (3) inhibition of tumor-induced angiogenesis, and (4) direct inhibitory actions on endothelial cells. Diphosphonates 15-30 fms related receptor tyrosine kinase 1 Homo sapiens 190-196