PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11697801-7 2001 Phosphorylation of ERK1/2 was induced by the BPs olpadronate and pamidronate within 30 s, followed by rapid dephosphorylation, whereas etidronate induced phosphorylation of ERKs only after 90 s of incubation and returned to basal levels within 15-30 minutes. Diphosphonates 45-48 mitogen activated protein kinase 3 Rattus norvegicus 19-25 11697801-9 2001 These results show that BP-induced proliferation of osteoblastic cells is mediated by activation of ERKs and suggest that this effect requires influx of Ca2+ from the extracellular space through calcium channels. Diphosphonates 24-26 mitogen activated protein kinase 3 Rattus norvegicus 100-104