PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15930357-11 2005 Thus, blockage of PTHrP functions by a neutralizing antibody against PTHrP would benefit patients who develop bisphosphonate- or calcitonin-refractory HHM. Diphosphonates 110-124 parathyroid hormone like hormone Homo sapiens 18-23 15930357-11 2005 Thus, blockage of PTHrP functions by a neutralizing antibody against PTHrP would benefit patients who develop bisphosphonate- or calcitonin-refractory HHM. Diphosphonates 110-124 parathyroid hormone like hormone Homo sapiens 69-74 11741801-8 2001 During treatment with bisphosphonates, elevated plasma levels of PTHrP are associated with a weak response. Diphosphonates 22-37 parathyroid hormone like hormone Homo sapiens 65-70 15577056-3 2004 A recent investigation suggested that bisphosphonates might prevent arterial calcification through a mechanism associated with the enhanced production of parathyroid hormone-related peptide from vascular smooth muscle cells. Diphosphonates 38-53 parathyroid hormone like hormone Homo sapiens 154-189 12729778-11 2003 The patients with HHM who were administrated drugs such as bisphosphonate and calcitonin showed a reduction in their Ca and PTH-rP levels, and the six of ten EORTC QLQ-C30 subscales (emotional functioning, cognitive functioning, fatigue, dyspnoea, nausea/vomiting and appetite loss) were also improved after the anti-hypercalcemic therapy. Diphosphonates 59-73 parathyroid hormone like hormone Homo sapiens 124-130 8156530-0 1994 Significance of plasma PTH-rp in patients with hypercalcemia of malignancy treated with bisphosphonate. Diphosphonates 88-102 parathyroid hormone like hormone Homo sapiens 23-29 8175989-11 1994 We conclude that in hypercalcemia of malignancy raised serum levels of PTHrP indicate a reduced hypocalcemic response to bisphosphonates, a more advanced tumor state and, therefore, an extremely poor prognosis. Diphosphonates 121-136 parathyroid hormone like hormone Homo sapiens 71-76 8018531-1 1994 Plasma parathyroid hormone related-protein (PTHrP) may inhibit the calcium-lowering effect of bisphosphonate therapy. Diphosphonates 94-108 parathyroid hormone like hormone Homo sapiens 7-42 8018531-1 1994 Plasma parathyroid hormone related-protein (PTHrP) may inhibit the calcium-lowering effect of bisphosphonate therapy. Diphosphonates 94-108 parathyroid hormone like hormone Homo sapiens 44-49 8018531-6 1994 Patients who responded to bisphosphonate therapy by becoming normocalcaemic had significantly lower basal plasma PTHrP levels, mean 4.06 vs 8.2 pmol l-1 (P < 0.04). Diphosphonates 26-40 parathyroid hormone like hormone Homo sapiens 113-118 8156530-14 1994 CONCLUSIONS: The plasma PTH-rp levels may help to predict the calcium-lowering effect of bisphosphonate and give an indication of the prognosis in patients with HM. Diphosphonates 89-103 parathyroid hormone like hormone Homo sapiens 24-30 1835397-6 1991 This type of therapeutic response can be reproduced experimentally in bisphosphonate-treated animals receiving a constant infusion of parathyroid hormone-related peptide, a peptide isolated from various tumour types including lung, kidney, breast and neuroendocrine tumour of the pancreas. Diphosphonates 70-84 parathyroid hormone like hormone Homo sapiens 134-169 8030440-2 1994 We conducted this study to examine the effects of treatment with a bisphosphonate on serum PTHrP. Diphosphonates 67-81 parathyroid hormone like hormone Homo sapiens 91-96 8328312-0 1993 Circulating PTHrP concentrations in tumor-induced hypercalcemia: influence on the response to bisphosphonate and changes after therapy. Diphosphonates 94-108 parathyroid hormone like hormone Homo sapiens 12-17 8328312-1 1993 We studied the influence of circulating parathyroid hormone-related protein (PTHrP) concentrations on the response of hypercalcemic cancer patients to bisphosphonate therapy. Diphosphonates 151-165 parathyroid hormone like hormone Homo sapiens 40-75 8328312-1 1993 We studied the influence of circulating parathyroid hormone-related protein (PTHrP) concentrations on the response of hypercalcemic cancer patients to bisphosphonate therapy. Diphosphonates 151-165 parathyroid hormone like hormone Homo sapiens 77-82 8428711-2 1993 In 10 patients with hypercalcemia of malignancy the levels of the midregional fragment of PTHrP in serum were determined by radioimmunoassay over 7 days during a calcium-lowering treatment with a single dose of the bisphosphonate BM 21.0955. Diphosphonates 215-229 parathyroid hormone like hormone Homo sapiens 90-95 1338636-4 1992 The PTHrP-stimulated bone resorption can be totally inhibited by bisphosphonate therapy. Diphosphonates 65-79 parathyroid hormone like hormone Homo sapiens 4-9 2137362-6 1990 This type of therapeutic response can be experimentally reproduced in diphosphonate-treated animals receiving a constant infusion of parathyroid hormone-related peptide, a peptide isolated from lung, kidney and breast carcinomas. Diphosphonates 70-83 parathyroid hormone like hormone Homo sapiens 133-168 34024253-10 2021 Altogether, PTHrP can inhibit nitrogen-containing BP-induced apoptosis of HPdLFs by activating MKP1 phosphatase. Diphosphonates 50-52 parathyroid hormone like hormone Homo sapiens 12-17 34024253-0 2021 Parathyroid hormone-related protein inhibits nitrogen-containing bisphosphonate-induced apoptosis of human periodontal ligament fibroblasts by activating MKP1 phosphatase. Diphosphonates 65-79 parathyroid hormone like hormone Homo sapiens 0-35 34024253-4 2021 Therefore, it is speculated that PTHrP can inhibit the apoptosis of HPdLFs caused by nitrogen-containing BP via regulating the expression levels of MKP1. Diphosphonates 105-107 parathyroid hormone like hormone Homo sapiens 33-38