PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11222875-7 2001 Inducibility of CYP1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or beta-naphthoflavone (BNF) was measured in primary hepatocyte cultures prepared from SC and NBH fish. beta-Naphthoflavone 72-91 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 16-22 11222875-7 2001 Inducibility of CYP1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or beta-naphthoflavone (BNF) was measured in primary hepatocyte cultures prepared from SC and NBH fish. beta-Naphthoflavone 93-96 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 16-22 11222875-10 2001 The nonhalogenated AhR agonist BNF also induced CYP1A1 in cells from both populations, although with only a 3-fold difference in sensitivity (NBH < SC). beta-Naphthoflavone 31-34 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 48-54 9224217-8 1997 The inducibility of human BEC CYP1A1 gene by PAH exposure was confirmed in vitro by incubating cultured immortalized human BEC with beta-naphthoflavone and observing a > 6-fold induction of CYP1A1 after 24 h. In contrast to BEC, alveolar macrophages expressed CYP1A1 at low (30-70 molecules/10(6) beta-actin molecules) to unmeasurable levels in both smokers and nonsmokers. beta-Naphthoflavone 132-151 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 30-36 11080670-2 2000 The genotoxicity was monitored in HUVEC pretreated with the Ah-receptor agonist beta-naphthoflavone (BNF), previously shown to induce cytochrome P4501A1 (CYP1A1) activity in these cells, and in vehicle-treated HUVEC with only constitutive levels of this enzyme. beta-Naphthoflavone 80-99 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 134-152 11080670-2 2000 The genotoxicity was monitored in HUVEC pretreated with the Ah-receptor agonist beta-naphthoflavone (BNF), previously shown to induce cytochrome P4501A1 (CYP1A1) activity in these cells, and in vehicle-treated HUVEC with only constitutive levels of this enzyme. beta-Naphthoflavone 80-99 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 154-160 10923861-6 2000 Beta-naphthoflavone, at an optimal concentration of 50 microM and after a 3-day treatment, specifically and potently induced 7-ethoxyresorufin (10.4 +/- 10.4-fold, n = 74) and phenacetin (6.6 +/- 6.4-fold, n = 60) O-deethylation processes, markers for CYP1A1 and CYP1A2 isoforms respectively. beta-Naphthoflavone 0-19 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 252-258 10659949-10 2000 Western blotting provided additional evidence for the expression of CYP1A1 and CYP3A4 at the protein level and treatment of cultured enterocytes with 30 microM Aroclor 1254 or 50 microM beta-NF resulted in enhanced expression of the CYP1A protein, and CYP3A4 protein expression was induced following treatment with 50 microM DEX, 2 mM PB, 30 microM Aroclor 1254 or 50 microM beta-NF. beta-Naphthoflavone 375-382 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 68-74 9860486-6 1998 Known prototype inducers such as beta-naphthoflavone and 3-methylcholanthrene exhibited the highest inducing potency quantified with an Imax value (maximal induction of cytochrome P450 1A1 mRNA synthesis) of 5.48 and 10.7 x 10(6) mRNA molecules per 150 ng of total RNA, respectively. beta-Naphthoflavone 33-52 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 169-188 11082432-7 2000 The cytochrome P450 (CYP) 1A1 inhibitor alpha-naphthoflavone inhibited the metabolism of all-trans-RA, whereas the CYP1A1 inducer beta-naphthoflavone induced the metabolism of all-trans-RA, suggesting that CYP1A1 is involved. beta-Naphthoflavone 130-149 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 115-121 11082432-7 2000 The cytochrome P450 (CYP) 1A1 inhibitor alpha-naphthoflavone inhibited the metabolism of all-trans-RA, whereas the CYP1A1 inducer beta-naphthoflavone induced the metabolism of all-trans-RA, suggesting that CYP1A1 is involved. beta-Naphthoflavone 130-149 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 206-212 10659949-10 2000 Western blotting provided additional evidence for the expression of CYP1A1 and CYP3A4 at the protein level and treatment of cultured enterocytes with 30 microM Aroclor 1254 or 50 microM beta-NF resulted in enhanced expression of the CYP1A protein, and CYP3A4 protein expression was induced following treatment with 50 microM DEX, 2 mM PB, 30 microM Aroclor 1254 or 50 microM beta-NF. beta-Naphthoflavone 186-193 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 68-74 10375802-4 1998 RESULTS: Both the CAT expression and CYP1A1 activity increased with the concentrations of beta-naphthoflavone from 2.5 to 10 mumol.L-1. beta-Naphthoflavone 90-109 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 37-43 10375802-5 1998 At 10 mumol.L-1 of beta-naphthoflavone, the levels of CAT and CYP1A1 were 94-fold and 2.8-fold those of the corresponding control, respectively. beta-Naphthoflavone 19-38 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 62-68 9103269-0 1997 Effect of glucosinolate breakdown products on beta-naphthoflavone-induced expression of human cytochrome P450 1A1 via the Ah receptor in Hep G2 cells. beta-Naphthoflavone 46-65 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 94-113 9211658-11 1997 Response elements for human CYP1A1, glutathione S-transferase lambda a and the xenobiotic response element (XRE) in HepG2 cells were activated by beta-naphthoflavone but not by genistein or equol. beta-Naphthoflavone 146-165 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 28-34 9103269-1 1997 The ability of glucosinolates, the main bioactive components of brassica vegetables, to influence beta-naphthoflavone-induced transcription of human cytochrome P450 1A1 was examined. beta-Naphthoflavone 98-117 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 149-168 19470599-3 2009 Cotreatment with 17beta-estradiol significantly increased beta-naphthoflavone (BNF)- and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced recruitment of ERalpha to CYP1A1, whereas 3,3"-diindolylmethane induced promoter occupancy of ERalpha at CYP1A1 that was unaffected by cotreatment with 17beta-estradiol. beta-Naphthoflavone 58-77 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 159-165 25218365-2 2014 In this study the effect of administration of beta-naphthoflavone (BNF), potent AhR ligand, on the expression of AhR, AhRR, CYP1A1, CYP1A2, CYP1B1, NQO1, GSTA1, ALDH3A1 and UGT1A genes encoding the enzymes controlled by AhR were examined in thirteen laryngeal tumor cell lines and in HepaRG cell line. beta-Naphthoflavone 46-65 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 124-130 7557864-6 1995 When cells were treated with the CYP inducer alone, large increases in the expression of CYP1A1 and CYP1A2 by beta-naphthoflavone and of CYP3A4 by rifampicin were observed at messenger RNA (mRNA) and protein levels, by ribonuclease protection and immunoblotting, respectively. beta-Naphthoflavone 110-129 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 89-95 7646562-6 1995 7-Ethoxyresorufin-O-dealkylation activity, supported by cytochrome P4501A1, was induced more than 1000-times in Caco-2 cells by beta-naphthoflavone treatment, and this effect was partially abolished by alpha-naphthoflavone treatment. beta-Naphthoflavone 128-147 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 56-74 7811300-7 1994 Attempts to identify the regiospecific factors involved were made by comparing the in vitro induction of CYP1A1 by beta-naphthoflavone and 3-methylcholanthrene in hepatocytes isolated from the periportal and perivenous region. beta-Naphthoflavone 115-134 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 105-111 8380963-4 1993 3-Methylcholanthrene, beta-naphthoflavone, and benz[alpha]anthracene were strong inducers of CYP1A1, benzo[alpha]pyrene induced CYP1A1 activity only weakly, while benzo[e]pyrene and phenobarbital were essentially inactive as inducers. beta-Naphthoflavone 22-41 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 93-99 8380963-4 1993 3-Methylcholanthrene, beta-naphthoflavone, and benz[alpha]anthracene were strong inducers of CYP1A1, benzo[alpha]pyrene induced CYP1A1 activity only weakly, while benzo[e]pyrene and phenobarbital were essentially inactive as inducers. beta-Naphthoflavone 22-41 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 128-134 30592088-9 2019 Exposure to beta-naphthoflavone led to approximately 900- and 9-fold increases in Cyp1a1 and Cyp1a2 gene expression, respectively, and approximately twofold induction in cytochrome P450 (CYP) 1A1/1A2 activity. beta-Naphthoflavone 12-31 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 82-88 30592088-9 2019 Exposure to beta-naphthoflavone led to approximately 900- and 9-fold increases in Cyp1a1 and Cyp1a2 gene expression, respectively, and approximately twofold induction in cytochrome P450 (CYP) 1A1/1A2 activity. beta-Naphthoflavone 12-31 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 170-199 21666223-4 2011 In this article, we show that only CYP1A1 messenger RNA (mRNA), but not CYP1A2, CYP1B1, UGT1A1, BCRP, AHR, ARNT, and AHRR mRNAs, is significantly induced in human term placental trophoblast cultures after exposure to prototype AHR ligands/activators 2,3,7,8-tetrachlorodibenzo-p-dioxin, 3-methylcholanthrene, omeprazole, and beta-naphthoflavone. beta-Naphthoflavone 325-344 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 35-41 20080079-6 2010 As they contain inducers of cytochrome P450 1A1 (CYP1A1), we explored the activity of CYP1A1-related enzymes, i.e. 7-ethoxycoumarin- and 7-ethoxyresorufin-O-deethylase (ECOD and EROD) in both cell systems in basal conditions and after exposure to non-cytotoxic doses of beta-naphthoflavone (BNF), a well-known PAH-type inducer. beta-Naphthoflavone 270-289 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 49-55 20080079-6 2010 As they contain inducers of cytochrome P450 1A1 (CYP1A1), we explored the activity of CYP1A1-related enzymes, i.e. 7-ethoxycoumarin- and 7-ethoxyresorufin-O-deethylase (ECOD and EROD) in both cell systems in basal conditions and after exposure to non-cytotoxic doses of beta-naphthoflavone (BNF), a well-known PAH-type inducer. beta-Naphthoflavone 270-289 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 86-92 20080079-6 2010 As they contain inducers of cytochrome P450 1A1 (CYP1A1), we explored the activity of CYP1A1-related enzymes, i.e. 7-ethoxycoumarin- and 7-ethoxyresorufin-O-deethylase (ECOD and EROD) in both cell systems in basal conditions and after exposure to non-cytotoxic doses of beta-naphthoflavone (BNF), a well-known PAH-type inducer. beta-Naphthoflavone 291-294 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 49-55 20080079-6 2010 As they contain inducers of cytochrome P450 1A1 (CYP1A1), we explored the activity of CYP1A1-related enzymes, i.e. 7-ethoxycoumarin- and 7-ethoxyresorufin-O-deethylase (ECOD and EROD) in both cell systems in basal conditions and after exposure to non-cytotoxic doses of beta-naphthoflavone (BNF), a well-known PAH-type inducer. beta-Naphthoflavone 291-294 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 86-92 19470599-3 2009 Cotreatment with 17beta-estradiol significantly increased beta-naphthoflavone (BNF)- and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced recruitment of ERalpha to CYP1A1, whereas 3,3"-diindolylmethane induced promoter occupancy of ERalpha at CYP1A1 that was unaffected by cotreatment with 17beta-estradiol. beta-Naphthoflavone 58-77 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 238-244 19470599-3 2009 Cotreatment with 17beta-estradiol significantly increased beta-naphthoflavone (BNF)- and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced recruitment of ERalpha to CYP1A1, whereas 3,3"-diindolylmethane induced promoter occupancy of ERalpha at CYP1A1 that was unaffected by cotreatment with 17beta-estradiol. beta-Naphthoflavone 79-82 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 159-165 19470599-3 2009 Cotreatment with 17beta-estradiol significantly increased beta-naphthoflavone (BNF)- and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced recruitment of ERalpha to CYP1A1, whereas 3,3"-diindolylmethane induced promoter occupancy of ERalpha at CYP1A1 that was unaffected by cotreatment with 17beta-estradiol. beta-Naphthoflavone 79-82 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 238-244 18824009-8 2008 MTT reduction assays showed attenuation of cell injury with the CYP1A1 inducer beta-naphthoflavone (BNF). beta-Naphthoflavone 79-98 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 64-70 18987596-7 2008 In small intestine, beta-naphthoflavone, diallyl sulphide and curcumin induced CYP1A1 and CYP2B1. beta-Naphthoflavone 20-39 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 79-85 17011724-4 2007 beta-naphthoflavone (BNF), a potent CYP1A1 inducer, significantly (P<0.05) down-regulated MDR1 transcriptional activity at 10 microM concentration, causing a 33-fold decrease relative to vector control values. beta-Naphthoflavone 0-19 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 36-42 18502397-10 2008 The present results suggest that omeprazole as well as BNF and 3MC activates both human CYP1A1 and CYP1A2 expression through the common regulatory region despite that omeprazole may involve a different cellular signal(s) from BNF and 3MC. beta-Naphthoflavone 55-58 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 88-94 18094037-7 2008 beta-Naphthoflavone (aryl hydrocarbon receptor ligand) induced CYP1A1 (132-fold in colon and 362-fold in proximal jejunum) and UDP glucuronosyltransferase (UGT) 1A6 mRNA (9.8-fold in colon and 3.2-fold in proximal jejunum). beta-Naphthoflavone 0-19 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 63-69 17011724-4 2007 beta-naphthoflavone (BNF), a potent CYP1A1 inducer, significantly (P<0.05) down-regulated MDR1 transcriptional activity at 10 microM concentration, causing a 33-fold decrease relative to vector control values. beta-Naphthoflavone 21-24 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 36-42 17159770-6 2006 Moreover, synthetic beta-naphthoflavone and naturally occurring chrysin, quercetin and diosmin induced CYP1A1 in both tissues. beta-Naphthoflavone 20-39 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 103-109 12623754-5 2003 beta-Naphthoflavone, primaquine, omeprazole and lansoprazole increased mRNA levels of CYP1A1, CYP1A2 and CYP1B1. beta-Naphthoflavone 0-19 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 86-92 15860653-3 2005 The luciferase reporter assay using the CYP1A1 promoter reporter in HeLa cells treated with beta-naphthoflavone or 3-methylcholanthrene, which are known as typical agonists for AhR, showed that reporter activities of the K401R and N487D variants were reduced to 40 to 58% of those of wild-type (WT) but not of the other variants. beta-Naphthoflavone 92-111 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 40-46 15203874-8 2004 beta-Naphthoflavone up-regulated CYP1A1 18.3 +/- 4.2-fold, and CYP1B1 4.1 +/- 0.3-fold in HUVECs. beta-Naphthoflavone 0-19 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 33-39 14599235-9 2003 Treatment with beta-naphthoflavone (10 microM) for 3 d increased ethoxyresorufin-O-deethylase activity (CYP1A1/2) by 6- to 11-fold over untreated cultures and increased CYP1A2 messenger ribonucleic acid (mRNA) expression by three- to eightfold. beta-Naphthoflavone 15-34 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 104-110 15507517-2 2005 3-Methylcholantherene, phenobarbital (broad-spectrum CYP450 inducers), and beta-naphthoflavone (CYP1A1/1A2 inducer) augmented, and 1-aminobenzotriazole (broad-spectrum CYP450 inhibitor) blocked, the inhibitory effects of estradiol on serum-induced CF growth (DNA synthesis, cell number, and collagen synthesis). beta-Naphthoflavone 75-94 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 96-102 15276331-3 2004 The treatment with beta-naphthoflavone resulted in an induction in the liver of a CYP1A and the induction was manifested by (a) immunoblot analysis using anti-rat CYP1A1, (b) an increase of CYP1A-mediated methoxyresorufin-O-demethylase and ethoxyresorufin-O-deethylase activities. beta-Naphthoflavone 19-38 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 163-169 12843640-7 2003 Exposure to beta-naphthoflavone reduced CYP1A1 mRNA levels in a concentration-dependent manner for donors 1 and 2. beta-Naphthoflavone 12-31 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 40-46 12147246-7 2002 It unexpectedly enhanced the beta-naphthoflavone-mediated CYP1A1 and CYP1A2 induction. beta-Naphthoflavone 29-48 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 58-64