PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8386241-5	1993	Covalent binding was increased markedly by pretreatment with dexamethasone (an inducer of the cytochrome P-450 3A subfamily) and moderately by pretreatment with beta-naphthoflavone (an inducer of the 1A family).	beta-Naphthoflavone	161-180	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	94-110	
10948089-4	2000	The CYP inducer beta-naphthoflavone and the Ca(2+) antagonist nifedipine significantly increased CYP2C mRNA but did not change the expression of CYP2J or CYP2B.	beta-Naphthoflavone	16-35	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	4-7	
17011724-0	2007	Significant transcriptional down-regulation of the human MDR1 gene by beta-naphthoflavone: a proposed hypothesis linking potent CYP gene induction to MDR1 inhibition.	beta-Naphthoflavone	70-89	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	128-131	
10709852-5	2000	Down-regulation of CYP 2C protein by transfection of porcine coronary arteries with anti-sense oligonucleotides decreased EDHF-mediated vascular responses while EDHF-mediated hyperpolarisation and relaxation were potentiated by the CYP-inducing compound beta-naphthoflavone.	beta-Naphthoflavone	254-273	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	19-22	
6747992-5	1984	On the basis of these results, the hemiketal form is proposed as the preferred solution conformation of warfarin in the lipid environment of the active site of cytochrome P-450 and the relationship between solution conformation and stereoselectivity of warfarin metabolism by beta-naphthoflavone inducible cytochrome P-450 is discussed.	beta-Naphthoflavone	276-295	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	160-176	
1819909-5	1991	The phenobarbital-induced BND activity and the cytochrome P-450 content were not changed, while the beta-naphthoflavone-induced EROD activity and cytochrome P-450 and cytochrome b5 content decreased, the ECOD activity remaining unchanged.	beta-Naphthoflavone	100-119	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	146-180	
1819909-9	1991	Nifedipine administered at a single dose, one hour before beta-naphthoflavone had no effect per se but potentiated the enzyme-inducing effect of beta-naphthoflavone on the EROD activity and the cytochrome P-450 content but not on the ECOD activity.	beta-Naphthoflavone	145-164	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	194-210	
3986002-0	1985	Altered induction response of hepatic cytochrome P-450 to phenobarbital, 3-methylcholanthrene, and beta-naphthoflavone in organotin-treated animals.	beta-Naphthoflavone	99-118	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	38-54	
3986002-1	1985	The effects of tricyclohexyltin hydroxide on the induction of cytochrome P-450 in liver by phenobarbital, 3-methylcholanthrene and beta-naphthoflavone were studied.	beta-Naphthoflavone	131-150	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	62-78	
6747992-5	1984	On the basis of these results, the hemiketal form is proposed as the preferred solution conformation of warfarin in the lipid environment of the active site of cytochrome P-450 and the relationship between solution conformation and stereoselectivity of warfarin metabolism by beta-naphthoflavone inducible cytochrome P-450 is discussed.	beta-Naphthoflavone	276-295	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	306-322	
6186523-0	1982	Differential effect of phenobarbital and beta-naphthoflavone on the mRNAs coding for cytochrome P450 and NADPH cytochrome P450 reductase.	beta-Naphthoflavone	41-60	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	85-100	
32791187-6	2020	OBJECTIVE: To test the hypothesis that hyperoxia induces greater lung injury and inflammation in Nrf2-/- mice compared to wild type (WT) that differs between sexes, and that this phenotype will be rescued by the administration of the cytochrome P450 (CYP) 1A inducer beta-naphthoflavone (BNF).	beta-Naphthoflavone	267-286	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	234-258	
7285278-3	1981	Both NADPH oxidation and metabolite production are inhibited by CO, SKF 525A and/or metyrapone The induction of cytochrome P-450 with phenobarbital enhances the binding and metabolism of the chloroalkanes, while the induction of cytochrome P-448 with beta-naphthoflavone does not.	beta-Naphthoflavone	251-270	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	112-128	
7115427-6	1982	The binding and metabolism of the 1,2-dichloroethylenes and the 1,2-dichloroethylene-mediated inactivation of cytochrome P-450 were enhanced per mg of microsomal protein, but generally not per nmole of cytochrome P-450 by prior induction with beta-naphthoflavone or phenobarbital.	beta-Naphthoflavone	243-262	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	110-126	
7054190-0	1982	Effects of 3-methylcholanthrene, beta-naphthoflavone, and phenobarbital on the 3-methylcholanthrene-inducible isozyme of cytochrome P-450 within centrilobular, midzonal, and periportal hepatocytes.	beta-Naphthoflavone	33-52	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	121-137	
32791187-6	2020	OBJECTIVE: To test the hypothesis that hyperoxia induces greater lung injury and inflammation in Nrf2-/- mice compared to wild type (WT) that differs between sexes, and that this phenotype will be rescued by the administration of the cytochrome P450 (CYP) 1A inducer beta-naphthoflavone (BNF).	beta-Naphthoflavone	288-291	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	234-258	
32486438-3	2020	In order to study a possible role for CYP induction in neurorepair, we designed an in vitro model where undifferentiated neuroblastoma SH-SY5Y cells were treated with the CYP inducers beta-naphthoflavone (betaNF) and ethanol (EtOH) before and during exposure to the parkinsonian neurotoxin, MPP+.	beta-Naphthoflavone	184-203	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	171-174	
30373287-4	2018	We have studied the inducibility of CYP isozymes in human neuroblastoma SH-SY5Y cells, treated with beta-naphtoflavone (beta-NF) or ethanol (EtOH) as inducers, by qRT-PCR, Western blot (WB), and metabolic activity assays.	beta-Naphthoflavone	120-127	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	36-39