PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30280784-0 2018 Jagged2 promotes cancer stem cell properties of triple negative breast cancer cells and paclitaxel resistance via regulating microRNA-200. Paclitaxel 88-98 jagged canonical Notch ligand 2 Homo sapiens 0-7 30280784-4 2018 Jagged2 expression in paclitaxel-resistant group and non-resistance group before and after treatment was detected by quantitative Real-time-polymerase chain reaction (qRT-PCR), respectively. Paclitaxel 22-32 jagged canonical Notch ligand 2 Homo sapiens 0-7 30280784-5 2018 After Jagged2 knockdown in paclitaxel-resistant MDA-MB-231 cells (MDA-MB-231/TXR), expression of CD44+CD24-ESA+ subset was detected by flow cytometry. Paclitaxel 27-37 jagged canonical Notch ligand 2 Homo sapiens 6-13 30280784-7 2018 RESULTS: Jagged2 was highly expressed in paclitaxel-resistant TNBC tissues and cells. Paclitaxel 41-51 jagged canonical Notch ligand 2 Homo sapiens 9-16 30280784-9 2018 Knockdown of Jagged2 inhibited CSC properties and paclitaxel resistance, whereas upregulated microRNA-200 expression. Paclitaxel 50-60 jagged canonical Notch ligand 2 Homo sapiens 13-20 30280784-10 2018 The inhibited CSC properties and paclitaxel resistance induced by Jagged2 knockdown were reversed by microRNA-200 knockdown. Paclitaxel 33-43 jagged canonical Notch ligand 2 Homo sapiens 66-73 30280784-11 2018 CONCLUSIONS: Jagged2 maintains CSC properties of TNBC cells and paclitaxel resistance via regulating microRNA-200. Paclitaxel 64-74 jagged canonical Notch ligand 2 Homo sapiens 13-20