PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34284854-0 2021 Phosphorylation of Cofilin-1 Enhances Paclitaxel Resistance of Epithelial Ovarian Cancer Cells by Inhibiting Apoptosis. Paclitaxel 38-48 cofilin 1 Homo sapiens 19-28 33790078-12 2021 Moreover, the RAC1/p21 (RAC1) activated kinase 1 (PAK1)/LIM kinase 1 (LIMK1)/Cofilin pathway was significantly activated in paclitaxel-resistant HCC94 and C-33A cells, while miR-509-3p overexpression significantly inactivated this pathway. Paclitaxel 124-134 cofilin 1 Homo sapiens 77-84 23064469-0 2013 Upregulation of phosphorylated cofilin 1 correlates with taxol resistance in human ovarian cancer in vitro and in vivo. Paclitaxel 57-62 cofilin 1 Homo sapiens 31-40 23064469-3 2013 In this study, we demonstrated that the protein, phosphorylated cofilin 1 (p-CFL1) correlates with taxol resistance in human ovarian cancer cells. Paclitaxel 111-116 cofilin 1 Homo sapiens 76-85 23064469-3 2013 In this study, we demonstrated that the protein, phosphorylated cofilin 1 (p-CFL1) correlates with taxol resistance in human ovarian cancer cells. Paclitaxel 111-116 cofilin 1 Homo sapiens 89-93 23064469-6 2013 Cofilin 1 (CFL1) was selected as a candidate which may play an important role in taxol resistance. Paclitaxel 93-98 cofilin 1 Homo sapiens 0-9 23064469-6 2013 Cofilin 1 (CFL1) was selected as a candidate which may play an important role in taxol resistance. Paclitaxel 93-98 cofilin 1 Homo sapiens 23-27 29434713-0 2018 Paclitaxel inhibits breast cancer metastasis via suppression of Aurora kinase-mediated cofilin-1 activity. Paclitaxel 0-10 cofilin 1 Homo sapiens 87-96 29434713-6 2018 Results additionally demonstrated that Paclitaxel treatment suppressed Aurora kinase and cofilin-1 activity in breast cancer cells. Paclitaxel 39-49 cofilin 1 Homo sapiens 89-98 29434713-7 2018 The potential mechanism indicated that activation of Aurora kinase activity stimulated cofilin-1 activity, which canceled Paclitaxel-inhibited growth and aggressiveness of breast cancer cells. Paclitaxel 122-132 cofilin 1 Homo sapiens 87-96 29434713-10 2018 Notably, Aurora kinase and cofilin-1 activity were downregulated by Paclitaxel in tumor tissues. Paclitaxel 68-78 cofilin 1 Homo sapiens 27-36 29434713-11 2018 In conclusion, these results indicated that Paclitaxel inhibited breast cancer cell growth and metastasis via suppression of Aurora kinase-mediated cofilin-1 activity, suggesting Paclitaxel may be an efficient anticancer agent for the treatment of this disease. Paclitaxel 44-54 cofilin 1 Homo sapiens 148-157 29434713-11 2018 In conclusion, these results indicated that Paclitaxel inhibited breast cancer cell growth and metastasis via suppression of Aurora kinase-mediated cofilin-1 activity, suggesting Paclitaxel may be an efficient anticancer agent for the treatment of this disease. Paclitaxel 179-189 cofilin 1 Homo sapiens 148-157 23064469-7 2013 Higher expression levels of p-CFL1 in taxol-resistant cells were demonstrated. Paclitaxel 38-43 cofilin 1 Homo sapiens 30-34 23064469-9 2013 These findings suggest that p-CFL1 is upregulated in taxol-resistant ovarian cancer and this upregulation is a chara-cteristic of taxol resistance both in vitro and in vivo. Paclitaxel 53-58 cofilin 1 Homo sapiens 30-34 23064469-9 2013 These findings suggest that p-CFL1 is upregulated in taxol-resistant ovarian cancer and this upregulation is a chara-cteristic of taxol resistance both in vitro and in vivo. Paclitaxel 142-147 cofilin 1 Homo sapiens 30-34 34839191-6 2022 Cofilin-1 knockdown in FBXO31-overexpression cells reversed FBXO31-induced suppression of cell apoptosis, suggesting FBXO31-mediated Taxol chemoresistance is associated with cofilin-1. Paclitaxel 133-138 cofilin 1 Homo sapiens 0-9 34839191-6 2022 Cofilin-1 knockdown in FBXO31-overexpression cells reversed FBXO31-induced suppression of cell apoptosis, suggesting FBXO31-mediated Taxol chemoresistance is associated with cofilin-1. Paclitaxel 133-138 cofilin 1 Homo sapiens 174-183 34284854-1 2021 Objective: To investigate the molecular mechanism of high phosphorylation levels of cofilin-1 (p-CFL-1) associated with paclitaxel resistance in epithelial ovarian cancer (EOC) cells. Paclitaxel 120-130 cofilin 1 Homo sapiens 84-93 34284854-1 2021 Objective: To investigate the molecular mechanism of high phosphorylation levels of cofilin-1 (p-CFL-1) associated with paclitaxel resistance in epithelial ovarian cancer (EOC) cells. Paclitaxel 120-130 cofilin 1 Homo sapiens 97-102 34284854-7 2021 Results: High levels of p-CFL-1 were observed in EOC cells that survived treatment with high doses of paclitaxel. Paclitaxel 102-112 cofilin 1 Homo sapiens 26-31 34284854-9 2021 Cytoplasmic accumulation of p-CFL-1 inhibited paclitaxel-induced mitochondrial apoptosis. Paclitaxel 46-56 cofilin 1 Homo sapiens 30-35 34284854-10 2021 SSH-1 silencing mediated CFL-1 phosphorylation in paclitaxel-resistant SKOV3 cells. Paclitaxel 50-60 cofilin 1 Homo sapiens 25-30 34284854-12 2021 Conclusion: The SSH-1/p-CFL-1 signaling pathway mediates paclitaxel resistance by apoptosis inhibition in EOC and is expected to be a potential prognostic predictor. Paclitaxel 57-67 cofilin 1 Homo sapiens 24-29