PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32425595-8 2020 Xenograft tumor assay was applied for assessing the influence of UCA1 on PTX resistance of BC in vivo. Paclitaxel 73-76 urothelial cancer associated 1 Homo sapiens 65-69 32425595-9 2020 Results: UCA1 expressed highly in PTX-resistant BC tissues and cells and regulated PTX resistance in BC cells by affecting cell viability and apoptosis in part. Paclitaxel 34-37 urothelial cancer associated 1 Homo sapiens 9-13 32425595-9 2020 Results: UCA1 expressed highly in PTX-resistant BC tissues and cells and regulated PTX resistance in BC cells by affecting cell viability and apoptosis in part. Paclitaxel 83-86 urothelial cancer associated 1 Homo sapiens 9-13 32425595-10 2020 UCA1 negatively interacted with miR-613 and modulated PTX resistance via sponging miR-613. Paclitaxel 54-57 urothelial cancer associated 1 Homo sapiens 0-4 32425595-13 2020 The regulatory role of UCA1 in PTX resistance of BC was achieved by miR-613/CDK12 axis in vivo. Paclitaxel 31-34 urothelial cancer associated 1 Homo sapiens 23-27 32425595-14 2020 Conclusion: UCA1 mediated PTX resistance in BC through the miR-613/CDK12 axis, manifesting that UCA1 might improve the PTX treatment of BC as a significant therapeutic biomarker. Paclitaxel 26-29 urothelial cancer associated 1 Homo sapiens 12-16 32425595-14 2020 Conclusion: UCA1 mediated PTX resistance in BC through the miR-613/CDK12 axis, manifesting that UCA1 might improve the PTX treatment of BC as a significant therapeutic biomarker. Paclitaxel 119-122 urothelial cancer associated 1 Homo sapiens 12-16 32425595-14 2020 Conclusion: UCA1 mediated PTX resistance in BC through the miR-613/CDK12 axis, manifesting that UCA1 might improve the PTX treatment of BC as a significant therapeutic biomarker. Paclitaxel 119-122 urothelial cancer associated 1 Homo sapiens 96-100 32016960-0 2020 Long non-coding RNA UCA1 promotes the progression of paclitaxel resistance in ovarian cancer by regulating the miR-654-5p/SIK2 axis. Paclitaxel 53-63 urothelial cancer associated 1 Homo sapiens 20-24 32425595-0 2020 Long Non-Coding RNA UCA1 Modulates Paclitaxel Resistance in Breast Cancer via miR-613/CDK12 Axis. Paclitaxel 35-45 urothelial cancer associated 1 Homo sapiens 20-24 32425595-2 2020 This study was designed to explore the molecular mechanism of long non-coding RNA (lncRNA) urothelial carcinoma-associated 1 (UCA1) in PTX resistance of BC. Paclitaxel 135-138 urothelial cancer associated 1 Homo sapiens 91-124 32425595-2 2020 This study was designed to explore the molecular mechanism of long non-coding RNA (lncRNA) urothelial carcinoma-associated 1 (UCA1) in PTX resistance of BC. Paclitaxel 135-138 urothelial cancer associated 1 Homo sapiens 126-130 32016960-3 2020 However, the function of lncRNA urothelial carcinoma associated1 (UCA1) in paclitaxel (PTX) resistance of OC is not well elucidated. Paclitaxel 75-85 urothelial cancer associated 1 Homo sapiens 66-70 32016960-3 2020 However, the function of lncRNA urothelial carcinoma associated1 (UCA1) in paclitaxel (PTX) resistance of OC is not well elucidated. Paclitaxel 87-90 urothelial cancer associated 1 Homo sapiens 66-70 32016960-9 2020 RESULTS: UCA1 was markedly upregulated in OC tissues and PTX-resistant OC cells. Paclitaxel 57-60 urothelial cancer associated 1 Homo sapiens 9-13 32016960-10 2020 Silencing of UCA1 restrained the PTX resistance, reduced the proliferation, migration, invasion and enhanced the apoptosis of PTX-resistant OC cells. Paclitaxel 33-36 urothelial cancer associated 1 Homo sapiens 13-17 32016960-10 2020 Silencing of UCA1 restrained the PTX resistance, reduced the proliferation, migration, invasion and enhanced the apoptosis of PTX-resistant OC cells. Paclitaxel 126-129 urothelial cancer associated 1 Homo sapiens 13-17 32016960-11 2020 MiR-654-5p could be sponged by UCA1, and the inhibitory effect of its overexpression on the progression of PTX-resistant OC cells could be reversed by overexpressed-UCA1. Paclitaxel 107-110 urothelial cancer associated 1 Homo sapiens 165-169 32016960-15 2020 CONCLUSIONS: LncRNA UCA1 plays an active role in PTX resistance of OC and is crucial to maintain the development of PTX resistance in OC, which provides a new therapeutic target for the study of OC chemoresistance. Paclitaxel 49-52 urothelial cancer associated 1 Homo sapiens 20-24 32016960-15 2020 CONCLUSIONS: LncRNA UCA1 plays an active role in PTX resistance of OC and is crucial to maintain the development of PTX resistance in OC, which provides a new therapeutic target for the study of OC chemoresistance. Paclitaxel 116-119 urothelial cancer associated 1 Homo sapiens 20-24 29777711-0 2018 UCA1 confers paclitaxel resistance to ovarian cancer through miR-129/ABCB1 axis. Paclitaxel 13-23 urothelial cancer associated 1 Homo sapiens 0-4 31011626-4 2019 Microarray analysis identified long non-coding RNA urothelial carcinoma-associated 1 (UCA1) upregulation, which contributed to both enhanced paclitaxel resistance and OVV spread. Paclitaxel 141-151 urothelial cancer associated 1 Homo sapiens 51-84 31011626-4 2019 Microarray analysis identified long non-coding RNA urothelial carcinoma-associated 1 (UCA1) upregulation, which contributed to both enhanced paclitaxel resistance and OVV spread. Paclitaxel 141-151 urothelial cancer associated 1 Homo sapiens 86-90 29777711-3 2018 The objective of this work was to investigate the role and molecular mechanisms of urothelial carcinoma associated 1 (UCA1) in paclitaxel (PTX) resistance in OC. Paclitaxel 127-137 urothelial cancer associated 1 Homo sapiens 83-116 29777711-3 2018 The objective of this work was to investigate the role and molecular mechanisms of urothelial carcinoma associated 1 (UCA1) in paclitaxel (PTX) resistance in OC. Paclitaxel 127-137 urothelial cancer associated 1 Homo sapiens 118-122 29777711-3 2018 The objective of this work was to investigate the role and molecular mechanisms of urothelial carcinoma associated 1 (UCA1) in paclitaxel (PTX) resistance in OC. Paclitaxel 139-142 urothelial cancer associated 1 Homo sapiens 83-116 29777711-3 2018 The objective of this work was to investigate the role and molecular mechanisms of urothelial carcinoma associated 1 (UCA1) in paclitaxel (PTX) resistance in OC. Paclitaxel 139-142 urothelial cancer associated 1 Homo sapiens 118-122 29777711-4 2018 Our results indicated that UCA1 was significantly up-regulated in PTX-resistant OC cells (SKOV3/PTX and HeyA-8/PTX) compared with their parental cells (SKOV3 and HeyA-8). Paclitaxel 66-69 urothelial cancer associated 1 Homo sapiens 27-31 29777711-4 2018 Our results indicated that UCA1 was significantly up-regulated in PTX-resistant OC cells (SKOV3/PTX and HeyA-8/PTX) compared with their parental cells (SKOV3 and HeyA-8). Paclitaxel 96-99 urothelial cancer associated 1 Homo sapiens 27-31 29777711-4 2018 Our results indicated that UCA1 was significantly up-regulated in PTX-resistant OC cells (SKOV3/PTX and HeyA-8/PTX) compared with their parental cells (SKOV3 and HeyA-8). Paclitaxel 96-99 urothelial cancer associated 1 Homo sapiens 27-31 29777711-5 2018 Functionally, UCA1 knockdown sensitized SKOV3/PTX and HeyA-8/PTX cells to PTX through enhancing PTX-induced apoptosis. Paclitaxel 46-49 urothelial cancer associated 1 Homo sapiens 14-18 29777711-5 2018 Functionally, UCA1 knockdown sensitized SKOV3/PTX and HeyA-8/PTX cells to PTX through enhancing PTX-induced apoptosis. Paclitaxel 61-64 urothelial cancer associated 1 Homo sapiens 14-18 29777711-5 2018 Functionally, UCA1 knockdown sensitized SKOV3/PTX and HeyA-8/PTX cells to PTX through enhancing PTX-induced apoptosis. Paclitaxel 61-64 urothelial cancer associated 1 Homo sapiens 14-18 29777711-5 2018 Functionally, UCA1 knockdown sensitized SKOV3/PTX and HeyA-8/PTX cells to PTX through enhancing PTX-induced apoptosis. Paclitaxel 61-64 urothelial cancer associated 1 Homo sapiens 14-18 29777711-6 2018 Mechanistically, UCA1 silencing induced PTX sensitivity of SKOV3/PTX and HeyA-8/PTX cells by de-repressing ABCB1 through sponging miR-129. Paclitaxel 40-43 urothelial cancer associated 1 Homo sapiens 17-21 29777711-6 2018 Mechanistically, UCA1 silencing induced PTX sensitivity of SKOV3/PTX and HeyA-8/PTX cells by de-repressing ABCB1 through sponging miR-129. Paclitaxel 65-68 urothelial cancer associated 1 Homo sapiens 17-21 29777711-6 2018 Mechanistically, UCA1 silencing induced PTX sensitivity of SKOV3/PTX and HeyA-8/PTX cells by de-repressing ABCB1 through sponging miR-129. Paclitaxel 65-68 urothelial cancer associated 1 Homo sapiens 17-21 29777711-7 2018 Collectively, our study elaborated a novel UCA1/miR-129/ABCB1 regulatory axis underlying PTX resistance of OC cells, providing a potential therapeutic target for OC. Paclitaxel 89-92 urothelial cancer associated 1 Homo sapiens 43-47 33818320-2 2021 This study investigated the roles of lncRNA urothelial carcinoma-associated 1 (UCA1) in the modulation of Taxol resistance in human colorectal cancer cells. Paclitaxel 106-111 urothelial cancer associated 1 Homo sapiens 44-77 33818320-2 2021 This study investigated the roles of lncRNA urothelial carcinoma-associated 1 (UCA1) in the modulation of Taxol resistance in human colorectal cancer cells. Paclitaxel 106-111 urothelial cancer associated 1 Homo sapiens 79-83 33818320-4 2021 Construction of the UCA1 overexpression vector revealed that high UCA1 expression was responsible for Taxol resistance and that Taxol can induce UCA1 expression. Paclitaxel 102-107 urothelial cancer associated 1 Homo sapiens 20-24 33818320-4 2021 Construction of the UCA1 overexpression vector revealed that high UCA1 expression was responsible for Taxol resistance and that Taxol can induce UCA1 expression. Paclitaxel 102-107 urothelial cancer associated 1 Homo sapiens 66-70 33818320-4 2021 Construction of the UCA1 overexpression vector revealed that high UCA1 expression was responsible for Taxol resistance and that Taxol can induce UCA1 expression. Paclitaxel 102-107 urothelial cancer associated 1 Homo sapiens 66-70 33818320-4 2021 Construction of the UCA1 overexpression vector revealed that high UCA1 expression was responsible for Taxol resistance and that Taxol can induce UCA1 expression. Paclitaxel 128-133 urothelial cancer associated 1 Homo sapiens 20-24 33818320-6 2021 Further research demonstrated that UCA1 could directly regulate glycolysis by regulating HK2 and LDHA expression, which contributes to Taxol resistance. Paclitaxel 135-140 urothelial cancer associated 1 Homo sapiens 35-39 33818320-8 2021 We report the modulation of UCA-1-regulated glycolysis as a novel anticancer strategy along with the novel role of UCA1 in Taxol resistance. Paclitaxel 123-128 urothelial cancer associated 1 Homo sapiens 115-119