PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34426249-9 2021 This study demonstrated that liposomal paclitaxel formulations are less toxic to normal tissues than free paclitaxel and are more effective in inhibiting tumor cell proliferation/migration and inducing ZEB1/TGF-beta2 gene expression. Paclitaxel 39-49 zinc finger E-box binding homeobox 1 Homo sapiens 202-206 34426249-9 2021 This study demonstrated that liposomal paclitaxel formulations are less toxic to normal tissues than free paclitaxel and are more effective in inhibiting tumor cell proliferation/migration and inducing ZEB1/TGF-beta2 gene expression. Paclitaxel 106-116 zinc finger E-box binding homeobox 1 Homo sapiens 202-206 34163033-0 2021 A novel homeostatic loop of sorcin drives paclitaxel-resistance and malignant progression via Smad4/ZEB1/miR-142-5p in human ovarian cancer. Paclitaxel 42-52 zinc finger E-box binding homeobox 1 Homo sapiens 100-104 34175815-6 2021 Upstream mediators of EMT such as ZEB1/2, TGF-beta, microRNAs, and so on are involved in regulating response of cancer cells to PTX and DTX. Paclitaxel 128-131 zinc finger E-box binding homeobox 1 Homo sapiens 34-40 34163033-10 2021 Targeting this SRI/Smad4/ZEB1/miR-142-5p loop may reverse the PTX-resistance. Paclitaxel 62-65 zinc finger E-box binding homeobox 1 Homo sapiens 25-29 31793989-0 2019 Circular RNA circ-PVT1 contributes to paclitaxel resistance of gastric cancer cells through regulates ZEB1 expression by sponging miR-124-3p. Paclitaxel 38-48 zinc finger E-box binding homeobox 1 Homo sapiens 102-106 33151424-0 2021 Long noncoding RNA ZEB1-AS1 affects paclitaxel and cisplatin resistance by regulating MMP19 in epithelial ovarian cancer cells. Paclitaxel 36-46 zinc finger E-box binding homeobox 1 Homo sapiens 19-23 33151424-6 2021 RESULTS: ZEB1-AS1 depletion using siRNA in chemosensitive A2780 cells significantly increased PTX and DDP resistance. Paclitaxel 94-97 zinc finger E-box binding homeobox 1 Homo sapiens 9-13 33151424-7 2021 In contrast, ZEB1-AS1 overexpression in PTX- and DDP-resistant A2780/resistant (A2780/R) cells reversed the observed drug resistance. Paclitaxel 40-43 zinc finger E-box binding homeobox 1 Homo sapiens 13-17 33151424-8 2021 Thus, ZEB1-AS1 plays an important role in PTX and DDP resistance in EOC cells. Paclitaxel 42-45 zinc finger E-box binding homeobox 1 Homo sapiens 6-10 33151424-13 2021 CCK8 assay results suggested that MMP19 knockdown promoted ZEB1-AS1-induced chemoresistance to PTX and DDP in A2780 cells. Paclitaxel 95-98 zinc finger E-box binding homeobox 1 Homo sapiens 59-63 31793989-5 2019 In the present study, the expression levels of circ-PVT1, miR-124-3p and ZEB1 in PTX-resistant GC tissues and cells were detected by quantitative real-time polymerase chain reaction (RT-qPCR). Paclitaxel 81-84 zinc finger E-box binding homeobox 1 Homo sapiens 73-77 31793989-16 2019 Taken together, our studies disclosed that circ-PVT1 facilitated PTX resistance by upregulating ZEB1 mediated via miR-124-3p, suggesting an underlying therapeutic strategy for GC. Paclitaxel 65-68 zinc finger E-box binding homeobox 1 Homo sapiens 96-100 29180871-0 2017 LncRNA NEAT1 contributes to paclitaxel resistance of ovarian cancer cells by regulating ZEB1 expression via miR-194. Paclitaxel 28-38 zinc finger E-box binding homeobox 1 Homo sapiens 88-92 29245917-7 2017 Although PTX-sensitivity was not changed by silencing ZEB1 in parental EOC cells, the depletion of ZEB1 made the PTX-resistant EOC cells more sensitive to PTX treatment. Paclitaxel 113-116 zinc finger E-box binding homeobox 1 Homo sapiens 99-103 29245917-10 2017 The current data indicate the possible involvement of ZEB1 in the metastasis and paclitaxel resistance of EOC, and suggest that targeting this molecule may reverse the malignant potential and improve the oncologic outcome for EOC patients. Paclitaxel 81-91 zinc finger E-box binding homeobox 1 Homo sapiens 54-58 23869586-15 2013 Our work indicates that paclitaxel-induced reduction of ZEB1 and beta-tubulin isotypes are, in part, due to increased activity of miR-200c. Paclitaxel 24-34 zinc finger E-box binding homeobox 1 Homo sapiens 56-60 31467112-0 2019 Breast cancer risk-associated SNPs in the mTOR promoter form de novo KLF5 and ZEB1 binding sites that influence the cellular response to paclitaxel. Paclitaxel 137-147 zinc finger E-box binding homeobox 1 Homo sapiens 78-82 31467112-5 2019 Mechanistically, the -141T allele of Ht2 creates a novel ZEB1 binding site; meanwhile, the -78C allele of Ht1 exists as an emerging KLF5 binding site, which synergistically induces promote/inhibit mTOR expression, cell proliferation and excretion of cytotoxic drugs through the ZEB1/KLF5-mTOR-CCND1/ABCB1 cascade, thereby affecting the response to PTX treatment in vivo and in vitro. Paclitaxel 348-351 zinc finger E-box binding homeobox 1 Homo sapiens 57-61 31467112-5 2019 Mechanistically, the -141T allele of Ht2 creates a novel ZEB1 binding site; meanwhile, the -78C allele of Ht1 exists as an emerging KLF5 binding site, which synergistically induces promote/inhibit mTOR expression, cell proliferation and excretion of cytotoxic drugs through the ZEB1/KLF5-mTOR-CCND1/ABCB1 cascade, thereby affecting the response to PTX treatment in vivo and in vitro. Paclitaxel 348-351 zinc finger E-box binding homeobox 1 Homo sapiens 278-282 31467112-6 2019 Our results suggest the existence of a ZEB1/KLF5-mTOR-CCND1/ABCB1 axis in human cells that could be involved in PTX response pathways and functionally regulate inter-individualized breast cancer susceptibility and prognosis. Paclitaxel 112-115 zinc finger E-box binding homeobox 1 Homo sapiens 39-43 31467112-7 2019 Implications: The current study highlights the function of haplotypes of mTOR -78C/-141G and -78G/-141T, in affecting breast cancer susceptibility and PTX response regulated by ZEB1/KLF5-mTOR-CCND1/ABCB1 axis. Paclitaxel 151-154 zinc finger E-box binding homeobox 1 Homo sapiens 177-181 29180871-11 2017 Mechanistically, NEAT1-knockdown-induced PTX sensitivity was mediated by miR-194/ZEB1 axis. Paclitaxel 41-44 zinc finger E-box binding homeobox 1 Homo sapiens 81-85 29180871-13 2017 Conclusion: NEAT1 contributed to PTX resistance of ovarian cancer cells at least partly through upregulating ZEB1 expression by sponging miR-194, elucidating a novel regulatory pathway of chemoresistance in PTX-resistant ovarian cancer cells and providing a possible long noncoding RNA (lncRNA)-targeted therapy for ovarian cancer. Paclitaxel 33-36 zinc finger E-box binding homeobox 1 Homo sapiens 109-113 29180871-13 2017 Conclusion: NEAT1 contributed to PTX resistance of ovarian cancer cells at least partly through upregulating ZEB1 expression by sponging miR-194, elucidating a novel regulatory pathway of chemoresistance in PTX-resistant ovarian cancer cells and providing a possible long noncoding RNA (lncRNA)-targeted therapy for ovarian cancer. Paclitaxel 207-210 zinc finger E-box binding homeobox 1 Homo sapiens 109-113 29245917-0 2017 Inhibition of ZEB1 leads to inversion of metastatic characteristics and restoration of paclitaxel sensitivity of chronic chemoresistant ovarian carcinoma cells. Paclitaxel 87-97 zinc finger E-box binding homeobox 1 Homo sapiens 14-18 29245917-6 2017 Additionally, cell migration and invasion were significantly decreased by ZEB1 silencing in both PTX-sensitive and PTX- resistant cells. Paclitaxel 97-100 zinc finger E-box binding homeobox 1 Homo sapiens 74-78 29245917-6 2017 Additionally, cell migration and invasion were significantly decreased by ZEB1 silencing in both PTX-sensitive and PTX- resistant cells. Paclitaxel 115-118 zinc finger E-box binding homeobox 1 Homo sapiens 74-78 29245917-7 2017 Although PTX-sensitivity was not changed by silencing ZEB1 in parental EOC cells, the depletion of ZEB1 made the PTX-resistant EOC cells more sensitive to PTX treatment. Paclitaxel 113-116 zinc finger E-box binding homeobox 1 Homo sapiens 99-103 23807165-9 2013 Modulation of these microRNAs resensitizes PTX-resistant cancer cells by targeting BCL10, caspase-7, and ZEB1. Paclitaxel 43-46 zinc finger E-box binding homeobox 1 Homo sapiens 105-109