PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26146988-0	2015	CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis.	Paclitaxel	15-25	cyclin dependent kinase 5	Homo sapiens	0-4	
26146988-10	2015	CDK5 modulates paclitaxel sensitivity by regulating AKT activation, the cell cycle and caspase-dependent apoptosis.	Paclitaxel	15-25	cyclin dependent kinase 5	Homo sapiens	0-4	
26146988-2	2015	Knockdown of CDK5 enhances paclitaxel sensitivity in human ovarian cancer cells.	Paclitaxel	27-37	cyclin dependent kinase 5	Homo sapiens	13-17	
26146988-11	2015	CDK5 inhibition can potentiate paclitaxel activity in human ovarian cancer cells.	Paclitaxel	31-41	cyclin dependent kinase 5	Homo sapiens	0-4	
26146988-3	2015	This study explores the mechanisms by which CDK5 regulates paclitaxel sensitivity in human ovarian cancers.	Paclitaxel	59-69	cyclin dependent kinase 5	Homo sapiens	44-48	
26146988-6	2015	Knockdown of CDK5 with siRNAs inhibits activation of AKT which significantly correlates with decreased cell growth and enhanced paclitaxel sensitivity in ovarian cancer cell lines.	Paclitaxel	128-138	cyclin dependent kinase 5	Homo sapiens	13-17	
26146988-7	2015	In addition, CDK5 knockdown alone and in combination with paclitaxel induced G1 cell cycle arrest and caspase 3 dependent apoptotic cell death associated with post-translational upregulation and nuclear translocation of TP53 and p27(Kip1) as well as TP53-dependent transcriptional induction of p21(Cip1) in wild type TP53 cancer cells.	Paclitaxel	58-68	cyclin dependent kinase 5	Homo sapiens	13-17	
25827073-0	2015	AC1MMYR2 impairs high dose paclitaxel-induced tumor metastasis by targeting miR-21/CDK5 axis.	Paclitaxel	27-37	cyclin dependent kinase 5	Homo sapiens	83-87	
25827073-4	2015	Here we showed that abnormal activation of miR-21/CDK5 axis was associated with breast cancer lymph node metastasis, which was also contribute to high dose taxol-induced invasion and epithelial mesenchymal transition (EMT) in both breast cancer cell line MDA-MB-231 and glioblastoma cell line U87VIII.	Paclitaxel	156-161	cyclin dependent kinase 5	Homo sapiens	50-54	
25827073-9	2015	Taken together, our work demonstrated that AC1MMYR2 appeared to be a promising strategy in combating taxol induced cancer metastasis by targeting miR-21/CDK5 axis, which highlighted the potential for development of therapeutic modalities for better clinic taxol application.	Paclitaxel	101-106	cyclin dependent kinase 5	Homo sapiens	153-157	
30666557-4	2020	We also provided an overview of genes, including RSF1, CDK5, and SGOL1, whose disruption can synergize with the currently available drugs such as paclitaxel and sorafenib.	Paclitaxel	146-156	cyclin dependent kinase 5	Homo sapiens	55-59	
12540054-4	2002	In an in vitro kinase assay, Taxol inhibited activation of cdk5 by Abeta.	Paclitaxel	29-34	cyclin dependent kinase 5	Homo sapiens	59-63