PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15152939-4 2004 RESULTS: We identified several novel 5-FU-inducible target genes that have not previously been linked to 5-FU response, including spermine/spermidine acetyl transferase (SSAT) and annexin II. Fluorouracil 37-41 annexin A2 Homo sapiens 180-190 15152939-4 2004 RESULTS: We identified several novel 5-FU-inducible target genes that have not previously been linked to 5-FU response, including spermine/spermidine acetyl transferase (SSAT) and annexin II. Fluorouracil 105-109 annexin A2 Homo sapiens 180-190 15152939-6 2004 Inactivation of wild-type p53 abrogated the 5-FU-mediated induction of SSAT and annexin II. Fluorouracil 44-48 annexin A2 Homo sapiens 80-90 15152939-8 2004 Furthermore, basal expression of SSAT and annexin II was elevated in cells resistant to 5-FU. Fluorouracil 88-92 annexin A2 Homo sapiens 42-52 12907638-7 2003 The 5-FU-induced activation of MAT-8, thymosin-beta-10, and chaperonin-10 was abrogated by inactivation of p53 in MCF-7 cells, whereas induction of SSAT and annexin II was significantly reduced in the absence of p53. Fluorouracil 4-8 annexin A2 Homo sapiens 157-167 25385370-0 2015 Annexin A2 knockdown inhibits hepatoma cell growth and sensitizes hepatoma cells to 5-fluorouracil by regulating beta-catenin and cyclin D1 expression. Fluorouracil 84-98 annexin A2 Homo sapiens 0-10 25385370-5 2015 We also investigated the role of ANXA2 in chemotherapeutic treatment with 5-FU. Fluorouracil 74-78 annexin A2 Homo sapiens 33-38 25385370-6 2015 5-FU inhibited hepatoma cell growth, while ANXA2 overexpression reduced, and knockdown enhanced, the effects of 5-FU on hepatoma cell growth. Fluorouracil 112-116 annexin A2 Homo sapiens 43-48 25385370-8 2015 Taken together, our data suggest that the ANXA2 protein is a critical factor in HCC and that its downregulation can enhance chemotherapeutic treatment with 5-FU. Fluorouracil 156-160 annexin A2 Homo sapiens 42-47 25150310-11 2014 After knock-down ANXA2 expression using ANXA2 small interfering RNA, the drug sensitivity of SGC7901/DDP cells to doxorubicin, 5-FU and DDP increased. Fluorouracil 127-131 annexin A2 Homo sapiens 17-22