PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21737644-6 2011 NK4 gene expression enhanced 5-FU-induced caspase-3 and -7 activation of CT26. Fluorouracil 29-33 caspase 3 Mus musculus 42-58 34257696-12 2021 The numbers of TUNEL+ cells and the expression of Bax and caspase-3 proteins were significantly increased in the 5-FU + ETSJC groups when compared with the 5-FU group. Fluorouracil 113-117 caspase 3 Mus musculus 58-67 34257696-12 2021 The numbers of TUNEL+ cells and the expression of Bax and caspase-3 proteins were significantly increased in the 5-FU + ETSJC groups when compared with the 5-FU group. Fluorouracil 156-160 caspase 3 Mus musculus 58-67 33886055-6 2021 Also, where 5-FU is in the concentration of caspase-3 and 8-OHdG immune-positive cells and therefore causes apoptosis and DNA damage in kidney tissue cells. Fluorouracil 12-16 caspase 3 Mus musculus 44-53 27177453-7 2016 Cells combined treatment with allicin and 5-FU increased intracellular reactive oxygen species (ROS) level, reduced mitochondrial membrane potential (DeltaPsim), activated caspase-3 and PARP, and down-regulated Bcl-2 compared with DMSO, allicin and 5-FU treated alone. Fluorouracil 42-46 caspase 3 Mus musculus 172-181 34245831-10 2021 When OP9 cells were treated with both SIP (10 g L-1) and 5-FU (2.5 x 10-2 g L-1) for 24 h, compared with the model group, the early apoptosis rates significantly decreased, and the activity of caspase 3 was significantly reduced. Fluorouracil 57-61 caspase 3 Mus musculus 193-202 31843717-8 2020 The 5Fu in CS-GCNCs retained high cancer cell killing bioactivity by enhancing the caspase-3 expression level. Fluorouracil 4-7 caspase 3 Mus musculus 83-92 31288002-7 2019 RESULTS: combined administration of luteolin and 5-FU in SEC model increased levels of p53, p21, caspase 3, DRAM and survivability while, tumor volume, weight, thioredoxin reductase one (TR1) activity and cyclin D1 expression showed the reverse with restoration of oxidant/antioxidant indices. Fluorouracil 49-53 caspase 3 Mus musculus 97-106 27385218-0 2016 SEP enhanced the antitumor activity of 5-fluorouracil by up-regulating NKG2D/MICA and reversed immune suppression via inhibiting ROS and caspase-3 in mice. Fluorouracil 39-53 caspase 3 Mus musculus 137-146 27385218-8 2016 Moreover, in H22- or Lewis lung cancer (LLC)-bearing mouse models, SEP reversed 5-FU-induced atrophy and apoptosis in both the spleen and bone marrow in vivo by suppressing ROS generation and caspase-3 activation. Fluorouracil 80-84 caspase 3 Mus musculus 192-201 26276288-1 2015 OBJECTIVE: To study the effect of lipoteichoic acid (LTA) and 5-FU on the expression of caspase-3, EGFR, TGF-alpha proteins of tumor tissue of H22 cancer bearing mice and its anti-tumor mechanism. Fluorouracil 62-66 caspase 3 Mus musculus 88-97 26276288-9 2015 CONCLUSIONS: LTA combined with 5-FU can effectively inhibit the tumorigenesis of H22 tumor bearing mice, increase the caspase-3 protein expression, inhibit TGF-alpha and EGFR protein expression, further promote tumor cell apoptosis and play a synergistic antitumor effect. Fluorouracil 31-35 caspase 3 Mus musculus 118-127 22403796-6 2012 The numbers of apoptotic caspase-3- and caspase-8-activated cells in the intestinal crypt increased 24 h after the first 5-FU administration but were overall significantly lower in Nox1KO than in WT mice. Fluorouracil 121-125 caspase 3 Mus musculus 25-34 15720820-6 2005 Downregulation of PKB/Akt, NF-kappaB, and cyclin D1, and upregulation of caspase-3 protein expression level were observed in cells and tumor lesions on treatment with a combination of CF101 and 5-FU. Fluorouracil 194-198 caspase 3 Mus musculus 73-82 21223795-9 2010 The average gray value of caspase-3 protein expressed in the control group was 46.12 +- 0.33 and the relative expression of caspase-3 mRNA was 0.14 +- 0.03, both were significantly lower than that in the ATRA group, 5-Fu group and the two-drugs combination group (P < 0.05). Fluorouracil 216-220 caspase 3 Mus musculus 26-35 21223795-9 2010 The average gray value of caspase-3 protein expressed in the control group was 46.12 +- 0.33 and the relative expression of caspase-3 mRNA was 0.14 +- 0.03, both were significantly lower than that in the ATRA group, 5-Fu group and the two-drugs combination group (P < 0.05). Fluorouracil 216-220 caspase 3 Mus musculus 124-133 18266059-0 2008 In vivo 5-fluorouracil-[corrected]induced apoptosis on murine thymocytes: involvement of FAS, Bax and Caspase3. Fluorouracil 8-22 caspase 3 Mus musculus 102-110 18266059-12 2008 This study revealed that in vivo apoptosis in normal thymus after 5-FU administration is related to FAS, Bax, and Caspase 3 co-expressions under the current experimental conditions, these findings, therefore, contribute to a new insight into the molecular mechanisms involved during 5-FU administration upon the thymus and the possible events committed in the lymphophenia associated with chemotherapy. Fluorouracil 66-70 caspase 3 Mus musculus 114-123 17589894-0 2007 Effect of targeted magnetic nanoparticles containing 5-FU on expression of bcl-2, bax and caspase 3 in nude mice with transplanted human liver cancer. Fluorouracil 53-57 caspase 3 Mus musculus 90-99 17589894-9 2007 CONCLUSION: The targeted magnetic nanoparticles containing 5-FU can improve the chemotherapeutic effect of 5-FU against hepatocellular carcinoma by decreasing the expression of bcl-2 gene, and increasing the expression of bax and caspase 3 genes. Fluorouracil 59-63 caspase 3 Mus musculus 230-239 17589894-9 2007 CONCLUSION: The targeted magnetic nanoparticles containing 5-FU can improve the chemotherapeutic effect of 5-FU against hepatocellular carcinoma by decreasing the expression of bcl-2 gene, and increasing the expression of bax and caspase 3 genes. Fluorouracil 107-111 caspase 3 Mus musculus 230-239