PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29053388-7 2018 The cells treated with 5-FU or IRINO exhibited several hallmarks of SIPS: growth arrest, increased size and granularity, polyploidization, augmented activity of the SA-beta-galactosidase, accumulation of P21 and CYCLIN D1 proteins, and the senescence-associated secretory phenotype. Fluorouracil 23-27 H3 histone pseudogene 16 Homo sapiens 204-207 33240430-9 2021 5-FU induced apoptosis through p53-p21 activity, while chrysin arrested the cell cycle in the G2/M phase. Fluorouracil 0-4 H3 histone pseudogene 16 Homo sapiens 35-38 31366086-10 2019 Intriguingly, the combination of LA and anticancer drugs (doxorubicin, 5-fluorouracil) attenuated p53-mediated stabilization of p21 and resulted in synergistic killing in CRC cells in a p53-dependant manner. Fluorouracil 71-85 H3 histone pseudogene 16 Homo sapiens 128-131 31097925-0 2019 Coelomic Fluid of Lumbricus rubellus Synergistically Enhances Cytotoxic Effect of 5-Fluorouracil through Modulation of Focal Adhesion Kinase and p21 in HT-29 Cancer Cell Line. Fluorouracil 82-96 H3 histone pseudogene 16 Homo sapiens 145-148 31097925-3 2019 This study aims to investigate whether the combination of CFL and 5-fluorouracil could reduce FAK protein level and iCa2+ and enhance p21 level. Fluorouracil 66-80 H3 histone pseudogene 16 Homo sapiens 134-137 31097925-9 2019 Combination of CFL and 5-fluorouracil significantly decreased FAK expression (p<0.05), iCa2+ (p<0.05), and increased p21 expression (p<0.05) in HT-29 cells. Fluorouracil 23-37 H3 histone pseudogene 16 Homo sapiens 123-126 29702091-5 2018 Significantly, MALAT1 deletion sensitized HepG2 cells to 5-FU-induced cell cycle arrest in G1 phase, as evidenced by the significant reduction in Cyclin D1 and CDK4 and increase in p53, p21 and p27 protein levels. Fluorouracil 57-61 H3 histone pseudogene 16 Homo sapiens 186-189 30304835-0 2018 Cytoplasmic p21 Mediates 5-Fluorouracil Resistance by Inhibiting Pro-Apoptotic Chk2. Fluorouracil 25-39 H3 histone pseudogene 16 Homo sapiens 12-15 30304835-3 2018 Here, we show for the first time that cytoplasmic p21 mediates 5-Fluorouracil (5FU) resistance by shuttling p-Chk2 out of the nucleus to protect the tumor cells from its pro-apoptotic functions. Fluorouracil 63-77 H3 histone pseudogene 16 Homo sapiens 50-53 30304835-3 2018 Here, we show for the first time that cytoplasmic p21 mediates 5-Fluorouracil (5FU) resistance by shuttling p-Chk2 out of the nucleus to protect the tumor cells from its pro-apoptotic functions. Fluorouracil 79-82 H3 histone pseudogene 16 Homo sapiens 50-53 26687645-5 2016 Co-treatment with OMT and 5-Fu caused G0/G1 phase arrest by upregulating P21 and P27 and downregulating cyclin D, and induced apoptosis through increasing the production of reactive oxygen species (ROS) and decreasing the levels of p-ERK. Fluorouracil 26-30 H3 histone pseudogene 16 Homo sapiens 73-76 28382142-7 2017 Results: Ectopic expression of PRC1 significantly increased the chemoresistance, promoted the tumor growth and abrogated 5-FU-induced G2/M phase arrest via p21/p27-pRBs pathway. Fluorouracil 121-125 H3 histone pseudogene 16 Homo sapiens 156-159 27871087-0 2018 The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in the p53wild type Neuroendocrine Tumor Cell Line GOT1. Fluorouracil 103-117 H3 histone pseudogene 16 Homo sapiens 129-132 27871087-10 2018 NVP-CGM097 and 5-fluorouracil increased p53 and p21 expression in an additive manner. Fluorouracil 15-29 H3 histone pseudogene 16 Homo sapiens 48-51 28816773-5 2017 In our study, combined 3-BP and 5-FU treatment upregulated p53 and p21, whereas cyclin-dependent kinase CDK4 and CDK2 were downregulated, which led to G0/G1 phase arrest. Fluorouracil 32-36 H3 histone pseudogene 16 Homo sapiens 67-70 27509880-0 2016 Combination of the histone deacetylase inhibitor depsipeptide and 5-fluorouracil upregulates major histocompatibility complex class II and p21 genes and activates caspase-3/7 in human colon cancer HCT-116 cells. Fluorouracil 66-80 H3 histone pseudogene 16 Homo sapiens 139-142 24708484-0 2014 P21 and CD166 as predictive markers of poor response and outcome after fluorouracil-based chemoradiotherapy for the patients with rectal cancer. Fluorouracil 71-83 H3 histone pseudogene 16 Homo sapiens 0-3 26785286-10 2016 CONCLUSION: These data reveal that 5-FU-induced cellular apoptosis in corneal epithelial cells may be mediated through caspase-8, caspase-9, and mitochondria-regulated pathways, as well as by upregulation of p21 and downregulation of Bcl-2-dependent signal transduction pathways. Fluorouracil 35-39 H3 histone pseudogene 16 Homo sapiens 208-211 26774139-8 2016 In addition, chidamide alone or in combination with 5-Fu increased the p53, phosphorylated-p53 (p-p53), p21 and gammaH2AX levels, but suppressed cyclin dependent kinase 4 (CDK4) expression in tumor cells. Fluorouracil 52-56 H3 histone pseudogene 16 Homo sapiens 104-107 24919507-9 2014 In in vitro studies, we observed increased expression of p21 and p-ERK1/2 diminution via use of both analogs as compared to use of 5-FU alone. Fluorouracil 131-135 H3 histone pseudogene 16 Homo sapiens 57-60 24919507-12 2014 Our results suggest that the mechanism of potentiation of 5-FU antitumor action by both analogs is realized via increased p21 expression and decreased p-ERK1/2 level which may lead to diminution of thymidylate synthase expression. Fluorouracil 58-62 H3 histone pseudogene 16 Homo sapiens 122-125 24708484-9 2014 CONCLUSION: These show high p21 and CD166 expression at the pretreatment biopsy were associated with tumor regression and poor prognosis in patients treated with 5-FU based CRT. Fluorouracil 162-166 H3 histone pseudogene 16 Homo sapiens 28-31 14751837-6 2003 The antisense oligonucleotides also potentiated the effects of p53 activation and p21 induction by chemotherapeutic agents 10-hydroxycamptothecin, adriamycin, 5-fluorouracil, and paclitaxel. Fluorouracil 159-173 H3 histone pseudogene 16 Homo sapiens 82-85 23810214-6 2013 By contrast, 5-fluorouracil induced G2 cell-cycle arrest and apoptosis that may be associated with p53 activation and p21 up-regulation. Fluorouracil 13-27 H3 histone pseudogene 16 Homo sapiens 118-121 20633010-6 2010 5-FU induced p53 and p21 accumulation together with a decrease in cyclin B1 and Bcl-2 levels in treated keloid fibroblasts. Fluorouracil 0-4 H3 histone pseudogene 16 Homo sapiens 21-24 19621385-12 2010 The combination of Ki23057 and 5-FU decreased DPD expression and increased apoptosis rates and p21 expression level of SGC cells. Fluorouracil 31-35 H3 histone pseudogene 16 Homo sapiens 95-98 18834353-8 2008 When cells were treated with 20 microM 5-fluorouracil and 200 microg/ml Bupleuri Radix simultaneously, Bax protein increased in HepG2 cells at 24 hr; however, p21 and p53 proteins were up-regulated in normal human lymphocytes. Fluorouracil 39-53 H3 histone pseudogene 16 Homo sapiens 159-162 23787902-8 2013 Ectopic expression of DACH1 enhanced chemosensitivity to 5-fluorouracil (5-FU) by inducing p21 expression in HCC cells. Fluorouracil 57-71 H3 histone pseudogene 16 Homo sapiens 91-94 23787902-8 2013 Ectopic expression of DACH1 enhanced chemosensitivity to 5-fluorouracil (5-FU) by inducing p21 expression in HCC cells. Fluorouracil 73-77 H3 histone pseudogene 16 Homo sapiens 91-94 12518324-7 2003 The antisense oligonucleotide also potentiated the effects of p53 activation and p21 induction by chemotherapeutic agents 10-hydroxycamptothecin, adriamycin, 5-fluorouracil, and paclitaxel. Fluorouracil 158-172 H3 histone pseudogene 16 Homo sapiens 81-84 11299739-6 2001 We therefore concluded that immunohistochemical studies for p53 and p21 were useful for predicting the chemosensitivities of colon and gastric cancer to MMC and 5-FU. Fluorouracil 161-165 H3 histone pseudogene 16 Homo sapiens 68-71 10424768-6 1999 FUra exposure resulted in transient induction of p53 and p21, which returned to basal levels 24 hr after drug removal. Fluorouracil 0-4 H3 histone pseudogene 16 Homo sapiens 57-60 10785598-4 2000 Exposure to 5-FU (50 and 100 microM) and ZD1694 (50 and 100 nM) for 24 and 48 h induced p53 and p21 expression in wt p53 cells, but not in mt p53 cells. Fluorouracil 12-16 H3 histone pseudogene 16 Homo sapiens 96-99 35245520-3 2022 KEY FINDINGS: TQ monotherapy had greater anticancer effects to active VD3 or 5-FU, revealing higher expression of p21/p27/PTEN/BAX/Cyto-C/Casp-3 and increased levels of total glutathione, with inhibitions in CCND1/CCND3/BCL-2 and PI3K/AKT/mTOR molecules, alongside higher rates of apoptosis in HT29, SW480 and SW620 cells (P < 0.005 for all markers). Fluorouracil 77-81 H3 histone pseudogene 16 Homo sapiens 114-117 9930367-0 1998 p53- and p21-independent apoptosis of squamous cell carcinoma cells induced by 5-fluorouracil and radiation. Fluorouracil 79-93 H3 histone pseudogene 16 Homo sapiens 9-12 9930367-12 1998 These findings indicate that 5-FU and gamma-rays induce apoptosis of squamous cell carcinoma cells in p53- and p21-independent manners, in the S and G2/M phases, respectively. Fluorouracil 29-33 H3 histone pseudogene 16 Homo sapiens 111-114 34970530-8 2021 Mechanistically, 2b induced apoptosis-dependent anticancer effect (43%) higher than that of 5-fluorouracil (34.95%) in three studied cancer cell lines, activated p53 (47%), downregulated the Bcl2 gene (1.25-fold), and upregulated p21 (2-fold) in the treated cancer cells. Fluorouracil 92-106 H3 histone pseudogene 16 Homo sapiens 230-233 35354250-5 2022 Mechanismly, PFKFB3 facilitated pro-apoptotic transcription factor FOXO3A and its downstream gene expressions, including p21, p27, FAS after 5FU treatment in vitro. Fluorouracil 141-144 H3 histone pseudogene 16 Homo sapiens 121-124 35326689-11 2022 Moreover, 5-FU/VD3/Met revealed maximal inhibitions of cell cycle inducers (CCND1/CCND3), cell survival (BCL2), and the PI3K/Akt/mTOR molecules alongside the highest expression of cell cycle inhibitors (p21/p27), proapoptotic markers (BAX/cytochrome C/caspase-3), and PTEN in both cell lines. Fluorouracil 10-14 H3 histone pseudogene 16 Homo sapiens 203-206 35096810-6 2021 Moreover, combination of HAUS6 knockdown and 5-FU treatment further enhanced the suppression of cell proliferation of CRC cells by increasing activation of the p53/p21 pathway. Fluorouracil 45-49 H3 histone pseudogene 16 Homo sapiens 164-167