PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15269599-3 2004 Recently described in this context was the dUTPase, which may confer resistance to fluoropyrimidine drugs such as 5-fluorouracil (5-FU). Fluorouracil 114-128 Deoxyuridine triphosphatase Drosophila melanogaster 43-50 15269599-3 2004 Recently described in this context was the dUTPase, which may confer resistance to fluoropyrimidine drugs such as 5-fluorouracil (5-FU). Fluorouracil 130-134 Deoxyuridine triphosphatase Drosophila melanogaster 43-50 22339362-1 2012 Inhibition of human deoxyuridine triphosphatase (dUTPase) has been identified as a promising approach to enhance the efficacy of 5-fluorouracil (5-FU)-based chemotherapy. Fluorouracil 129-143 Deoxyuridine triphosphatase Drosophila melanogaster 49-56 12096336-0 2002 Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil. Fluorouracil 115-129 Deoxyuridine triphosphatase Drosophila melanogaster 66-73 12096336-6 2002 Using tetracycline-regulated retroviral vectors for conditional expression of p53 mutants, we found that transcription of the dUTPase gene is increased within 24 h after tetracycline withdrawal, and the cells acquire higher resistance to 5-FU. Fluorouracil 238-242 Deoxyuridine triphosphatase Drosophila melanogaster 126-133 10910061-3 2000 In this study, we have determined the expression patterns of dUTPase in normal and neoplastic tissues and examined the association between dUTPase expression and response to 5-fluorouracil (5-FU)-based chemotherapy and overall survival in colorectal cancer. Fluorouracil 174-188 Deoxyuridine triphosphatase Drosophila melanogaster 139-146 10910061-3 2000 In this study, we have determined the expression patterns of dUTPase in normal and neoplastic tissues and examined the association between dUTPase expression and response to 5-fluorouracil (5-FU)-based chemotherapy and overall survival in colorectal cancer. Fluorouracil 190-194 Deoxyuridine triphosphatase Drosophila melanogaster 139-146 10910061-13 2000 To examine the association between dUTPase expression and response to 5-FU-based chemotherapy and overall survival, we initiated a retrospective study including tumor specimens from 20 patients who had received protracted infusion of 5-FU and leucovorin for treatment of metastatic colon cancer. Fluorouracil 70-74 Deoxyuridine triphosphatase Drosophila melanogaster 35-42 10910061-21 2000 This study demonstrates that low intratumoral levels of nuclear dUTPase protein expression is associated with response to 5-FU-based chemotherapy, greater time to progression, and greater overall survival in colorectal cancer. Fluorouracil 122-126 Deoxyuridine triphosphatase Drosophila melanogaster 64-71 10567908-9 1999 Since it has been demonstrated that dUTPase expression can mediate resistance to 5-fluorouracil, it is also possible that these MAbs may be helpful in identifying patients with colorectal carcinomas resistant to adjuvant chemotherapy using this and related compounds. Fluorouracil 81-95 Deoxyuridine triphosphatase Drosophila melanogaster 36-43 28423595-0 2017 dUTPase inhibition augments replication defects of 5-Fluorouracil. Fluorouracil 51-65 Deoxyuridine triphosphatase Drosophila melanogaster 0-7 28423595-4 2017 Interestingly, these effects can be reinforced by either depletion or inhibition of the deoxyuridine triphosphatase (dUTPase, also known as DUT), highlighting the importance of (5-F)dUTP accumulation for cytotoxicity.With this study, we not only extend the current understanding of the mechanism of action of 5-FU, but also contribute to the characterization of dUTPase inhibitors. Fluorouracil 309-313 Deoxyuridine triphosphatase Drosophila melanogaster 117-124 28423595-4 2017 Interestingly, these effects can be reinforced by either depletion or inhibition of the deoxyuridine triphosphatase (dUTPase, also known as DUT), highlighting the importance of (5-F)dUTP accumulation for cytotoxicity.With this study, we not only extend the current understanding of the mechanism of action of 5-FU, but also contribute to the characterization of dUTPase inhibitors. Fluorouracil 309-313 Deoxyuridine triphosphatase Drosophila melanogaster 362-369 28423595-5 2017 We demonstrate that pharmacological inhibition of dUTPase is a promising approach that may improve the efficacy of 5-FU treatment in the clinic. Fluorouracil 115-119 Deoxyuridine triphosphatase Drosophila melanogaster 50-57 33140501-7 2021 Base excision repair (BER) and homologous recombination (HR) were found to be involved in the DNA repair of 5-FU and uracil misincorporation caused by dUTPase inhibition in genetically modified chicken DT40 cell lines and siRNA-treated HeLa cells. Fluorouracil 108-112 Deoxyuridine triphosphatase Drosophila melanogaster 151-158 22404301-1 2012 Recently, deoxyuridine triphosphatase (dUTPase) has emerged as a potential target for drug development as part of a new strategy of 5-fluorouracil-based combination chemotherapy. Fluorouracil 132-146 Deoxyuridine triphosphatase Drosophila melanogaster 39-46 22339362-1 2012 Inhibition of human deoxyuridine triphosphatase (dUTPase) has been identified as a promising approach to enhance the efficacy of 5-fluorouracil (5-FU)-based chemotherapy. Fluorouracil 145-149 Deoxyuridine triphosphatase Drosophila melanogaster 49-56 19015155-3 2009 Importantly, uracil misincorporation is a mechanism of cytotoxicity induced by fluoropyrimidine chemotherapeutic agents including 5-fluorouracil (5-FU) and elevated expression of dUTPase is negatively correlated with clinical response to 5-FU-therapy. Fluorouracil 238-242 Deoxyuridine triphosphatase Drosophila melanogaster 179-186 19968781-7 2010 Suppression of dUTPase expression using short interfering RNAs inhibited cell proliferation and sensitized HuH7 cells to 5-fluorouracil treatment. Fluorouracil 121-135 Deoxyuridine triphosphatase Drosophila melanogaster 15-22 19052026-6 2009 RESULTS: Of the six 5-FU-related enzymes, the numbers of patients with expression of dUTPase (54% versus 15%; p = 0.005), TK (26% versus 0%; p = 0.019) and DPD (17% versus 45%; p = 0.033) were significantly different in those with primary tumours with metastasis compared with those with non-metastasis, respectively. Fluorouracil 20-24 Deoxyuridine triphosphatase Drosophila melanogaster 85-92 19052026-9 2009 CONCLUSIONS: From this comparative study of the six 5-FU-related enzymes in colorectal cancer, the expression of dUTPase was most significantly different between primary tumours and their corresponding metastatic tumour. Fluorouracil 52-56 Deoxyuridine triphosphatase Drosophila melanogaster 113-120 21780905-3 2011 Repression of dUTPase induced specific expression level increments for thymidylate kinase and thymidine kinase, and also an increased sensitization to 5-fluoro-2"-deoxyuridine and 5-fluoro-uracil. Fluorouracil 180-195 Deoxyuridine triphosphatase Drosophila melanogaster 14-21 19015155-9 2009 The novel observation that oxaliplatin downregulates dUTPase expression may provide a mechanistic basis contributing to the synergy observed between 5-FU and oxaliplatin in the clinic. Fluorouracil 149-153 Deoxyuridine triphosphatase Drosophila melanogaster 53-60 18790783-7 2008 In this article, we present further evidence showing that elevated expression of dUTPase can protect breast cancer cells from the expansion of the intracellular uracil pool, translating to reduced growth inhibition following treatment with 5-FU. Fluorouracil 240-244 Deoxyuridine triphosphatase Drosophila melanogaster 81-88 18790783-9 2008 As 5-FU and the oral 5-FU prodrug capecitabine remain central agents in the treatment of a variety of malignancies, the clinical utility of a small-molecule inhibitor to dUTPase represents a viable strategy to improve the clinical efficacy of these mainstay chemotherapeutic agents. Fluorouracil 3-7 Deoxyuridine triphosphatase Drosophila melanogaster 170-177 18790783-9 2008 As 5-FU and the oral 5-FU prodrug capecitabine remain central agents in the treatment of a variety of malignancies, the clinical utility of a small-molecule inhibitor to dUTPase represents a viable strategy to improve the clinical efficacy of these mainstay chemotherapeutic agents. Fluorouracil 21-25 Deoxyuridine triphosphatase Drosophila melanogaster 170-177