PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25375110-2	2014	TDG preferentially catalyzes the removal of thymine and uracil paired with guanine, and is also active on 5-fluorouracil (5-FU) paired with adenine or guanine.	Fluorouracil	106-120	thymine DNA glycosylase	Homo sapiens	0-3	
35436101-1	2022	Thymine DNA glycosylase (TDG) is tasked with initiating DNA base excision repair by recognizing and removing T, U, the chemotherapeutic 5-fluorouracil (5-FU), and many other oxidized and halogenated pyrimidine bases.	Fluorouracil	136-150	thymine DNA glycosylase	Homo sapiens	0-23	
35436101-1	2022	Thymine DNA glycosylase (TDG) is tasked with initiating DNA base excision repair by recognizing and removing T, U, the chemotherapeutic 5-fluorouracil (5-FU), and many other oxidized and halogenated pyrimidine bases.	Fluorouracil	136-150	thymine DNA glycosylase	Homo sapiens	25-28	
35436101-1	2022	Thymine DNA glycosylase (TDG) is tasked with initiating DNA base excision repair by recognizing and removing T, U, the chemotherapeutic 5-fluorouracil (5-FU), and many other oxidized and halogenated pyrimidine bases.	Fluorouracil	152-156	thymine DNA glycosylase	Homo sapiens	0-23	
35436101-1	2022	Thymine DNA glycosylase (TDG) is tasked with initiating DNA base excision repair by recognizing and removing T, U, the chemotherapeutic 5-fluorouracil (5-FU), and many other oxidized and halogenated pyrimidine bases.	Fluorouracil	152-156	thymine DNA glycosylase	Homo sapiens	25-28	
25375110-2	2014	TDG preferentially catalyzes the removal of thymine and uracil paired with guanine, and is also active on 5-fluorouracil (5-FU) paired with adenine or guanine.	Fluorouracil	122-126	thymine DNA glycosylase	Homo sapiens	0-3	
23952905-7	2013	Although acetylated TDG has reduced glycosylase activity towards T/G, 5-formylcytosine/G and 5-carboxylcytosine/G, it has a stronger activity towards a 5-fluorouracil/G substrate as compared with unmodified TDG.	Fluorouracil	152-166	thymine DNA glycosylase	Homo sapiens	20-23	
24962565-2	2014	TDG mediates the cytotoxicity of the anti-cancer chemotherapeutic drug 5-fluorouracil (5-FU) by prolonging S phase, generating DNA strand breaks, and inducing DNA damage signaling.	Fluorouracil	71-85	thymine DNA glycosylase	Homo sapiens	0-3	
24962565-2	2014	TDG mediates the cytotoxicity of the anti-cancer chemotherapeutic drug 5-fluorouracil (5-FU) by prolonging S phase, generating DNA strand breaks, and inducing DNA damage signaling.	Fluorouracil	87-91	thymine DNA glycosylase	Homo sapiens	0-3	
24962565-8	2014	Compared with forced expression of wild type TDG, CRL4(Cdt2)- resistant TDG (DeltaPIP) slows cell proliferation and slightly increases the toxicity of 5-FU.	Fluorouracil	151-155	thymine DNA glycosylase	Homo sapiens	72-75	
23952905-10	2013	The physical and functional interactions between SIRT1 and TDG may mediate DNA repair, gene expression and FU (5-fluorouracil)-mediated cytotoxicity.	Fluorouracil	111-125	thymine DNA glycosylase	Homo sapiens	59-62	
16984202-7	2006	We find that hTDG removes 5-fluorouracil 78-fold faster than uracil, and 5-chlorouracil, 572-fold faster than thymine, differences that can be attributed predominantly to leaving-group ability.	Fluorouracil	26-40	thymine DNA glycosylase	Homo sapiens	13-17	
19402749-0	2009	Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil.	Fluorouracil	79-93	thymine DNA glycosylase	Homo sapiens	17-40	
19402749-3	2009	In this study, we investigated a possible role of thymine DNA glycosylase (TDG), one of four mammalian uracil DNA glycosylases (UDGs), in the cellular response to 5-FU.	Fluorouracil	163-167	thymine DNA glycosylase	Homo sapiens	50-73	
19402749-3	2009	In this study, we investigated a possible role of thymine DNA glycosylase (TDG), one of four mammalian uracil DNA glycosylases (UDGs), in the cellular response to 5-FU.	Fluorouracil	163-167	thymine DNA glycosylase	Homo sapiens	75-78	
19402749-5	2009	We show that excision of DNA-incorporated 5-FU by TDG generates persistent DNA strand breaks, delays S-phase progression, and activates DNA damage signaling, and that the repair of 5-FU-induced DNA strand breaks is more efficient in the absence of TDG.	Fluorouracil	42-46	thymine DNA glycosylase	Homo sapiens	50-53	
19402749-6	2009	Hence, excision of 5-FU by TDG, but not by other UDGs (UNG2 and SMUG1), prevents efficient downstream processing of the repair intermediate, thereby mediating DNA-directed cytotoxicity.	Fluorouracil	19-23	thymine DNA glycosylase	Homo sapiens	27-30	
19402749-7	2009	The status of TDG expression in a cancer is therefore likely to determine its response to 5-FU-based chemotherapy.	Fluorouracil	90-94	thymine DNA glycosylase	Homo sapiens	14-17