PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31702387-5 2020 Functionally, knockdown of UCA1 remarkably inhibited proliferation and sensitized retinoblastoma cells to multiple chemotherapy drugs, including vincristine (VCR), carboplatin (CBP), cisplatin (DDP), VP-16 (etoposide), and 5-fluorouracil (5-Fu). Fluorouracil 223-237 urothelial cancer associated 1 Homo sapiens 27-31 33961855-12 2021 UCA1 enhanced cell proliferation, migration/invasion, angiogenesis, epithelial-mesenchymal transition, and resistance to 5-FU in CRC cell lines. Fluorouracil 121-125 urothelial cancer associated 1 Homo sapiens 0-4 32801774-0 2020 lncRNA UCA1 Contributes to 5-Fluorouracil Resistance of Colorectal Cancer Cells Through miR-23b-3p/ZNF281 Axis. Fluorouracil 27-41 urothelial cancer associated 1 Homo sapiens 7-11 32801774-8 2020 Murine xenograft model was established to verify the role of UCA1 on the 5-FU resistance of CRC in vivo. Fluorouracil 73-77 urothelial cancer associated 1 Homo sapiens 61-65 32801774-9 2020 Results: The 5-FU resistance of CRC was positively related to the level of UCA1 and autophagy. Fluorouracil 13-17 urothelial cancer associated 1 Homo sapiens 75-79 32801774-10 2020 UCA1 accelerated the 5-FU resistance of CRC cells through facilitating autophagy and suppressing apoptosis. Fluorouracil 21-25 urothelial cancer associated 1 Homo sapiens 0-4 32801774-12 2020 The knockdown of miR-23b-3p reversed the inhibitory effects of UCA1 interference on the 5-FU resistance and autophagy and the promoting impact on the apoptosis of CRC cells. Fluorouracil 88-92 urothelial cancer associated 1 Homo sapiens 63-67 32801774-15 2020 UCA1 interference enhanced the 5-FU sensitivity of CRC through miR-23b-3p/ZNF281 axis in vivo. Fluorouracil 31-35 urothelial cancer associated 1 Homo sapiens 0-4 32801774-16 2020 Conclusion: UCA1 mediated 5-FU resistance of CRC cells through facilitating autophagy and inhibiting apoptosis via miR-23b-3p/ZNF281 axis in vivo and in vitro. Fluorouracil 26-30 urothelial cancer associated 1 Homo sapiens 12-16 31702387-5 2020 Functionally, knockdown of UCA1 remarkably inhibited proliferation and sensitized retinoblastoma cells to multiple chemotherapy drugs, including vincristine (VCR), carboplatin (CBP), cisplatin (DDP), VP-16 (etoposide), and 5-fluorouracil (5-Fu). Fluorouracil 239-243 urothelial cancer associated 1 Homo sapiens 27-31 31638183-0 2019 In vitro and in vivo studies on the association of long non-coding RNAs H19 and urothelial cancer associated 1 with the susceptibility to 5-fluorouracil in rectal cancer. Fluorouracil 138-152 urothelial cancer associated 1 Homo sapiens 80-110 31638183-4 2019 Bioinformatic analysis identified H19 and urothelial cancer associated 1 (UCA1) as candidate biomarkers for 5FU susceptibility. Fluorouracil 108-111 urothelial cancer associated 1 Homo sapiens 42-72 31638183-4 2019 Bioinformatic analysis identified H19 and urothelial cancer associated 1 (UCA1) as candidate biomarkers for 5FU susceptibility. Fluorouracil 108-111 urothelial cancer associated 1 Homo sapiens 74-78 31638183-6 2019 The ratios of changes of H19 and UCA1 expression in response to 5FU were low in cells resistant to 5FU, whereas ratios were high in cells susceptible to 5FU. Fluorouracil 64-67 urothelial cancer associated 1 Homo sapiens 33-37 31638183-6 2019 The ratios of changes of H19 and UCA1 expression in response to 5FU were low in cells resistant to 5FU, whereas ratios were high in cells susceptible to 5FU. Fluorouracil 99-102 urothelial cancer associated 1 Homo sapiens 33-37 31638183-6 2019 The ratios of changes of H19 and UCA1 expression in response to 5FU were low in cells resistant to 5FU, whereas ratios were high in cells susceptible to 5FU. Fluorouracil 99-102 urothelial cancer associated 1 Homo sapiens 33-37 31638183-11 2019 The increase in H19 and UCA1 expression may represent the response to impaired cell cycle in cells susceptible to 5FU. Fluorouracil 114-117 urothelial cancer associated 1 Homo sapiens 24-28 31638183-12 2019 Our results indicate that changes in H19 and UCA1 expression may be considered for predicting the susceptibility to 5FU-based NAC in rectal cancer. Fluorouracil 116-119 urothelial cancer associated 1 Homo sapiens 45-49 28969100-2 2017 Overexpression of lncRNA UCA1 correlates with resistance to chemotherapeutics such as cisplatin, gemcitabine, 5-FU, tamoxifen, imatinib and EGFR-TKIs, whereas lncRNA UCA1 knockdown restores drug sensitivity. Fluorouracil 110-114 urothelial cancer associated 1 Homo sapiens 25-29 30321081-6 2018 SND1 affected the 5-Fu-induced apoptosis levels of HCC cells by modulating the expression of UCA1 (urothelial cancer associated 1), which is a lncRNA (long non-coding RNA). Fluorouracil 18-22 urothelial cancer associated 1 Homo sapiens 93-97 30321081-6 2018 SND1 affected the 5-Fu-induced apoptosis levels of HCC cells by modulating the expression of UCA1 (urothelial cancer associated 1), which is a lncRNA (long non-coding RNA). Fluorouracil 18-22 urothelial cancer associated 1 Homo sapiens 99-129 27046651-0 2016 LncRNA-UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p. Fluorouracil 44-58 urothelial cancer associated 1 Homo sapiens 7-11 27046651-5 2016 Functional assays revealed the in vitro and in vivo growth-promoting function of UCA1 and revealed that UCA1 can decrease the sensitivity of CRC cells to 5-FU by attenuating apoptosis. Fluorouracil 154-158 urothelial cancer associated 1 Homo sapiens 104-108